Morgane Thion
@morganethion.bsky.social
Developmental neurobiologist, microglia, neuroimmune and immunovascular interactions, environment.
Group leader at CIRB, Collège de France, CNRS
Group leader at CIRB, Collège de France, CNRS
🧠 Check out our new study!
Cécile Bridlance et al. reveal how distinct, local, and cell-type–specific sources of CSF-1 orchestrate microglial colonization during early brain development.
🙏🙏🙏 A big thank you to everyone involved!
Cécile Bridlance et al. reveal how distinct, local, and cell-type–specific sources of CSF-1 orchestrate microglial colonization during early brain development.
🙏🙏🙏 A big thank you to everyone involved!
Microglial colonization of the developing mouse brain is controlled by both microglial and neural CSF-1
Sonia Garel, @morganethion.bsky.social and collaborators
www.embopress.org/doi/full/10....
Sonia Garel, @morganethion.bsky.social and collaborators
www.embopress.org/doi/full/10....
November 20, 2025 at 2:35 PM
🧠 Check out our new study!
Cécile Bridlance et al. reveal how distinct, local, and cell-type–specific sources of CSF-1 orchestrate microglial colonization during early brain development.
🙏🙏🙏 A big thank you to everyone involved!
Cécile Bridlance et al. reveal how distinct, local, and cell-type–specific sources of CSF-1 orchestrate microglial colonization during early brain development.
🙏🙏🙏 A big thank you to everyone involved!
Reposted by Morgane Thion
Mark your calendars!
The 28th Meeting of the French Glial Cell Club will take place Nov 17–20, 2026, in Sète.
🔹 Plenary lectures by Fiona Doetsch & Leda Dimou
🔹 5 symposia on glial diversity, astrocytes, human glia, EVs & modeling
👉 Full program available on our website: frenchglialcellclub.fr
The 28th Meeting of the French Glial Cell Club will take place Nov 17–20, 2026, in Sète.
🔹 Plenary lectures by Fiona Doetsch & Leda Dimou
🔹 5 symposia on glial diversity, astrocytes, human glia, EVs & modeling
👉 Full program available on our website: frenchglialcellclub.fr
October 20, 2025 at 2:38 PM
Mark your calendars!
The 28th Meeting of the French Glial Cell Club will take place Nov 17–20, 2026, in Sète.
🔹 Plenary lectures by Fiona Doetsch & Leda Dimou
🔹 5 symposia on glial diversity, astrocytes, human glia, EVs & modeling
👉 Full program available on our website: frenchglialcellclub.fr
The 28th Meeting of the French Glial Cell Club will take place Nov 17–20, 2026, in Sète.
🔹 Plenary lectures by Fiona Doetsch & Leda Dimou
🔹 5 symposia on glial diversity, astrocytes, human glia, EVs & modeling
👉 Full program available on our website: frenchglialcellclub.fr
Reposted by Morgane Thion
Interested in the heterogeneity of blood vessels in the CNS? Here we review the unique features of the spinal cord vasculature, its barrier properties and neurovascular interactions, highlighting unknown aspects and future research directions.
@CRC1366
@erc.europa.eu @immunosens.bsky.social
@CRC1366
@erc.europa.eu @immunosens.bsky.social
October 14, 2025 at 5:16 PM
Interested in the heterogeneity of blood vessels in the CNS? Here we review the unique features of the spinal cord vasculature, its barrier properties and neurovascular interactions, highlighting unknown aspects and future research directions.
@CRC1366
@erc.europa.eu @immunosens.bsky.social
@CRC1366
@erc.europa.eu @immunosens.bsky.social
Reposted by Morgane Thion
1/ 💡We are excited to share our latest paper, continuing our exploration of how maternal obesity programs offspring health via #macrophages - this time using #Drosophila as a model: shorturl.at/28tFo
#MaternalObesity #Drosophila #Neurodegeneration #DOHaD #FlyResearch #MacrophageBiology
#MaternalObesity #Drosophila #Neurodegeneration #DOHaD #FlyResearch #MacrophageBiology
Developmental programming by maternal obesity alters offspring lifespan and immune responses in a diet- and sex-specific manner
Maternal obesity is a growing health concern that predisposes offspring to metabolic dysfunction, immune system alterations, and neurodegenerative dis…
shorturl.at
July 17, 2025 at 7:19 PM
1/ 💡We are excited to share our latest paper, continuing our exploration of how maternal obesity programs offspring health via #macrophages - this time using #Drosophila as a model: shorturl.at/28tFo
#MaternalObesity #Drosophila #Neurodegeneration #DOHaD #FlyResearch #MacrophageBiology
#MaternalObesity #Drosophila #Neurodegeneration #DOHaD #FlyResearch #MacrophageBiology
Reposted by Morgane Thion
🧠 New book chapter out!
We review the developmental origin and functional diversity of #microglia - key players at the crossroads of #immunity and #neurodevelopment.
🔹 Ontogeny & specialization
🔹 Transcriptional & metabolic shifts
🔹 Roles in disease & repair
👉 authors.elsevier.com/a/1lKxcErwXf...
We review the developmental origin and functional diversity of #microglia - key players at the crossroads of #immunity and #neurodevelopment.
🔹 Ontogeny & specialization
🔹 Transcriptional & metabolic shifts
🔹 Roles in disease & repair
👉 authors.elsevier.com/a/1lKxcErwXf...
July 17, 2025 at 7:43 PM
🧠 New book chapter out!
We review the developmental origin and functional diversity of #microglia - key players at the crossroads of #immunity and #neurodevelopment.
🔹 Ontogeny & specialization
🔹 Transcriptional & metabolic shifts
🔹 Roles in disease & repair
👉 authors.elsevier.com/a/1lKxcErwXf...
We review the developmental origin and functional diversity of #microglia - key players at the crossroads of #immunity and #neurodevelopment.
🔹 Ontogeny & specialization
🔹 Transcriptional & metabolic shifts
🔹 Roles in disease & repair
👉 authors.elsevier.com/a/1lKxcErwXf...
Reposted by Morgane Thion
We are SO EXCITED to share our story @nature.com:
🧵1/
Maternal obesity reprograms fetal liver macrophages, triggering adult fatty liver disease in the offspring.
This study uncovers how Kupffer cells act as intergenerational messengers in metabolic disease.
👉 Read here: rdcu.be/erD3b
🧵1/
Maternal obesity reprograms fetal liver macrophages, triggering adult fatty liver disease in the offspring.
This study uncovers how Kupffer cells act as intergenerational messengers in metabolic disease.
👉 Read here: rdcu.be/erD3b
Kupffer cell programming by maternal obesity triggers fatty liver disease
Nature - In a mouse model, maternal obesity during pregnancy can lead to fatty liver disease in the offspring, driven by aberrant developmental programming of Kuppfer cells.
rdcu.be
June 18, 2025 at 4:41 PM
We are SO EXCITED to share our story @nature.com:
🧵1/
Maternal obesity reprograms fetal liver macrophages, triggering adult fatty liver disease in the offspring.
This study uncovers how Kupffer cells act as intergenerational messengers in metabolic disease.
👉 Read here: rdcu.be/erD3b
🧵1/
Maternal obesity reprograms fetal liver macrophages, triggering adult fatty liver disease in the offspring.
This study uncovers how Kupffer cells act as intergenerational messengers in metabolic disease.
👉 Read here: rdcu.be/erD3b
Reposted by Morgane Thion
#NewResearch from the #VcoelhoSantosLab and #ShihLab used #two-photon live imaging to reveal how #microglia 🧠 evolve across across #lifespan.
Key findings:
👶 Neonatal: Active but clumsy
🧍♂️ Adult: Calm but sharp
👵 Aged: Quiet and slow
@ucoimbra.bsky.social @lacaixa.bsky.social
Key findings:
👶 Neonatal: Active but clumsy
🧍♂️ Adult: Calm but sharp
👵 Aged: Quiet and slow
@ucoimbra.bsky.social @lacaixa.bsky.social
Physiological and injury-induced microglial dynamics across the lifespan
Tieu, T. et al. leveraged in vivo two-photon live imaging of microglia, the brain’s
resident immune cells, to reveal striking differences in their morphology, basal dynamics,
and injury responses acro...
www.cell.com
July 18, 2025 at 3:36 PM
#NewResearch from the #VcoelhoSantosLab and #ShihLab used #two-photon live imaging to reveal how #microglia 🧠 evolve across across #lifespan.
Key findings:
👶 Neonatal: Active but clumsy
🧍♂️ Adult: Calm but sharp
👵 Aged: Quiet and slow
@ucoimbra.bsky.social @lacaixa.bsky.social
Key findings:
👶 Neonatal: Active but clumsy
🧍♂️ Adult: Calm but sharp
👵 Aged: Quiet and slow
@ucoimbra.bsky.social @lacaixa.bsky.social
Reposted by Morgane Thion
📣Join us for the DEVELOPMENTAL BIOLOGY COURSE @institutcurie.bsky.social @sorbonne-universite.fr
We have fantastic speakers and registration is free!
training.institut-curie.org/courses/deve...
@karinayaniv.bsky.social @doetschlab.bsky.social @eileen-furlong.bsky.social @jesseveenvliet.bsky.social
We have fantastic speakers and registration is free!
training.institut-curie.org/courses/deve...
@karinayaniv.bsky.social @doetschlab.bsky.social @eileen-furlong.bsky.social @jesseveenvliet.bsky.social
June 16, 2025 at 9:59 AM
📣Join us for the DEVELOPMENTAL BIOLOGY COURSE @institutcurie.bsky.social @sorbonne-universite.fr
We have fantastic speakers and registration is free!
training.institut-curie.org/courses/deve...
@karinayaniv.bsky.social @doetschlab.bsky.social @eileen-furlong.bsky.social @jesseveenvliet.bsky.social
We have fantastic speakers and registration is free!
training.institut-curie.org/courses/deve...
@karinayaniv.bsky.social @doetschlab.bsky.social @eileen-furlong.bsky.social @jesseveenvliet.bsky.social
Reposted by Morgane Thion
Still openings, check it out!
🧠Job Opening!🧠
We are opening 2️⃣! positions
– bioinformatics / molecular biology –
in a project studying how temporal patterns set up connectivity in human brain tissue.
@institutimagine.bsky.social.
Full details below, contact me for details if interested.
And please retweet (re-bluesky?)!
We are opening 2️⃣! positions
– bioinformatics / molecular biology –
in a project studying how temporal patterns set up connectivity in human brain tissue.
@institutimagine.bsky.social.
Full details below, contact me for details if interested.
And please retweet (re-bluesky?)!
May 28, 2025 at 5:02 AM
Still openings, check it out!
Reposted by Morgane Thion
Our special issue on #neuroimmunology is online! Check out the collection, with reviews from @jonykipnis.bsky.social @michellemonje.bsky.social @ugolinis.bsky.social @bethstevenslab.bsky.social @movahedilab.bsky.social Matteoli, Butovsky, Kim, Artis, & Prinz! www.cell.com/immunity/col... #AAI2025
May 6, 2025 at 9:40 PM
Our special issue on #neuroimmunology is online! Check out the collection, with reviews from @jonykipnis.bsky.social @michellemonje.bsky.social @ugolinis.bsky.social @bethstevenslab.bsky.social @movahedilab.bsky.social Matteoli, Butovsky, Kim, Artis, & Prinz! www.cell.com/immunity/col... #AAI2025
Reposted by Morgane Thion
Online now: Interleukin-34-dependent perivascular macrophages promote vascular function in the brain
Interleukin-34-dependent perivascular macrophages promote vascular function in the brain
The niche signals critical for the homeostasis and functions of the brain border-associated macrophages (BAMs) are not well understood. Van Hove et al. demonstrate that BAMs require IL-34 derived from mural cells and perivascular fibroblasts for their maintenance in adulthood. They show that BAMs are required to promote normal vascular function in the brain.
dlvr.it
May 1, 2025 at 7:55 PM
Online now: Interleukin-34-dependent perivascular macrophages promote vascular function in the brain
Reposted by Morgane Thion
🎉 Excited to share that our paper on FCDII is out today! 🙌🏻 Huge thanks to @sbaulac.bsky.social and @sara baldassari for bringing me on board and introducing me to the complexity of somatic mutations. Hope our work helps advance understanding of the disease mechanisms.
Single-cell genotyping and transcriptomic analysis reveals cell-type specific and non-autonomous effects of mTOR pathway mutations in mosaic focal cortical dysplasia type II (FCDII) 🧠🧪
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Single-cell genotyping and transcriptomic profiling of mosaic focal cortical dysplasia - Nature Neuroscience
In this work, the authors performed a single-cell genotyping and transcriptomics analysis, revealing cell-type-specific and nonautonomous effects of mTOR pathway mutations in mosaic focal cortical dys...
www.nature.com
April 30, 2025 at 7:47 PM
🎉 Excited to share that our paper on FCDII is out today! 🙌🏻 Huge thanks to @sbaulac.bsky.social and @sara baldassari for bringing me on board and introducing me to the complexity of somatic mutations. Hope our work helps advance understanding of the disease mechanisms.
Reposted by Morgane Thion
#Communiqué | L'Université PSL et ses établissements s’associent au mouvement @standupforscience.bsky.social et invitent toutes leurs communautés académiques, scientifiques, étudiantes et administratives à participer à la journée du jeudi 3 avril 2025.
Infos 👉 psl.eu/actualites/d...
Infos 👉 psl.eu/actualites/d...
April 2, 2025 at 9:47 AM
#Communiqué | L'Université PSL et ses établissements s’associent au mouvement @standupforscience.bsky.social et invitent toutes leurs communautés académiques, scientifiques, étudiantes et administratives à participer à la journée du jeudi 3 avril 2025.
Infos 👉 psl.eu/actualites/d...
Infos 👉 psl.eu/actualites/d...
Reposted by Morgane Thion
📢New webinar coming soon📢
Prof. Steffen Jung from Weizmann Institute of Science will be our next speaker on April 1st. Check all the information in the flyer and add it to your calendar! 🧠🔬
Prof. Steffen Jung from Weizmann Institute of Science will be our next speaker on April 1st. Check all the information in the flyer and add it to your calendar! 🧠🔬
March 24, 2025 at 10:44 AM
📢New webinar coming soon📢
Prof. Steffen Jung from Weizmann Institute of Science will be our next speaker on April 1st. Check all the information in the flyer and add it to your calendar! 🧠🔬
Prof. Steffen Jung from Weizmann Institute of Science will be our next speaker on April 1st. Check all the information in the flyer and add it to your calendar! 🧠🔬
Reposted by Morgane Thion
We are pleased to announce that the registration for the 2nd Young Glial Cell Day which will take place in Montpellier on May 13, 2025!
👉 club-de-cellules-gliales.assoconnect.com/collect/desc...
Abstract submissions for oral and poster presentations will close on March 28, 2025.
See you soon!
👉 club-de-cellules-gliales.assoconnect.com/collect/desc...
Abstract submissions for oral and poster presentations will close on March 28, 2025.
See you soon!
Registration to the Glial Cell Day for Young Researchers - May 13, 2025 - Montpellier (France) | Club des Cellules Gliales
The French Glial Cell Club is happy to organize a new meeting focused on glial cells on May 13, 2025 in Montpellier, just before the NeuroFrance...
club-de-cellules-gliales.assoconnect.com
March 13, 2025 at 8:10 AM
We are pleased to announce that the registration for the 2nd Young Glial Cell Day which will take place in Montpellier on May 13, 2025!
👉 club-de-cellules-gliales.assoconnect.com/collect/desc...
Abstract submissions for oral and poster presentations will close on March 28, 2025.
See you soon!
👉 club-de-cellules-gliales.assoconnect.com/collect/desc...
Abstract submissions for oral and poster presentations will close on March 28, 2025.
See you soon!
Reposted by Morgane Thion
#StandUpForScience
Science not silence!
Science not silence!
March 7, 2025 at 1:53 PM
#StandUpForScience
Science not silence!
Science not silence!
Reposted by Morgane Thion
We stand in solidarity with the #StandUpForScience movement and with all researchers working in the United States, where academic freedom is currently being challenged.
March 6, 2025 at 3:32 PM
We stand in solidarity with the #StandUpForScience movement and with all researchers working in the United States, where academic freedom is currently being challenged.
Reposted by Morgane Thion
✨ We tend to think of species-specific differences as resulting from the presence of species-specific genes. In our latest work with @djabaudon.bsky.social, we show that building brains is not only about which genes you use, but also about when and where you do.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
February 20, 2025 at 8:11 AM
✨ We tend to think of species-specific differences as resulting from the presence of species-specific genes. In our latest work with @djabaudon.bsky.social, we show that building brains is not only about which genes you use, but also about when and where you do.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Morgane Thion
À l’occasion de la Journée internationale des femmes et filles de science, testez vos connaissances sur les femmes scientifiques et l’égalité dans la recherche.
👉 mpdf.cnrs.fr/le-quiz-femm...
#FemmesEnScience #WomenInScience
👉 mpdf.cnrs.fr/le-quiz-femm...
#FemmesEnScience #WomenInScience
February 11, 2025 at 6:13 PM
À l’occasion de la Journée internationale des femmes et filles de science, testez vos connaissances sur les femmes scientifiques et l’égalité dans la recherche.
👉 mpdf.cnrs.fr/le-quiz-femm...
#FemmesEnScience #WomenInScience
👉 mpdf.cnrs.fr/le-quiz-femm...
#FemmesEnScience #WomenInScience
Reposted by Morgane Thion
A valuable post to educate our peers on this #InternationalDayofWomenandGirlsinScience
Thanks @frantecol.bsky.social for putting this together.
Especially relevant for these dark days for USA science🧪
Thanks @frantecol.bsky.social for putting this together.
Especially relevant for these dark days for USA science🧪
On #InternationalDayofWomenandGirlsinScience let me remind you that we are NOWHERE NEAR parity. A few examples.
1. Women are credited less in science than men.
www.nature.com/articles/s41...
1. Women are credited less in science than men.
www.nature.com/articles/s41...
Women are credited less in science than men - Nature
The difference between the number of men and women listed as authors on scientific papers and inventors on patents is at least partly attributable to unacknowledged contributions by women scientists.
www.nature.com
February 11, 2025 at 6:39 PM
A valuable post to educate our peers on this #InternationalDayofWomenandGirlsinScience
Thanks @frantecol.bsky.social for putting this together.
Especially relevant for these dark days for USA science🧪
Thanks @frantecol.bsky.social for putting this together.
Especially relevant for these dark days for USA science🧪
Reposted by Morgane Thion
How does pregnancy change a mum's brain? 🤰
Òscar Vilarroya, at Universitat Autònoma de Barcelona, investigates these transformations, seeking to understand how a mother's brain adapts during this life-changing period.
Read more about his recent results. erc.europa.eu/projects-sta...
Òscar Vilarroya, at Universitat Autònoma de Barcelona, investigates these transformations, seeking to understand how a mother's brain adapts during this life-changing period.
Read more about his recent results. erc.europa.eu/projects-sta...
February 9, 2025 at 11:41 AM
How does pregnancy change a mum's brain? 🤰
Òscar Vilarroya, at Universitat Autònoma de Barcelona, investigates these transformations, seeking to understand how a mother's brain adapts during this life-changing period.
Read more about his recent results. erc.europa.eu/projects-sta...
Òscar Vilarroya, at Universitat Autònoma de Barcelona, investigates these transformations, seeking to understand how a mother's brain adapts during this life-changing period.
Read more about his recent results. erc.europa.eu/projects-sta...
Reposted by Morgane Thion
🧠Job Opening!🧠
We are opening 2️⃣! positions
– bioinformatics / molecular biology –
in a project studying how temporal patterns set up connectivity in human brain tissue.
@institutimagine.bsky.social.
Full details below, contact me for details if interested.
And please retweet (re-bluesky?)!
We are opening 2️⃣! positions
– bioinformatics / molecular biology –
in a project studying how temporal patterns set up connectivity in human brain tissue.
@institutimagine.bsky.social.
Full details below, contact me for details if interested.
And please retweet (re-bluesky?)!
February 2, 2025 at 9:27 AM
🧠Job Opening!🧠
We are opening 2️⃣! positions
– bioinformatics / molecular biology –
in a project studying how temporal patterns set up connectivity in human brain tissue.
@institutimagine.bsky.social.
Full details below, contact me for details if interested.
And please retweet (re-bluesky?)!
We are opening 2️⃣! positions
– bioinformatics / molecular biology –
in a project studying how temporal patterns set up connectivity in human brain tissue.
@institutimagine.bsky.social.
Full details below, contact me for details if interested.
And please retweet (re-bluesky?)!
Reposted by Morgane Thion
Cette année, mon cours @collegedefrance.bsky.social traitera de la régulation des gènes par les séquences enhancers. Une des clés de notre développement. Premier cours le vendredi 21 février à 10h. Entrée libre, salle chauffée. Amis et Collègues parisiens, merci de diffuser!
February 4, 2025 at 9:33 AM
Cette année, mon cours @collegedefrance.bsky.social traitera de la régulation des gènes par les séquences enhancers. Une des clés de notre développement. Premier cours le vendredi 21 février à 10h. Entrée libre, salle chauffée. Amis et Collègues parisiens, merci de diffuser!
Reposted by Morgane Thion
Le projet de loi de finances 2025, adopté hier au Sénat, prévoit un coup de rabot conséquent sur le budget de la recherche et de l’enseignement supérieur, avec 630 millions d’euros d’économies.
www.radiofrance.fr/franceinter/...
www.radiofrance.fr/franceinter/...
Baisse annoncée du budget de la recherche et de l’enseignement supérieur : quel avenir pour la recherche scientifique ?
Le projet de loi de finances 2025, adopté hier au Sénat, prévoit un coup de rabot conséquent sur le budget de la recherche et de l’enseignement supérieur, avec 630 millions d’euros d’économies. Ces re...
www.radiofrance.fr
January 24, 2025 at 6:35 PM
Le projet de loi de finances 2025, adopté hier au Sénat, prévoit un coup de rabot conséquent sur le budget de la recherche et de l’enseignement supérieur, avec 630 millions d’euros d’économies.
www.radiofrance.fr/franceinter/...
www.radiofrance.fr/franceinter/...
Reposted by Morgane Thion
January 24, 2025 at 7:03 PM