Theodore Zwang
@tjzwang.bsky.social
Assistant Professor of Neurology, Massachusetts General Hospital and Harvard Medical School
My research combines electrophysiology, histology, and behavioral tasks to study aging and Alzheimer’s disease.
My research combines electrophysiology, histology, and behavioral tasks to study aging and Alzheimer’s disease.
New preprint from the lab that I'm very proud of! We found mutant tau can disconnect neurons from their networks by temporarily silencing a neuron's activity. This leads to breakdown in the coherent activity between the hippocampus and entorhinal cortex. www.biorxiv.org/content/10.1...
Tau drives cell specific functional isolation of the hippocampal formation
A major challenge in understanding Alzheimer's disease is linking changes that occur across different biological scales. For example, how do changes in individual neurons build into widespread network...
www.biorxiv.org
August 12, 2025 at 1:34 AM
New preprint from the lab that I'm very proud of! We found mutant tau can disconnect neurons from their networks by temporarily silencing a neuron's activity. This leads to breakdown in the coherent activity between the hippocampus and entorhinal cortex. www.biorxiv.org/content/10.1...
Reposted by Theodore Zwang
Yesterday, the NIH R35 “Outstanding Investigator” grant to fund scientists in my lab studying antibiotic resistance was terminated for reasons not related to the content of the science, or any actions taken by me or members of my lab
May 13, 2025 at 11:37 PM
Yesterday, the NIH R35 “Outstanding Investigator” grant to fund scientists in my lab studying antibiotic resistance was terminated for reasons not related to the content of the science, or any actions taken by me or members of my lab
Our team at MGH is looking to hire a research technician to help us follow up our recent study exploring the death of neurons related to tau pathology. Anyone interested please reach out to me. #ADRD #Alzheimer's #Neurodegeneration #EndAlz
www.cell.com/cell-reports...
www.cell.com/cell-reports...
Neurofibrillary tangle-bearing neurons have reduced risk of cell death in mice with Alzheimer’s pathology
Zwang et al. used two-photon microscopy to track neurofibrillary tangle (NFT) formation
and neuron loss in model mice. They observed that neurons with NFTs died less frequently
than neurons without NF...
www.cell.com
November 19, 2024 at 8:47 PM
Our team at MGH is looking to hire a research technician to help us follow up our recent study exploring the death of neurons related to tau pathology. Anyone interested please reach out to me. #ADRD #Alzheimer's #Neurodegeneration #EndAlz
www.cell.com/cell-reports...
www.cell.com/cell-reports...