@meisellab.bsky.social
Assistant Professor, Dept. Immunology, University of Pittsburgh; scientist, athlete, mom 👦🐈
Pinned
Exercise-induced microbiota metabolite enhances CD8 T cell antitumor immunity promoting immunotherapy efficacy
Exercise enhances antitumor immunity and immunotherapy effectiveness by increasing
microbiota-derived formate, which boosts CD8 T cell function and may serve as a biomarker
of melanoma suppression.
www.cell.com
Our lab just completed a +6 year #marathon, describing for the first time that the #microbiome is critical for #exercise - induced increases in antitumor CD8 T cell immunity and improved of #cancer #immunotherapy.
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
Reposted
Preview @cp-immunity.bsky.social
Cutting the Gordian knot: Untangling gasdermin C from pyroptosis
www.cell.com/immunity/ful...
on
www.cell.com/immunity/ful...
Cutting the Gordian knot: Untangling gasdermin C from pyroptosis
www.cell.com/immunity/ful...
on
www.cell.com/immunity/ful...
October 14, 2025 at 9:47 PM
Preview @cp-immunity.bsky.social
Cutting the Gordian knot: Untangling gasdermin C from pyroptosis
www.cell.com/immunity/ful...
on
www.cell.com/immunity/ful...
Cutting the Gordian knot: Untangling gasdermin C from pyroptosis
www.cell.com/immunity/ful...
on
www.cell.com/immunity/ful...
Thanks for highlighting our work!
How exercise promotes the immune system vs cancer, working through a gut bacteria metabolite
www.cell.com/cell/abstrac...
www.cell.com/cell/abstrac...
October 2, 2025 at 11:30 PM
Thanks for highlighting our work!
Reposted
Congrats, @catmphelps.bsky.social !
Congratulations to PMI student @catmphelps.bsky.social who is the recipient of the 23rd Stephen L. Phillips Scientific Achievement award for a Pitt School of Medicine graduate student who authored the best peer-review scientific journal author this year!
September 24, 2025 at 9:06 PM
Congrats, @catmphelps.bsky.social !
Reposted
Congratulations to PMI student @catmphelps.bsky.social who is the recipient of the 23rd Stephen L. Phillips Scientific Achievement award for a Pitt School of Medicine graduate student who authored the best peer-review scientific journal author this year!
September 24, 2025 at 6:40 PM
Congratulations to PMI student @catmphelps.bsky.social who is the recipient of the 23rd Stephen L. Phillips Scientific Achievement award for a Pitt School of Medicine graduate student who authored the best peer-review scientific journal author this year!
Reposted
🔬 OBS Seminar
Shaping CD8+ T Cell Response Through Microbiota Metabolites
🗣️ Joseph Stevens @cincyresearch.bsky.social @cincykidsallergyim.bsky.social
🗣️@catmphelps.bsky.social @meisellab.bsky.social
🗓️ Thu, September 4th, 11 AM EDT, 3 pm GMT, 5 pm CET
👇 us02web.zoom.us/meeting/regi...
Shaping CD8+ T Cell Response Through Microbiota Metabolites
🗣️ Joseph Stevens @cincyresearch.bsky.social @cincykidsallergyim.bsky.social
🗣️@catmphelps.bsky.social @meisellab.bsky.social
🗓️ Thu, September 4th, 11 AM EDT, 3 pm GMT, 5 pm CET
👇 us02web.zoom.us/meeting/regi...
August 28, 2025 at 4:58 PM
🔬 OBS Seminar
Shaping CD8+ T Cell Response Through Microbiota Metabolites
🗣️ Joseph Stevens @cincyresearch.bsky.social @cincykidsallergyim.bsky.social
🗣️@catmphelps.bsky.social @meisellab.bsky.social
🗓️ Thu, September 4th, 11 AM EDT, 3 pm GMT, 5 pm CET
👇 us02web.zoom.us/meeting/regi...
Shaping CD8+ T Cell Response Through Microbiota Metabolites
🗣️ Joseph Stevens @cincyresearch.bsky.social @cincykidsallergyim.bsky.social
🗣️@catmphelps.bsky.social @meisellab.bsky.social
🗓️ Thu, September 4th, 11 AM EDT, 3 pm GMT, 5 pm CET
👇 us02web.zoom.us/meeting/regi...
Reposted
#ResearchHighlight
In a study published in #Cell, Phelps et al. find a mechanism connecting exercise, gut microbiota & anti-tumour immunity; exercise induces microbiota to produce formate, which in turn enhances CD8+ T cell functionality.
👇
In a study published in #Cell, Phelps et al. find a mechanism connecting exercise, gut microbiota & anti-tumour immunity; exercise induces microbiota to produce formate, which in turn enhances CD8+ T cell functionality.
👇
No strain, no formate gains - Nature Reviews Cancer
In a study published in Cell, Phelps et al. find a mechanism connecting exercise, gut microbiota and anti-tumour immunity; exercise induces microbiota to produce formate, which in turn enhances CD8+ T cell functionality.
www.nature.com
August 5, 2025 at 2:40 PM
#ResearchHighlight
In a study published in #Cell, Phelps et al. find a mechanism connecting exercise, gut microbiota & anti-tumour immunity; exercise induces microbiota to produce formate, which in turn enhances CD8+ T cell functionality.
👇
In a study published in #Cell, Phelps et al. find a mechanism connecting exercise, gut microbiota & anti-tumour immunity; exercise induces microbiota to produce formate, which in turn enhances CD8+ T cell functionality.
👇
Congratulations to the team! Excited to see the study in print!!
Excited to share our new publication in collaboration with Yi-Nan Gong: Gasdermin C cleavage by Cathepsin S modulates Rab7 vesicles in intestinal epithelial cells to amplify anti-helminth immunity: Immunity www.cell.com/immunity/ful...
Gasdermin C cleavage by Cathepsin S modulates Rab7 vesicles in intestinal epithelial cells to amplify anti-helminth immunity
Pandey et al. identify Cathepsin S (CTSS) as the direct protease that cleaves Gasdermin
C (GsdmC) in the intestine. Type 2 immune-promoting microbes trigger CTSS-dependent
GsdmC activation in intestin...
www.cell.com
July 22, 2025 at 3:42 PM
Congratulations to the team! Excited to see the study in print!!
Reposted
Excited to share our new publication in collaboration with Yi-Nan Gong: Gasdermin C cleavage by Cathepsin S modulates Rab7 vesicles in intestinal epithelial cells to amplify anti-helminth immunity: Immunity www.cell.com/immunity/ful...
Gasdermin C cleavage by Cathepsin S modulates Rab7 vesicles in intestinal epithelial cells to amplify anti-helminth immunity
Pandey et al. identify Cathepsin S (CTSS) as the direct protease that cleaves Gasdermin
C (GsdmC) in the intestine. Type 2 immune-promoting microbes trigger CTSS-dependent
GsdmC activation in intestin...
www.cell.com
July 22, 2025 at 3:26 PM
Excited to share our new publication in collaboration with Yi-Nan Gong: Gasdermin C cleavage by Cathepsin S modulates Rab7 vesicles in intestinal epithelial cells to amplify anti-helminth immunity: Immunity www.cell.com/immunity/ful...
Reposted
AAI Members in the News! For her grad thesis with Dr. Marlies Meisel at @pittdeptofmed.bsky.social, @catmphelps.bsky.social showed how #exercise improves #cancer outcomes and enhances the response to #immunotherapy in mice by reshaping the gut #microbiome
🔗 www.medschool.pitt.edu/news/gut-mic...
🔗 www.medschool.pitt.edu/news/gut-mic...
July 15, 2025 at 4:46 PM
AAI Members in the News! For her grad thesis with Dr. Marlies Meisel at @pittdeptofmed.bsky.social, @catmphelps.bsky.social showed how #exercise improves #cancer outcomes and enhances the response to #immunotherapy in mice by reshaping the gut #microbiome
🔗 www.medschool.pitt.edu/news/gut-mic...
🔗 www.medschool.pitt.edu/news/gut-mic...
Exercise helps the immune system to fight tumours by stimulating microbes in the gut to make a compound known as formate
go.nature.com/4lIZx2m
go.nature.com/4lIZx2m
Workouts can help gut microbes to quell cancer
Mice that exercised produced higher levels of an immune-cell-stimulating molecule than sedentary rodents did.
go.nature.com
July 11, 2025 at 2:46 AM
Reposted
Exercise seems to help prevent cancer and reduce the growth of tumours, but until now, we didn’t know why. The key seems to lie in the gut’s microbiome.
Exercise helps fight cancer – and we may finally know why
Exercise seems to help prevent cancer and reduce the growth of tumours, and that protective effect may be due to the way working out changes the gut microbiome
www.newscientist.com
July 9, 2025 at 4:50 PM
Exercise seems to help prevent cancer and reduce the growth of tumours, but until now, we didn’t know why. The key seems to lie in the gut’s microbiome.
Reposted
Exercise enhances antitumor immunity and immunotherapy effectiveness by increasing microbiota-derived formate, which boosts CD8 T cell function and may serve as a biomarker of melanoma suppression @cellcellpress.bsky.social @catmphelps.bsky.social @meisellab.bsky.social
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
July 10, 2025 at 10:01 PM
Exercise enhances antitumor immunity and immunotherapy effectiveness by increasing microbiota-derived formate, which boosts CD8 T cell function and may serve as a biomarker of melanoma suppression @cellcellpress.bsky.social @catmphelps.bsky.social @meisellab.bsky.social
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
Reposted
📄🧫🔬🐭What are you reading this weekend? Check out @catmphelps.bsky.social, @meisellab.bsky.social, et al’s brand new work! #H2P
Our lab just completed a +6 year #marathon, describing for the first time that the #microbiome is critical for #exercise - induced increases in antitumor CD8 T cell immunity and improved of #cancer #immunotherapy.
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
Exercise-induced microbiota metabolite enhances CD8 T cell antitumor immunity promoting immunotherapy efficacy
Exercise enhances antitumor immunity and immunotherapy effectiveness by increasing
microbiota-derived formate, which boosts CD8 T cell function and may serve as a biomarker
of melanoma suppression.
www.cell.com
July 10, 2025 at 12:01 PM
📄🧫🔬🐭What are you reading this weekend? Check out @catmphelps.bsky.social, @meisellab.bsky.social, et al’s brand new work! #H2P
Reposted
Now online! Exercise-induced microbiota metabolite enhances CD8 T cell antitumor immunity promoting immunotherapy efficacy
Exercise-induced microbiota metabolite enhances CD8 T cell antitumor immunity promoting immunotherapy efficacy
Exercise enhances antitumor immunity and immunotherapy effectiveness by increasing microbiota-derived formate, which boosts CD8 T cell function and may serve as a biomarker of melanoma suppression.
dlvr.it
July 9, 2025 at 3:00 PM
Now online! Exercise-induced microbiota metabolite enhances CD8 T cell antitumor immunity promoting immunotherapy efficacy
Reposted
I am BEYOND excited to share that my PhD thesis research is officially published in @cellpress.bsky.social today.
Read on for an exciting story about how #exercise promotes antitumor #immunity by modulating behavior of the #microbiome 🏃♀️🦠
authors.elsevier.com/c/1lPCrL7PXu...
Read on for an exciting story about how #exercise promotes antitumor #immunity by modulating behavior of the #microbiome 🏃♀️🦠
authors.elsevier.com/c/1lPCrL7PXu...
authors.elsevier.com
July 9, 2025 at 3:41 PM
I am BEYOND excited to share that my PhD thesis research is officially published in @cellpress.bsky.social today.
Read on for an exciting story about how #exercise promotes antitumor #immunity by modulating behavior of the #microbiome 🏃♀️🦠
authors.elsevier.com/c/1lPCrL7PXu...
Read on for an exciting story about how #exercise promotes antitumor #immunity by modulating behavior of the #microbiome 🏃♀️🦠
authors.elsevier.com/c/1lPCrL7PXu...
Reposted
How exercise works through the gut microbiome to enhance response to cancer immunotherapy
www.cell.com/cell/fulltex... @cellpress.bsky.social
www.cell.com/cell/fulltex... @cellpress.bsky.social
July 9, 2025 at 2:57 PM
How exercise works through the gut microbiome to enhance response to cancer immunotherapy
www.cell.com/cell/fulltex... @cellpress.bsky.social
www.cell.com/cell/fulltex... @cellpress.bsky.social
Our lab just completed a +6 year #marathon, describing for the first time that the #microbiome is critical for #exercise - induced increases in antitumor CD8 T cell immunity and improved of #cancer #immunotherapy.
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
Exercise-induced microbiota metabolite enhances CD8 T cell antitumor immunity promoting immunotherapy efficacy
Exercise enhances antitumor immunity and immunotherapy effectiveness by increasing
microbiota-derived formate, which boosts CD8 T cell function and may serve as a biomarker
of melanoma suppression.
www.cell.com
July 9, 2025 at 6:12 PM
Our lab just completed a +6 year #marathon, describing for the first time that the #microbiome is critical for #exercise - induced increases in antitumor CD8 T cell immunity and improved of #cancer #immunotherapy.
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
Reposted
A first-of-its kind study adds powerful new evidence to research showing that exercise improves cancer survival. Here's what the trial, in people treated for colon cancer, showed.
Exercise Extends Life for People With Cancer, Study Shows
The trial, in people treated for colon cancer, showed clear evidence that an exercise program lowered the risk of disease recurrence and death.
trib.al
June 2, 2025 at 4:30 PM
A first-of-its kind study adds powerful new evidence to research showing that exercise improves cancer survival. Here's what the trial, in people treated for colon cancer, showed.
Reposted
The remarkable benefit of exercise was just extended to improved survival after cancer in a randomized trial
@nejm.org
nejm.org/doi/full/10....
@nejm.org
nejm.org/doi/full/10....
June 1, 2025 at 2:52 PM
The remarkable benefit of exercise was just extended to improved survival after cancer in a randomized trial
@nejm.org
nejm.org/doi/full/10....
@nejm.org
nejm.org/doi/full/10....
not posting much these days…but this is just too positive not to share- 2 of my trainees (current) Catherine (@Catmphelps.bsky.social) and (former) Mackenzie received the AAI Trainee Achievement Award! Could not be prouder…#WomeninSTEM
May 5, 2025 at 12:01 AM
not posting much these days…but this is just too positive not to share- 2 of my trainees (current) Catherine (@Catmphelps.bsky.social) and (former) Mackenzie received the AAI Trainee Achievement Award! Could not be prouder…#WomeninSTEM
Reposted
also a new N&V www.nature.com/articles/d41...
Microbial molecule of ageing gut nudges blood stem cells towards cancer
The risk of developing blood cancer increases with age. The finding that a molecule from gut bacteria plays a part points to new ways to intervene.
www.nature.com
May 1, 2025 at 8:16 AM
also a new N&V www.nature.com/articles/d41...
Reposted
Having a great time at #AACR25 in Chicago! Join me Sunday afternoon at the Overcoming Tumor Immune Suppression Minisymposium where I'll be discussing new @meisellab.bsky.social research on #exercise, #microbiome, and cancer immunity🏃 #WICR #WomenInSTEM
April 27, 2025 at 3:09 PM
Having a great time at #AACR25 in Chicago! Join me Sunday afternoon at the Overcoming Tumor Immune Suppression Minisymposium where I'll be discussing new @meisellab.bsky.social research on #exercise, #microbiome, and cancer immunity🏃 #WICR #WomenInSTEM
Reposted
Excellent excellent excellent from Princeton president and constitutional/ political theorist Chris Eisgruber. There's been far too little of this kind of thing; here's hoping others follow his good example.
www.theatlantic.com/ideas/archiv...
www.theatlantic.com/ideas/archiv...
The Cost of the Government’s Attack on Columbia
American universities have given the country prosperity and security. The Trump administration’s attack on academic freedom endangers all of that.
www.theatlantic.com
March 19, 2025 at 1:04 PM
Excellent excellent excellent from Princeton president and constitutional/ political theorist Chris Eisgruber. There's been far too little of this kind of thing; here's hoping others follow his good example.
www.theatlantic.com/ideas/archiv...
www.theatlantic.com/ideas/archiv...
Reposted
Some scientists in the United States have told Nature that they are considering leaving the country in the wake of widespread disruption to research brought in by the Trump administration
Are you thinking about leaving?
https://go.nature.com/424ejK8
Are you thinking about leaving?
https://go.nature.com/424ejK8
These frustrated scientists want to leave the United States – do you? Take Nature’s poll
In the wake of the Trump administration’s funding freezes and job cuts, some researchers are planning their next move.
go.nature.com
March 13, 2025 at 11:22 AM
Some scientists in the United States have told Nature that they are considering leaving the country in the wake of widespread disruption to research brought in by the Trump administration
Are you thinking about leaving?
https://go.nature.com/424ejK8
Are you thinking about leaving?
https://go.nature.com/424ejK8