Pavan Chaggar
@pavanchaggar.bsky.social
Mathematician and neuroscientist working on Alzheimer’s disease
Currently at Lund University, previously at Ox Maths
Currently at Lund University, previously at Ox Maths
Reposted by Pavan Chaggar
🚨PREPRINT
Coarse-graining diffusions with discrete-state approximations is an easy and effective way to build stochastic models from observed trajectories, but how valid is this approximation?
arxiv.org/pdf/2511.05366
We focus on this problem, with an emphasis on the nonequilibrium steady-state.
Coarse-graining diffusions with discrete-state approximations is an easy and effective way to build stochastic models from observed trajectories, but how valid is this approximation?
arxiv.org/pdf/2511.05366
We focus on this problem, with an emphasis on the nonequilibrium steady-state.
November 10, 2025 at 9:39 AM
🚨PREPRINT
Coarse-graining diffusions with discrete-state approximations is an easy and effective way to build stochastic models from observed trajectories, but how valid is this approximation?
arxiv.org/pdf/2511.05366
We focus on this problem, with an emphasis on the nonequilibrium steady-state.
Coarse-graining diffusions with discrete-state approximations is an easy and effective way to build stochastic models from observed trajectories, but how valid is this approximation?
arxiv.org/pdf/2511.05366
We focus on this problem, with an emphasis on the nonequilibrium steady-state.
Reposted by Pavan Chaggar
Our review paper on nonequilibrium physics in the brain is now out in Physics Reports!
doi.org/10.1016/j.ph...
doi.org/10.1016/j.ph...
October 24, 2025 at 8:34 AM
Our review paper on nonequilibrium physics in the brain is now out in Physics Reports!
doi.org/10.1016/j.ph...
doi.org/10.1016/j.ph...
Reposted by Pavan Chaggar
How does the 🧠 process information?
In this review we show how to use the tools of non-equilibrium thermodynamics to understand brain dynamics in discrete and continuous state spaces
Great work led by Ramon as part of his PhD
kwnsfk27.r.eu-west-1.awstrack.me/L0/https:%2F...
In this review we show how to use the tools of non-equilibrium thermodynamics to understand brain dynamics in discrete and continuous state spaces
Great work led by Ramon as part of his PhD
kwnsfk27.r.eu-west-1.awstrack.me/L0/https:%2F...
ScienceDirect.com | Science, health and medical journals, full text articles and books.
kwnsfk27.r.eu-west-1.awstrack.me
October 24, 2025 at 4:51 AM
How does the 🧠 process information?
In this review we show how to use the tools of non-equilibrium thermodynamics to understand brain dynamics in discrete and continuous state spaces
Great work led by Ramon as part of his PhD
kwnsfk27.r.eu-west-1.awstrack.me/L0/https:%2F...
In this review we show how to use the tools of non-equilibrium thermodynamics to understand brain dynamics in discrete and continuous state spaces
Great work led by Ramon as part of his PhD
kwnsfk27.r.eu-west-1.awstrack.me/L0/https:%2F...
Reposted by Pavan Chaggar
does brain connectivity drive spread of pathological proteins in Alzheimer’s disease?
✨ preprint: www.biorxiv.org/content/10.1...
if the question intrigues you, please read on 🧵⤵️
✨ preprint: www.biorxiv.org/content/10.1...
if the question intrigues you, please read on 🧵⤵️
October 7, 2025 at 8:59 AM
does brain connectivity drive spread of pathological proteins in Alzheimer’s disease?
✨ preprint: www.biorxiv.org/content/10.1...
if the question intrigues you, please read on 🧵⤵️
✨ preprint: www.biorxiv.org/content/10.1...
if the question intrigues you, please read on 🧵⤵️
I'm thrilled that our paper "Personalised regional modelling predicts tau progression in the human brain" is finally published in PLoS Biology!
Here's a short thread about the main findings of the paper...
Here's a short thread about the main findings of the paper...
Accumulation of aggregated tau shows a complex spatio-temporal pattern during #AlzheimersDisease, but why? @pavanchaggar.bsky.social @alaingoriely.bsky.social &co describes #TauProtein dynamics in AD, showing stage-specific shifts in production & transport @plosbiology.org 🧪 plos.io/4kNA6vX
![Simulated transport and production dynamics in the local FKPP model. Left: Simulation from the local FKPP model using carrying capacities derived from Gaussian mixture models (shown top right). Each line in the middle panel represents the SUVR trajectory of one DK atlas brain region. Values at time points years are projected onto a cortical rendering in the top panel. Each line in the bottom panel represents concentration averaged over Braak regions. Top right: Two component Gaussian mixture model fit to a multi-cohort tau PET dataset [24] and data from ADNI for right inferior temporal lobe. Bottom right: Right hemisphere cortical rendering of the SUVR carrying capacities as determined through Gaussian mixture modelling.](https://cdn.bsky.app/img/feed_thumbnail/plain/did:plc:5522ztebtekoor5efelihqhb/bafkreidvyyx2seiwefemwo6bvbfw6q7chuhw627ppxyixeminyueea7tzq@jpeg)
August 11, 2025 at 2:39 PM
I'm thrilled that our paper "Personalised regional modelling predicts tau progression in the human brain" is finally published in PLoS Biology!
Here's a short thread about the main findings of the paper...
Here's a short thread about the main findings of the paper...
Reposted by Pavan Chaggar
I am so very proud announce my lab's first preprint!!
@xiaoyucaly.bsky.social delves into the mechanisms driving tau distribution:
* Tau sequence driven by connectivity dynamics
* Tau load driven by local factors
Check out her thread below
@xiaoyucaly.bsky.social delves into the mechanisms driving tau distribution:
* Tau sequence driven by connectivity dynamics
* Tau load driven by local factors
Check out her thread below
🧠New preprint! What drives tau, the pathological protein in AD, to spread?
We found that WHERE tau appears and HOW MUCH accumulates are governed by different mechanisms. Check it out: www.biorxiv.org/content/10.1...
#MedSky #neuroskyence #neurosky #alzsky #compneuro #MRI #neuroimaging #neurology
We found that WHERE tau appears and HOW MUCH accumulates are governed by different mechanisms. Check it out: www.biorxiv.org/content/10.1...
#MedSky #neuroskyence #neurosky #alzsky #compneuro #MRI #neuroimaging #neurology
www.biorxiv.org
April 24, 2025 at 9:24 PM
I am so very proud announce my lab's first preprint!!
@xiaoyucaly.bsky.social delves into the mechanisms driving tau distribution:
* Tau sequence driven by connectivity dynamics
* Tau load driven by local factors
Check out her thread below
@xiaoyucaly.bsky.social delves into the mechanisms driving tau distribution:
* Tau sequence driven by connectivity dynamics
* Tau load driven by local factors
Check out her thread below
Reposted by Pavan Chaggar
🧠New preprint! What drives tau, the pathological protein in AD, to spread?
We found that WHERE tau appears and HOW MUCH accumulates are governed by different mechanisms. Check it out: www.biorxiv.org/content/10.1...
#MedSky #neuroskyence #neurosky #alzsky #compneuro #MRI #neuroimaging #neurology
We found that WHERE tau appears and HOW MUCH accumulates are governed by different mechanisms. Check it out: www.biorxiv.org/content/10.1...
#MedSky #neuroskyence #neurosky #alzsky #compneuro #MRI #neuroimaging #neurology
www.biorxiv.org
April 24, 2025 at 7:42 PM
🧠New preprint! What drives tau, the pathological protein in AD, to spread?
We found that WHERE tau appears and HOW MUCH accumulates are governed by different mechanisms. Check it out: www.biorxiv.org/content/10.1...
#MedSky #neuroskyence #neurosky #alzsky #compneuro #MRI #neuroimaging #neurology
We found that WHERE tau appears and HOW MUCH accumulates are governed by different mechanisms. Check it out: www.biorxiv.org/content/10.1...
#MedSky #neuroskyence #neurosky #alzsky #compneuro #MRI #neuroimaging #neurology
Reposted by Pavan Chaggar
🚨REVIEW
We have written a review on the emerging topic of nonequilibrium, irreversible dynamics in the brain.
Now out on the arXiv: arxiv.org/abs/2504.12188
We introduce the relevant mathematical frameworks, discuss recent interesting results, and look to the future of this research direction!
We have written a review on the emerging topic of nonequilibrium, irreversible dynamics in the brain.
Now out on the arXiv: arxiv.org/abs/2504.12188
We introduce the relevant mathematical frameworks, discuss recent interesting results, and look to the future of this research direction!
April 17, 2025 at 11:21 AM
🚨REVIEW
We have written a review on the emerging topic of nonequilibrium, irreversible dynamics in the brain.
Now out on the arXiv: arxiv.org/abs/2504.12188
We introduce the relevant mathematical frameworks, discuss recent interesting results, and look to the future of this research direction!
We have written a review on the emerging topic of nonequilibrium, irreversible dynamics in the brain.
Now out on the arXiv: arxiv.org/abs/2504.12188
We introduce the relevant mathematical frameworks, discuss recent interesting results, and look to the future of this research direction!
Reposted by Pavan Chaggar
Modelling cerebrovascular pathology and the spread of amyloid beta in Alzheimer’s disease: royalsocietypublishing.org/doi/10.1098/... #ProcA #Alzheimers #biophysics
royalsocietypublishing.org
April 4, 2025 at 6:05 PM
Modelling cerebrovascular pathology and the spread of amyloid beta in Alzheimer’s disease: royalsocietypublishing.org/doi/10.1098/... #ProcA #Alzheimers #biophysics
Reposted by Pavan Chaggar
In this paper, we connect local damage to brain vasculature to global progression of toxic proteins leading to neurodegenerative diseases.
royalsocietypublishing.org/doi/epdf/10....
We identify situations where disease initiation can be caused by focal hypoperfusion following vascular injury.
royalsocietypublishing.org/doi/epdf/10....
We identify situations where disease initiation can be caused by focal hypoperfusion following vascular injury.
April 2, 2025 at 5:30 PM
In this paper, we connect local damage to brain vasculature to global progression of toxic proteins leading to neurodegenerative diseases.
royalsocietypublishing.org/doi/epdf/10....
We identify situations where disease initiation can be caused by focal hypoperfusion following vascular injury.
royalsocietypublishing.org/doi/epdf/10....
We identify situations where disease initiation can be caused by focal hypoperfusion following vascular injury.
Reposted by Pavan Chaggar
🚨PERSPECTIVE
We have written a perspective calling for a holistic approach to mathematical modelling for biological systems - it now out on the arXiv: arxiv.org/abs/2503.20511
A thread 🧵
We have written a perspective calling for a holistic approach to mathematical modelling for biological systems - it now out on the arXiv: arxiv.org/abs/2503.20511
A thread 🧵
From reductionism to realism: Holistic mathematical modelling for complex biological systems
At its core, the physics paradigm adopts a reductionist approach to modelling, aiming to understand fundamental phenomena by decomposing them into simpler, elementary processes. While this strategy ha...
arxiv.org
March 27, 2025 at 9:13 AM
🚨PERSPECTIVE
We have written a perspective calling for a holistic approach to mathematical modelling for biological systems - it now out on the arXiv: arxiv.org/abs/2503.20511
A thread 🧵
We have written a perspective calling for a holistic approach to mathematical modelling for biological systems - it now out on the arXiv: arxiv.org/abs/2503.20511
A thread 🧵
Reposted by Pavan Chaggar
🚨 NEW PAPER ALERT!
After such a long journey, I am so glad to see this published in
@PNASNews:
pnas.org/doi/10.1073/...
Big thanks to @leonardobonetti.bsky.social, Gemma Fernandez-Rubio, Peter Vuust, Gustavo Deco, Morten Kringelbach, Renaud Lambiotte and @alaingoriely.bsky.social
A thread...
After such a long journey, I am so glad to see this published in
@PNASNews:
pnas.org/doi/10.1073/...
Big thanks to @leonardobonetti.bsky.social, Gemma Fernandez-Rubio, Peter Vuust, Gustavo Deco, Morten Kringelbach, Renaud Lambiotte and @alaingoriely.bsky.social
A thread...
Multilevel irreversibility reveals higher-order organization of nonequilibrium interactions in human brain dynamics | PNAS
Information processing in the human brain can be modeled as a complex dynamical system
operating out of equilibrium with multiple regions interacti...
pnas.org
March 7, 2025 at 4:47 PM
🚨 NEW PAPER ALERT!
After such a long journey, I am so glad to see this published in
@PNASNews:
pnas.org/doi/10.1073/...
Big thanks to @leonardobonetti.bsky.social, Gemma Fernandez-Rubio, Peter Vuust, Gustavo Deco, Morten Kringelbach, Renaud Lambiotte and @alaingoriely.bsky.social
A thread...
After such a long journey, I am so glad to see this published in
@PNASNews:
pnas.org/doi/10.1073/...
Big thanks to @leonardobonetti.bsky.social, Gemma Fernandez-Rubio, Peter Vuust, Gustavo Deco, Morten Kringelbach, Renaud Lambiotte and @alaingoriely.bsky.social
A thread...
Reposted by Pavan Chaggar
Why academia is sleepwalking into self-destruction. My editorial @brain1878.bsky.social If you agree with the sentiments please repost. It's important for all our sakes to stop the madness
academic.oup.com/brain/articl...
academic.oup.com/brain/articl...
March 6, 2025 at 7:16 PM
Why academia is sleepwalking into self-destruction. My editorial @brain1878.bsky.social If you agree with the sentiments please repost. It's important for all our sakes to stop the madness
academic.oup.com/brain/articl...
academic.oup.com/brain/articl...