Misha Zilberter
@mzilberter.bsky.social
Neuroscientist at Gladstone Institutes /UCSF: electrophysiology & hippocampal network function, APOE4, and glucose metabolism in Alzheimer’s disease
ORCID: 0000-0001-7164-8312
ORCID: 0000-0001-7164-8312
Reposted by Misha Zilberter
How does neuronal gene expression evolve over time in response to experience? CytoTape will help us find out - a major milestone for neuroscience, providing new ways to study memory & aging 🧠
Congrats to the whole team! Looking forward to our continued collaboration on this work 🎉
Congrats to the whole team! Looking forward to our continued collaboration on this work 🎉
Our CytoTape work is published today in Nature @nature.com! CytoTape is a genetically encoded, flexible, intracellular protein tape recorder for spatiotemporally scalable and multiplexed recording of cellular activities continuously across weeks in vitro and in vivo. www.nature.com/articles/s41...
February 6, 2026 at 4:24 PM
How does neuronal gene expression evolve over time in response to experience? CytoTape will help us find out - a major milestone for neuroscience, providing new ways to study memory & aging 🧠
Congrats to the whole team! Looking forward to our continued collaboration on this work 🎉
Congrats to the whole team! Looking forward to our continued collaboration on this work 🎉
Reposted by Misha Zilberter
The Pearson lab is looking for an enthusiastic research technician to join our team! Come join us in New York City! 🍎🧪
jobs.weill.cornell.edu/NY/job/New-Y...
#science #neurobiology #devbio
jobs.weill.cornell.edu/NY/job/New-Y...
#science #neurobiology #devbio
Research Technician I
Research Technician I
jobs.weill.cornell.edu
February 4, 2026 at 11:27 PM
The Pearson lab is looking for an enthusiastic research technician to join our team! Come join us in New York City! 🍎🧪
jobs.weill.cornell.edu/NY/job/New-Y...
#science #neurobiology #devbio
jobs.weill.cornell.edu/NY/job/New-Y...
#science #neurobiology #devbio
Reposted by Misha Zilberter
Excited to share newly minted PhD Anu Korukonda's tour de force thesis work describing the impact of pathogenic tau on #locuscoeruleus function in a mouse model of early #Alzheimers. A must for #BlueSpot researchers! www.biorxiv.org/content/10.6...
1/3
1/3
www.biorxiv.org
February 2, 2026 at 1:12 PM
Excited to share newly minted PhD Anu Korukonda's tour de force thesis work describing the impact of pathogenic tau on #locuscoeruleus function in a mouse model of early #Alzheimers. A must for #BlueSpot researchers! www.biorxiv.org/content/10.6...
1/3
1/3
Reposted by Misha Zilberter
Because of technical issues with the SciENcv website, NIH is extending a period of leniency accepting old format biosketches through May 2026 (see FAQ #5):
grants.nih.gov/faqs#/common...
grants.nih.gov/faqs#/common...
Frequently Asked Questions (FAQs) | Grants & Funding
grants.nih.gov
January 29, 2026 at 8:30 PM
Because of technical issues with the SciENcv website, NIH is extending a period of leniency accepting old format biosketches through May 2026 (see FAQ #5):
grants.nih.gov/faqs#/common...
grants.nih.gov/faqs#/common...
Reposted by Misha Zilberter
Our paper is (finally) out in Cell today!
CRISPR screens in iPSC-derived neurons reveal principles of tau proteostasis
www.cell.com/cell/fulltex...
Great collaborative effort - read more from first author @asamelson.bsky.social below:
CRISPR screens in iPSC-derived neurons reveal principles of tau proteostasis
www.cell.com/cell/fulltex...
Great collaborative effort - read more from first author @asamelson.bsky.social below:
January 28, 2026 at 5:24 PM
Our paper is (finally) out in Cell today!
CRISPR screens in iPSC-derived neurons reveal principles of tau proteostasis
www.cell.com/cell/fulltex...
Great collaborative effort - read more from first author @asamelson.bsky.social below:
CRISPR screens in iPSC-derived neurons reveal principles of tau proteostasis
www.cell.com/cell/fulltex...
Great collaborative effort - read more from first author @asamelson.bsky.social below:
Reposted by Misha Zilberter
New work from our lab! Link: rdcu.be/e0sfU
𝗧𝗮𝘂 𝗛𝗶𝗷𝗮𝗰𝗸𝘀 𝗕𝗿𝗮𝗶𝗻 𝗠𝗲𝘁𝗮𝗯𝗼𝗹𝗶𝘀𝗺, 𝗗𝗿𝗶𝘃𝗶𝗻𝗴 𝗦𝗹𝗲𝗲𝗽 𝗟𝗼𝘀𝘀 𝗶𝗻 𝗔𝗹𝘇𝗵𝗲𝗶𝗺𝗲𝗿’𝘀 𝗗𝗶𝘀𝗲𝗮𝘀𝗲
A quick thread on our findings!
𝗧𝗮𝘂 𝗛𝗶𝗷𝗮𝗰𝗸𝘀 𝗕𝗿𝗮𝗶𝗻 𝗠𝗲𝘁𝗮𝗯𝗼𝗹𝗶𝘀𝗺, 𝗗𝗿𝗶𝘃𝗶𝗻𝗴 𝗦𝗹𝗲𝗲𝗽 𝗟𝗼𝘀𝘀 𝗶𝗻 𝗔𝗹𝘇𝗵𝗲𝗶𝗺𝗲𝗿’𝘀 𝗗𝗶𝘀𝗲𝗮𝘀𝗲
A quick thread on our findings!
Tau pathology reprograms glucose metabolism to support cortical hyperexcitability, excitatory/inhibitory imbalance, and sleep loss
npj Dementia - Tau pathology reprograms glucose metabolism to support cortical hyperexcitability, excitatory/inhibitory imbalance, and sleep loss
rdcu.be
January 23, 2026 at 6:13 PM
New work from our lab! Link: rdcu.be/e0sfU
𝗧𝗮𝘂 𝗛𝗶𝗷𝗮𝗰𝗸𝘀 𝗕𝗿𝗮𝗶𝗻 𝗠𝗲𝘁𝗮𝗯𝗼𝗹𝗶𝘀𝗺, 𝗗𝗿𝗶𝘃𝗶𝗻𝗴 𝗦𝗹𝗲𝗲𝗽 𝗟𝗼𝘀𝘀 𝗶𝗻 𝗔𝗹𝘇𝗵𝗲𝗶𝗺𝗲𝗿’𝘀 𝗗𝗶𝘀𝗲𝗮𝘀𝗲
A quick thread on our findings!
𝗧𝗮𝘂 𝗛𝗶𝗷𝗮𝗰𝗸𝘀 𝗕𝗿𝗮𝗶𝗻 𝗠𝗲𝘁𝗮𝗯𝗼𝗹𝗶𝘀𝗺, 𝗗𝗿𝗶𝘃𝗶𝗻𝗴 𝗦𝗹𝗲𝗲𝗽 𝗟𝗼𝘀𝘀 𝗶𝗻 𝗔𝗹𝘇𝗵𝗲𝗶𝗺𝗲𝗿’𝘀 𝗗𝗶𝘀𝗲𝗮𝘀𝗲
A quick thread on our findings!
Reposted by Misha Zilberter
Excited to be on the organization meeting for the 6th annual NCM conference on Neural Circuits in Health & Disease. Terrific line up of speakers!
January 22, 2026 at 5:56 PM
Excited to be on the organization meeting for the 6th annual NCM conference on Neural Circuits in Health & Disease. Terrific line up of speakers!
Reposted by Misha Zilberter
Hi ephys enthusiasts! We have available slots for speakers for the King's Ephys Club editions in March, April and May. We usually run these on the last Thursday of the month at 16:30 at KCL (but no need to be from KCL!).
Drop me an email if you're interested at ana.dorrego-rivas[at]kcl.ac.uk
Drop me an email if you're interested at ana.dorrego-rivas[at]kcl.ac.uk
January 13, 2026 at 2:06 PM
Hi ephys enthusiasts! We have available slots for speakers for the King's Ephys Club editions in March, April and May. We usually run these on the last Thursday of the month at 16:30 at KCL (but no need to be from KCL!).
Drop me an email if you're interested at ana.dorrego-rivas[at]kcl.ac.uk
Drop me an email if you're interested at ana.dorrego-rivas[at]kcl.ac.uk
Reposted by Misha Zilberter
Out now!!
www.nature.com/articles/s44...
Intro to this paper pictured below
Huge thanks to collaborators @neilmdavies.bsky.social, @emmylooroll.bsky.social at @uclbrainscience.bsky.social & Sami Heikkinen and Mikko Hiltunen at @uniuef.bsky.social ...
#endalz #episky #medsky
www.nature.com/articles/s44...
Intro to this paper pictured below
Huge thanks to collaborators @neilmdavies.bsky.social, @emmylooroll.bsky.social at @uclbrainscience.bsky.social & Sami Heikkinen and Mikko Hiltunen at @uniuef.bsky.social ...
#endalz #episky #medsky
January 9, 2026 at 2:39 PM
Out now!!
www.nature.com/articles/s44...
Intro to this paper pictured below
Huge thanks to collaborators @neilmdavies.bsky.social, @emmylooroll.bsky.social at @uclbrainscience.bsky.social & Sami Heikkinen and Mikko Hiltunen at @uniuef.bsky.social ...
#endalz #episky #medsky
www.nature.com/articles/s44...
Intro to this paper pictured below
Huge thanks to collaborators @neilmdavies.bsky.social, @emmylooroll.bsky.social at @uclbrainscience.bsky.social & Sami Heikkinen and Mikko Hiltunen at @uniuef.bsky.social ...
#endalz #episky #medsky
Reposted by Misha Zilberter
Happy to announce the 2nd Hippocampus Green Meeting
📍 Barcelona, Spain
🗓️ May 11–12, 2026
Organized together with Manu Valero, Lisa Roux and Dan Bendor
🎤 Keynotes: Nachum Ulanovsky & György Buzsáki
‼️ Call for abstracts now open
🔗 hippocampusgreen.net/wp/
#HippocampusGreen
📍 Barcelona, Spain
🗓️ May 11–12, 2026
Organized together with Manu Valero, Lisa Roux and Dan Bendor
🎤 Keynotes: Nachum Ulanovsky & György Buzsáki
‼️ Call for abstracts now open
🔗 hippocampusgreen.net/wp/
#HippocampusGreen
December 7, 2025 at 11:51 AM
Happy to announce the 2nd Hippocampus Green Meeting
📍 Barcelona, Spain
🗓️ May 11–12, 2026
Organized together with Manu Valero, Lisa Roux and Dan Bendor
🎤 Keynotes: Nachum Ulanovsky & György Buzsáki
‼️ Call for abstracts now open
🔗 hippocampusgreen.net/wp/
#HippocampusGreen
📍 Barcelona, Spain
🗓️ May 11–12, 2026
Organized together with Manu Valero, Lisa Roux and Dan Bendor
🎤 Keynotes: Nachum Ulanovsky & György Buzsáki
‼️ Call for abstracts now open
🔗 hippocampusgreen.net/wp/
#HippocampusGreen
Reposted by Misha Zilberter
Neuronal APOE4 reduction with an APOE-I3-targeting ASO protects against neurodegeneration and neuroinflammation in an Alzheimer's disease mouse model https://www.biorxiv.org/content/10.64898/2025.12.10.693468v1
December 13, 2025 at 8:16 PM
Neuronal APOE4 reduction with an APOE-I3-targeting ASO protects against neurodegeneration and neuroinflammation in an Alzheimer's disease mouse model https://www.biorxiv.org/content/10.64898/2025.12.10.693468v1
Cracking open a celebratory bottle of brandy with our first author, Dennis, to mark the paper’s acceptance. Moments like this make it all worth it.
December 12, 2025 at 5:28 PM
Cracking open a celebratory bottle of brandy with our first author, Dennis, to mark the paper’s acceptance. Moments like this make it all worth it.
Reposted by Misha Zilberter
Neuronal APOE4 drives damaging lipid accumulation via contact-dependent neuron-oligodendrocyte-microglia interaction in Alzheimer's disease https://www.biorxiv.org/content/10.64898/2025.12.04.692390v1
December 9, 2025 at 6:19 PM
Neuronal APOE4 drives damaging lipid accumulation via contact-dependent neuron-oligodendrocyte-microglia interaction in Alzheimer's disease https://www.biorxiv.org/content/10.64898/2025.12.04.692390v1
Reposted by Misha Zilberter
Reviewers in December
December 4, 2025 at 7:53 PM
Reviewers in December
Reposted by Misha Zilberter
How cool is this new work from the Bienkowski lab?
CA1 of mouse hippocampus has 4 layers of specialized cell types. "This...changes our understanding of how information is processed...and could explain why certain cells are more vulnerable in diseases like Alzheimer’s and epilepsy."
Read more ⬇️
CA1 of mouse hippocampus has 4 layers of specialized cell types. "This...changes our understanding of how information is processed...and could explain why certain cells are more vulnerable in diseases like Alzheimer’s and epilepsy."
Read more ⬇️
🚨 Our latest study from @neuralmapping.bsky.social and his team is out in @nature.com and reveals a hidden set of cellular layers inside the hippocampus, the brain’s key center for learning and memory 🧠
Learn more about this work and its implications for memory and disease: bit.ly/48NtGdf
Learn more about this work and its implications for memory and disease: bit.ly/48NtGdf
USC study reveals hidden cellular layers in the brain’s memory center
Researchers at the Mark and Mary Stevens Neuroimaging and Informatics Institute (Stevens INI) at the Keck School of Medicine of USC have identified a previously unknown pattern of organization in one ...
bit.ly
December 3, 2025 at 6:05 PM
How cool is this new work from the Bienkowski lab?
CA1 of mouse hippocampus has 4 layers of specialized cell types. "This...changes our understanding of how information is processed...and could explain why certain cells are more vulnerable in diseases like Alzheimer’s and epilepsy."
Read more ⬇️
CA1 of mouse hippocampus has 4 layers of specialized cell types. "This...changes our understanding of how information is processed...and could explain why certain cells are more vulnerable in diseases like Alzheimer’s and epilepsy."
Read more ⬇️
Reposted by Misha Zilberter
Another great preprint on neuronal APOE4 from the Huang lab!
Neuronal APOE4 alone is sufficient to drive tau pathology, neurodegeneration, and neuroinflammation in an Alzheimer's disease mouse model https://www.biorxiv.org/content/10.1101/2025.11.25.690488v1
November 29, 2025 at 5:27 PM
Another great preprint on neuronal APOE4 from the Huang lab!
Reposted by Misha Zilberter
Our new review is out today!
𝗧𝗵𝗲 𝗘𝗻𝗲𝗿𝗴𝗲𝘁𝗶𝗰 𝗖𝗼𝗹𝗹𝗮𝗽𝘀𝗲 𝗼𝗳 𝘁𝗵𝗲 𝗔𝗹𝘇𝗵𝗲𝗶𝗺𝗲𝗿’𝘀 𝗕𝗿𝗮𝗶𝗻: 𝗠𝗲𝘁𝗮𝗯𝗼𝗹𝗶𝗰 𝗜𝗻𝗳𝗹𝗲𝘅𝗶𝗯𝗶𝗹𝗶𝘁𝘆 𝗔𝗰𝗿𝗼𝘀𝘀 𝗖𝗲𝗹𝗹𝘀 𝗮𝗻𝗱 𝗡𝗲𝘁𝘄𝗼𝗿𝗸𝘀
We argue that Alzheimer’s disease is not just a problem of brain hypometabolism, but a disorder of metabolic inflexibility.
onlinelibrary.wiley.com/doi/10.1111/...
𝗧𝗵𝗲 𝗘𝗻𝗲𝗿𝗴𝗲𝘁𝗶𝗰 𝗖𝗼𝗹𝗹𝗮𝗽𝘀𝗲 𝗼𝗳 𝘁𝗵𝗲 𝗔𝗹𝘇𝗵𝗲𝗶𝗺𝗲𝗿’𝘀 𝗕𝗿𝗮𝗶𝗻: 𝗠𝗲𝘁𝗮𝗯𝗼𝗹𝗶𝗰 𝗜𝗻𝗳𝗹𝗲𝘅𝗶𝗯𝗶𝗹𝗶𝘁𝘆 𝗔𝗰𝗿𝗼𝘀𝘀 𝗖𝗲𝗹𝗹𝘀 𝗮𝗻𝗱 𝗡𝗲𝘁𝘄𝗼𝗿𝗸𝘀
We argue that Alzheimer’s disease is not just a problem of brain hypometabolism, but a disorder of metabolic inflexibility.
onlinelibrary.wiley.com/doi/10.1111/...
The Energetic Collapse of the Alzheimer's Brain: Metabolic Inflexibility Across Cells and Networks
Metabolic inflexibility in Alzheimer's disease. Schematic illustrating the biphasic trajectory of metabolic activity relative to canonical Alzheimer's disease (AD) biomarkers. In the presymptomatic p...
onlinelibrary.wiley.com
November 13, 2025 at 8:17 PM
Our new review is out today!
𝗧𝗵𝗲 𝗘𝗻𝗲𝗿𝗴𝗲𝘁𝗶𝗰 𝗖𝗼𝗹𝗹𝗮𝗽𝘀𝗲 𝗼𝗳 𝘁𝗵𝗲 𝗔𝗹𝘇𝗵𝗲𝗶𝗺𝗲𝗿’𝘀 𝗕𝗿𝗮𝗶𝗻: 𝗠𝗲𝘁𝗮𝗯𝗼𝗹𝗶𝗰 𝗜𝗻𝗳𝗹𝗲𝘅𝗶𝗯𝗶𝗹𝗶𝘁𝘆 𝗔𝗰𝗿𝗼𝘀𝘀 𝗖𝗲𝗹𝗹𝘀 𝗮𝗻𝗱 𝗡𝗲𝘁𝘄𝗼𝗿𝗸𝘀
We argue that Alzheimer’s disease is not just a problem of brain hypometabolism, but a disorder of metabolic inflexibility.
onlinelibrary.wiley.com/doi/10.1111/...
𝗧𝗵𝗲 𝗘𝗻𝗲𝗿𝗴𝗲𝘁𝗶𝗰 𝗖𝗼𝗹𝗹𝗮𝗽𝘀𝗲 𝗼𝗳 𝘁𝗵𝗲 𝗔𝗹𝘇𝗵𝗲𝗶𝗺𝗲𝗿’𝘀 𝗕𝗿𝗮𝗶𝗻: 𝗠𝗲𝘁𝗮𝗯𝗼𝗹𝗶𝗰 𝗜𝗻𝗳𝗹𝗲𝘅𝗶𝗯𝗶𝗹𝗶𝘁𝘆 𝗔𝗰𝗿𝗼𝘀𝘀 𝗖𝗲𝗹𝗹𝘀 𝗮𝗻𝗱 𝗡𝗲𝘁𝘄𝗼𝗿𝗸𝘀
We argue that Alzheimer’s disease is not just a problem of brain hypometabolism, but a disorder of metabolic inflexibility.
onlinelibrary.wiley.com/doi/10.1111/...
Reposted by Misha Zilberter
Apolipoprotein ε4 exacerbates white matter impairment in a mouse model of Aβ amyloidosis by decreasing actively myelinating oligodendrocytes - Al‐Amin - 2025 - Alzheimer's & Dementia - Wiley Online Library alz-journals.onlinelibrary.wiley.com/doi/10.1002/...
Apolipoprotein ε4 exacerbates white matter impairment in a mouse model of Aβ amyloidosis by decreasing actively myelinating oligodendrocytes
INTRODUCTION
The ε4 allele of the apolipoprotein E (APOE) gene is a risk factor for the development of Alzheimer's disease (AD). APOE4 isoform is associated with increased white matter lesions in hu.....
alz-journals.onlinelibrary.wiley.com
November 11, 2025 at 4:37 AM
Apolipoprotein ε4 exacerbates white matter impairment in a mouse model of Aβ amyloidosis by decreasing actively myelinating oligodendrocytes - Al‐Amin - 2025 - Alzheimer's & Dementia - Wiley Online Library alz-journals.onlinelibrary.wiley.com/doi/10.1002/...
Mitochondrial bioenergetic signatures differentiate asymptomatic from symptomatic Alzheimer’s disease: www.biorxiv.org/content/10.1...
Mitochondrial bioenergetic signatures differentiate asymptomatic from symptomatic Alzheimer’s disease
Asymptomatic Alzheimer’s disease (AsymAD) refers to individuals who, despite exhibiting amyloid-β plaques and tau pathology comparable to Alzheimer’s disease (AD), maintain cognitive performance simil...
www.biorxiv.org
November 10, 2025 at 7:55 PM
Mitochondrial bioenergetic signatures differentiate asymptomatic from symptomatic Alzheimer’s disease: www.biorxiv.org/content/10.1...
Reposted by Misha Zilberter
Reposted by Misha Zilberter
⚠️SAVE THE DATE⚠️
🧠CAJAL CONFERENCE 2026
📍Cádiz, April 15–17
“Novel Insights into Brain Energy Metabolism in Health and Disease”
Join an outstanding lineup of keynote speakers!👇🏻
🧠CAJAL CONFERENCE 2026
📍Cádiz, April 15–17
“Novel Insights into Brain Energy Metabolism in Health and Disease”
Join an outstanding lineup of keynote speakers!👇🏻
November 3, 2025 at 7:31 PM
⚠️SAVE THE DATE⚠️
🧠CAJAL CONFERENCE 2026
📍Cádiz, April 15–17
“Novel Insights into Brain Energy Metabolism in Health and Disease”
Join an outstanding lineup of keynote speakers!👇🏻
🧠CAJAL CONFERENCE 2026
📍Cádiz, April 15–17
“Novel Insights into Brain Energy Metabolism in Health and Disease”
Join an outstanding lineup of keynote speakers!👇🏻
Submitted reviews for the upcoming NIA study section (hasn't been cancelled yet). Looks like I was the only one....
November 3, 2025 at 5:34 PM
Submitted reviews for the upcoming NIA study section (hasn't been cancelled yet). Looks like I was the only one....
Reposted by Misha Zilberter
While you are all waiting for treat or treaters & the blue jay game … take a look at our newest from
@bonniee-leee.bsky.social where we look at neural networks in middle aged female rats based on APOE genotype and parity history www.sciencedirect.com/science/arti...
@bonniee-leee.bsky.social where we look at neural networks in middle aged female rats based on APOE genotype and parity history www.sciencedirect.com/science/arti...
Sex-specific factors and APOEε4 genotype alter functional connectivity at middle age
Cognitive aging is influenced by sex and sex-specific factors. Indeed, research has shown that parity (pregnancy and parenthood) uniquely alters bioma…
www.sciencedirect.com
October 31, 2025 at 5:59 PM
While you are all waiting for treat or treaters & the blue jay game … take a look at our newest from
@bonniee-leee.bsky.social where we look at neural networks in middle aged female rats based on APOE genotype and parity history www.sciencedirect.com/science/arti...
@bonniee-leee.bsky.social where we look at neural networks in middle aged female rats based on APOE genotype and parity history www.sciencedirect.com/science/arti...
Reposted by Misha Zilberter
🚨New in Lancet Neurology: Autopsy study of aducanumab in #Alzheimer’s shows superficial cortical Aβ cleared, but deeper persists. ARIA showed inflammation+ microinfarcts in leptomeningeal/penetrating vessels. Some path is PET-invisible. @drneurochic.bsky.social
authors.elsevier.com/a/1lxn85FFzL...
authors.elsevier.com/a/1lxn85FFzL...
October 16, 2025 at 10:33 AM
🚨New in Lancet Neurology: Autopsy study of aducanumab in #Alzheimer’s shows superficial cortical Aβ cleared, but deeper persists. ARIA showed inflammation+ microinfarcts in leptomeningeal/penetrating vessels. Some path is PET-invisible. @drneurochic.bsky.social
authors.elsevier.com/a/1lxn85FFzL...
authors.elsevier.com/a/1lxn85FFzL...