Anna Gloyn
@annagloyn.bsky.social
Professor of Pediatrics (Endocrinology) & Genetics @stanford
Interested in diabetes /human genetics / islet biology / precision medicine
Women in science 🧬🧫🔬
Interested in diabetes /human genetics / islet biology / precision medicine
Women in science 🧬🧫🔬
Reposted by Anna Gloyn
Anna Gloyn (@annagloyn.bsky.social), Jie Liu, Noel Burtt, and Marcela Brissova from the PanKbase team gave a webinar for the HIRN webinar series. If you missed it and want to know how PanKbase might help compliment your type I diabetes research, watch it here: youtu.be/3qLiBdIOJhY?...
HIRN Webinar: PanKbase: A Centralized Knowledge Base of the Human Pancreas for Diabetes Research
YouTube video by Human Islet Research Network
youtu.be
September 5, 2025 at 5:06 PM
Anna Gloyn (@annagloyn.bsky.social), Jie Liu, Noel Burtt, and Marcela Brissova from the PanKbase team gave a webinar for the HIRN webinar series. If you missed it and want to know how PanKbase might help compliment your type I diabetes research, watch it here: youtu.be/3qLiBdIOJhY?...
Reposted by Anna Gloyn
It's a big day at the Academy as we welcome our 2025 Fellows 🎉
We’re celebrating 54 remarkable scientists joining our esteemed Fellowship of 1,450 leading researchers.
📣 Meet our new Fellows: ow.ly/VtGs50WmPqc
🌟 And our Honorary Fellows: ow.ly/4syL50WmPyi
And stay tuned for highlights!
We’re celebrating 54 remarkable scientists joining our esteemed Fellowship of 1,450 leading researchers.
📣 Meet our new Fellows: ow.ly/VtGs50WmPqc
🌟 And our Honorary Fellows: ow.ly/4syL50WmPyi
And stay tuned for highlights!
July 9, 2025 at 9:13 AM
It's a big day at the Academy as we welcome our 2025 Fellows 🎉
We’re celebrating 54 remarkable scientists joining our esteemed Fellowship of 1,450 leading researchers.
📣 Meet our new Fellows: ow.ly/VtGs50WmPqc
🌟 And our Honorary Fellows: ow.ly/4syL50WmPyi
And stay tuned for highlights!
We’re celebrating 54 remarkable scientists joining our esteemed Fellowship of 1,450 leading researchers.
📣 Meet our new Fellows: ow.ly/VtGs50WmPqc
🌟 And our Honorary Fellows: ow.ly/4syL50WmPyi
And stay tuned for highlights!
Reposted by Anna Gloyn
🎉 Our New Fellows Admissions Day is in full swing!
We're welcoming an inspiring group of leaders advancing research and shaping the future of medicine! 💡
We're welcoming an inspiring group of leaders advancing research and shaping the future of medicine! 💡
July 9, 2025 at 5:13 PM
🎉 Our New Fellows Admissions Day is in full swing!
We're welcoming an inspiring group of leaders advancing research and shaping the future of medicine! 💡
We're welcoming an inspiring group of leaders advancing research and shaping the future of medicine! 💡
Reposted by Anna Gloyn
Really proud of this Exeter–Stanford collaboration identifying bi-allelic variants in PAX4 as a novel cause of transient neonatal diabetes—the first new genetic cause of this subtype described in over a decade. This work expands our understanding of beta cell development.
🔗 doi.org/10.1016/j.mo...
🔗 doi.org/10.1016/j.mo...
Complete Loss of PAX4 causes Transient Neonatal Diabetes in Humans
Gene discovery studies in individuals with diabetes diagnosed within 6 months of life (neonatal diabetes, NDM) can provide unique insights into the de…
www.sciencedirect.com
July 3, 2025 at 2:23 PM
Really proud of this Exeter–Stanford collaboration identifying bi-allelic variants in PAX4 as a novel cause of transient neonatal diabetes—the first new genetic cause of this subtype described in over a decade. This work expands our understanding of beta cell development.
🔗 doi.org/10.1016/j.mo...
🔗 doi.org/10.1016/j.mo...
Reposted by Anna Gloyn
Our DEG explorer enables interactive visualizations of differential gene expression within human pancreatic islets. Data was generated from the integrated single-cell RNA sequencing from 140 human donors sourced from HPAP, IIDP, and Prodo. Check out the tutorial here: youtu.be/jL8SgEMF_sg?...
PanKbase Differential Gene Expression Browser - June 2025
YouTube video by PanKbase
youtu.be
July 3, 2025 at 4:55 PM
Our DEG explorer enables interactive visualizations of differential gene expression within human pancreatic islets. Data was generated from the integrated single-cell RNA sequencing from 140 human donors sourced from HPAP, IIDP, and Prodo. Check out the tutorial here: youtu.be/jL8SgEMF_sg?...
Reposted by Anna Gloyn
Please check out our new paper on bioRxiv evaluating genetic background influences on heterogenous responses to S64F MAFA!: www.biorxiv.org/content/10.1...
Genetic background influences the heterogeneous phenotypes driven by the MAFAS64F MODY variant in male mice
Pancreatic β-cells require several key factors to appropriately secrete insulin to maintain euglycemia. One such factor is MafA, a transcription factor fundamental to β-cell function. We previously id...
www.biorxiv.org
May 25, 2025 at 7:44 PM
Please check out our new paper on bioRxiv evaluating genetic background influences on heterogenous responses to S64F MAFA!: www.biorxiv.org/content/10.1...
Reposted by Anna Gloyn
Thrilled and honored to be a part of this amazing session on rare genetics and GWAS in diabetes with @Romina39356029 @annagloyn.bsky.social and @miriam_udler ! #ADA2025
June 23, 2025 at 2:56 PM
Thrilled and honored to be a part of this amazing session on rare genetics and GWAS in diabetes with @Romina39356029 @annagloyn.bsky.social and @miriam_udler ! #ADA2025
Reposted by Anna Gloyn
Dr. Anna Gloyn at #ADA2025: Multiomic data reveals diabetes heterogeneity, linking polygenic scores, islet traits, and regulatory networks.
@amdiabetesassn.bsky.social @annagloyn.bsky.social
#ADASciSessions #T2D #genomics #multiomics
@amdiabetesassn.bsky.social @annagloyn.bsky.social
#ADASciSessions #T2D #genomics #multiomics
June 23, 2025 at 4:04 AM
Dr. Anna Gloyn at #ADA2025: Multiomic data reveals diabetes heterogeneity, linking polygenic scores, islet traits, and regulatory networks.
@amdiabetesassn.bsky.social @annagloyn.bsky.social
#ADASciSessions #T2D #genomics #multiomics
@amdiabetesassn.bsky.social @annagloyn.bsky.social
#ADASciSessions #T2D #genomics #multiomics
Reposted by Anna Gloyn
PanKbase #ADA spotlight: PanKbase PI, Dr. Jie Liu, Associate Professor of Computational Medicine and Bioinformatics
Michigan Medical School will be presenting during the session "Decoding Diabetes—AI-Driven Advances in Genetic Research". June 23rd 3:15 PM - 4:15 PM. Look forward to seeing you there!
Michigan Medical School will be presenting during the session "Decoding Diabetes—AI-Driven Advances in Genetic Research". June 23rd 3:15 PM - 4:15 PM. Look forward to seeing you there!
June 16, 2025 at 2:25 PM
PanKbase #ADA spotlight: PanKbase PI, Dr. Jie Liu, Associate Professor of Computational Medicine and Bioinformatics
Michigan Medical School will be presenting during the session "Decoding Diabetes—AI-Driven Advances in Genetic Research". June 23rd 3:15 PM - 4:15 PM. Look forward to seeing you there!
Michigan Medical School will be presenting during the session "Decoding Diabetes—AI-Driven Advances in Genetic Research". June 23rd 3:15 PM - 4:15 PM. Look forward to seeing you there!
Reposted by Anna Gloyn
Edit to the time, Julie will now be presenting at 5:30pm.
June 16, 2025 at 8:13 PM
Edit to the time, Julie will now be presenting at 5:30pm.
Reposted by Anna Gloyn
PanKbase #ADA poster alert!!! Dr. Ha Vu (@hahvu.bsky.social) will be presenting her work on our PanKbase platform: "PanKbase Integrated Single-Cell Map—A Comprehensive Atlas of Human Pancreatic Islets Unlocking Insights into Type 1 and Type 2 Diabetes" Sunday, June 22 at 12:30p CT (Poster 2121-LB).
June 17, 2025 at 1:06 PM
PanKbase #ADA poster alert!!! Dr. Ha Vu (@hahvu.bsky.social) will be presenting her work on our PanKbase platform: "PanKbase Integrated Single-Cell Map—A Comprehensive Atlas of Human Pancreatic Islets Unlocking Insights into Type 1 and Type 2 Diabetes" Sunday, June 22 at 12:30p CT (Poster 2121-LB).
Reposted by Anna Gloyn
Planning your #ADA2025 visit? Don’t miss the NIDDK #DataScience Corner hosted by #dkNET!
📍 Between ADA Member Lounge & Product Theater 1
🗓 Visit during the reception or exhibit hours
🎉 Celebrate 75 years of #NIDDK!
🔗 dknet.org/data-science...
#ADASciSessions
📍 Between ADA Member Lounge & Product Theater 1
🗓 Visit during the reception or exhibit hours
🎉 Celebrate 75 years of #NIDDK!
🔗 dknet.org/data-science...
#ADASciSessions
June 17, 2025 at 2:45 PM
Planning your #ADA2025 visit? Don’t miss the NIDDK #DataScience Corner hosted by #dkNET!
📍 Between ADA Member Lounge & Product Theater 1
🗓 Visit during the reception or exhibit hours
🎉 Celebrate 75 years of #NIDDK!
🔗 dknet.org/data-science...
#ADASciSessions
📍 Between ADA Member Lounge & Product Theater 1
🗓 Visit during the reception or exhibit hours
🎉 Celebrate 75 years of #NIDDK!
🔗 dknet.org/data-science...
#ADASciSessions
Reposted by Anna Gloyn
Welcome to Chicago! If you're at the 85th Scientific Sessions of the #ADA, stop by the PanKbase booth 1047 in the exhibit hall to learn about the our updated single cell browser, ask questions, or give us feedback. youtu.be/sNEGvSIjh3M?...
PanKbase Single Cell Browser Tutorial - June 2025
YouTube video by PanKbase
youtu.be
June 20, 2025 at 2:09 AM
Welcome to Chicago! If you're at the 85th Scientific Sessions of the #ADA, stop by the PanKbase booth 1047 in the exhibit hall to learn about the our updated single cell browser, ask questions, or give us feedback. youtu.be/sNEGvSIjh3M?...
Reposted by Anna Gloyn
Romina Bevacqua and PanKbase PI Anna Gloyn (@annagloyn.bsky.social) preview the presentations of #ADA session Genetic Regulation of Beta-Cell Mass and Function in Humans—Lessons from GWAS and Rare Genetics happening June 22, at 1:30 p.m. CT in Room W194 AB www.adameetingnews.org/genetic-regu...
Genetic Regulation of Beta-Cell Mass and Function in Humans—Lessons from GWAS and Rare Genetics - ADA Meeting News
Anna Gloyn, DPhil, and Romina J. Bevacqua, PhD, preview presentations at the 85th Scientific Sessions. Attendees in Chicago can watch the session in-person Sunday, June 22, at 1:30 p.m. CT.
www.adameetingnews.org
June 18, 2025 at 9:54 PM
Romina Bevacqua and PanKbase PI Anna Gloyn (@annagloyn.bsky.social) preview the presentations of #ADA session Genetic Regulation of Beta-Cell Mass and Function in Humans—Lessons from GWAS and Rare Genetics happening June 22, at 1:30 p.m. CT in Room W194 AB www.adameetingnews.org/genetic-regu...
Reposted by Anna Gloyn
Check out the platform at pankbase.org. Come see us at the 85th Scientific Sessions of the American Diabetes Association #ADA2025 #DataScience Booth 1047!!! We'd love to discuss more what we're doing and hear your feedback.
PanKbase | PanKBase
pankbase.org
June 2, 2025 at 6:10 PM
Check out the platform at pankbase.org. Come see us at the 85th Scientific Sessions of the American Diabetes Association #ADA2025 #DataScience Booth 1047!!! We'd love to discuss more what we're doing and hear your feedback.
Reposted by Anna Gloyn
What is PanKbase? Watch our introduction video to find out: youtu.be/glGHni2tXGg?....
PanKbase Introduction Video
YouTube video by PanKbase
youtu.be
June 2, 2025 at 6:10 PM
What is PanKbase? Watch our introduction video to find out: youtu.be/glGHni2tXGg?....
Reposted by Anna Gloyn
We're less than two weeks away from #ADA2025. PanKbase, booth 1047 will be located in the NIDDK #DataScience corner. Come see us to learn more about the platform and meet the PanKbase team.
June 9, 2025 at 7:24 PM
We're less than two weeks away from #ADA2025. PanKbase, booth 1047 will be located in the NIDDK #DataScience corner. Come see us to learn more about the platform and meet the PanKbase team.
Reposted by Anna Gloyn
PanKbase #ADA2025 spotlight: PI @annagloyn.bsky.social presents Sun. the 22nd at 2pm CDT. Session: Genetic Regulation of Beta-Cell Mass and Function in Humans: Lessons from GWAS and Rare Genetics. Her talk: "Integrating Multiomic Data to Understand Complex Gene Regulatory Networks in Islets"
June 10, 2025 at 1:48 PM
PanKbase #ADA2025 spotlight: PI @annagloyn.bsky.social presents Sun. the 22nd at 2pm CDT. Session: Genetic Regulation of Beta-Cell Mass and Function in Humans: Lessons from GWAS and Rare Genetics. Her talk: "Integrating Multiomic Data to Understand Complex Gene Regulatory Networks in Islets"
Reposted by Anna Gloyn
Progress in Polygenic Risk Scores (PRS), which take multiple disease-modifying variants into account, are increasingly powerful tools to identify, predict and classify #diabetes mellitus @natrevendo.nature.com www.nature.com/articles/s41...
Diabetes mellitus polygenic risk scores: heterogeneity and clinical translation - Nature Reviews Endocrinology
In this Review, the authors discuss different methods for assessing polygenic risk of diabetes mellitus and the utility of polygenic risk scores in classifying and screening for diabetes mellitus. The...
www.nature.com
June 4, 2025 at 6:59 PM
Progress in Polygenic Risk Scores (PRS), which take multiple disease-modifying variants into account, are increasingly powerful tools to identify, predict and classify #diabetes mellitus @natrevendo.nature.com www.nature.com/articles/s41...
Reposted by Anna Gloyn
📣 Latest from the lab: Performance of deep-learning-based approaches to improve polygenic scores www.nature.com/articles/s41...
Its thought deep learning will substantially improve PGS but the reality is MANY have tried but no/little gain has been seen so far. Here we report our negative results.
Its thought deep learning will substantially improve PGS but the reality is MANY have tried but no/little gain has been seen so far. Here we report our negative results.
June 5, 2025 at 1:37 PM
📣 Latest from the lab: Performance of deep-learning-based approaches to improve polygenic scores www.nature.com/articles/s41...
Its thought deep learning will substantially improve PGS but the reality is MANY have tried but no/little gain has been seen so far. Here we report our negative results.
Its thought deep learning will substantially improve PGS but the reality is MANY have tried but no/little gain has been seen so far. Here we report our negative results.
Reposted by Anna Gloyn
Wishing I were Ferris!
🤯 40 years ago!
🤯 40 years ago!
June 5, 2025 at 3:31 PM
Wishing I were Ferris!
🤯 40 years ago!
🤯 40 years ago!
Reposted by Anna Gloyn
New content online: Diabetes mellitus polygenic risk scores: heterogeneity and clinical translation
Diabetes mellitus polygenic risk scores: heterogeneity and clinical translation
Nature Reviews Endocrinology, Published online: 04 June 2025; doi:10.1038/s41574-025-01132-wIn this Review, the authors discuss different methods for assessing polygenic risk of diabetes mellitus and the utility of polygenic risk scores in classifying and screening for diabetes mellitus. The current limitations of these scores and ways of overcoming these limitations are also covered.
www.nature.com
June 4, 2025 at 2:43 PM
New content online: Diabetes mellitus polygenic risk scores: heterogeneity and clinical translation
Out today from #HectorOrtega & #SethASharp A state of the art review on polygenic risk scores (#PRS) in diabetes. This is your #101 on what we currently know about them and their application to understanding disease heterogeneity & clinical translation.
Read for free here - rdcu.be/eprel
Read for free here - rdcu.be/eprel
June 4, 2025 at 11:22 PM
Out today from #HectorOrtega & #SethASharp A state of the art review on polygenic risk scores (#PRS) in diabetes. This is your #101 on what we currently know about them and their application to understanding disease heterogeneity & clinical translation.
Read for free here - rdcu.be/eprel
Read for free here - rdcu.be/eprel
Honoured to have been elected to the fellowship and excited to contribute to the academy’s mission. This recognition reflects the amazing scientific community I am part of and the incredible trainees and collaborators I’m privileged to work with. Thankful 🙏
Congratulations to the 54 exceptional scientists who have been elected to the Academy Fellowship today in recognition of their remarkable contributions to biomedical and health sciences 🎉
👉 Discover more: ow.ly/Cf7K50VWSRi
#HealthResearch #HealthInnovation #AcademyFellows
👉 Discover more: ow.ly/Cf7K50VWSRi
#HealthResearch #HealthInnovation #AcademyFellows
May 22, 2025 at 6:47 PM
Honoured to have been elected to the fellowship and excited to contribute to the academy’s mission. This recognition reflects the amazing scientific community I am part of and the incredible trainees and collaborators I’m privileged to work with. Thankful 🙏
Reposted by Anna Gloyn
Our new paper updating GRS2 with a new tool to easily generate standardised T1DGRS 🧬 Thanks to Seth Sharp, @annagloyn.bsky.social, Richard Oram and @mnweedon.bsky.social for a great collaboration! tinyurl.com/4bsaz9hx
Standardized Measurement of Type 1 Diabetes Polygenic Risk Across Multiancestry Population Cohorts
Amber M. Luckett, Richard A. Oram, Aaron J. Deutsch, Hector I. Ortega, Diane P. Fraser, Kaavya Ashok, Alisa K. Manning, Josep M. Mercader, Manuel A. Rivas,
tinyurl.com
April 25, 2025 at 10:44 AM
Our new paper updating GRS2 with a new tool to easily generate standardised T1DGRS 🧬 Thanks to Seth Sharp, @annagloyn.bsky.social, Richard Oram and @mnweedon.bsky.social for a great collaboration! tinyurl.com/4bsaz9hx