Meg T (she/her/hers)
@megthescientist.bsky.social
Bio x ML @ Romero lab, @dukeubme.bsky.social
@ml4proteins.bsky.social co-organizer
@ml4proteins.bsky.social co-organizer
Excited to be at the Carolina Biophysics Symposium the next two days to hear and talk about protein eng and design in many therapeutic and green science spaces!! Special thanks to our friends at
@unc-bcbp.bsky.social for organizing! Gonna be an exciting time!
cbs.web.unc.edu
@unc-bcbp.bsky.social for organizing! Gonna be an exciting time!
cbs.web.unc.edu
November 6, 2025 at 12:45 PM
Excited to be at the Carolina Biophysics Symposium the next two days to hear and talk about protein eng and design in many therapeutic and green science spaces!! Special thanks to our friends at
@unc-bcbp.bsky.social for organizing! Gonna be an exciting time!
cbs.web.unc.edu
@unc-bcbp.bsky.social for organizing! Gonna be an exciting time!
cbs.web.unc.edu
Reposted by Meg T (she/her/hers)
Design stable, folded proteins using only the 10 "ancient" amino acids.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
October 31, 2025 at 7:40 PM
Design stable, folded proteins using only the 10 "ancient" amino acids.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Meg T (she/her/hers)
Three BioML starter packs now!
Pack 1: go.bsky.app/2VWBcCd
Pack 2: go.bsky.app/Bw84Hmc
Pack 3: go.bsky.app/NAKYUok
DM if you want to be included (or nominate people who should be!)
Pack 1: go.bsky.app/2VWBcCd
Pack 2: go.bsky.app/Bw84Hmc
Pack 3: go.bsky.app/NAKYUok
DM if you want to be included (or nominate people who should be!)
December 3, 2024 at 3:27 AM
Three BioML starter packs now!
Pack 1: go.bsky.app/2VWBcCd
Pack 2: go.bsky.app/Bw84Hmc
Pack 3: go.bsky.app/NAKYUok
DM if you want to be included (or nominate people who should be!)
Pack 1: go.bsky.app/2VWBcCd
Pack 2: go.bsky.app/Bw84Hmc
Pack 3: go.bsky.app/NAKYUok
DM if you want to be included (or nominate people who should be!)
Reposted by Meg T (she/her/hers)
Please share with anyone who cares about NSF support for graduate students and take 30 seconds to sign and leave a comment.
The deadline for the 2025 Graduate Research Fellowship Program is about one month away and literally no one can apply. #NSFGRFP
jasonjwilliamsny.github.io/grfp2025/
The deadline for the 2025 Graduate Research Fellowship Program is about one month away and literally no one can apply. #NSFGRFP
jasonjwilliamsny.github.io/grfp2025/
An Open Letter to U.S. STEM Leadership on the NSF Graduate Research Fellowship Program
An Open Letter to U.S. STEM Leadership on the NSF Graduate Research Fellowship Program
jasonjwilliamsny.github.io
September 25, 2025 at 10:09 PM
Please share with anyone who cares about NSF support for graduate students and take 30 seconds to sign and leave a comment.
The deadline for the 2025 Graduate Research Fellowship Program is about one month away and literally no one can apply. #NSFGRFP
jasonjwilliamsny.github.io/grfp2025/
The deadline for the 2025 Graduate Research Fellowship Program is about one month away and literally no one can apply. #NSFGRFP
jasonjwilliamsny.github.io/grfp2025/
Reposted by Meg T (she/her/hers)
I'm really proud of this work by Jae Kennemur and Yueming Long. #Enzymes rock, with some help from #directed evolution to do chemistry not known in nature (and really hard for humans, too). @caltechcce.bsky.social
pubs.acs.org/doi/10.1021/...
pubs.acs.org/doi/10.1021/...
Enzymatic Stereodivergent Synthesis of Azaspiro[2.y]alkanes
Azaspiro[2.y]alkanes are increasingly valuable scaffolds in pharmaceutical drug discovery; however, an asymmetric catalytic method for their synthesis remains unknown. Here, we present a stereodiverge...
pubs.acs.org
July 22, 2025 at 7:29 PM
I'm really proud of this work by Jae Kennemur and Yueming Long. #Enzymes rock, with some help from #directed evolution to do chemistry not known in nature (and really hard for humans, too). @caltechcce.bsky.social
pubs.acs.org/doi/10.1021/...
pubs.acs.org/doi/10.1021/...
Reposted by Meg T (she/her/hers)
The posting is unfortunately not super clear on this, but please apply if you want to do BioML research, especially around machine learning for molecular biology and bioengineering!
I get sad if there are no applicants with this profile in the pool!
I get sad if there are no applicants with this profile in the pool!
If you're an undergrad and want to intern with me, this is where you need to apply!
The Microsoft Research Undergraduate Internship Program offers 12-week internships in our Redmond, NYC, or New England labs for rising juniors and seniors who are passionate about technology. Apply by October 6: msft.it/6015scgSJ
September 15, 2025 at 1:58 PM
The posting is unfortunately not super clear on this, but please apply if you want to do BioML research, especially around machine learning for molecular biology and bioengineering!
I get sad if there are no applicants with this profile in the pool!
I get sad if there are no applicants with this profile in the pool!
Reposted by Meg T (she/her/hers)
Very excited about our latest all-atom generative model proteina, check out the project page (research.nvidia.com/labs/genair/...) and stay tuned for the code release soon!
July 19, 2025 at 8:46 PM
Very excited about our latest all-atom generative model proteina, check out the project page (research.nvidia.com/labs/genair/...) and stay tuned for the code release soon!
Reposted by Meg T (she/her/hers)
Really nice metastudy of citizen science contributing to ecology & biodiversity research @inaturalist.bsky.social @aibsbiology.bsky.social
👀🔎🍄🧪🌎🌐
iNaturalist accelerates biodiversity research academic.oup.com/bioscience/a...
👀🔎🍄🧪🌎🌐
iNaturalist accelerates biodiversity research academic.oup.com/bioscience/a...
iNaturalist accelerates biodiversity research
Abstract. Participatory citizen science is expanding, with iNaturalist emerging as one of the most widely used platforms globally. However, its application
academic.oup.com
July 28, 2025 at 9:57 PM
Really nice metastudy of citizen science contributing to ecology & biodiversity research @inaturalist.bsky.social @aibsbiology.bsky.social
👀🔎🍄🧪🌎🌐
iNaturalist accelerates biodiversity research academic.oup.com/bioscience/a...
👀🔎🍄🧪🌎🌐
iNaturalist accelerates biodiversity research academic.oup.com/bioscience/a...
Reposted by Meg T (she/her/hers)
The MLSB workshop will be in San Diego, CA (co-located with NeurIPS) this year for its 6th edition in December 🧬🔬
Stay tuned @workshopmlsb.bsky.social as we share details about the stellar lineup of speakers, the official call for papers, and other announcements!🌟
Stay tuned @workshopmlsb.bsky.social as we share details about the stellar lineup of speakers, the official call for papers, and other announcements!🌟
July 28, 2025 at 3:40 PM
The MLSB workshop will be in San Diego, CA (co-located with NeurIPS) this year for its 6th edition in December 🧬🔬
Stay tuned @workshopmlsb.bsky.social as we share details about the stellar lineup of speakers, the official call for papers, and other announcements!🌟
Stay tuned @workshopmlsb.bsky.social as we share details about the stellar lineup of speakers, the official call for papers, and other announcements!🌟
Reposted by Meg T (she/her/hers)
Reposted by Meg T (she/her/hers)
In 1965, Margaret Dayhoff published the Atlas of Protein Sequence and Structure, which collated the 65 proteins whose amino acid sequences were then known.
Inspired by that Atlas, today we are releasing the Dayhoff Atlas of protein sequence data and protein language models.
Inspired by that Atlas, today we are releasing the Dayhoff Atlas of protein sequence data and protein language models.
July 25, 2025 at 10:05 PM
In 1965, Margaret Dayhoff published the Atlas of Protein Sequence and Structure, which collated the 65 proteins whose amino acid sequences were then known.
Inspired by that Atlas, today we are releasing the Dayhoff Atlas of protein sequence data and protein language models.
Inspired by that Atlas, today we are releasing the Dayhoff Atlas of protein sequence data and protein language models.
“Writing compels us to think — not in the chaotic, non-linear way our minds typically wander, but in a structured, intentional manner. By writing it down, we can sort years of research, data and analysis into an actual story, thereby identifying our main message and the influence of our work.”
Writing is thinking | Nature Reviews Bioengineering
Writing is thinking | Nature Reviews Bioengineering
On the value of human-generated scientific writing in the age of large-language models.
www.nature.com
July 21, 2025 at 3:23 PM
“Writing compels us to think — not in the chaotic, non-linear way our minds typically wander, but in a structured, intentional manner. By writing it down, we can sort years of research, data and analysis into an actual story, thereby identifying our main message and the influence of our work.”
Reposted by Meg T (she/her/hers)
🧪 The EPA is eliminating its scientific research arm and firing hundreds of scientists.
This move, enabled by a Supreme Court ruling, dismantles the office providing independent research for environmental policies.
#Climate
This move, enabled by a Supreme Court ruling, dismantles the office providing independent research for environmental policies.
#Climate
E.P.A. Says It Will Eliminate Its Scientific Research Arm
www.nytimes.com
July 19, 2025 at 2:02 AM
🧪 The EPA is eliminating its scientific research arm and firing hundreds of scientists.
This move, enabled by a Supreme Court ruling, dismantles the office providing independent research for environmental policies.
#Climate
This move, enabled by a Supreme Court ruling, dismantles the office providing independent research for environmental policies.
#Climate
Reposted by Meg T (she/her/hers)
We're sponsoring the use of ESM3 and EMSC to help researchers engineer improved PETase enzymes in the @AlignBio 2025 Protein Engineering Tournament.
Get started using ESMC to predict protein function and ESM3 to generate new enzymes here: github.com/evolutionary...
Get started using ESMC to predict protein function and ESM3 to generate new enzymes here: github.com/evolutionary...
July 8, 2025 at 6:01 PM
We're sponsoring the use of ESM3 and EMSC to help researchers engineer improved PETase enzymes in the @AlignBio 2025 Protein Engineering Tournament.
Get started using ESMC to predict protein function and ESM3 to generate new enzymes here: github.com/evolutionary...
Get started using ESMC to predict protein function and ESM3 to generate new enzymes here: github.com/evolutionary...
Reposted by Meg T (she/her/hers)
1/4
🚀 Announcing the 2025 Protein Engineering Tournament.
This year’s challenge: design PETase enzymes, which degrade the type of plastic in bottles. Can AI-guided protein design help solve the climate crisis? Let’s find out! ⬇️
#AIforBiology #ClimateTech #ProteinEngineering #OpenScience
🚀 Announcing the 2025 Protein Engineering Tournament.
This year’s challenge: design PETase enzymes, which degrade the type of plastic in bottles. Can AI-guided protein design help solve the climate crisis? Let’s find out! ⬇️
#AIforBiology #ClimateTech #ProteinEngineering #OpenScience
July 8, 2025 at 4:26 PM
1/4
🚀 Announcing the 2025 Protein Engineering Tournament.
This year’s challenge: design PETase enzymes, which degrade the type of plastic in bottles. Can AI-guided protein design help solve the climate crisis? Let’s find out! ⬇️
#AIforBiology #ClimateTech #ProteinEngineering #OpenScience
🚀 Announcing the 2025 Protein Engineering Tournament.
This year’s challenge: design PETase enzymes, which degrade the type of plastic in bottles. Can AI-guided protein design help solve the climate crisis? Let’s find out! ⬇️
#AIforBiology #ClimateTech #ProteinEngineering #OpenScience
Reposted by Meg T (she/her/hers)
Unfortunately, the MLSB Workshop @ NeurIPS (@workshopmlsb.bsky.social) was rejected this year.
Feedback from the deciding committee indicates it was a coin flip decision, with 283 proposals & a number related to “computational biology”
More on the future of MLSB soon…
Feedback from the deciding committee indicates it was a coin flip decision, with 283 proposals & a number related to “computational biology”
More on the future of MLSB soon…
July 7, 2025 at 2:21 PM
Unfortunately, the MLSB Workshop @ NeurIPS (@workshopmlsb.bsky.social) was rejected this year.
Feedback from the deciding committee indicates it was a coin flip decision, with 283 proposals & a number related to “computational biology”
More on the future of MLSB soon…
Feedback from the deciding committee indicates it was a coin flip decision, with 283 proposals & a number related to “computational biology”
More on the future of MLSB soon…
Pls tell me im living under a rock and we have citation managers compatible with iPads where your writing & highlighting can be automatically transcribed into notes and key words attached to a pdf (vs me manually transcribing over from edits I make in Adobe??) In the age of AI, we have this, right??
June 30, 2025 at 6:51 AM
Pls tell me im living under a rock and we have citation managers compatible with iPads where your writing & highlighting can be automatically transcribed into notes and key words attached to a pdf (vs me manually transcribing over from edits I make in Adobe??) In the age of AI, we have this, right??
Reposted by Meg T (she/her/hers)
With contributions from fantastic colleagues @martinsteinegger.bsky.social , @mikeinouye.bsky.social, @jlistgarten.bsky.social , @ideasbyjin.bsky.social, @michael-heinzinger.bsky.social, and many more, the first CSHL volume on ML for Protein Science and Engineering is out: lnkd.in/dQdgGPpp
June 15, 2025 at 11:30 AM
With contributions from fantastic colleagues @martinsteinegger.bsky.social , @mikeinouye.bsky.social, @jlistgarten.bsky.social , @ideasbyjin.bsky.social, @michael-heinzinger.bsky.social, and many more, the first CSHL volume on ML for Protein Science and Engineering is out: lnkd.in/dQdgGPpp
Reposted by Meg T (she/her/hers)
Physics-based design of efficient Kemp eliminases
@lynnkamerlin.bsky.social
www.nature.com/articles/s41...
@lynnkamerlin.bsky.social
www.nature.com/articles/s41...
June 19, 2025 at 9:18 PM
Physics-based design of efficient Kemp eliminases
@lynnkamerlin.bsky.social
www.nature.com/articles/s41...
@lynnkamerlin.bsky.social
www.nature.com/articles/s41...
Reposted by Meg T (she/her/hers)
June 25, 2025 at 2:19 PM
Reposted by Meg T (she/her/hers)
End-to-end differentiable homology search for protein fitness prediction.
@yaringal.bsky.social @deboramarks.bsky.social @pascalnotin.bsky.social
arxiv.org/abs/2506.089...
@yaringal.bsky.social @deboramarks.bsky.social @pascalnotin.bsky.social
arxiv.org/abs/2506.089...
June 11, 2025 at 7:00 PM
End-to-end differentiable homology search for protein fitness prediction.
@yaringal.bsky.social @deboramarks.bsky.social @pascalnotin.bsky.social
arxiv.org/abs/2506.089...
@yaringal.bsky.social @deboramarks.bsky.social @pascalnotin.bsky.social
arxiv.org/abs/2506.089...
Reposted by Meg T (she/her/hers)
🚨 New paper 🚨 RNA modeling just got its own Gym! 🏋️ Introducing RNAGym, large-scale benchmarks for RNA fitness and structure prediction.
🧵 1/9
🧵 1/9
June 18, 2025 at 7:35 PM
🚨 New paper 🚨 RNA modeling just got its own Gym! 🏋️ Introducing RNAGym, large-scale benchmarks for RNA fitness and structure prediction.
🧵 1/9
🧵 1/9
Reposted by Meg T (she/her/hers)
Which RNAs are functional? Been a long time goal of @deboramarks.bsky.social to start an RNA sequence —> function and structure mapping.
Huge thx to team for pushing on this when - led by Rohit Arora and Murphy Angelo for seeing this thru and Pascal Notin for pulling together!!!
Huge thx to team for pushing on this when - led by Rohit Arora and Murphy Angelo for seeing this thru and Pascal Notin for pulling together!!!
🚨 New paper 🚨 RNA modeling just got its own Gym! 🏋️ Introducing RNAGym, large-scale benchmarks for RNA fitness and structure prediction.
🧵 1/9
🧵 1/9
June 18, 2025 at 7:47 PM
Which RNAs are functional? Been a long time goal of @deboramarks.bsky.social to start an RNA sequence —> function and structure mapping.
Huge thx to team for pushing on this when - led by Rohit Arora and Murphy Angelo for seeing this thru and Pascal Notin for pulling together!!!
Huge thx to team for pushing on this when - led by Rohit Arora and Murphy Angelo for seeing this thru and Pascal Notin for pulling together!!!
Reposted by Meg T (she/her/hers)
RNA, RNA, RNA -> RNAGym!
read all about it! biorxiv.org/content/10.110…
Been a long time goal of @deboramarks.bsky.social We tried a million years ago,
sciencedirect.com/science/articl���
Now total refresh led by Rohit Arora and Murphy Angelo and Pascal Notin for pulling together!!
read all about it! biorxiv.org/content/10.110…
Been a long time goal of @deboramarks.bsky.social We tried a million years ago,
sciencedirect.com/science/articl���
Now total refresh led by Rohit Arora and Murphy Angelo and Pascal Notin for pulling together!!
https://biorxiv.org/content/10.110…
June 18, 2025 at 8:13 PM
RNA, RNA, RNA -> RNAGym!
read all about it! biorxiv.org/content/10.110…
Been a long time goal of @deboramarks.bsky.social We tried a million years ago,
sciencedirect.com/science/articl���
Now total refresh led by Rohit Arora and Murphy Angelo and Pascal Notin for pulling together!!
read all about it! biorxiv.org/content/10.110…
Been a long time goal of @deboramarks.bsky.social We tried a million years ago,
sciencedirect.com/science/articl���
Now total refresh led by Rohit Arora and Murphy Angelo and Pascal Notin for pulling together!!
Reposted by Meg T (she/her/hers)
Happy to release our breakthrough AI-model: RareFold, which predicts and designs proteins with noncanonical AAs. With EvoBindRare, we designed linear & cyclic peptide binders with high affinity & novel binding modes, wet lab validated.
📄 biorxiv.org/content/10.1...
💻 github.com/patrickbryan...
📄 biorxiv.org/content/10.1...
💻 github.com/patrickbryan...
May 25, 2025 at 2:11 PM
Happy to release our breakthrough AI-model: RareFold, which predicts and designs proteins with noncanonical AAs. With EvoBindRare, we designed linear & cyclic peptide binders with high affinity & novel binding modes, wet lab validated.
📄 biorxiv.org/content/10.1...
💻 github.com/patrickbryan...
📄 biorxiv.org/content/10.1...
💻 github.com/patrickbryan...