Santiago Rodríguez Seguí
@rseguilab.bsky.social
Bioengineer. Group leader at the IFYBINE, CONICET-Universidad de Buenos Aires. @ifibyne #betacell #pancreas #development #regeneration
Opinions are my own.
Opinions are my own.
Hoy sábado a medianoche sale nuestra entrevista en el programa "Desde el Conocimiento" por #C5N ¡Gracias a la producción del canal por la invitación para difundir nuestro trabajo en el #IFIBYNE! Transmisión online: www.c5n.com/vivo
August 2, 2025 at 4:33 PM
Hoy sábado a medianoche sale nuestra entrevista en el programa "Desde el Conocimiento" por #C5N ¡Gracias a la producción del canal por la invitación para difundir nuestro trabajo en el #IFIBYNE! Transmisión online: www.c5n.com/vivo
Already on my way back to Argentina! Every trip must come to an end, but this one has truly been an amazing experience that will leave a lasting mark. Looking forward to consolidating the exciting new collaborations that will drive future work!
June 13, 2025 at 7:28 PM
Already on my way back to Argentina! Every trip must come to an end, but this one has truly been an amazing experience that will leave a lasting mark. Looking forward to consolidating the exciting new collaborations that will drive future work!
Amazing talks by @diegobalboa.bsky.social, @labspagnoli.bsky.social, Simona Chera and many other colleagues yesterday at @eisg2025.bsky.social ! I'm also really glad for the opportunity to share our recently published work. Looking forward to more exciting talks today!
June 13, 2025 at 6:30 AM
Amazing talks by @diegobalboa.bsky.social, @labspagnoli.bsky.social, Simona Chera and many other colleagues yesterday at @eisg2025.bsky.social ! I'm also really glad for the opportunity to share our recently published work. Looking forward to more exciting talks today!
Great opening yesterday @eisg2025.bsky.social meeting! Glad to see many interesting talks using INS-1 rat cells to study β-cell function—I couldn’t help but wonder how these treatments might affect Ri-lnc1 expression, our recently reported novel rat long non-coding RNA enriched in mature β-cells 👇
June 12, 2025 at 8:23 AM
Great opening yesterday @eisg2025.bsky.social meeting! Glad to see many interesting talks using INS-1 rat cells to study β-cell function—I couldn’t help but wonder how these treatments might affect Ri-lnc1 expression, our recently reported novel rat long non-coding RNA enriched in mature β-cells 👇
Did you know that the glucocorticoid receptor fine-tunes physiological pancreas development from the earliest progenitor stages? Below, an image worth a thousand words. Want to know more? Visit us at Poster #135 @eisg2025.bsky.social today, Wednesday, at 16:55!
June 11, 2025 at 9:03 AM
Did you know that the glucocorticoid receptor fine-tunes physiological pancreas development from the earliest progenitor stages? Below, an image worth a thousand words. Want to know more? Visit us at Poster #135 @eisg2025.bsky.social today, Wednesday, at 16:55!
Thank you, Philip Allan Seymour, for the great meeting today in Copenhagen and for contributing key experiments to our follow-up work on the role of glucocorticoids in pancreas development. Looking forward to getting this continuation story out soon!
June 10, 2025 at 10:05 PM
Thank you, Philip Allan Seymour, for the great meeting today in Copenhagen and for contributing key experiments to our follow-up work on the role of glucocorticoids in pancreas development. Looking forward to getting this continuation story out soon!
Finally! All the pieces are in place for the last stage of an amazing trip. Excited to share our results @eisg2025.bsky.social, showing that endogenous glucocorticoid receptor activation modulates early-stage cell differentiation in pancreatic progenitors of mice and humans!
June 9, 2025 at 7:45 AM
Finally! All the pieces are in place for the last stage of an amazing trip. Excited to share our results @eisg2025.bsky.social, showing that endogenous glucocorticoid receptor activation modulates early-stage cell differentiation in pancreatic progenitors of mice and humans!
It was an honor to present our most recent results on the characterization of Procr-like cells in #pancreas #development at the Shanghai Institute of Biochemistry and Cell Biology. Thank you, Dr. Yi Zeng and team, for the warm reception and the engaging perspectives!
June 7, 2025 at 2:59 AM
It was an honor to present our most recent results on the characterization of Procr-like cells in #pancreas #development at the Shanghai Institute of Biochemistry and Cell Biology. Thank you, Dr. Yi Zeng and team, for the warm reception and the engaging perspectives!
Everything is ready for the second stage of my trip. Shanghai awaits—looking forward to interesting discussions on the characterization and role of Procr-like cells in #pancreas #development! @ifibyne @ubaglobal #DiabetesResearch
June 3, 2025 at 11:42 PM
Everything is ready for the second stage of my trip. Shanghai awaits—looking forward to interesting discussions on the characterization and role of Procr-like cells in #pancreas #development! @ifibyne @ubaglobal #DiabetesResearch
It was a pleasure discussing our latest results with Prof. Cheng-Ran Xu today at Peking University and learning more about his breakthrough advances in endocrine cell specification in mice and humans. Looking forward to a productive follow-up! #StemCells #DiabetesResearch
May 30, 2025 at 8:37 AM
It was a pleasure discussing our latest results with Prof. Cheng-Ran Xu today at Peking University and learning more about his breakthrough advances in endocrine cell specification in mice and humans. Looking forward to a productive follow-up! #StemCells #DiabetesResearch
It was great to present the work of our lab at #IFIBYNE, for the Endocrinology Department at #PekingUniversity . Thank you, Wei Rui and team, for the warm welcome and very interesting feedback! Thank you #UBAInternacional for supporting this #InternationalResearch between #Argentina & #China.
May 26, 2025 at 2:44 PM
It was great to present the work of our lab at #IFIBYNE, for the Endocrinology Department at #PekingUniversity . Thank you, Wei Rui and team, for the warm welcome and very interesting feedback! Thank you #UBAInternacional for supporting this #InternationalResearch between #Argentina & #China.
Ten years ago we reported TEAD/YAP as pancreas development gatekeepers in mouse and human. Now we propose adding Glucocorticoid Receptor (GR) to this selective club - with one key difference! It plays the opposite role: GR activation (→ nuclear localization) promotes progenitor differentiation.
May 26, 2025 at 6:11 AM
Ten years ago we reported TEAD/YAP as pancreas development gatekeepers in mouse and human. Now we propose adding Glucocorticoid Receptor (GR) to this selective club - with one key difference! It plays the opposite role: GR activation (→ nuclear localization) promotes progenitor differentiation.
Balanced work & relaxation today—excited to present the work of our lab @ifibyne tomorrow at Peking University Third Hospital’s Endocrinology Department! #BetaCell #DiabetesResearch #StemCells
May 25, 2025 at 10:36 AM
Balanced work & relaxation today—excited to present the work of our lab @ifibyne tomorrow at Peking University Third Hospital’s Endocrinology Department! #BetaCell #DiabetesResearch #StemCells
Everything is ready for my first-day visit to the lab of Prof. WEI Rui at Peking University!
May 21, 2025 at 12:31 AM
Everything is ready for my first-day visit to the lab of Prof. WEI Rui at Peking University!
Embarking on my most epic trip yet—looking forward to exploring new collaborations for our lab @ifibyne in Beijing and Shanghai, and to presenting our latest lab results @eisg2025.bsky.social on my way back!
May 18, 2025 at 11:06 PM
Embarking on my most epic trip yet—looking forward to exploring new collaborations for our lab @ifibyne in Beijing and Shanghai, and to presenting our latest lab results @eisg2025.bsky.social on my way back!
6/ Our findings position the GR pathway as an endogenous developmental modulator of early-stage pancreatic progenitor cell differentiation and provide insights into the underlying transcriptional mechanisms involved.
May 15, 2025 at 7:27 PM
6/ Our findings position the GR pathway as an endogenous developmental modulator of early-stage pancreatic progenitor cell differentiation and provide insights into the underlying transcriptional mechanisms involved.
5/ At later in vitro differentiation stages, GR activation enhanced NEUROG3 and NKX2.2 expression in bipotent-like pancreatic progenitors
May 15, 2025 at 7:27 PM
5/ At later in vitro differentiation stages, GR activation enhanced NEUROG3 and NKX2.2 expression in bipotent-like pancreatic progenitors
4/ Our combined epigenomic and single-cell transcriptomic analyses suggest that these novel marker genes may play important roles in human pancreas development.
May 15, 2025 at 7:27 PM
4/ Our combined epigenomic and single-cell transcriptomic analyses suggest that these novel marker genes may play important roles in human pancreas development.
3/ Surprisingly, GR activation in human in vitro-derived MPCs steers lineage commitment toward a bipotent/endocrine trajectory and upregulates novel genes with expression profiles resembling SOX9 & HES1 during embryonic pancreatic endocrine fate choice.
May 15, 2025 at 7:27 PM
3/ Surprisingly, GR activation in human in vitro-derived MPCs steers lineage commitment toward a bipotent/endocrine trajectory and upregulates novel genes with expression profiles resembling SOX9 & HES1 during embryonic pancreatic endocrine fate choice.
2/ In mouse pancreatic explants, ectopic GR activation by dexamethasone (Dex) globally promotes multipotent pancreatic progenitor cell (MPC) commitment to the acinar fate.
May 15, 2025 at 7:27 PM
2/ In mouse pancreatic explants, ectopic GR activation by dexamethasone (Dex) globally promotes multipotent pancreatic progenitor cell (MPC) commitment to the acinar fate.
1/ We show that, under physiological conditions, the glucocorticoid receptor (GR) is selectively active in mouse pro-acinar and early endocrine cells from E11.5, silenced in bipotent progenitors, and reactivated during endocrine commitment.
May 15, 2025 at 7:27 PM
1/ We show that, under physiological conditions, the glucocorticoid receptor (GR) is selectively active in mouse pro-acinar and early endocrine cells from E11.5, silenced in bipotent progenitors, and reactivated during endocrine commitment.
Thrilled to announce a major milestone for our lab @ifibyne @Exactas_UBA — our paper on the glucocorticoid receptor's role in early pancreas development is now published in @Dev_journal!
Huge thanks to @vallierlab.bsky.social for this long-term collaboration!👇🧵
🔗 doi.org/10.1242/dev....
Huge thanks to @vallierlab.bsky.social for this long-term collaboration!👇🧵
🔗 doi.org/10.1242/dev....
May 15, 2025 at 7:27 PM
Thrilled to announce a major milestone for our lab @ifibyne @Exactas_UBA — our paper on the glucocorticoid receptor's role in early pancreas development is now published in @Dev_journal!
Huge thanks to @vallierlab.bsky.social for this long-term collaboration!👇🧵
🔗 doi.org/10.1242/dev....
Huge thanks to @vallierlab.bsky.social for this long-term collaboration!👇🧵
🔗 doi.org/10.1242/dev....
5/ At later in vitro differentiation stages, GR activation enhanced NEUROG3 and NKX2.2 expression in bipotent-like pancreatic progenitors
May 15, 2025 at 7:22 PM
5/ At later in vitro differentiation stages, GR activation enhanced NEUROG3 and NKX2.2 expression in bipotent-like pancreatic progenitors
4/ Our combined epigenomic and single-cell transcriptomic analyses suggest that these novel marker genes may play important roles in human pancreas development.
May 15, 2025 at 7:22 PM
4/ Our combined epigenomic and single-cell transcriptomic analyses suggest that these novel marker genes may play important roles in human pancreas development.
3/ Surprisingly, GR activation in human in vitro-derived MPCs steers lineage commitment toward a bipotent/endocrine trajectory and upregulates novel genes with expression profiles resembling SOX9 & HES1 during embryonic pancreatic endocrine fate choice.
May 15, 2025 at 7:22 PM
3/ Surprisingly, GR activation in human in vitro-derived MPCs steers lineage commitment toward a bipotent/endocrine trajectory and upregulates novel genes with expression profiles resembling SOX9 & HES1 during embryonic pancreatic endocrine fate choice.