Jake Vogel
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jwvogel.bsky.social
Jake Vogel
@jwvogel.bsky.social
200 followers 160 following 16 posts
Assistant Professor @Lund University | Neurodegenerative disease | Neuroimaging | AI | Multi-omics |
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Reposted by Jake Vogel
hansonmark.bsky.social
We wrote the Strain on scientific publishing to highlight the problems of time & trust. With a fantastic group of co-authors, we present The Drain of Scientific Publishing:

a 🧵 1/n

Drain: arxiv.org/abs/2511.04820
Strain: direct.mit.edu/qss/article/...
Oligopoly: direct.mit.edu/qss/article/...
A table showing profit margins of major publishers. A snippet of text related to this table is below. 1. The four-fold drain 1.1 Money Currently, academic publishing is dominated by profit-oriented, multinational companies for whom scientific knowledge is a commodity to be sold back to the academic community who created it. The dominant four are Elsevier, Springer Nature, Wiley and Taylor & Francis, which collectively generated over US$7.1 billion in revenue from journal publishing in 2024 alone, and over US$12 billion in profits between 2019 and 2024 (Table 1A). Their profit margins have always been over 30% in the last five years, and for the largest publisher (Elsevier) always over 37%. Against many comparators, across many sectors, scientific publishing is one of the most consistently profitable industries (Table S1). These financial arrangements make a substantial difference to science budgets. In 2024, 46% of Elsevier revenues and 53% of Taylor & Francis revenues were generated in North America, meaning that North American researchers were charged over US$2.27 billion by just two for-profit publishers. The Canadian research councils and the US National Science Foundation were allocated US$9.3 billion in that year. A figure detailing the drain on researcher time. 1. The four-fold drain 1.2 Time The number of papers published each year is growing faster than the scientific workforce, with the number of papers per researcher almost doubling between 1996 and 2022 (Figure 1A). This reflects the fact that publishers’ commercial desire to publish (sell) more material has aligned well with the competitive prestige culture in which publications help secure jobs, grants, promotions, and awards. To the extent that this growth is driven by a pressure for profit, rather than scholarly imperatives, it distorts the way researchers spend their time. The publishing system depends on unpaid reviewer labour, estimated to be over 130 million unpaid hours annually in 2020 alone (9). Researchers have complained about the demands of peer-review for decades, but the scale of the problem is now worse, with editors reporting widespread difficulties recruiting reviewers. The growth in publications involves not only the authors’ time, but that of academic editors and reviewers who are dealing with so many review demands. Even more seriously, the imperative to produce ever more articles reshapes the nature of scientific inquiry. Evidence across multiple fields shows that more papers result in ‘ossification’, not new ideas (10). It may seem paradoxical that more papers can slow progress until one considers how it affects researchers’ time. While rewards remain tied to volume, prestige, and impact of publications, researchers will be nudged away from riskier, local, interdisciplinary, and long-term work. The result is a treadmill of constant activity with limited progress whereas core scholarly practices – such as reading, reflecting and engaging with others’ contributions – is de-prioritized. What looks like productivity often masks intellectual exhaustion built on a demoralizing, narrowing scientific vision. A table of profit margins across industries. The section of text related to this table is below: 1. The four-fold drain 1.1 Money Currently, academic publishing is dominated by profit-oriented, multinational companies for whom scientific knowledge is a commodity to be sold back to the academic community who created it. The dominant four are Elsevier, Springer Nature, Wiley and Taylor & Francis, which collectively generated over US$7.1 billion in revenue from journal publishing in 2024 alone, and over US$12 billion in profits between 2019 and 2024 (Table 1A). Their profit margins have always been over 30% in the last five years, and for the largest publisher (Elsevier) always over 37%. Against many comparators, across many sectors, scientific publishing is one of the most consistently profitable industries (Table S1). These financial arrangements make a substantial difference to science budgets. In 2024, 46% of Elsevier revenues and 53% of Taylor & Francis revenues were generated in North America, meaning that North American researchers were charged over US$2.27 billion by just two for-profit publishers. The Canadian research councils and the US National Science Foundation were allocated US$9.3 billion in that year. The costs of inaction are plain: wasted public funds, lost researcher time, compromised scientific integrity and eroded public trust. Today, the system rewards commercial publishers first, and science second. Without bold action from the funders we risk continuing to pour resources into a system that prioritizes profit over the advancement of scientific knowledge.
November 11, 2025 at 11:52 AM
Reposted by Jake Vogel
wandedob.bsky.social
October 9, 2025 at 2:44 AM
Reposted by Jake Vogel
biofinder.bsky.social
🚨New paper alert! Our study led by @teanijarv.bsky.social
investigated why some individuals with Alzheimer’s disease (AD) develop hemispheric asymmetry in tau pathology and what drives this phenomenon.
Out now in Nature Communications! 🔗Full article: doi.org/10.1038/s414...
A thread🧵👇
Hemispheric asymmetry of tau pathology is related to asymmetric amyloid deposition in Alzheimer’s Disease - Nature Communications
Asymmetrical distribution of tau pathology in Alzheimer’s disease is linked to asymmetrical amyloid-beta deposition, not reduced brain connectivity, suggesting regional vulnerability plays a key role ...
doi.org
September 5, 2025 at 2:39 PM
jwvogel.bsky.social
Really compelling evidence in humans for network propagation hypothesis of tau spread: individualized connectivity helps resolve individualized tau patterns.

#MedSky #neuroskyence #neurosky #alzsky #compneuro #ai #datascience #bioinformatics #neurology
aitchbi.bsky.social Harry H Behjat @aitchbi.bsky.social · Oct 7
does brain connectivity drive spread of pathological proteins in Alzheimer’s disease?

✨ preprint: www.biorxiv.org/content/10.1...

if the question intrigues you, please read on 🧵⤵️
October 8, 2025 at 7:13 AM
Reposted by Jake Vogel
pavanchaggar.bsky.social
I'm thrilled that our paper "Personalised regional modelling predicts tau progression in the human brain" is finally published in PLoS Biology!

Here's a short thread about the main findings of the paper...
plosbiology.org PLOS Biology @plosbiology.org · Jul 22
Accumulation of aggregated tau shows a complex spatio-temporal pattern during #AlzheimersDisease, but why? @pavanchaggar.bsky.social @alaingoriely.bsky.social &co describes #TauProtein dynamics in AD, showing stage-specific shifts in production & transport @plosbiology.org 🧪 plos.io/4kNA6vX
Simulated transport and production dynamics in the local FKPP model. Left: Simulation from the local FKPP model using carrying capacities derived from Gaussian mixture models (shown top right). Each line in the middle panel represents the SUVR trajectory of one DK atlas brain region. Values at time points years are projected onto a cortical rendering in the top panel. Each line in the bottom panel represents concentration averaged over Braak regions. Top right: Two component Gaussian mixture model fit to a multi-cohort tau PET dataset [24] and data from ADNI for right inferior temporal lobe. Bottom right: Right hemisphere cortical rendering of the SUVR carrying capacities as determined through Gaussian mixture modelling.
August 11, 2025 at 2:39 PM
Reposted by Jake Vogel
labliston.bsky.social
🧵How to write and manage your first research budgets

The point of funding is to convert it into quality research. A well-spent research budget should fund the idea it was raised on, plus revision experiments, plus preliminary data for the next grant. So you need to spend, while avoiding waste.
September 3, 2025 at 4:03 PM
Reposted by Jake Vogel
colleensteckel.bsky.social
We need higher resolution brain scans for people with #MyalgicEncephalomyelitis. This is an exciting development that could lead to better clinical understanding for many of us. #Neuroskyence #medsky
jwvogel.bsky.social Jake Vogel @jwvogel.bsky.social · Jul 22
‼️NEW PREPRINT‼️

What if you could take a normal 3T T1w MRI and make it look like it was acquired from a 7T scanner?

That's exactly what we do using AI in our new preprint!

Link: arxiv.org/abs/2507.13782

#neuroskyence #neurosky #compneuro #AI #datascience #neurology #mrisky #neuroimaging
July 23, 2025 at 2:53 PM
Reposted by Jake Vogel
davidhfriedeljr.bsky.social
If clinically validated, it could democratize access to advanced imaging, improve neuro-diagnostic precision, and streamline both research and patient care without requiring costly hardware upgrades.

A win for everyone
jwvogel.bsky.social Jake Vogel @jwvogel.bsky.social · Jul 22
‼️NEW PREPRINT‼️

What if you could take a normal 3T T1w MRI and make it look like it was acquired from a 7T scanner?

That's exactly what we do using AI in our new preprint!

Link: arxiv.org/abs/2507.13782

#neuroskyence #neurosky #compneuro #AI #datascience #neurology #mrisky #neuroimaging
July 22, 2025 at 3:29 PM
jwvogel.bsky.social
‼️NEW PREPRINT‼️

What if you could take a normal 3T T1w MRI and make it look like it was acquired from a 7T scanner?

That's exactly what we do using AI in our new preprint!

Link: arxiv.org/abs/2507.13782

#neuroskyence #neurosky #compneuro #AI #datascience #neurology #mrisky #neuroimaging
July 22, 2025 at 3:34 AM
jwvogel.bsky.social
Incredibly excited for this new work from our lab. We test the potential of AI-based neurodegenerative disease diagnostics using plasma proteomics data from n>17,000 people, led by the brilliant and indefatigable @anlijuncn.bsky.social Check it out!👇
July 17, 2025 at 5:51 AM
Reposted by Jake Vogel
alexfornito.bsky.social
Have recent changes led to uncertainty in your future scientific career?

Wonder it's like in Australia?

Good news!

Monash's is seeking to hire talented EMCRs from other countries.

Come join a wonderful community of brain mappers & modellers!

www.monash.edu/research/eme...
EMERGE
www.monash.edu
May 27, 2025 at 10:49 PM
jwvogel.bsky.social
‼️Preprint alert‼️

Star PhD student @jorittmo.bsky.social uses functional gradients as a framework to study longitudinal brain functional reorganization in aging and AD.

Check out the thread
👇🏼

#MedSky #neuroskyence #neurosky #alzsky #compneuro #MRI #neuroimaging
#neurology
jorittmo.bsky.social Jonathan Rittmo @jorittmo.bsky.social · May 27
How does the brain reorganize in the context of age and AD?

Are functional changes in age and AD similar?

Are these changes dynamic across the age/AD spectrum?

We unpack these questions in a sample of N=973 with AD biomarkers

Preprint: tinyurl.com/ymv8s7h8

⬇️🧵

1/
May 27, 2025 at 4:20 PM
Reposted by Jake Vogel
benjaminkay.bsky.social
My med school textbook says stimulants like Ritalin treat hyperactivity by “stimulating” the brain’s attention and cognitive control systems. We studied children taking stimulants in the ABCD Study, and the largest differences were actually in arousal and reward networks! Check out our preprint!
May 22, 2025 at 9:33 PM
Reposted by Jake Vogel
evp82.bsky.social
Our new @NatureComms paper: We used UK Biobank data (n≈193K) to build ML models predicting tinnitus presence (driven by hearing health) and severity (influenced by mood, neuroticism & sleep). A simple 6-item POST questionnaire forecasts 9-yr outcomes. shorturl.at/4AF4P
Tinnitus risk factors and its evolution over time - Nature Communications
Improving tinnitus prevention and clinical management by identifying key associated risk factors is crucial. Here, the authors use machine learning in a large cohort to identify key predictors of tinn...
shorturl.at
May 9, 2025 at 5:22 PM
Reposted by Jake Vogel
lindenmp.bsky.social
Excited to share the first major piece of work and preprint from my lab! Led by Jason Kim! 🥳🎉🤘

www.biorxiv.org/content/10.1...
a man applauds with the words so proud of my team above him
ALT: a man applauds with the words so proud of my team above him
media.tenor.com
April 28, 2025 at 12:56 PM
Reposted by Jake Vogel
biofinder.bsky.social
‼️New preprint!
We are happy to share our latest work led by @teanijarv.bsky.social investigating why tau pathology in AD often accumulates more in one hemisphere of the brain than the other.

Check out 🔗https://biorxiv.org/content/10.1101/2025.04.15.648728v1 or dive into the details below👇
April 25, 2025 at 9:35 AM
Reposted by Jake Vogel
biofinder.bsky.social
🧠Exciting new findings from a great collaboration between the BioFINDER study and the talented
@xiaoyucaly.bsky.social from @jwvogel.bsky.social group!! In their preprint, they show that tau presence and tau load are guided by unique brain mechanisms. Dive into the details here 👇
xiaoyucaly.bsky.social Yu Xiao (肖燏) @xiaoyucaly.bsky.social · Apr 24
🧠New preprint! What drives tau, the pathological protein in AD, to spread?
We found that WHERE tau appears and HOW MUCH accumulates are governed by different mechanisms. Check it out:
www.biorxiv.org/content/10.1...


#MedSky #neuroskyence #neurosky #alzsky #compneuro #MRI #neuroimaging #neurology
www.biorxiv.org
April 25, 2025 at 9:38 AM
jwvogel.bsky.social
I am so very proud announce my lab's first preprint!!

@xiaoyucaly.bsky.social delves into the mechanisms driving tau distribution:
* Tau sequence driven by connectivity dynamics
* Tau load driven by local factors

Check out her thread below
xiaoyucaly.bsky.social Yu Xiao (肖燏) @xiaoyucaly.bsky.social · Apr 24
🧠New preprint! What drives tau, the pathological protein in AD, to spread?
We found that WHERE tau appears and HOW MUCH accumulates are governed by different mechanisms. Check it out:
www.biorxiv.org/content/10.1...


#MedSky #neuroskyence #neurosky #alzsky #compneuro #MRI #neuroimaging #neurology
www.biorxiv.org
April 24, 2025 at 9:24 PM