Catherine Phelps
@catmphelps.bsky.social
PhD Candidate in the @MeiselLab at University of Pittsburgh @Pitt_PMI | Aspiring Immunologist & Microbiologist | ACPHS '20 |🏃♀️🛼👩🔬
Pinned
Catherine Phelps
@catmphelps.bsky.social
· Jul 11
Now online! Exercise-induced microbiota metabolite enhances CD8 T cell antitumor immunity promoting immunotherapy efficacy
Exercise-induced microbiota metabolite enhances CD8 T cell antitumor immunity promoting immunotherapy efficacy
Exercise enhances antitumor immunity and immunotherapy effectiveness by increasing microbiota-derived formate, which boosts CD8 T cell function and may serve as a biomarker of melanoma suppression.
dlvr.it
I am BEYOND excited to share that my PhD thesis research is officially published in Cell @cellcellpress.bsky.social.
Read on for an exciting story about how #exercise promotes antitumor #immunity by modulating behavior of the #microbiome to help fight #cancer 🏃♀️🦠
Read on for an exciting story about how #exercise promotes antitumor #immunity by modulating behavior of the #microbiome to help fight #cancer 🏃♀️🦠
Reposted by Catherine Phelps
Catherine Phelps from @upmc.com representing #SITC Talks on how #exercise can improve outcome - role for #microbial #metabolite #formate on mediating #anticancer #immunity / #WIC2025 #SITC2025
November 5, 2025 at 3:22 PM
Catherine Phelps from @upmc.com representing #SITC Talks on how #exercise can improve outcome - role for #microbial #metabolite #formate on mediating #anticancer #immunity / #WIC2025 #SITC2025
What a fantastic opportunity to share our work! Thank you organizers for a great pre-conference event at #SITC25
Looking forward to even more awesome science in the days to come!
Looking forward to even more awesome science in the days to come!
Bernard A. Fox, Michael Geuenich, Catherine Phelps and other international investigators highlight groundbreaking IO advances during the 6th World Immunotherapy Council #SITC25
November 7, 2025 at 4:12 PM
What a fantastic opportunity to share our work! Thank you organizers for a great pre-conference event at #SITC25
Looking forward to even more awesome science in the days to come!
Looking forward to even more awesome science in the days to come!
What a great opportunity to share our story! Thank you to all the organizers for putting this event together!
Our first talk is this year’s Stephen L Phillips Scientific Achievement Awardee, Catherine Phelps @catmphelps.bsky.social (PMI)
#symposium #GSR #bgsa
#symposium #GSR #bgsa
October 1, 2025 at 3:35 PM
What a great opportunity to share our story! Thank you to all the organizers for putting this event together!
Reposted by Catherine Phelps
Check out PMI talks tomorrow at the SOM Grad Student Symposium:
@catmphelps.bsky.social (in @meisellab.bsky.social ), Daria Jelic (Doug Reed lab), Kelsey Ertwine (Abby Overacre lab), @febrigunawan48.bsky.social (in Renfeng Li lab), and @dariavantyne.bsky.social !
@catmphelps.bsky.social (in @meisellab.bsky.social ), Daria Jelic (Doug Reed lab), Kelsey Ertwine (Abby Overacre lab), @febrigunawan48.bsky.social (in Renfeng Li lab), and @dariavantyne.bsky.social !
Tomorrow from 8am-6pm, The Assembly transforms into a celebration of graduate research, innovation, and sustainability at the 30th School of Medicine Graduate Student Research Symposium.
See you tomorrow—bring your energy, your ideas, and join a scientific experience that is setting new standards!
See you tomorrow—bring your energy, your ideas, and join a scientific experience that is setting new standards!
October 1, 2025 at 2:35 AM
Check out PMI talks tomorrow at the SOM Grad Student Symposium:
@catmphelps.bsky.social (in @meisellab.bsky.social ), Daria Jelic (Doug Reed lab), Kelsey Ertwine (Abby Overacre lab), @febrigunawan48.bsky.social (in Renfeng Li lab), and @dariavantyne.bsky.social !
@catmphelps.bsky.social (in @meisellab.bsky.social ), Daria Jelic (Doug Reed lab), Kelsey Ertwine (Abby Overacre lab), @febrigunawan48.bsky.social (in Renfeng Li lab), and @dariavantyne.bsky.social !
Reposted by Catherine Phelps
Congratulations to PMI student @catmphelps.bsky.social who is the recipient of the 23rd Stephen L. Phillips Scientific Achievement award for a Pitt School of Medicine graduate student who authored the best peer-review scientific journal author this year!
September 24, 2025 at 6:40 PM
Congratulations to PMI student @catmphelps.bsky.social who is the recipient of the 23rd Stephen L. Phillips Scientific Achievement award for a Pitt School of Medicine graduate student who authored the best peer-review scientific journal author this year!
Reposted by Catherine Phelps
Congrats, @catmphelps.bsky.social !
Congratulations to PMI student @catmphelps.bsky.social who is the recipient of the 23rd Stephen L. Phillips Scientific Achievement award for a Pitt School of Medicine graduate student who authored the best peer-review scientific journal author this year!
September 24, 2025 at 9:06 PM
Congrats, @catmphelps.bsky.social !
Awesome write-up! 🦠 🏃♀️ 💨
#ResearchHighlight
In a study published in #Cell, Phelps et al. find a mechanism connecting exercise, gut microbiota & anti-tumour immunity; exercise induces microbiota to produce formate, which in turn enhances CD8+ T cell functionality.
👇
In a study published in #Cell, Phelps et al. find a mechanism connecting exercise, gut microbiota & anti-tumour immunity; exercise induces microbiota to produce formate, which in turn enhances CD8+ T cell functionality.
👇
No strain, no formate gains - Nature Reviews Cancer
In a study published in Cell, Phelps et al. find a mechanism connecting exercise, gut microbiota and anti-tumour immunity; exercise induces microbiota to produce formate, which in turn enhances CD8+ T cell functionality.
www.nature.com
August 5, 2025 at 3:52 PM
Awesome write-up! 🦠 🏃♀️ 💨
Reposted by Catherine Phelps
Excited to share our new publication in collaboration with Yi-Nan Gong: Gasdermin C cleavage by Cathepsin S modulates Rab7 vesicles in intestinal epithelial cells to amplify anti-helminth immunity: Immunity www.cell.com/immunity/ful...
Gasdermin C cleavage by Cathepsin S modulates Rab7 vesicles in intestinal epithelial cells to amplify anti-helminth immunity
Pandey et al. identify Cathepsin S (CTSS) as the direct protease that cleaves Gasdermin
C (GsdmC) in the intestine. Type 2 immune-promoting microbes trigger CTSS-dependent
GsdmC activation in intestin...
www.cell.com
July 22, 2025 at 3:26 PM
Excited to share our new publication in collaboration with Yi-Nan Gong: Gasdermin C cleavage by Cathepsin S modulates Rab7 vesicles in intestinal epithelial cells to amplify anti-helminth immunity: Immunity www.cell.com/immunity/ful...
Reposted by Catherine Phelps
Online now: Gasdermin C cleavage by Cathepsin S modulates Rab7 vesicles in intestinal epithelial cells to amplify anti-helminth immunity
Gasdermin C cleavage by Cathepsin S modulates Rab7 vesicles in intestinal epithelial cells to amplify anti-helminth immunity
Pandey et al. identify Cathepsin S (CTSS) as the direct protease that cleaves Gasdermin C (GsdmC) in the intestine. Type 2 immune-promoting microbes trigger CTSS-dependent GsdmC activation in intestinal epithelial cells, targeting Rab7+ vesicles, altering lipid metabolism, and modulating anti-helminth immunity, revealing a non-pyroptotic function of GsdmC in mucosal immune regulation.
dlvr.it
July 22, 2025 at 2:48 PM
Online now: Gasdermin C cleavage by Cathepsin S modulates Rab7 vesicles in intestinal epithelial cells to amplify anti-helminth immunity
I am BEYOND excited to share that my PhD thesis research is officially published in Cell @cellcellpress.bsky.social.
Read on for an exciting story about how #exercise promotes antitumor #immunity by modulating behavior of the #microbiome to help fight #cancer 🏃♀️🦠
Read on for an exciting story about how #exercise promotes antitumor #immunity by modulating behavior of the #microbiome to help fight #cancer 🏃♀️🦠
Now online! Exercise-induced microbiota metabolite enhances CD8 T cell antitumor immunity promoting immunotherapy efficacy
Exercise-induced microbiota metabolite enhances CD8 T cell antitumor immunity promoting immunotherapy efficacy
Exercise enhances antitumor immunity and immunotherapy effectiveness by increasing microbiota-derived formate, which boosts CD8 T cell function and may serve as a biomarker of melanoma suppression.
dlvr.it
July 11, 2025 at 7:46 PM
I am BEYOND excited to share that my PhD thesis research is officially published in Cell @cellcellpress.bsky.social.
Read on for an exciting story about how #exercise promotes antitumor #immunity by modulating behavior of the #microbiome to help fight #cancer 🏃♀️🦠
Read on for an exciting story about how #exercise promotes antitumor #immunity by modulating behavior of the #microbiome to help fight #cancer 🏃♀️🦠
Reposted by Catherine Phelps
Exercise enhances antitumor immunity and immunotherapy effectiveness by increasing microbiota-derived formate, which boosts CD8 T cell function and may serve as a biomarker of melanoma suppression @cellcellpress.bsky.social @catmphelps.bsky.social @meisellab.bsky.social
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
July 10, 2025 at 10:01 PM
Exercise enhances antitumor immunity and immunotherapy effectiveness by increasing microbiota-derived formate, which boosts CD8 T cell function and may serve as a biomarker of melanoma suppression @cellcellpress.bsky.social @catmphelps.bsky.social @meisellab.bsky.social
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
Reposted by Catherine Phelps
Exercise helps the immune system to fight tumours by stimulating microbes in the gut to make a compound known as formate
go.nature.com/4lIZx2m
go.nature.com/4lIZx2m
Workouts can help gut microbes to quell cancer
Mice that exercised produced higher levels of an immune-cell-stimulating molecule than sedentary rodents did.
go.nature.com
July 11, 2025 at 2:46 AM
Reposted by Catherine Phelps
📄🧫🔬🐭What are you reading this weekend? Check out @catmphelps.bsky.social, @meisellab.bsky.social, et al’s brand new work! #H2P
Our lab just completed a +6 year #marathon, describing for the first time that the #microbiome is critical for #exercise - induced increases in antitumor CD8 T cell immunity and improved of #cancer #immunotherapy.
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
Exercise-induced microbiota metabolite enhances CD8 T cell antitumor immunity promoting immunotherapy efficacy
Exercise enhances antitumor immunity and immunotherapy effectiveness by increasing
microbiota-derived formate, which boosts CD8 T cell function and may serve as a biomarker
of melanoma suppression.
www.cell.com
July 10, 2025 at 12:01 PM
📄🧫🔬🐭What are you reading this weekend? Check out @catmphelps.bsky.social, @meisellab.bsky.social, et al’s brand new work! #H2P
Reposted by Catherine Phelps
Now online! Exercise-induced microbiota metabolite enhances CD8 T cell antitumor immunity promoting immunotherapy efficacy
Exercise-induced microbiota metabolite enhances CD8 T cell antitumor immunity promoting immunotherapy efficacy
Exercise enhances antitumor immunity and immunotherapy effectiveness by increasing microbiota-derived formate, which boosts CD8 T cell function and may serve as a biomarker of melanoma suppression.
dlvr.it
July 9, 2025 at 3:00 PM
Now online! Exercise-induced microbiota metabolite enhances CD8 T cell antitumor immunity promoting immunotherapy efficacy
Reposted by Catherine Phelps
Our lab just completed a +6 year #marathon, describing for the first time that the #microbiome is critical for #exercise - induced increases in antitumor CD8 T cell immunity and improved of #cancer #immunotherapy.
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
Exercise-induced microbiota metabolite enhances CD8 T cell antitumor immunity promoting immunotherapy efficacy
Exercise enhances antitumor immunity and immunotherapy effectiveness by increasing
microbiota-derived formate, which boosts CD8 T cell function and may serve as a biomarker
of melanoma suppression.
www.cell.com
July 9, 2025 at 6:12 PM
Our lab just completed a +6 year #marathon, describing for the first time that the #microbiome is critical for #exercise - induced increases in antitumor CD8 T cell immunity and improved of #cancer #immunotherapy.
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
I am BEYOND excited to share that my PhD thesis research is officially published in @cellpress.bsky.social today.
Read on for an exciting story about how #exercise promotes antitumor #immunity by modulating behavior of the #microbiome 🏃♀️🦠
authors.elsevier.com/c/1lPCrL7PXu...
Read on for an exciting story about how #exercise promotes antitumor #immunity by modulating behavior of the #microbiome 🏃♀️🦠
authors.elsevier.com/c/1lPCrL7PXu...
authors.elsevier.com
July 9, 2025 at 3:41 PM
I am BEYOND excited to share that my PhD thesis research is officially published in @cellpress.bsky.social today.
Read on for an exciting story about how #exercise promotes antitumor #immunity by modulating behavior of the #microbiome 🏃♀️🦠
authors.elsevier.com/c/1lPCrL7PXu...
Read on for an exciting story about how #exercise promotes antitumor #immunity by modulating behavior of the #microbiome 🏃♀️🦠
authors.elsevier.com/c/1lPCrL7PXu...
Reposted by Catherine Phelps
The remarkable benefit of exercise was just extended to improved survival after cancer in a randomized trial
@nejm.org
nejm.org/doi/full/10....
@nejm.org
nejm.org/doi/full/10....
June 1, 2025 at 2:52 PM
The remarkable benefit of exercise was just extended to improved survival after cancer in a randomized trial
@nejm.org
nejm.org/doi/full/10....
@nejm.org
nejm.org/doi/full/10....
Reposted by Catherine Phelps
A first-of-its kind study adds powerful new evidence to research showing that exercise improves cancer survival. Here's what the trial, in people treated for colon cancer, showed.
Exercise Extends Life for People With Cancer, Study Shows
The trial, in people treated for colon cancer, showed clear evidence that an exercise program lowered the risk of disease recurrence and death.
trib.al
June 2, 2025 at 4:30 PM
A first-of-its kind study adds powerful new evidence to research showing that exercise improves cancer survival. Here's what the trial, in people treated for colon cancer, showed.
Reposted by Catherine Phelps
not posting much these days…but this is just too positive not to share- 2 of my trainees (current) Catherine (@Catmphelps.bsky.social) and (former) Mackenzie received the AAI Trainee Achievement Award! Could not be prouder…#WomeninSTEM
May 5, 2025 at 12:01 AM
not posting much these days…but this is just too positive not to share- 2 of my trainees (current) Catherine (@Catmphelps.bsky.social) and (former) Mackenzie received the AAI Trainee Achievement Award! Could not be prouder…#WomeninSTEM
Having a great time at #AACR25 in Chicago! Join me Sunday afternoon at the Overcoming Tumor Immune Suppression Minisymposium where I'll be discussing new @meisellab.bsky.social research on #exercise, #microbiome, and cancer immunity🏃 #WICR #WomenInSTEM
April 27, 2025 at 3:09 PM
Having a great time at #AACR25 in Chicago! Join me Sunday afternoon at the Overcoming Tumor Immune Suppression Minisymposium where I'll be discussing new @meisellab.bsky.social research on #exercise, #microbiome, and cancer immunity🏃 #WICR #WomenInSTEM
So excited to be in Banff for the @keystonesymposia.bsky.social with a focus on #microbiome! Loving the views on a beautiful trail #run today... RIP to my old cramp-ons though 😆
February 19, 2025 at 8:16 PM
So excited to be in Banff for the @keystonesymposia.bsky.social with a focus on #microbiome! Loving the views on a beautiful trail #run today... RIP to my old cramp-ons though 😆