Nico Franzmeier
@nfranzme.bsky.social
Neuroimaging Researcher | LMU Munich | Institute for Stroke and Dementia Research | studying disease mechanisms in Alzheimer’s disease and primary tauopathies
Pinned
Nico Franzmeier
@nfranzme.bsky.social
· Mar 18
Alpha synuclein co-pathology is associated with accelerated amyloid-driven tau accumulation in Alzheimer’s disease - Molecular Neurodegeneration
Background Aggregated alpha-Synuclein (αSyn) is a hallmark pathology in Parkinson’s disease but also one of the most common co-pathologies in Alzheimer’s disease (AD). Preclinical studies suggest that...
doi.org
Excited to share our new work in Molecular Neurodegeneration, showing that α-synuclein co-pathology is common in Alzheimer’s and accelerates amyloid-related tau accumulation, supporting its role as a tau co-aggregation factor.
doi.org/10.1186/s130...
doi.org/10.1186/s130...
New paper out!
We systematically compared how ATN biomarker changes track cognitive decline in AD:
Tau-PET, plasma ptau217 & cortical thickness changes track cognition, amyloid-PET does not.
Ptau217 = cost-effective proxy for monitoring cognitive changes in AD
doi.org/10.1002/alz....
We systematically compared how ATN biomarker changes track cognitive decline in AD:
Tau-PET, plasma ptau217 & cortical thickness changes track cognition, amyloid-PET does not.
Ptau217 = cost-effective proxy for monitoring cognitive changes in AD
doi.org/10.1002/alz....
A systematic comparison of ATN biomarkers for monitoring longitudinal cognitive changes in Alzheimer's disease
INTRODUCTION
With anti-amyloid beta (Aβ) therapies approved for Alzheimer's disease (AD), surrogate biomarkers are needed to monitor clinical treatment efficacy. Therefore, we systematically compare.....
doi.org
October 25, 2025 at 5:26 AM
New paper out!
We systematically compared how ATN biomarker changes track cognitive decline in AD:
Tau-PET, plasma ptau217 & cortical thickness changes track cognition, amyloid-PET does not.
Ptau217 = cost-effective proxy for monitoring cognitive changes in AD
doi.org/10.1002/alz....
We systematically compared how ATN biomarker changes track cognitive decline in AD:
Tau-PET, plasma ptau217 & cortical thickness changes track cognition, amyloid-PET does not.
Ptau217 = cost-effective proxy for monitoring cognitive changes in AD
doi.org/10.1002/alz....
Reposted by Nico Franzmeier
I'm thrilled that our paper "Personalised regional modelling predicts tau progression in the human brain" is finally published in PLoS Biology!
Here's a short thread about the main findings of the paper...
Here's a short thread about the main findings of the paper...
Accumulation of aggregated tau shows a complex spatio-temporal pattern during #AlzheimersDisease, but why? @pavanchaggar.bsky.social @alaingoriely.bsky.social &co describes #TauProtein dynamics in AD, showing stage-specific shifts in production & transport @plosbiology.org 🧪 plos.io/4kNA6vX
![Simulated transport and production dynamics in the local FKPP model. Left: Simulation from the local FKPP model using carrying capacities derived from Gaussian mixture models (shown top right). Each line in the middle panel represents the SUVR trajectory of one DK atlas brain region. Values at time points years are projected onto a cortical rendering in the top panel. Each line in the bottom panel represents concentration averaged over Braak regions. Top right: Two component Gaussian mixture model fit to a multi-cohort tau PET dataset [24] and data from ADNI for right inferior temporal lobe. Bottom right: Right hemisphere cortical rendering of the SUVR carrying capacities as determined through Gaussian mixture modelling.](https://cdn.bsky.app/img/feed_thumbnail/plain/did:plc:5522ztebtekoor5efelihqhb/bafkreidvyyx2seiwefemwo6bvbfw6q7chuhw627ppxyixeminyueea7tzq@jpeg)
August 11, 2025 at 2:39 PM
I'm thrilled that our paper "Personalised regional modelling predicts tau progression in the human brain" is finally published in PLoS Biology!
Here's a short thread about the main findings of the paper...
Here's a short thread about the main findings of the paper...
Reposted by Nico Franzmeier
🚨Postdoc position open at @BarcelonaBeta🚨
We're looking someone to work on a project at the intersection of cardiovascular and neurodegenerative research 🫀🧠
Fully funded position!!!
More details: www.imim.cat/media/upload...
Please share!
#Alzheimer's #ENDALZ
We're looking someone to work on a project at the intersection of cardiovascular and neurodegenerative research 🫀🧠
Fully funded position!!!
More details: www.imim.cat/media/upload...
Please share!
#Alzheimer's #ENDALZ
www.imim.cat
September 18, 2025 at 1:24 PM
🚨Postdoc position open at @BarcelonaBeta🚨
We're looking someone to work on a project at the intersection of cardiovascular and neurodegenerative research 🫀🧠
Fully funded position!!!
More details: www.imim.cat/media/upload...
Please share!
#Alzheimer's #ENDALZ
We're looking someone to work on a project at the intersection of cardiovascular and neurodegenerative research 🫀🧠
Fully funded position!!!
More details: www.imim.cat/media/upload...
Please share!
#Alzheimer's #ENDALZ
Reposted by Nico Franzmeier
I have just dropped a new version of my academicdb project, which helps prolific researchers generate a CV automatically. Now with a web interface! If you are interested, please try it out and let me know what you think - it takes a bit of setup work but then runs easily using Docker.
GitHub - poldrack/academicdb: Project to maintain a database for CV/website rendering
Project to maintain a database for CV/website rendering - poldrack/academicdb
github.com
September 18, 2025 at 7:39 PM
I have just dropped a new version of my academicdb project, which helps prolific researchers generate a CV automatically. Now with a web interface! If you are interested, please try it out and let me know what you think - it takes a bit of setup work but then runs easily using Docker.
Out now in Brain: Our new study shows that tau deposits in Alzheimer’s disease not affect gray matter but also drive degeneration of connected white matter tracts, offering mechanistic insight into how tau disrupts brain networks
academic.oup.com/brain/articl...
academic.oup.com/brain/articl...
September 15, 2025 at 7:55 AM
Out now in Brain: Our new study shows that tau deposits in Alzheimer’s disease not affect gray matter but also drive degeneration of connected white matter tracts, offering mechanistic insight into how tau disrupts brain networks
academic.oup.com/brain/articl...
academic.oup.com/brain/articl...
Reposted by Nico Franzmeier
🔥Recent advances in #neuroimaging of #Alzheimers disease 🧠✨
dx.doi.org/10.1002/alz....
➡️ Valuable resource for both researchers & clinicians!
➡️ ATNIV biomarkers, staging, connectomics & more
➡️ Plus: how are sex & country represented in first/last authorship?
@istaart.bsky.social Neuroimaging PIA
dx.doi.org/10.1002/alz....
➡️ Valuable resource for both researchers & clinicians!
➡️ ATNIV biomarkers, staging, connectomics & more
➡️ Plus: how are sex & country represented in first/last authorship?
@istaart.bsky.social Neuroimaging PIA
September 9, 2025 at 7:38 PM
🔥Recent advances in #neuroimaging of #Alzheimers disease 🧠✨
dx.doi.org/10.1002/alz....
➡️ Valuable resource for both researchers & clinicians!
➡️ ATNIV biomarkers, staging, connectomics & more
➡️ Plus: how are sex & country represented in first/last authorship?
@istaart.bsky.social Neuroimaging PIA
dx.doi.org/10.1002/alz....
➡️ Valuable resource for both researchers & clinicians!
➡️ ATNIV biomarkers, staging, connectomics & more
➡️ Plus: how are sex & country represented in first/last authorship?
@istaart.bsky.social Neuroimaging PIA
Very happy to share our 2nd paper today, led by Lukas Frontzkowski: We developed a novel data driven reference region for PI-2620 PET tailored to assess 4R tauopathies, improving i) PSP vs. control separation and ii) PET associations with clinical scores
doi.org/10.1007/s002...
doi.org/10.1007/s002...
June 10, 2025 at 1:39 PM
Very happy to share our 2nd paper today, led by Lukas Frontzkowski: We developed a novel data driven reference region for PI-2620 PET tailored to assess 4R tauopathies, improving i) PSP vs. control separation and ii) PET associations with clinical scores
doi.org/10.1007/s002...
doi.org/10.1007/s002...
Happy to share our new work by Carla Palleis in Movement Disorders showing that brain networks shape neurodegeneration patterns in PSP
=> This suggests that grey matter atrophy expands across connected brain regions, potentially following tau accumulation in PSP
doi.org/10.1002/mds....
=> This suggests that grey matter atrophy expands across connected brain regions, potentially following tau accumulation in PSP
doi.org/10.1002/mds....
June 10, 2025 at 1:24 PM
Happy to share our new work by Carla Palleis in Movement Disorders showing that brain networks shape neurodegeneration patterns in PSP
=> This suggests that grey matter atrophy expands across connected brain regions, potentially following tau accumulation in PSP
doi.org/10.1002/mds....
=> This suggests that grey matter atrophy expands across connected brain regions, potentially following tau accumulation in PSP
doi.org/10.1002/mds....
Reposted by Nico Franzmeier
Alzheimer's disease drug development pipeline: 2025 - Cummings - 2025 - Alzheimer's & Dementia: Translational Research & Clinical Interventions - Wiley Online Library alz-journals.onlinelibrary.wiley.com/doi/10.1002/...
Alzheimer's disease drug development pipeline: 2025
Clinical trials for Alzheimer's disease (AD) must be registered on clinicaltrials.gov. The registry presents a variety of types of information related to the planned clinical trial. We assess clinic...
alz-journals.onlinelibrary.wiley.com
June 4, 2025 at 7:12 PM
Alzheimer's disease drug development pipeline: 2025 - Cummings - 2025 - Alzheimer's & Dementia: Translational Research & Clinical Interventions - Wiley Online Library alz-journals.onlinelibrary.wiley.com/doi/10.1002/...
Reposted by Nico Franzmeier
“I would like to cure brain cancer. I think that's not particularly controversial.” Be that as it may, the NIH terminated that scientist's grant. Here's a huge survey of the 2,500 grants that NIH has killed or delayed...so far. Gift link: nyti.ms/43Jz1yJ
June 4, 2025 at 2:30 PM
“I would like to cure brain cancer. I think that's not particularly controversial.” Be that as it may, the NIH terminated that scientist's grant. Here's a huge survey of the 2,500 grants that NIH has killed or delayed...so far. Gift link: nyti.ms/43Jz1yJ
Reposted by Nico Franzmeier
This is a well done study! congrats www.cell.com/cell-reports...
Astrocyte induction of disease-associated microglia is suppressed by acute exposure to fAD neurons in human iPSC triple cultures
Lish et al. present a co-culture system of iPSC-derived human microglia, astrocytes,
and neurons to investigate intercellular communication across different environmental
and genetic contexts. Transcr...
www.cell.com
June 5, 2025 at 4:03 AM
This is a well done study! congrats www.cell.com/cell-reports...
Reposted by Nico Franzmeier
Hiring! We're looking for a postdoc to join my lab at the @ukdri.ac.uk @ucl.ac.uk We’re investigating neuronal and circuit dysfunction in Alzheimer's, and developing innovative new treatments.
Apply here👇
shorturl.at/LpCAq
Apply here👇
shorturl.at/LpCAq
UCL – University College London
UCL is consistently ranked as one of the top ten universities in the world (QS World University Rankings 2010-2022) and is No.2 in the UK for research power (Research Excellence Framework 2021).
shorturl.at
May 16, 2025 at 8:48 AM
Hiring! We're looking for a postdoc to join my lab at the @ukdri.ac.uk @ucl.ac.uk We’re investigating neuronal and circuit dysfunction in Alzheimer's, and developing innovative new treatments.
Apply here👇
shorturl.at/LpCAq
Apply here👇
shorturl.at/LpCAq
Reposted by Nico Franzmeier
Our latest work, published in @cellpress.bsky.social, identifies a rare soluble #tau species in human #Alzheimer’s brain that suppresses CA1 complex-spike bursting, a hippocampal neuronal firing pattern that is critical for learning and memory.
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
Alzheimer’s disease patient-derived high-molecular-weight tau impairs bursting in hippocampal neurons
In mouse models, tau impairs neuronal complex spike bursting and associated network
processes in hippocampus CA1 alongside CaV2.3 downregulation. Soluble high-molecular-weight
tau species drive these ...
www.cell.com
April 28, 2025 at 10:35 PM
Our latest work, published in @cellpress.bsky.social, identifies a rare soluble #tau species in human #Alzheimer’s brain that suppresses CA1 complex-spike bursting, a hippocampal neuronal firing pattern that is critical for learning and memory.
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
Reposted by Nico Franzmeier
Super excited to announce a PhD position on polypathology in the medial temporal lobe at the Paris Brain Institute together with @nvillain-alz.bsky.social and @robindeflores.bsky.social!
offres.institutducerveau-icm.org/fr/jobs/1935...
Please repost!
offres.institutducerveau-icm.org/fr/jobs/1935...
Please repost!
Nos super offres || PhD - polypathology in the medial temporal lobe
offres.institutducerveau-icm.org
April 23, 2025 at 7:16 AM
Super excited to announce a PhD position on polypathology in the medial temporal lobe at the Paris Brain Institute together with @nvillain-alz.bsky.social and @robindeflores.bsky.social!
offres.institutducerveau-icm.org/fr/jobs/1935...
Please repost!
offres.institutducerveau-icm.org/fr/jobs/1935...
Please repost!
Reposted by Nico Franzmeier
When I was a student, I dreamed of one day publishing in Trends In Neurosciences. So I'm proud that we had the opportunity to write an invited review on BIN1, a major genetic determinant of Alzheimer's disease that we've been working on for over 10 years.
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
BIN1 and Alzheimer’s disease: the tau connection
Bridging integrator 1 (BIN1) is a ubiquitously expressed protein that plays a critical role in endocytosis, trafficking and cytoskeletal dynamics. In …
www.sciencedirect.com
April 22, 2025 at 5:15 AM
When I was a student, I dreamed of one day publishing in Trends In Neurosciences. So I'm proud that we had the opportunity to write an invited review on BIN1, a major genetic determinant of Alzheimer's disease that we've been working on for over 10 years.
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Reposted by Nico Franzmeier
Just out in JAMA Neurol blood biomarkers are powerful—but without cognitive phenotyping, we risk more noise than signal.
Plasma p-tau217 needs clinical context or we’ll end up in a false-positive factory!
Clinico-biological AD is a reality!
👉🏻 jamanetwork.com/journals/jam...
bsky.app/profile/vinc...
Plasma p-tau217 needs clinical context or we’ll end up in a false-positive factory!
Clinico-biological AD is a reality!
👉🏻 jamanetwork.com/journals/jam...
bsky.app/profile/vinc...
April 5, 2025 at 8:03 AM
Just out in JAMA Neurol blood biomarkers are powerful—but without cognitive phenotyping, we risk more noise than signal.
Plasma p-tau217 needs clinical context or we’ll end up in a false-positive factory!
Clinico-biological AD is a reality!
👉🏻 jamanetwork.com/journals/jam...
bsky.app/profile/vinc...
Plasma p-tau217 needs clinical context or we’ll end up in a false-positive factory!
Clinico-biological AD is a reality!
👉🏻 jamanetwork.com/journals/jam...
bsky.app/profile/vinc...
Reposted by Nico Franzmeier
We are HIRING!! Postdoc for multimodal imaging lab at Yale. If you get excited about preclinical and prodromal states, atypical Alzheimer’s, graph theory, predictive modeling, and/or baked goods at lab meetings, come join us: postdocs.yale.edu/postdoctoral...
Please share with your circles!
Please share with your circles!
March 28, 2025 at 5:26 PM
We are HIRING!! Postdoc for multimodal imaging lab at Yale. If you get excited about preclinical and prodromal states, atypical Alzheimer’s, graph theory, predictive modeling, and/or baked goods at lab meetings, come join us: postdocs.yale.edu/postdoctoral...
Please share with your circles!
Please share with your circles!
Also out today in EJNMMI, led by @matthiasbrendel.bsky.social and Johannes Gnörich:
Ever wondered about the strong PI-2620 tau-PET signal in the vermis and superior cerebellum? We found that this signal is driven by leptomeningeal melanozytes rather than tau deposits.
doi.org/10.1007/s002...
Ever wondered about the strong PI-2620 tau-PET signal in the vermis and superior cerebellum? We found that this signal is driven by leptomeningeal melanozytes rather than tau deposits.
doi.org/10.1007/s002...
Exploring the origins of frequent tau-PET signal in vermal and adjacent regions - European Journal of Nuclear Medicine and Molecular Imaging
Purpose Off-target binding remains a significant challenge in tau-PET neuroimaging. While off-targets including monoamine oxidase enzymes and neuromelanin-containing cells have been identified, recent...
doi.org
March 18, 2025 at 1:18 PM
Also out today in EJNMMI, led by @matthiasbrendel.bsky.social and Johannes Gnörich:
Ever wondered about the strong PI-2620 tau-PET signal in the vermis and superior cerebellum? We found that this signal is driven by leptomeningeal melanozytes rather than tau deposits.
doi.org/10.1007/s002...
Ever wondered about the strong PI-2620 tau-PET signal in the vermis and superior cerebellum? We found that this signal is driven by leptomeningeal melanozytes rather than tau deposits.
doi.org/10.1007/s002...
Excited to share our new work in Molecular Neurodegeneration, showing that α-synuclein co-pathology is common in Alzheimer’s and accelerates amyloid-related tau accumulation, supporting its role as a tau co-aggregation factor.
doi.org/10.1186/s130...
doi.org/10.1186/s130...
Alpha synuclein co-pathology is associated with accelerated amyloid-driven tau accumulation in Alzheimer’s disease - Molecular Neurodegeneration
Background Aggregated alpha-Synuclein (αSyn) is a hallmark pathology in Parkinson’s disease but also one of the most common co-pathologies in Alzheimer’s disease (AD). Preclinical studies suggest that...
doi.org
March 18, 2025 at 9:15 AM
Excited to share our new work in Molecular Neurodegeneration, showing that α-synuclein co-pathology is common in Alzheimer’s and accelerates amyloid-related tau accumulation, supporting its role as a tau co-aggregation factor.
doi.org/10.1186/s130...
doi.org/10.1186/s130...
Reposted by Nico Franzmeier
Great working with Sujala Ghatamaneni, Val Lowe, and colleagues on this high resolution autoradiography study of MK-6240 and flortaucipir🧠🖥️
link.springer.com/article/10.1...
@drchristinamoloney.bsky.social @davidjonesbrain.bsky.social
link.springer.com/article/10.1...
@drchristinamoloney.bsky.social @davidjonesbrain.bsky.social
High resolution autoradiography of [18F]MK-6240 and [18F]Flortaucipir shows similar neurofibrillary tangle binding patterns preferentially recognizing middling neurofibrillary tangle maturity - Acta N...
Recent developments in tau positron emission tomography (PET) radiotracers have enhanced the visualization of tau aggregates in Alzheimer’s disease (AD). The maturity level of neurofibrillary tangles ...
link.springer.com
March 17, 2025 at 4:32 PM
Great working with Sujala Ghatamaneni, Val Lowe, and colleagues on this high resolution autoradiography study of MK-6240 and flortaucipir🧠🖥️
link.springer.com/article/10.1...
@drchristinamoloney.bsky.social @davidjonesbrain.bsky.social
link.springer.com/article/10.1...
@drchristinamoloney.bsky.social @davidjonesbrain.bsky.social
Reposted by Nico Franzmeier
Open #Postdoc position @isd-research.bsky.social @lmumuenchen.bsky.social to develop an #iPSC-derived #BBB model. Fully funded and embedded in our international Foundation Leducq Network of Excellence www.brenda-leducq.de Experience in vascular biology or related field required. Please RP and apply
March 12, 2025 at 4:42 PM
Open #Postdoc position @isd-research.bsky.social @lmumuenchen.bsky.social to develop an #iPSC-derived #BBB model. Fully funded and embedded in our international Foundation Leducq Network of Excellence www.brenda-leducq.de Experience in vascular biology or related field required. Please RP and apply
Reposted by Nico Franzmeier
Why academia is sleepwalking into self-destruction. My editorial @brain1878.bsky.social If you agree with the sentiments please repost. It's important for all our sakes to stop the madness
academic.oup.com/brain/articl...
academic.oup.com/brain/articl...
March 6, 2025 at 7:16 PM
Why academia is sleepwalking into self-destruction. My editorial @brain1878.bsky.social If you agree with the sentiments please repost. It's important for all our sakes to stop the madness
academic.oup.com/brain/articl...
academic.oup.com/brain/articl...
Reposted by Nico Franzmeier
March 1, 2025 at 6:59 PM
Reposted by Nico Franzmeier
Zelensky is a wartime leader watching his people suffer and die under Russian attacks every day. To be lectured and lied to by Trump and Vance, as they defend the war criminal dictator committing these atrocities, is unimaginable agony. An everlasting shame for America.
Trump has not uttered a critical word about Putin but he and his VP publicly belittled the leader of the nation Putin invaded.
February 28, 2025 at 7:15 PM
Zelensky is a wartime leader watching his people suffer and die under Russian attacks every day. To be lectured and lied to by Trump and Vance, as they defend the war criminal dictator committing these atrocities, is unimaginable agony. An everlasting shame for America.
Reposted by Nico Franzmeier
We did it and now it is published: A highly Lewy-fold selective and quantitative Synuclein Aggregate Amplification Assay (SAA). Huge thanks to the amazing teams at MODAG GmbH, LMU Munich, and Bologna University!
rdcu.be/eaISM
rdcu.be/eaISM
A quantitative Lewy-fold-specific alpha-synuclein seed amplification assay as a progression marker for Parkinson’s disease
rdcu.be
February 21, 2025 at 5:23 PM
We did it and now it is published: A highly Lewy-fold selective and quantitative Synuclein Aggregate Amplification Assay (SAA). Huge thanks to the amazing teams at MODAG GmbH, LMU Munich, and Bologna University!
rdcu.be/eaISM
rdcu.be/eaISM