Laurent Sheybani
@laurentsheybani.bsky.social
Epilepsy
Sleep
Electrophysiology
Hiking - Cycling - Swimming - Music
Associate Editor @ Brain Comms https://academic.oup.com/braincomms
Sleep
Electrophysiology
Hiking - Cycling - Swimming - Music
Associate Editor @ Brain Comms https://academic.oup.com/braincomms
🚨 Great scientific commentary by Christos Lisgaras --> academic.oup.com/braincomms/a...
High frequency oscillations in neurodegenerative disorders. Have a look !
High frequency oscillations in neurodegenerative disorders. Have a look !
High frequency opportunities for Alzheimer’s disease
This scientific commentary refers to ‘High-frequency oscillations in epileptic and non-epileptic Alzheimer's disease patients and the differential effect o
academic.oup.com
October 4, 2025 at 7:44 AM
🚨 Great scientific commentary by Christos Lisgaras --> academic.oup.com/braincomms/a...
High frequency oscillations in neurodegenerative disorders. Have a look !
High frequency oscillations in neurodegenerative disorders. Have a look !
We are hiring !
👩🏼🎓👨🎓🧑🏼🎓👨🏿🎓👩🏿🎓👩🎓
I am looking for a motivated person interested in a PhD in basic neuroscience, for a project at the edge between epilepsy and sleep.
If you are interested, check the job announcement:
jobs.unige.ch/www/wd_porta...
👩🏼🎓👨🎓🧑🏼🎓👨🏿🎓👩🏿🎓👩🎓
I am looking for a motivated person interested in a PhD in basic neuroscience, for a project at the edge between epilepsy and sleep.
If you are interested, check the job announcement:
jobs.unige.ch/www/wd_porta...
Assistant-e (A2) (6548)
jobs.unige.ch
September 15, 2025 at 12:41 PM
We are hiring !
👩🏼🎓👨🎓🧑🏼🎓👨🏿🎓👩🏿🎓👩🎓
I am looking for a motivated person interested in a PhD in basic neuroscience, for a project at the edge between epilepsy and sleep.
If you are interested, check the job announcement:
jobs.unige.ch/www/wd_porta...
👩🏼🎓👨🎓🧑🏼🎓👨🏿🎓👩🏿🎓👩🎓
I am looking for a motivated person interested in a PhD in basic neuroscience, for a project at the edge between epilepsy and sleep.
If you are interested, check the job announcement:
jobs.unige.ch/www/wd_porta...
Reposted by Laurent Sheybani
This asymmetry is highly patient-specific and supports the hypothesis that generalized discharges are shaped by delimited areas of cortex.
doi.org/10.1111/epi....
#epilepsy #epilepsia #ILAE #amplitude #discharges #EEG #generalized #symmetry
doi.org/10.1111/epi....
#epilepsy #epilepsia #ILAE #amplitude #discharges #EEG #generalized #symmetry
July 16, 2025 at 6:10 PM
This asymmetry is highly patient-specific and supports the hypothesis that generalized discharges are shaped by delimited areas of cortex.
doi.org/10.1111/epi....
#epilepsy #epilepsia #ILAE #amplitude #discharges #EEG #generalized #symmetry
doi.org/10.1111/epi....
#epilepsy #epilepsia #ILAE #amplitude #discharges #EEG #generalized #symmetry
Thrilled to have been awarded an Ambizione grant from the @snsf.ch ! I will work under the auspices of Pr Serge Vulliémoz, Pr @anitaluthi.bsky.social and collaborate with Pr Matthew Walker (UCL), Dr Daniel Bush and Dr Tawfeeq Shekh-Ahmad for a project on epilepsy and sleep.
July 12, 2025 at 3:18 PM
Thrilled to have been awarded an Ambizione grant from the @snsf.ch ! I will work under the auspices of Pr Serge Vulliémoz, Pr @anitaluthi.bsky.social and collaborate with Pr Matthew Walker (UCL), Dr Daniel Bush and Dr Tawfeeq Shekh-Ahmad for a project on epilepsy and sleep.
Deep learning for epilepsy ! An impressive work by Sundrani and colleagues demonstrates the ability of convulational neural network to predict seizure onset zones -->
doi.org/10.1111/epi....
doi.org/10.1111/epi....
Deep learning on brief interictal intracranial recordings can accurately characterize seizure onset zones
Objective Epilepsy is a debilitating disorder affecting more than 50 million people worldwide, and one third of patients continue to have seizures despite maximal medical management. If patients' se...
doi.org
May 30, 2025 at 2:48 PM
Deep learning for epilepsy ! An impressive work by Sundrani and colleagues demonstrates the ability of convulational neural network to predict seizure onset zones -->
doi.org/10.1111/epi....
doi.org/10.1111/epi....
Interneurons promotes microglial activation, ultimately leading to phagocytosis of inhibitory synapses --> part of the mechanism of temporal lobe epilepsy?
doi.org/10.1038/s415...
doi.org/10.1038/s415...
GABA-dependent microglial elimination of inhibitory synapses underlies neuronal hyperexcitability in epilepsy - Nature Neuroscience
The microglia–neuron interactions contributing to neuronal hyperexcitability are unclear. Here, the authors show how GABA and C3 signaling coordinate microglial engulfment of inhibitory synapses, driv...
doi.org
May 30, 2025 at 2:46 PM
Interneurons promotes microglial activation, ultimately leading to phagocytosis of inhibitory synapses --> part of the mechanism of temporal lobe epilepsy?
doi.org/10.1038/s415...
doi.org/10.1038/s415...
Reposted by Laurent Sheybani
Just published my first paper!
Really grateful to everyone at the plasticity lab @oxcin.bsky.social who made this possible.
huge thanks to my co-authors — couldn’t have done it without you.
If you want to check it out:
📄 paper: www.nature.com/articles/s41...
Really grateful to everyone at the plasticity lab @oxcin.bsky.social who made this possible.
huge thanks to my co-authors — couldn’t have done it without you.
If you want to check it out:
📄 paper: www.nature.com/articles/s41...
Sleep regularity index as a novel indicator of sleep disturbance in stroke survivors: a secondary data analysis - Scientific Reports
Scientific Reports - Sleep regularity index as a novel indicator of sleep disturbance in stroke survivors: a secondary data analysis
www.nature.com
May 21, 2025 at 2:51 PM
Just published my first paper!
Really grateful to everyone at the plasticity lab @oxcin.bsky.social who made this possible.
huge thanks to my co-authors — couldn’t have done it without you.
If you want to check it out:
📄 paper: www.nature.com/articles/s41...
Really grateful to everyone at the plasticity lab @oxcin.bsky.social who made this possible.
huge thanks to my co-authors — couldn’t have done it without you.
If you want to check it out:
📄 paper: www.nature.com/articles/s41...
Reposted by Laurent Sheybani
Geneva
Explore Pint of Science Switzerland events in Geneva
pintofscience.ch
May 19, 2025 at 3:41 PM
Thorough electrophy study on cortical stimulation --> www.nature.com/articles/s41....
Fascinating to see this complex network elicited by 'artificial' stimulation.
Well done @simonerusso.bsky.social and team!
Fascinating to see this complex network elicited by 'artificial' stimulation.
Well done @simonerusso.bsky.social and team!
Thalamic feedback shapes brain responses evoked by cortical stimulation in mice and humans - Nature Communications
Neural mechanisms underlying thalamic contributions to evoked potentials by brain stimulation, which has been widely used for therapeutic interventions, are not fully understood. In this translational...
www.nature.com
April 20, 2025 at 6:11 AM
Thorough electrophy study on cortical stimulation --> www.nature.com/articles/s41....
Fascinating to see this complex network elicited by 'artificial' stimulation.
Well done @simonerusso.bsky.social and team!
Fascinating to see this complex network elicited by 'artificial' stimulation.
Well done @simonerusso.bsky.social and team!
Encouraging phase 2 trial in fronto-temporal dementia ->
Assogna et al. report that co-ultramicronised palmitoylethanolamide + luteoline slowed cognitive decline in FTD patients in a Phase 2 trial, showing promise for future treatment. Please read at: buff.ly/VlC9Kdd #FTD
March 31, 2025 at 3:16 PM
Encouraging phase 2 trial in fronto-temporal dementia ->
Excited to take part in tomorrow's webinar organized by the Young Epilepsy Session (YES) of the International League Against Epilepsy (ILAE). I will be discussing mechanisms of generation of HFOs and why this is important for clinical practice.
@ilae-epilepsy.bsky.social
@ilae-epilepsy.bsky.social
Join us next week for an @ilae-epilepsy.bsky.social webinar on High Frequency Oscillations! Dr. Sheybani @laurentsheybani.bsky.social and Dr. Jacobs will talk all about HFOs in epilepsy. #HFOnews
Register here: docs.google.com/forms/d/1e-x...
Register here: docs.google.com/forms/d/1e-x...
March 25, 2025 at 2:25 PM
Excited to take part in tomorrow's webinar organized by the Young Epilepsy Session (YES) of the International League Against Epilepsy (ILAE). I will be discussing mechanisms of generation of HFOs and why this is important for clinical practice.
@ilae-epilepsy.bsky.social
@ilae-epilepsy.bsky.social
Disrupting synaptic transmission affects sleep-wake dynamic --> www.cell.com/current-biol...
Deficient synaptic neurotransmission results in a persistent sleep-like cortical activity across vigilance states in mice
Using a mouse model of altered neurotransmission (Vamp2rlss), Guillaumin et al. show
that differences typically observed between vigilance states in neural dynamics and
spectral signatures can be mark...
www.cell.com
March 23, 2025 at 1:19 PM
Disrupting synaptic transmission affects sleep-wake dynamic --> www.cell.com/current-biol...
At the MicMac conference in Toulouse, listening to talks on HFOs, and look what comes out in Brain Communications:
doi.org/10.1093/brai...
doi.org/10.1093/brai...
March 20, 2025 at 10:37 AM
At the MicMac conference in Toulouse, listening to talks on HFOs, and look what comes out in Brain Communications:
doi.org/10.1093/brai...
doi.org/10.1093/brai...
Coupling of spindles to slow waves is important for memory, but this is disrupted in people with epilepsy -->
doi.org/10.1111/epi....
doi.org/10.1111/epi....
Widespread decoupling of spindles and slow waves in temporal lobe epilepsy
Objective Memory impairment is common in people with temporal lobe epilepsy (TLE). Recent studies in healthy subjects showed a positive correlation between sleep spindles coupled to slow waves (SWs)...
doi.org
March 16, 2025 at 2:01 PM
Coupling of spindles to slow waves is important for memory, but this is disrupted in people with epilepsy -->
doi.org/10.1111/epi....
doi.org/10.1111/epi....
Exciting work where we address the mechanisms underlying long held epidemiological associations between epilepsy and sleep.
Thanks to all co-authors: Birgit Frauscher, Christophe Bernard and Matthew C Walker. Thanks to my funding:
@snsf-ch.bsky.social
Guarantors of @brain1878.bsky.social
Thanks to all co-authors: Birgit Frauscher, Christophe Bernard and Matthew C Walker. Thanks to my funding:
@snsf-ch.bsky.social
Guarantors of @brain1878.bsky.social
New online! Mechanistic insights into the interaction between epilepsy and sleep https://bit.ly/4ixu2qu
March 10, 2025 at 2:51 PM
Exciting work where we address the mechanisms underlying long held epidemiological associations between epilepsy and sleep.
Thanks to all co-authors: Birgit Frauscher, Christophe Bernard and Matthew C Walker. Thanks to my funding:
@snsf-ch.bsky.social
Guarantors of @brain1878.bsky.social
Thanks to all co-authors: Birgit Frauscher, Christophe Bernard and Matthew C Walker. Thanks to my funding:
@snsf-ch.bsky.social
Guarantors of @brain1878.bsky.social
Is sleep the worst enemy of epilepsy? Is it promoting or preventing seizures? And how?
We present recent mechanistic insights on the interaction between epilepsy and sleep in a review published today in Nature Reviews Neurology:
doi.org/10.1038/s415...
@natrevneurol.bsky.social
We present recent mechanistic insights on the interaction between epilepsy and sleep in a review published today in Nature Reviews Neurology:
doi.org/10.1038/s415...
@natrevneurol.bsky.social
Mechanistic insights into the interaction between epilepsy and sleep - Nature Reviews Neurology
Epidemiological evidence has demonstrated associations between sleep and epilepsy, but we lack a mechanistic understanding of these associations. In this Review, Sheybani et al. consider the associati...
doi.org
March 10, 2025 at 2:18 PM
Is sleep the worst enemy of epilepsy? Is it promoting or preventing seizures? And how?
We present recent mechanistic insights on the interaction between epilepsy and sleep in a review published today in Nature Reviews Neurology:
doi.org/10.1038/s415...
@natrevneurol.bsky.social
We present recent mechanistic insights on the interaction between epilepsy and sleep in a review published today in Nature Reviews Neurology:
doi.org/10.1038/s415...
@natrevneurol.bsky.social
Thalamic activity during wake and sleep in 121 people with epilepsy -->
academic.oup.com/braincomms/a...
academic.oup.com/braincomms/a...
Interictal waking and sleep electrophysiological properties of the thalamus in focal epilepsies
Epilepsy is a cortico-subcortical network disorder. By analyzing thalamo-cortical relationships in 121 patients through stereotactic-EEG, Biagioni et al. i
academic.oup.com
March 8, 2025 at 9:42 AM
Thalamic activity during wake and sleep in 121 people with epilepsy -->
academic.oup.com/braincomms/a...
academic.oup.com/braincomms/a...
Matchin et al. report that sentence comprehension relies on distinct networks: working memory maps to dorsal stream damage, while syntax links to ventral stream lesions in post-stroke aphasia. Please read at:https://buff.ly/4ify9Yj @wmatchin @JuliusThor_VPR @Leo_Bonilha @GregoryHickok
March 5, 2025 at 9:00 PM
Can you learn while sleeping? Does sleep help you solve problems? What is the effect of sleep on brain metabolism?
--> my last editorial @braincomms.bsky.social
doi.org/10.1093/brai...
Sleep is not a homogenous state - just like wake. Asking the role of sleep is as fair as asking the role of wake!
--> my last editorial @braincomms.bsky.social
doi.org/10.1093/brai...
Sleep is not a homogenous state - just like wake. Asking the role of sleep is as fair as asking the role of wake!
pendingpublications
Pending Publication
doi.org
March 4, 2025 at 11:46 AM
Can you learn while sleeping? Does sleep help you solve problems? What is the effect of sleep on brain metabolism?
--> my last editorial @braincomms.bsky.social
doi.org/10.1093/brai...
Sleep is not a homogenous state - just like wake. Asking the role of sleep is as fair as asking the role of wake!
--> my last editorial @braincomms.bsky.social
doi.org/10.1093/brai...
Sleep is not a homogenous state - just like wake. Asking the role of sleep is as fair as asking the role of wake!
How can we improve the chance to record seizures during intracranial monitoring of people with drug resistant epilepsy?
Interesting to see that sleep deprivation does not contribute (reminds me of the works by Malow!)
--> doi.org/10.1111/epi....
Interesting to see that sleep deprivation does not contribute (reminds me of the works by Malow!)
--> doi.org/10.1111/epi....
doi.org
March 2, 2025 at 8:58 PM
How can we improve the chance to record seizures during intracranial monitoring of people with drug resistant epilepsy?
Interesting to see that sleep deprivation does not contribute (reminds me of the works by Malow!)
--> doi.org/10.1111/epi....
Interesting to see that sleep deprivation does not contribute (reminds me of the works by Malow!)
--> doi.org/10.1111/epi....
Pupil size as an index of sleep states -->
www.nature.com/articles/s41...
See also www.nature.com/articles/s43...
Sleep goes beyond the classical NREM/REM stages and pupil size might be a candidate tracker of these more subtle states.
www.nature.com/articles/s41...
See also www.nature.com/articles/s43...
Sleep goes beyond the classical NREM/REM stages and pupil size might be a candidate tracker of these more subtle states.
Pupil size reveals arousal level fluctuations in human sleep - Nature Communications
Arousal levels regulate sleep, but accurate noninvasive measures are lacking. Here, a novel method is introduced to track pupil-indexed arousal levels during human sleep, revealing pupil size changes ...
www.nature.com
March 2, 2025 at 7:04 PM
Pupil size as an index of sleep states -->
www.nature.com/articles/s41...
See also www.nature.com/articles/s43...
Sleep goes beyond the classical NREM/REM stages and pupil size might be a candidate tracker of these more subtle states.
www.nature.com/articles/s41...
See also www.nature.com/articles/s43...
Sleep goes beyond the classical NREM/REM stages and pupil size might be a candidate tracker of these more subtle states.
Very interesting paper by Alfonsa et al. @currentbiology.bsky.social. Switch in EGABA associated with long period of wakefulness shapes LTP.
@vyazovskiy.bsky.social
doi.org/10.1016/j.cu...
@vyazovskiy.bsky.social
doi.org/10.1016/j.cu...
Redirecting
doi.org
February 24, 2025 at 11:00 AM
Very interesting paper by Alfonsa et al. @currentbiology.bsky.social. Switch in EGABA associated with long period of wakefulness shapes LTP.
@vyazovskiy.bsky.social
doi.org/10.1016/j.cu...
@vyazovskiy.bsky.social
doi.org/10.1016/j.cu...
Great work on substantia nigra and locus ceruleus microstructural abnormalities in REM sleep behavior disorder and Parkinson's disease. Now in @braincomms.bsky.social
doi.org/10.1093/brai...
doi.org/10.1093/brai...
Substantia nigra and locus coeruleus microstructural abnormalities in isolated rapid eye movement sleep behaviour disorder and Parkinson’s disease
Pasquini et al. explore microstructural abnormalities in LC and SN through neuromelanin and diffusion MRI in Parkinson’s disease and iRBD. They also show a
doi.org
February 16, 2025 at 5:46 PM
Great work on substantia nigra and locus ceruleus microstructural abnormalities in REM sleep behavior disorder and Parkinson's disease. Now in @braincomms.bsky.social
doi.org/10.1093/brai...
doi.org/10.1093/brai...