Edward Moh
@mredwardmoh.bsky.social
Glycobiology, Mass spectrometry, Analytical biochemistry
Making social media profiles is a lot of work, too lazy to import stuff from Twitter
Making social media profiles is a lot of work, too lazy to import stuff from Twitter
Pinned
Edward Moh
@mredwardmoh.bsky.social
· Dec 31
SSSMuG: Same Sample Sequential Multi-Glycomics
The mammalian glycome is structurally complex and diverse, composed of many glycan classes such as N- and O-linked glycans, glycosaminoglycans (GAGs), glycosphingolipids (GSLs), and other distinct gly...
pubs.acs.org
First Bluesky post! Personal highlight of 2024, multi-glycomics method development that extracts multiple glycan types from the same sample for in-depth characterisation. #glycotime
pubs.acs.org/doi/10.1021/...
pubs.acs.org/doi/10.1021/...
Reposted by Edward Moh
Have you ever wondered how many N-Glycans or #glycoproteins there are on cells?
The numbers are massive: calculations suggest about 20 to 200 million N-glycans per human cell!
Read the full blog post: research.bidmc.org/ncfg/blog/24...
#glycobiology #glycotime #cells #biology
The numbers are massive: calculations suggest about 20 to 200 million N-glycans per human cell!
Read the full blog post: research.bidmc.org/ncfg/blog/24...
#glycobiology #glycotime #cells #biology
January 15, 2026 at 3:39 PM
Have you ever wondered how many N-Glycans or #glycoproteins there are on cells?
The numbers are massive: calculations suggest about 20 to 200 million N-glycans per human cell!
Read the full blog post: research.bidmc.org/ncfg/blog/24...
#glycobiology #glycotime #cells #biology
The numbers are massive: calculations suggest about 20 to 200 million N-glycans per human cell!
Read the full blog post: research.bidmc.org/ncfg/blog/24...
#glycobiology #glycotime #cells #biology
Reposted by Edward Moh
This is a fantastic day for Australian chemistry. First Australian chemistry Nobel prize since John Cornforth in 1975, but Richard Robson's work is at least as impactful. #ozchem
Fantastic to see one of my chemical heroes, Richard Robson, winning the Nobel Prize for coordination frameworks (MOFs), together with Kitagawa and Yaghi. #ozchem
October 8, 2025 at 10:12 AM
This is a fantastic day for Australian chemistry. First Australian chemistry Nobel prize since John Cornforth in 1975, but Richard Robson's work is at least as impactful. #ozchem
Reposted by Edward Moh
Super excited by our new #glycotime preprint! A long-term project from my group with awesome collaborator @elisafadda.bsky.social
Regulation of N-glycosylation efficiency by eukaryotic oligosaccharyltransferase www.biorxiv.org/content/10.1...
thread below 👇
Regulation of N-glycosylation efficiency by eukaryotic oligosaccharyltransferase www.biorxiv.org/content/10.1...
thread below 👇
a cartoon drawing of a pitcher and cup of sugar on a table
ALT: a cartoon drawing of a pitcher and cup of sugar on a table
media.tenor.com
September 9, 2025 at 7:32 AM
Super excited by our new #glycotime preprint! A long-term project from my group with awesome collaborator @elisafadda.bsky.social
Regulation of N-glycosylation efficiency by eukaryotic oligosaccharyltransferase www.biorxiv.org/content/10.1...
thread below 👇
Regulation of N-glycosylation efficiency by eukaryotic oligosaccharyltransferase www.biorxiv.org/content/10.1...
thread below 👇
Reposted by Edward Moh
How easy is it to fudge your scientific rank? Meet Larry, the world’s most cited cat www.science.org/content/arti...
"More than 130 citations in 4 years." Meow, Larry!
Oh wait. “All you have to do is put some fake papers on ResearchGate.” And buy citations.
Critical: Let's clean up research!
"More than 130 citations in 4 years." Meow, Larry!
Oh wait. “All you have to do is put some fake papers on ResearchGate.” And buy citations.
Critical: Let's clean up research!
How easy is it to fudge your scientific rank? Meet Larry, the world’s most cited cat
“Exercise in absurdity” reveals flaws in Google Scholar’s productivity metrics
www.science.org
August 9, 2025 at 2:41 PM
How easy is it to fudge your scientific rank? Meet Larry, the world’s most cited cat www.science.org/content/arti...
"More than 130 citations in 4 years." Meow, Larry!
Oh wait. “All you have to do is put some fake papers on ResearchGate.” And buy citations.
Critical: Let's clean up research!
"More than 130 citations in 4 years." Meow, Larry!
Oh wait. “All you have to do is put some fake papers on ResearchGate.” And buy citations.
Critical: Let's clean up research!
Australian Proteomics Analysis Facility (APAF) celebrating 30 year anniversary. Had a good morning on the past, present, and future of proteomics by the pioneers in the field, including Prof. Nicki Packer @sugar-princess.bsky.social, and Prof Mark Wilkins, who famously invented the word "Proteome"
June 30, 2025 at 5:46 AM
Australian Proteomics Analysis Facility (APAF) celebrating 30 year anniversary. Had a good morning on the past, present, and future of proteomics by the pioneers in the field, including Prof. Nicki Packer @sugar-princess.bsky.social, and Prof Mark Wilkins, who famously invented the word "Proteome"
Reposted by Edward Moh
When glycan recognition is linked to immune response, you need fine tuning! 😎
Here ⬇️ we show how human Siglecs act as molecular precision tools, recognising the glycan and also the biological environment (or context) these glycans are found in. A 1/5 #glycotime🧵 ⬇️
doi.org/10.1101/2025...
Here ⬇️ we show how human Siglecs act as molecular precision tools, recognising the glycan and also the biological environment (or context) these glycans are found in. A 1/5 #glycotime🧵 ⬇️
doi.org/10.1101/2025...
June 22, 2025 at 10:42 AM
When glycan recognition is linked to immune response, you need fine tuning! 😎
Here ⬇️ we show how human Siglecs act as molecular precision tools, recognising the glycan and also the biological environment (or context) these glycans are found in. A 1/5 #glycotime🧵 ⬇️
doi.org/10.1101/2025...
Here ⬇️ we show how human Siglecs act as molecular precision tools, recognising the glycan and also the biological environment (or context) these glycans are found in. A 1/5 #glycotime🧵 ⬇️
doi.org/10.1101/2025...
Reposted by Edward Moh
By deep characterisation of 186 N-glycan standards, we @thencfg.bsky.social have made the most comprehensive targeted LC-MS glycomic assay to date.
Non-reduced native glycan analysis is key.
We hope this enables anyone with QqQ and interest in #glycotime to measure specific N-glycan structures.
Non-reduced native glycan analysis is key.
We hope this enables anyone with QqQ and interest in #glycotime to measure specific N-glycan structures.
June 10, 2025 at 1:11 PM
By deep characterisation of 186 N-glycan standards, we @thencfg.bsky.social have made the most comprehensive targeted LC-MS glycomic assay to date.
Non-reduced native glycan analysis is key.
We hope this enables anyone with QqQ and interest in #glycotime to measure specific N-glycan structures.
Non-reduced native glycan analysis is key.
We hope this enables anyone with QqQ and interest in #glycotime to measure specific N-glycan structures.
Resonated so well with so many speakers that it gets quoted by almost every planery talk that follows on. #Glyco27 @sugar-princess.bsky.social
May 30, 2025 at 4:25 PM
Resonated so well with so many speakers that it gets quoted by almost every planery talk that follows on. #Glyco27 @sugar-princess.bsky.social
Imagine if more countries fund glyco like Canada #Glyco27 #glycotime
May 26, 2025 at 3:35 PM
Imagine if more countries fund glyco like Canada #Glyco27 #glycotime
Reposted by Edward Moh
📱 Don’t forget: our social media competition is live!
Follow us and use #Glyco27 when posting on LinkedIn, X (Twitter), or Bluesky for a chance to win a prize!
Let’s get the conversation going and have an amazing conference!
#Glycotime #Glycoscience #Glycobiology #Canada #YEG
Follow us and use #Glyco27 when posting on LinkedIn, X (Twitter), or Bluesky for a chance to win a prize!
Let’s get the conversation going and have an amazing conference!
#Glycotime #Glycoscience #Glycobiology #Canada #YEG
May 25, 2025 at 11:45 PM
📱 Don’t forget: our social media competition is live!
Follow us and use #Glyco27 when posting on LinkedIn, X (Twitter), or Bluesky for a chance to win a prize!
Let’s get the conversation going and have an amazing conference!
#Glycotime #Glycoscience #Glycobiology #Canada #YEG
Follow us and use #Glyco27 when posting on LinkedIn, X (Twitter), or Bluesky for a chance to win a prize!
Let’s get the conversation going and have an amazing conference!
#Glycotime #Glycoscience #Glycobiology #Canada #YEG
Congratulations to @nickescott.bsky.social on his dual MCR prize from both AGS @ozglyco.bsky.social and APS for his work on bacterial glycosylation! #glycotime
May 18, 2025 at 5:56 AM
Congratulations to @nickescott.bsky.social on his dual MCR prize from both AGS @ozglyco.bsky.social and APS for his work on bacterial glycosylation! #glycotime
Reposted by Edward Moh
Spatial mapping of the brain metabolome lipidome and glycome #NatCommun #MassSpec www.nature.com/articles/s41...
Spatial mapping of the brain metabolome lipidome and glycome - Nature Communications
Clarke et al. presents a framework for spatial analysis of the metabolome, lipidome, and glycome from a single tissue section using mass spectrometry imaging. Applying this approach, they revealed reg...
www.nature.com
May 14, 2025 at 5:45 PM
Spatial mapping of the brain metabolome lipidome and glycome #NatCommun #MassSpec www.nature.com/articles/s41...
Reposted by Edward Moh
Nice #glycotime review that pulls together the emerging story of glycosyltransferase specificity for cellular substrates
chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/...
chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/...
Glycoproteins, Glycolipids, or Both: Why do Glycosyltransferases Recognize Different Acceptors?
Glycosylation is an important post-translational modification catalyzed by glycosyltransferases (GTs), which comprise a large group of enzymes with diversified specificity. Most GTs show high specifi...
chemistry-europe.onlinelibrary.wiley.com
May 7, 2025 at 11:42 AM
Nice #glycotime review that pulls together the emerging story of glycosyltransferase specificity for cellular substrates
chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/...
chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/...
Reposted by Edward Moh
academic.oup.com/ecco-jcc/art...
Happy to share our most recent publication on how T cells glycosylation mediates #IBD progression to colorectal cancer defining the risk of colitis-associated cancer.
#glycotime Great work @eduardalgomes.bsky.social @i3suporto.bsky.social @GlycanTrigger
Happy to share our most recent publication on how T cells glycosylation mediates #IBD progression to colorectal cancer defining the risk of colitis-associated cancer.
#glycotime Great work @eduardalgomes.bsky.social @i3suporto.bsky.social @GlycanTrigger
T-cell branched glycosylation as a mediator of colitis-associated colorectal cancer progression: a potential new risk biomarker in inflammatory bowel disease
AbstractBackground and Aims. Inflammatory bowel disease (IBD) is a chronic inflammatory disorder of the gastrointestinal tract, established as a risk facto
academic.oup.com
April 30, 2025 at 5:06 PM
academic.oup.com/ecco-jcc/art...
Happy to share our most recent publication on how T cells glycosylation mediates #IBD progression to colorectal cancer defining the risk of colitis-associated cancer.
#glycotime Great work @eduardalgomes.bsky.social @i3suporto.bsky.social @GlycanTrigger
Happy to share our most recent publication on how T cells glycosylation mediates #IBD progression to colorectal cancer defining the risk of colitis-associated cancer.
#glycotime Great work @eduardalgomes.bsky.social @i3suporto.bsky.social @GlycanTrigger
Reposted by Edward Moh
There are great conferences and science in the US, but with the way things are right now, it’s too risky to attend.
Australian academics refuse to attend US conferences for fear of being detained
‘When academics fear travelling or partnering with US institutions, the impacts ripple through the entire global knowledge ecosystem,’ one says
www.theguardian.com
April 13, 2025 at 11:00 PM
There are great conferences and science in the US, but with the way things are right now, it’s too risky to attend.
Reposted by Edward Moh
Just out by Shelley Jager: rdcu.be/edEnO. One of the fastest & deepest plasma glycoproteomics studies. Take home message; we even detect glycosylated cytokines and chemokines, but also still need better software. #glycotime @utrechtuniversity.bsky.social @bijvoet-centre.bsky.social
In-depth plasma N-glycoproteome profiling using narrow-window data-independent acquisition on the Orbitrap Astral mass spectrometer
Nature Communications - While DIA has advanced standard proteomics, its application in glycoproteomics has remained limited. Here, the authors present an optimized narrow-window DIA method for...
rdcu.be
March 15, 2025 at 8:20 AM
Just out by Shelley Jager: rdcu.be/edEnO. One of the fastest & deepest plasma glycoproteomics studies. Take home message; we even detect glycosylated cytokines and chemokines, but also still need better software. #glycotime @utrechtuniversity.bsky.social @bijvoet-centre.bsky.social
Reposted by Edward Moh
Happy to share this new #glycotime work with collaborator Tony Wyss-Coray, led by grad student Sophia Shi, mucin loss at the BBB is associated with aging and cognitive decline, can be reversed by restoration with with gene therapy. Aging is a mucinopathy!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Glycocalyx dysregulation impairs blood–brain barrier in ageing and disease - Nature
Disruption of mucin-domain glycoprotein expression and function in the endothelial glycocalyx are associated with ageing and Alzheimer’s disease, leading to dysregulated blood–brain barrier function.
www.nature.com
February 26, 2025 at 9:58 PM
Happy to share this new #glycotime work with collaborator Tony Wyss-Coray, led by grad student Sophia Shi, mucin loss at the BBB is associated with aging and cognitive decline, can be reversed by restoration with with gene therapy. Aging is a mucinopathy!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Edward Moh
Picture this: your fav protein-protein interaction is *entirely* dependent on,
1) glycans 💥
2) the type of glycans 🤯💜
Check out this doi.org/10.1016/j.jb... 🔝 #glycotime fresh off the press in JBC led by Nicki Packer and Len Harrison 🇦🇺 + us 🇮🇪🇬🇧 + @ethangbaus.bsky.social 🇦🇺
🧵1/5
1) glycans 💥
2) the type of glycans 🤯💜
Check out this doi.org/10.1016/j.jb... 🔝 #glycotime fresh off the press in JBC led by Nicki Packer and Len Harrison 🇦🇺 + us 🇮🇪🇬🇧 + @ethangbaus.bsky.social 🇦🇺
🧵1/5
February 27, 2025 at 4:44 PM
Picture this: your fav protein-protein interaction is *entirely* dependent on,
1) glycans 💥
2) the type of glycans 🤯💜
Check out this doi.org/10.1016/j.jb... 🔝 #glycotime fresh off the press in JBC led by Nicki Packer and Len Harrison 🇦🇺 + us 🇮🇪🇬🇧 + @ethangbaus.bsky.social 🇦🇺
🧵1/5
1) glycans 💥
2) the type of glycans 🤯💜
Check out this doi.org/10.1016/j.jb... 🔝 #glycotime fresh off the press in JBC led by Nicki Packer and Len Harrison 🇦🇺 + us 🇮🇪🇬🇧 + @ethangbaus.bsky.social 🇦🇺
🧵1/5
Reposted by Edward Moh
Glycomics-Guided Glycoproteomics Facilitates Comprehensive Profiling of the Glycoproteome in Complex Tumor Microenvironments #JVisExp #MassSpec app.jove.com/t/67405/glyc...
Glycomics-Guided Glycoproteomics Facilitates Comprehensive Profiling of the Glycoproteome in Complex Tumor Microenvironments
Read this JoVE article on Glycomics-Guided Glycoproteomics Facilitates Comprehensive Profiling of the Glycoproteome in Complex Tumor Microenvironments
app.jove.com
February 25, 2025 at 9:02 PM
Glycomics-Guided Glycoproteomics Facilitates Comprehensive Profiling of the Glycoproteome in Complex Tumor Microenvironments #JVisExp #MassSpec app.jove.com/t/67405/glyc...
Reposted by Edward Moh
A POGase is a huge advance in the glycomics field, which has typically relied on chemical or incomplete enzymatic releases (no Sia).
Expect a lot of multi-omic studies enabled by this (N-glycomics, O-glycomics, and proteomics) since the peptide backbone is left intact.
www.nature.com/articles/s41...
Expect a lot of multi-omic studies enabled by this (N-glycomics, O-glycomics, and proteomics) since the peptide backbone is left intact.
www.nature.com/articles/s41...
February 25, 2025 at 11:49 PM
A POGase is a huge advance in the glycomics field, which has typically relied on chemical or incomplete enzymatic releases (no Sia).
Expect a lot of multi-omic studies enabled by this (N-glycomics, O-glycomics, and proteomics) since the peptide backbone is left intact.
www.nature.com/articles/s41...
Expect a lot of multi-omic studies enabled by this (N-glycomics, O-glycomics, and proteomics) since the peptide backbone is left intact.
www.nature.com/articles/s41...
Reposted by Edward Moh
🎉Announcing our ANZSMS 2025 Medalists 🎉
Congratulations to Prof Nicki Packer from Macquarie University and A/Prof Shane Ellis from University of Wollongong!
Join us at AUS-omics from May 18 - 21 to celebrate this wonderful achievement! 🏆
Read about our medalists here 👉 mailchi.mp/6c90f3d41712...
Congratulations to Prof Nicki Packer from Macquarie University and A/Prof Shane Ellis from University of Wollongong!
Join us at AUS-omics from May 18 - 21 to celebrate this wonderful achievement! 🏆
Read about our medalists here 👉 mailchi.mp/6c90f3d41712...
February 24, 2025 at 11:23 PM
🎉Announcing our ANZSMS 2025 Medalists 🎉
Congratulations to Prof Nicki Packer from Macquarie University and A/Prof Shane Ellis from University of Wollongong!
Join us at AUS-omics from May 18 - 21 to celebrate this wonderful achievement! 🏆
Read about our medalists here 👉 mailchi.mp/6c90f3d41712...
Congratulations to Prof Nicki Packer from Macquarie University and A/Prof Shane Ellis from University of Wollongong!
Join us at AUS-omics from May 18 - 21 to celebrate this wonderful achievement! 🏆
Read about our medalists here 👉 mailchi.mp/6c90f3d41712...
Reposted by Edward Moh
A robust glycomic study, can’t critique any aspect of the sample QC or methods used.
Really nice work.
#glycotime #TeamMassSpec
Really nice work.
#glycotime #TeamMassSpec
Blood N-glycomics reveals individuals at risk for cognitive decline and Alzheimer's disease #EBioMedicine #MassSpec www.thelancet.com/journals/ebi...
Blood N-glycomics reveals individuals at risk for cognitive decline and Alzheimer’s disease
Reduced blood N-glycan levels predict cognitive decline independent of amyloid or
tau status. Blood N-glycome profiling could be used to identify individuals at risk
for AD dementia.
www.thelancet.com
February 22, 2025 at 8:52 AM
A robust glycomic study, can’t critique any aspect of the sample QC or methods used.
Really nice work.
#glycotime #TeamMassSpec
Really nice work.
#glycotime #TeamMassSpec
Had a great time at GlycoBioTec2025 (www.mpi-magdeburg.mpg.de/glycobiotec2...), held once every 2 years, with a good amount of industry participants. Furthermore, food at Harnack Haus is fabulous!
GlycoBioTec2025
www.mpi-magdeburg.mpg.de
February 14, 2025 at 10:14 AM
Had a great time at GlycoBioTec2025 (www.mpi-magdeburg.mpg.de/glycobiotec2...), held once every 2 years, with a good amount of industry participants. Furthermore, food at Harnack Haus is fabulous!
Reposted by Edward Moh
Check it out, powerful new method for optical imaging of the live ECM, from @hhmijanelia.bsky.social Group Leader Kayvon Pedram #proudofalumni #glycotime
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Live imaging of the extracellular matrix with a glycan-binding fluorophore - Nature Methods
Rhobo6 is a cell-impermeable small-molecule fluorophore that displays reversible fluorogenic binding to glycans, making it a general, wash-free, and non-perturbative label for the extracellular matrix...
www.nature.com
February 6, 2025 at 10:59 PM
Check it out, powerful new method for optical imaging of the live ECM, from @hhmijanelia.bsky.social Group Leader Kayvon Pedram #proudofalumni #glycotime
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Edward Moh
Our latest work on Siglec binding to sulfated glycans. Great help: @khookh.bsky.social, @pengwu.bsky.social ,@raflynn5.bsky.social. Fom 1st PhD graduate of the lab (Jaesoo Jung) and help from Edward, Zeinab, Jhon, Kelli, @tayloregray.bsky.social, and Chris from my lab.
pubs.acs.org/doi/10.1021/...
pubs.acs.org/doi/10.1021/...
Understanding the Glycosylation Pathways Involved in the Biosynthesis of the Sulfated Glycan Ligands for Siglecs
Carbohydrate sulfation plays a pivotal role in modulating the strength of Siglec–glycan interactions. Recently, new aspects of Siglec binding to sulfated cell surface carbohydrates have been discovere...
pubs.acs.org
January 22, 2025 at 2:32 AM
Our latest work on Siglec binding to sulfated glycans. Great help: @khookh.bsky.social, @pengwu.bsky.social ,@raflynn5.bsky.social. Fom 1st PhD graduate of the lab (Jaesoo Jung) and help from Edward, Zeinab, Jhon, Kelli, @tayloregray.bsky.social, and Chris from my lab.
pubs.acs.org/doi/10.1021/...
pubs.acs.org/doi/10.1021/...