Christos Lisgaras
@chrislisgaras.bsky.social
Res. Assistant Professor at NYU Grossman School of Medicine, Department of Psychiatry.
Epilepsy, Alzheimer’s disease and Oscillations #HFOnews #ADEEGnews #CA2news
https://linktr.ee/clisgaras
https://med.nyu.edu/faculty/christos-lisgaras
Epilepsy, Alzheimer’s disease and Oscillations #HFOnews #ADEEGnews #CA2news
https://linktr.ee/clisgaras
https://med.nyu.edu/faculty/christos-lisgaras
Reposted by Christos Lisgaras
This scientific commentary refers to ‘High-frequency oscillations in epileptic and non-epileptic Alzheimer's disease patients and the differential effect of levetiracetam on the oscillations’, by Shandilya et al. @chrislisgaras.bsky.social
Read at 👉 buff.ly/r3IcOEE
Read at 👉 buff.ly/r3IcOEE
October 25, 2025 at 3:00 PM
This scientific commentary refers to ‘High-frequency oscillations in epileptic and non-epileptic Alzheimer's disease patients and the differential effect of levetiracetam on the oscillations’, by Shandilya et al. @chrislisgaras.bsky.social
Read at 👉 buff.ly/r3IcOEE
Read at 👉 buff.ly/r3IcOEE
New paper out! We show that EEG biomarkers interact in opposite ways in Alzheimer’s disease (AD) vs. epilepsy. This could explain why epileptiform activity is inconsistently seen in AD—and highlights the need for wideband EEG to uncover these dynamics. #HFOnews
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Opposing interictal dynamics in Alzheimer’s disease and epilepsy
Advanced EEG technology has revealed that epileptiform activity occurs more frequently in Alzheimer’s disease (AD) than previously recognized, prompti…
www.sciencedirect.com
November 7, 2025 at 12:51 PM
New paper out! We show that EEG biomarkers interact in opposite ways in Alzheimer’s disease (AD) vs. epilepsy. This could explain why epileptiform activity is inconsistently seen in AD—and highlights the need for wideband EEG to uncover these dynamics. #HFOnews
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Greatly enjoyed writing this piece for @braincomms.bsky.social!
🔹 "High frequency opportunities for Alzheimer's disease" academic.oup.com/braincomms/a...
This commentary calls for rethinking how we “listen to” and interpret abnormal electrical activity in Alzheimer’s disease and related dementias.
🔹 "High frequency opportunities for Alzheimer's disease" academic.oup.com/braincomms/a...
This commentary calls for rethinking how we “listen to” and interpret abnormal electrical activity in Alzheimer’s disease and related dementias.
High frequency opportunities for Alzheimer’s disease
This scientific commentary refers to ‘High-frequency oscillations in epileptic and non-epileptic Alzheimer's disease patients and the differential effect o
academic.oup.com
October 7, 2025 at 1:11 PM
Greatly enjoyed writing this piece for @braincomms.bsky.social!
🔹 "High frequency opportunities for Alzheimer's disease" academic.oup.com/braincomms/a...
This commentary calls for rethinking how we “listen to” and interpret abnormal electrical activity in Alzheimer’s disease and related dementias.
🔹 "High frequency opportunities for Alzheimer's disease" academic.oup.com/braincomms/a...
This commentary calls for rethinking how we “listen to” and interpret abnormal electrical activity in Alzheimer’s disease and related dementias.
Off to beautiful Lisbon to speak the XVIII Workshop on Neurobiology of Epilepsies. Excited about this year’s topic on the resilient brain! Who’s coming?! #HFOnews 🧠 #ILAE @ilae-epilepsy.bsky.social
August 24, 2025 at 11:31 PM
Off to beautiful Lisbon to speak the XVIII Workshop on Neurobiology of Epilepsies. Excited about this year’s topic on the resilient brain! Who’s coming?! #HFOnews 🧠 #ILAE @ilae-epilepsy.bsky.social
Exited to share our new work! We found scalp high frequency oscillations (HFOs) in adults with Down syndrome, before the clinical onset of Alzheimer’s dementia and late onset myoclonic epilepsy.
HFOs may hold the key to earlier diagnosis #HFOnews
alz-journals.onlinelibrary.wiley.com/doi/10.1002/...
HFOs may hold the key to earlier diagnosis #HFOnews
alz-journals.onlinelibrary.wiley.com/doi/10.1002/...
High‐frequency oscillations >250 Hz in people with Down syndrome and associated Alzheimer's disease dementia
INTRODUCTION Alzheimer's disease (AD) dementia has near full penetrance in adults with Down syndrome (DS) and is strongly linked to late-onset myoclonic epilepsy in Down syndrome (LOMEDS). However, ...
alz-journals.onlinelibrary.wiley.com
July 21, 2025 at 2:53 PM
Exited to share our new work! We found scalp high frequency oscillations (HFOs) in adults with Down syndrome, before the clinical onset of Alzheimer’s dementia and late onset myoclonic epilepsy.
HFOs may hold the key to earlier diagnosis #HFOnews
alz-journals.onlinelibrary.wiley.com/doi/10.1002/...
HFOs may hold the key to earlier diagnosis #HFOnews
alz-journals.onlinelibrary.wiley.com/doi/10.1002/...
Interested in how sleep is affected across the Alzheimer’s disease continuum in people with Down syndrome? 💤
Check our new publication with collaborators in Spain out in Alzheimer’s & Dementia: The Journal of the Alzheimer’s Association.
alz-journals.onlinelibrary.wiley.com/doi/10.1002/...
Check our new publication with collaborators in Spain out in Alzheimer’s & Dementia: The Journal of the Alzheimer’s Association.
alz-journals.onlinelibrary.wiley.com/doi/10.1002/...
Impact of Alzheimer's disease on sleep in adults with Down syndrome
INTRODUCTION Down syndrome (DS) is a genetic form of Alzheimer's disease (AD), with a high prevalence of sleep disorders, but data in adults with DS and dementia are lacking. We aim to assess sleep ...
alz-journals.onlinelibrary.wiley.com
July 8, 2025 at 3:19 PM
Interested in how sleep is affected across the Alzheimer’s disease continuum in people with Down syndrome? 💤
Check our new publication with collaborators in Spain out in Alzheimer’s & Dementia: The Journal of the Alzheimer’s Association.
alz-journals.onlinelibrary.wiley.com/doi/10.1002/...
Check our new publication with collaborators in Spain out in Alzheimer’s & Dementia: The Journal of the Alzheimer’s Association.
alz-journals.onlinelibrary.wiley.com/doi/10.1002/...
Interested in how preclinical studies can help understand EEG patterns? Take a look at our book chapter! With Marco de Curtis and Premysl Jiruska.
link.springer.com/chapter/10.1...
#HFOnews
link.springer.com/chapter/10.1...
#HFOnews
June 13, 2025 at 5:44 PM
Interested in how preclinical studies can help understand EEG patterns? Take a look at our book chapter! With Marco de Curtis and Premysl Jiruska.
link.springer.com/chapter/10.1...
#HFOnews
link.springer.com/chapter/10.1...
#HFOnews
#HFOnews! And first outcome publication of the Third International Workshop on High Frequency Oscillations in Epilepsy. 👇👇
Don’t miss our latest 📝 with @chrislisgaras.bsky.social & Rick Staba on high-frequency oscillations in preclinical 🧠 disease models, with guidelines for recording, detection and analysis. journals.sagepub.com/doi/10.1177/...
June 11, 2025 at 5:42 PM
#HFOnews! And first outcome publication of the Third International Workshop on High Frequency Oscillations in Epilepsy. 👇👇
Off to beautiful Verona for the Spring Hippocampal Research Conference! Who’s coming?! #HFOnews
hippo.euroconferences.org/scientific-p...
hippo.euroconferences.org/scientific-p...
Scientific Program
If you determine at the last minute that you cannot travel to Verona, you will have the option of providing a video of your presentation, which will be played in the session in which you are...
hippo.euroconferences.org
May 16, 2025 at 8:18 PM
Off to beautiful Verona for the Spring Hippocampal Research Conference! Who’s coming?! #HFOnews
hippo.euroconferences.org/scientific-p...
hippo.euroconferences.org/scientific-p...
Excited to be speaking about High Frequency Oscillations in Epilepsy and Sleep at the 2nd Annual Sleep Conference in NYC!
April 10, 2025 at 5:00 PM
Excited to be speaking about High Frequency Oscillations in Epilepsy and Sleep at the 2nd Annual Sleep Conference in NYC!
Join us next week for an @ilae-epilepsy.bsky.social webinar on High Frequency Oscillations! Dr. Sheybani @laurentsheybani.bsky.social and Dr. Jacobs will talk all about HFOs in epilepsy. #HFOnews
Register here: docs.google.com/forms/d/1e-x...
Register here: docs.google.com/forms/d/1e-x...
March 21, 2025 at 1:10 PM
Join us next week for an @ilae-epilepsy.bsky.social webinar on High Frequency Oscillations! Dr. Sheybani @laurentsheybani.bsky.social and Dr. Jacobs will talk all about HFOs in epilepsy. #HFOnews
Register here: docs.google.com/forms/d/1e-x...
Register here: docs.google.com/forms/d/1e-x...
A great one by @laurentsheybani.bsky.social - on the reading list!
Is sleep the worst enemy of epilepsy? Is it promoting or preventing seizures? And how?
We present recent mechanistic insights on the interaction between epilepsy and sleep in a review published today in Nature Reviews Neurology:
doi.org/10.1038/s415...
@natrevneurol.bsky.social
We present recent mechanistic insights on the interaction between epilepsy and sleep in a review published today in Nature Reviews Neurology:
doi.org/10.1038/s415...
@natrevneurol.bsky.social
Mechanistic insights into the interaction between epilepsy and sleep - Nature Reviews Neurology
Epidemiological evidence has demonstrated associations between sleep and epilepsy, but we lack a mechanistic understanding of these associations. In this Review, Sheybani et al. consider the associati...
doi.org
March 13, 2025 at 6:11 PM
A great one by @laurentsheybani.bsky.social - on the reading list!
Key point: High-density (HD) grid recordings can be used and interpreted for surgical guidance.
doi.org/10.1111/epi....
#epilepsy #ILAE #focalseizures #highfrequencyoscillations #intraoperativetailoring #subduralEEG
doi.org/10.1111/epi....
#epilepsy #ILAE #focalseizures #highfrequencyoscillations #intraoperativetailoring #subduralEEG
February 21, 2025 at 4:00 PM
Our #EEG Review was selected as @epilepsiajournal.bsky.social Editor’s Featured Article - give it a read here👇
onlinelibrary.wiley.com/doi/10.1111/...
onlinelibrary.wiley.com/doi/10.1111/...
February 17, 2025 at 4:23 PM
Our #EEG Review was selected as @epilepsiajournal.bsky.social Editor’s Featured Article - give it a read here👇
onlinelibrary.wiley.com/doi/10.1111/...
onlinelibrary.wiley.com/doi/10.1111/...
Super excited to see our 2022 animal model study (onlinelibrary.wiley.com/doi/10.1111/...) showing HFOs in Alzheimer’s model systems replicated in humans! @braincomms.bsky.social
The dream of every basic scientist 🤩
Our human study coming very soon :)
#HFOnews
academic.oup.com/braincomms/a...
The dream of every basic scientist 🤩
Our human study coming very soon :)
#HFOnews
academic.oup.com/braincomms/a...
High‐frequency oscillations (250–500 Hz) in animal models of Alzheimer's disease and two animal models of epilepsy
Objective
To test the hypothesis that high-frequency oscillations (HFOs) between 250 and 500 Hz occur in mouse models of Alzheimer's disease (AD) and thus are not unique to epilepsy.
Methods
Exper.....
onlinelibrary.wiley.com
February 15, 2025 at 6:05 PM
Super excited to see our 2022 animal model study (onlinelibrary.wiley.com/doi/10.1111/...) showing HFOs in Alzheimer’s model systems replicated in humans! @braincomms.bsky.social
The dream of every basic scientist 🤩
Our human study coming very soon :)
#HFOnews
academic.oup.com/braincomms/a...
The dream of every basic scientist 🤩
Our human study coming very soon :)
#HFOnews
academic.oup.com/braincomms/a...
Our review discussing the role of EEG in Epilepsy research is now out @epilepsiajournal.bsky.social @ilae-epilepsy.bsky.social
Thanks to all of my co-authors!
onlinelibrary.wiley.com/doi/10.1111/...
Thanks to all of my co-authors!
onlinelibrary.wiley.com/doi/10.1111/...
February 13, 2025 at 3:48 PM
Our review discussing the role of EEG in Epilepsy research is now out @epilepsiajournal.bsky.social @ilae-epilepsy.bsky.social
Thanks to all of my co-authors!
onlinelibrary.wiley.com/doi/10.1111/...
Thanks to all of my co-authors!
onlinelibrary.wiley.com/doi/10.1111/...
The time has come!
Neuropixels and Optogenetics are delighted to announce the birth of
Neuropixels Opto
Combining high-resolution electrophysiology and optogenetics
Today in bioRxiv
960 sites, 28 emitters, 2 colors
By Lakunina, @karolinazsocha.bsky.social, Ladd, et al
www.biorxiv.org/content/10.1...
(1/2)
Neuropixels Opto
Combining high-resolution electrophysiology and optogenetics
Today in bioRxiv
960 sites, 28 emitters, 2 colors
By Lakunina, @karolinazsocha.bsky.social, Ladd, et al
www.biorxiv.org/content/10.1...
(1/2)
February 7, 2025 at 2:06 PM
The time has come!
Reposted by Christos Lisgaras
New paper out in Cell Reports! Led by @susieyufeng.bsky.social, we found that chronic epilepsy in mice drives distinct synchronization deficits in hippocampus and MEC, with early changes in HPC and late-onset changes in MEC that align with progressive memory impairment.
www.cell.com/cell-reports...
www.cell.com/cell-reports...
January 28, 2025 at 8:17 PM
New paper out in Cell Reports! Led by @susieyufeng.bsky.social, we found that chronic epilepsy in mice drives distinct synchronization deficits in hippocampus and MEC, with early changes in HPC and late-onset changes in MEC that align with progressive memory impairment.
www.cell.com/cell-reports...
www.cell.com/cell-reports...
Reposted by Christos Lisgaras
🚨NIH-funded postdoc position! Looking for an electrophysiologist (ex/in-vivo) to work with us at Gladstone Institutes on mechanisms of oxidative stress, glucose metabolism, and network hyperexcitability in Alzheimer's disease 🧠 #neurojobs #postdocjob gladstone.wd5.myworkdayjobs.com/en-US/career...
January 13, 2025 at 4:15 PM
🚨NIH-funded postdoc position! Looking for an electrophysiologist (ex/in-vivo) to work with us at Gladstone Institutes on mechanisms of oxidative stress, glucose metabolism, and network hyperexcitability in Alzheimer's disease 🧠 #neurojobs #postdocjob gladstone.wd5.myworkdayjobs.com/en-US/career...
Reposted by Christos Lisgaras
SEEING THROUGH YOUR EYES 👁️:
Excited to share our new paper (which is out now @nature.com !!) with Wenbo Tang, Antonio Fernandez-Ruiz✉️, and Azahara Oliva✉️: we discovered a novel sleep microstructure that promotes memory replay! #Neuroscience #hippocampus
nature.com/articles/s41... 🧵 1/12👇
Excited to share our new paper (which is out now @nature.com !!) with Wenbo Tang, Antonio Fernandez-Ruiz✉️, and Azahara Oliva✉️: we discovered a novel sleep microstructure that promotes memory replay! #Neuroscience #hippocampus
nature.com/articles/s41... 🧵 1/12👇
Sleep microstructure organizes memory replay - Nature
The temporal microstructure of the brain can multiplex distinct cognitive processes during sleep to support continuous learning.
nature.com
January 2, 2025 at 2:51 AM
SEEING THROUGH YOUR EYES 👁️:
Excited to share our new paper (which is out now @nature.com !!) with Wenbo Tang, Antonio Fernandez-Ruiz✉️, and Azahara Oliva✉️: we discovered a novel sleep microstructure that promotes memory replay! #Neuroscience #hippocampus
nature.com/articles/s41... 🧵 1/12👇
Excited to share our new paper (which is out now @nature.com !!) with Wenbo Tang, Antonio Fernandez-Ruiz✉️, and Azahara Oliva✉️: we discovered a novel sleep microstructure that promotes memory replay! #Neuroscience #hippocampus
nature.com/articles/s41... 🧵 1/12👇
What a great weather in LA!!
December 5, 2024 at 11:56 PM
What a great weather in LA!!
On my way to sunny LA for the @amepilepsysoc.bsky.social Annual Meeting! Excited to be speaking about common EEG disturbances in Alzheimer’s Disease and Epilepsy models. Join our IW on AD and Epilepsy on Dec 8 at 3:15pm, Room 403A!
December 5, 2024 at 2:24 PM
On my way to sunny LA for the @amepilepsysoc.bsky.social Annual Meeting! Excited to be speaking about common EEG disturbances in Alzheimer’s Disease and Epilepsy models. Join our IW on AD and Epilepsy on Dec 8 at 3:15pm, Room 403A!
