Specialized macrophages are known to persist within tissue niches, but the molecular mechanisms guiding their sustained functional adaptation remain unclear. Kolter and Döring et al. show that local interactions between sensory nerves and macrophages activate TGF-β, which imprints and maintains nerve-associated macrophages that contribute to regeneration after tissue injury.

Ein Jahr vor der Entscheidung: So will die Uni Freiburg wieder Exzellenz-Universität werden | Die Uni Freiburg war eine der ersten deutschen Exzellenz-Universitäten seit 2007, verbunden mit hohem inte...

The cellular and molecular determinants of the antigenicity of brain tumors and the immunosuppressive brain tumor microenvironment are reviewed.

Small study suggests uniQure drug could be first successful treatment for devastating brain disorder

The cytokine messenger proteins known as interferons are central to protective immune responses against infections, but they are also involved in inflammatory and autoimmune diseases. This review maps...

Microglia-derived IGF1 promotes the proliferation of GABAergic progenitors and neuroblasts in the human medial ganglionic eminence, contributing to the extended production of GABAergic neurons and an expanded cognitive capacity in the human brain.

Nature - Microglia–neuron crosstalk via Hex–GM2–MGL2 maintains brain homeostasis

The dynamics of microglia states adjacent to or far from amyloid-beta plaques are unclear. Here the authors show that non-plaque-associated microglia modulate the cell population expansion in response...