Melissa E. Murray
@drneurochic.bsky.social
Digital pathology guru | Biomarker enthusiast | Hopeful scientist | Scientific program committee @HAIconference #AAIC25 | Advisory board #ADPD2025
Pinned
🧵 about "indirect costs"
Hi, it’s nice to meet you. I am a #brain scientist. My life's mission is to prevent #Alzheimer’s disease and related dementias...or to contribute enough puzzle pieces so that someone else can unlock the mysteries of disease.
Hi, it’s nice to meet you. I am a #brain scientist. My life's mission is to prevent #Alzheimer’s disease and related dementias...or to contribute enough puzzle pieces so that someone else can unlock the mysteries of disease.
Reposted by Melissa E. Murray
🚨New in Lancet Neurology: Autopsy study of aducanumab in #Alzheimer’s shows superficial cortical Aβ cleared, but deeper persists. ARIA showed inflammation+ microinfarcts in leptomeningeal/penetrating vessels. Some path is PET-invisible. @drneurochic.bsky.social
authors.elsevier.com/a/1lxn85FFzL...
authors.elsevier.com/a/1lxn85FFzL...
October 16, 2025 at 10:33 AM
🚨New in Lancet Neurology: Autopsy study of aducanumab in #Alzheimer’s shows superficial cortical Aβ cleared, but deeper persists. ARIA showed inflammation+ microinfarcts in leptomeningeal/penetrating vessels. Some path is PET-invisible. @drneurochic.bsky.social
authors.elsevier.com/a/1lxn85FFzL...
authors.elsevier.com/a/1lxn85FFzL...
Reposted by Melissa E. Murray
Why some people have more fit brain cells at 90 when others’ start dying at their 30s? Hard to say! It is hard to study because human 🧠 is the least accessible.
@drneurochic.bsky.social et al discuss how to accelerate biomedical discoveries in brain health via transformative neuropathology.
(1/5)
@drneurochic.bsky.social et al discuss how to accelerate biomedical discoveries in brain health via transformative neuropathology.
(1/5)
Accelerating biomedical discoveries in brain health through transformative neuropathology of aging and neurodegeneration
Murray et al. introduce “transformative neuropathology” through dynamic, technology-integrated
approaches to accelerate tissue-based discoveries and offer actionable strategies
to strengthen brain ban...
www.cell.com
August 8, 2025 at 8:09 PM
Why some people have more fit brain cells at 90 when others’ start dying at their 30s? Hard to say! It is hard to study because human 🧠 is the least accessible.
@drneurochic.bsky.social et al discuss how to accelerate biomedical discoveries in brain health via transformative neuropathology.
(1/5)
@drneurochic.bsky.social et al discuss how to accelerate biomedical discoveries in brain health via transformative neuropathology.
(1/5)
Reposted by Melissa E. Murray
Every day is #InternationalWolfDay in our eyes, but today’s a great reminder of how amazing wolves are! 🐺 Support wolf recovery and conservation by donating or advocating for stronger protections. 🌎🐾
Learn more about ways to make an impact: nywolf.org
Learn more about ways to make an impact: nywolf.org
August 13, 2025 at 3:32 PM
Every day is #InternationalWolfDay in our eyes, but today’s a great reminder of how amazing wolves are! 🐺 Support wolf recovery and conservation by donating or advocating for stronger protections. 🌎🐾
Learn more about ways to make an impact: nywolf.org
Learn more about ways to make an impact: nywolf.org
Reposted by Melissa E. Murray
Interested to see how advanced microscopy holds the power to transform our understanding of therapeutics🔬🧠…come see our latest work. #AAIC25
Hall G session 2-3.30 pm integrative neuropathology in ADRD at 2.20 pm sharp
@drneurochic.bsky.social
Hall G session 2-3.30 pm integrative neuropathology in ADRD at 2.20 pm sharp
@drneurochic.bsky.social
July 29, 2025 at 4:22 PM
Interested to see how advanced microscopy holds the power to transform our understanding of therapeutics🔬🧠…come see our latest work. #AAIC25
Hall G session 2-3.30 pm integrative neuropathology in ADRD at 2.20 pm sharp
@drneurochic.bsky.social
Hall G session 2-3.30 pm integrative neuropathology in ADRD at 2.20 pm sharp
@drneurochic.bsky.social
Reposted by Melissa E. Murray
@alzassociation.bsky.social #GlobalImmersionExperience reception at Thompson Landry Gallery #Toronto
July 27, 2025 at 5:33 PM
@alzassociation.bsky.social #GlobalImmersionExperience reception at Thompson Landry Gallery #Toronto
Reposted by Melissa E. Murray
#USPOINTER study #sciencerockstars report #structuredlifestyleintervention improves #cognitiveperformance 🤓💪🏼🥳💜🧠 #ENDALZ
July 28, 2025 at 7:14 PM
#USPOINTER study #sciencerockstars report #structuredlifestyleintervention improves #cognitiveperformance 🤓💪🏼🥳💜🧠 #ENDALZ
Reposted by Melissa E. Murray
NEWSFLASH #2: @alzassociation.bsky.social commits over $40M to translate the positive outcomes of #USPOINTER #structuredlifestyleintervention to preserve your 🧠 💜 # ENDALZ 💪🏼 from global to local.
July 28, 2025 at 7:27 PM
NEWSFLASH #2: @alzassociation.bsky.social commits over $40M to translate the positive outcomes of #USPOINTER #structuredlifestyleintervention to preserve your 🧠 💜 # ENDALZ 💪🏼 from global to local.
You can still be a grown a** adult and have an "I forgot my homework nightmare" ...There I sat in an audience and they call me as the next speaker and also from stage ask where my talk was😱
double booked today for two talks might have something to do with it😆 I'm excited though and pptx ready 💪
double booked today for two talks might have something to do with it😆 I'm excited though and pptx ready 💪
June 11, 2025 at 10:59 AM
You can still be a grown a** adult and have an "I forgot my homework nightmare" ...There I sat in an audience and they call me as the next speaker and also from stage ask where my talk was😱
double booked today for two talks might have something to do with it😆 I'm excited though and pptx ready 💪
double booked today for two talks might have something to do with it😆 I'm excited though and pptx ready 💪
Reposted by Melissa E. Murray
Thank you all for being great fan ❤
June 11, 2025 at 5:43 AM
Thank you all for being great fan ❤
Reposted by Melissa E. Murray
🧠 New preprint alert! We are excited to present the neurofibrillary tangle maturity scale, which integrates tangle maturity scores of pretangles, mature tangles, and ghost tangles to summarize tangle maturity predilection in the tissue. @drneurochic.bsky.social
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
The Neurofibrillary Tangle Maturity Scale: A Novel Framework for Tangle Pathology Evaluation in Alzheimer's Disease
Neurofibrillary tangles are dynamic neuropathologic hallmarks of Alzheimer's disease with a hypothesized lifespan morphologically-defined by three maturity levels: pretangles, mature tangles, and ghos...
www.biorxiv.org
June 6, 2025 at 7:21 PM
🧠 New preprint alert! We are excited to present the neurofibrillary tangle maturity scale, which integrates tangle maturity scores of pretangles, mature tangles, and ghost tangles to summarize tangle maturity predilection in the tissue. @drneurochic.bsky.social
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Melissa E. Murray
academic.oup.com/brain/articl...
My editorial on an actively immunised mouse model of NMDAR antibody encephalitis. Please note my scepticism of clinical trials in this field, towards the end!
My editorial on an actively immunised mouse model of NMDAR antibody encephalitis. Please note my scepticism of clinical trials in this field, towards the end!
Models of autoantibody mediated diseases: actively nearing the human gold standard
Human autoantibody-mediated diseases associated with a single autoantigenic target provide several valuable opportunities for precision medicine.1 The impl
academic.oup.com
June 3, 2025 at 11:02 AM
academic.oup.com/brain/articl...
My editorial on an actively immunised mouse model of NMDAR antibody encephalitis. Please note my scepticism of clinical trials in this field, towards the end!
My editorial on an actively immunised mouse model of NMDAR antibody encephalitis. Please note my scepticism of clinical trials in this field, towards the end!
Reposted by Melissa E. Murray
Nominate a deserving early-career investigator today for a chance to attend #CCAD2026. If selected, they will compete for a $100,000, 2-year grant from #NewVisionResearch!
View nomination criteria here 👉 newvisionresearch.org/ccad-2026/
Nominate here 👉 airtable.com/appjJE7FUGZY...
View nomination criteria here 👉 newvisionresearch.org/ccad-2026/
Nominate here 👉 airtable.com/appjJE7FUGZY...
May 20, 2025 at 11:07 PM
Nominate a deserving early-career investigator today for a chance to attend #CCAD2026. If selected, they will compete for a $100,000, 2-year grant from #NewVisionResearch!
View nomination criteria here 👉 newvisionresearch.org/ccad-2026/
Nominate here 👉 airtable.com/appjJE7FUGZY...
View nomination criteria here 👉 newvisionresearch.org/ccad-2026/
Nominate here 👉 airtable.com/appjJE7FUGZY...
Reposted by Melissa E. Murray
May 20, 2025 at 11:48 PM
Reposted by Melissa E. Murray
Read our latest review article out in @thelancetneuro.bsky.social if you want to know more about CSF transport across the different compartments of the brain-meningeal border and its importance for neurological diseases with strong neuroimmune components 😉
authors.elsevier.com/a/1l7l75FFzL...
authors.elsevier.com/a/1l7l75FFzL...
authors.elsevier.com
May 20, 2025 at 11:09 PM
Read our latest review article out in @thelancetneuro.bsky.social if you want to know more about CSF transport across the different compartments of the brain-meningeal border and its importance for neurological diseases with strong neuroimmune components 😉
authors.elsevier.com/a/1l7l75FFzL...
authors.elsevier.com/a/1l7l75FFzL...
Reposted by Melissa E. Murray
Learn about (generative) modeling in #ComputationalPsychiatry by attending the #CPCZurich2025.
The BEST course for learning about different models (incl. tutorials), best practices, math backgrounds, and showcase your research in the poster session:
www.translationalneuromodeling.org/cpcourse/
The BEST course for learning about different models (incl. tutorials), best practices, math backgrounds, and showcase your research in the poster session:
www.translationalneuromodeling.org/cpcourse/
Computational Psychiatry Course Zurich
An educational course about computational psychiatry from UZH & ETH Zurich.
www.translationalneuromodeling.org
May 21, 2025 at 1:21 AM
Learn about (generative) modeling in #ComputationalPsychiatry by attending the #CPCZurich2025.
The BEST course for learning about different models (incl. tutorials), best practices, math backgrounds, and showcase your research in the poster session:
www.translationalneuromodeling.org/cpcourse/
The BEST course for learning about different models (incl. tutorials), best practices, math backgrounds, and showcase your research in the poster session:
www.translationalneuromodeling.org/cpcourse/
Reposted by Melissa E. Murray
Curse of Neuroanatomy Training Part 4. Tessellation of Mona Lisa, but looks like gyri to us. Thanks to Dr. Jeff Browndyke. Original post by Kevin Atkinson Mathematical Tiling and Tessellation. #neuroskyence
May 8, 2025 at 3:36 PM
Curse of Neuroanatomy Training Part 4. Tessellation of Mona Lisa, but looks like gyri to us. Thanks to Dr. Jeff Browndyke. Original post by Kevin Atkinson Mathematical Tiling and Tessellation. #neuroskyence
Reposted by Melissa E. Murray
ATTENTION
New crowdsourced site collecting and sharing stories of public impact of research
publicusaresearchbenefits.com
Take a look and consider contributing. Let's make this as powerful as possible!
New crowdsourced site collecting and sharing stories of public impact of research
publicusaresearchbenefits.com
Take a look and consider contributing. Let's make this as powerful as possible!
Searchable database of tangible benefits that federally-funded research gave us.
A crowd-sourced site. Health and Well-being. National Security. Prosperity.
publicusaresearchbenefits.com
May 8, 2025 at 1:28 PM
ATTENTION
New crowdsourced site collecting and sharing stories of public impact of research
publicusaresearchbenefits.com
Take a look and consider contributing. Let's make this as powerful as possible!
New crowdsourced site collecting and sharing stories of public impact of research
publicusaresearchbenefits.com
Take a look and consider contributing. Let's make this as powerful as possible!
Reposted by Melissa E. Murray
quite extraordinary story. Sometimes I think it’s the weird people that will save the world,
May 3, 2025 at 5:40 AM
quite extraordinary story. Sometimes I think it’s the weird people that will save the world,
Reposted by Melissa E. Murray
Today a pupal #Drosophila #Brain (40 h APF)
for #fluorescencefriday.
🔵 Actin
🟠🟡 Anti-E-Cad
depth-coded color
I have 1 million versions of this picture, in which I tried different LUTs. I will put some in the comments!
#microscopy #cellbio #neuroscience #insect
for #fluorescencefriday.
🔵 Actin
🟠🟡 Anti-E-Cad
depth-coded color
I have 1 million versions of this picture, in which I tried different LUTs. I will put some in the comments!
#microscopy #cellbio #neuroscience #insect
May 2, 2025 at 5:59 PM
Today a pupal #Drosophila #Brain (40 h APF)
for #fluorescencefriday.
🔵 Actin
🟠🟡 Anti-E-Cad
depth-coded color
I have 1 million versions of this picture, in which I tried different LUTs. I will put some in the comments!
#microscopy #cellbio #neuroscience #insect
for #fluorescencefriday.
🔵 Actin
🟠🟡 Anti-E-Cad
depth-coded color
I have 1 million versions of this picture, in which I tried different LUTs. I will put some in the comments!
#microscopy #cellbio #neuroscience #insect
Reposted by Melissa E. Murray
Our perspective in @natrevimmunol.nature.com on new concepts in neuroimmune interactions that have challenged the old dogma that immune privilege is a result of the isolation of the nervous and immune systems.
@jonykipnis.bsky.social
www.nature.com/articles/s41...
@jonykipnis.bsky.social
www.nature.com/articles/s41...
Redefining CNS immune privilege - Nature Reviews Immunology
In this Perspective, Smyth and Kipnis reappraise the concept of immune privilege in the central nervous system. Although immune privilege was originally thought to involve isolation of the central ner...
www.nature.com
May 2, 2025 at 8:05 PM
Our perspective in @natrevimmunol.nature.com on new concepts in neuroimmune interactions that have challenged the old dogma that immune privilege is a result of the isolation of the nervous and immune systems.
@jonykipnis.bsky.social
www.nature.com/articles/s41...
@jonykipnis.bsky.social
www.nature.com/articles/s41...
Reposted by Melissa E. Murray
For #FluorescenceFriday - new experiments that I am really excited for! Really pretty tyrosine hydroxylase (TH) 🟢 labeling in human induced pluripotent stem cells that are differentiating into locus coeruleus-like cells. Image credit to the @lieberinstitute.bsky.social Imaging Development team 🧠🧪🔵
May 2, 2025 at 1:02 PM
For #FluorescenceFriday - new experiments that I am really excited for! Really pretty tyrosine hydroxylase (TH) 🟢 labeling in human induced pluripotent stem cells that are differentiating into locus coeruleus-like cells. Image credit to the @lieberinstitute.bsky.social Imaging Development team 🧠🧪🔵
Reposted by Melissa E. Murray
So excited and honored to be invited to present the opening plenary at #AIC2025 this year in Toronto! 🧠
🙏 I would be very grateful if you could help me gather the most inspiring papers (including your own!) of the past year by completing this ~5min survey: alz.surveymonkey.com/r/923BTQK
🙏 I would be very grateful if you could help me gather the most inspiring papers (including your own!) of the past year by completing this ~5min survey: alz.surveymonkey.com/r/923BTQK
🚨Calling all neuroimagers! Help
@emmacoomans.bsky.social shape the opening plenary at #AIC2025 (Toronto, July 26th) "Accomplishments of the Past Year" and share the most impactful neuroimaging research from the past year via this brief survey (~5min) by May 30th.
act.alz.org/site/R?i=eOe...
@emmacoomans.bsky.social shape the opening plenary at #AIC2025 (Toronto, July 26th) "Accomplishments of the Past Year" and share the most impactful neuroimaging research from the past year via this brief survey (~5min) by May 30th.
act.alz.org/site/R?i=eOe...
Neuroimaging PIA: The Past Year (since July 1, 2024) and The Future
Take this survey powered by surveymonkey.com. Create your own surveys for free.
act.alz.org
April 28, 2025 at 6:26 PM
So excited and honored to be invited to present the opening plenary at #AIC2025 this year in Toronto! 🧠
🙏 I would be very grateful if you could help me gather the most inspiring papers (including your own!) of the past year by completing this ~5min survey: alz.surveymonkey.com/r/923BTQK
🙏 I would be very grateful if you could help me gather the most inspiring papers (including your own!) of the past year by completing this ~5min survey: alz.surveymonkey.com/r/923BTQK
Reposted by Melissa E. Murray
@britishneuro.bsky.social has partnered with the Queens Reading Room! www.independent.co.uk/news/uk/home...
Queen’s reading charity partners with British Neuroscience Association
Experts say reading has positive effect on reducing stress and improving cognitive ability
www.independent.co.uk
April 28, 2025 at 8:13 AM
@britishneuro.bsky.social has partnered with the Queens Reading Room! www.independent.co.uk/news/uk/home...
Huge congratulations to Professor Bess Frost on receiving your well-deserved Rainwater prize at #Tau2025🎉👏👏👏 Loved hearing your journey and resolve to dig in deeper when naysayers may have prevented your innovative discoveries
rainwatercharitablefoundation.org/honoring-exc...
rainwatercharitablefoundation.org/honoring-exc...
April 24, 2025 at 4:46 PM
Huge congratulations to Professor Bess Frost on receiving your well-deserved Rainwater prize at #Tau2025🎉👏👏👏 Loved hearing your journey and resolve to dig in deeper when naysayers may have prevented your innovative discoveries
rainwatercharitablefoundation.org/honoring-exc...
rainwatercharitablefoundation.org/honoring-exc...
Love seeing the beautiful butterfly at #Tau2025 where 1000+ scientists and clinicians are gathering to share ideas to accelerate biomedical discoveries.
Here is a starter pack to quickly follow TAUrrific researchers. Let me know if I need to add anybody
go.bsky.app/KHno2VG
@millermb.bsky.social
Here is a starter pack to quickly follow TAUrrific researchers. Let me know if I need to add anybody
go.bsky.app/KHno2VG
@millermb.bsky.social
April 24, 2025 at 11:34 AM
Love seeing the beautiful butterfly at #Tau2025 where 1000+ scientists and clinicians are gathering to share ideas to accelerate biomedical discoveries.
Here is a starter pack to quickly follow TAUrrific researchers. Let me know if I need to add anybody
go.bsky.app/KHno2VG
@millermb.bsky.social
Here is a starter pack to quickly follow TAUrrific researchers. Let me know if I need to add anybody
go.bsky.app/KHno2VG
@millermb.bsky.social