Mast cells, traditionally known for their roles in allergic reactions and pathogen defense, have been revealed to possess significant functional diversity within the tumor microenvironment (TME). Through single-cell RNA sequencing analysis across 15 solid tumors (385 samples from 264 patients), 10...

The College is pleased to have endorsed the British Society for Haematology report “The Haematology Workforce: A Comprehensive View.” This report highlights the vital role of clinical pathology and laboratory services in the rapid diagnosis and management of haematological diseases. The report reveals the growing pressure on haematology professionals, as the gap between workforce capacity and clinical demand continues to widen. Supporting these findings, the College’s 2025 Workforce Census finds that 82% of haematologists believe current staffing levels are insufficient to ensure the long-term sustainability of services. The College agrees that robust workforce planning is essential to align haematology services with local and regional needs – factoring in population growth, diagnostic demand, evolving working patterns, and succession planning. Action and investment are urgently needed to future-proof the haematology workforce and ensure equitable access to high-quality care for all affected by blood diseases. Read more here: https://ow.ly/ptGN50X6bZL #Pathology #HealthcareWorkforce #RCPath #Haematology

The Nobel Prize in Physiology or Medicine 2025 was awarded to Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi “for their discoveries concerning peripheral immune tolerance.”

Europe PMC is an archive of life sciences journal literature.

Discover the many Confucius quotes that have been wrongly attributed to the great philosopher, or simply misinterpreted by modern society

Nicolas Kusser , Gemeinsame Kommission Informationskompetenz von dbv und VDB and Sabine Rauchmann   from Universitätsbibliothek Augsburg spo...

A fun paper to read. Check acknowledgments and footnotes below - this is a joke of course... except this "scientific" journal did not seem to care. Is anyone actually working at this publisher? Link to this gem in comments. In case you have any doubt: ACKNOWLEDGEMENTS The author thanks ChatGPT for making up the experiment, generating the data, writing the article, and for creative suggestions for the alien experimental condition. The author thanks Dall-E for generating all images. FOOTNOTES Institutional review board statement: The study was reviewed and approved by the Telepathy & Alien Institutional Review board. Conflict-of-interest statement: Stan van Pelt is a science journalist, and not an active scientist. Data sharing statement: There is no data to share, since no real measurements have been done.

The College’s Clinical Immunology Workforce Report finds critical staff shortages across services that diagnose and treat allergies, autoimmune diseases and immunodeficiencies.   Three quarters of UK immunology services report that they do not have enough staff to meet current clinical demand.   Dr Patrick Yong, Chair of the College Specialty Advisory Committee for Immunology, quotes: "This is a sobering report. Many services rely on goodwill and unpaid overtime to keep running. We urgently need to establish more training posts and focus on retaining experienced consultants to ensure safe, effective patient care.” Patients are facing delays to diagnosis and treatment, while consultants are at risk of burnout. The College is calling for more training posts, better support, and improved workforce planning. Read the full report and recommendations on our website. https://lnkd.in/eyavzHsp

Five Laws of Media and Information Literacy

Pathogen-consuming cells found in fat tissue also play a part in lipid balance.

Le Monde qui a choisi Perplexity a du soucis à se faire Jérôme Fenoglio. Ce printemps, c’était l’une des meilleures IA car elle moissonnait (LLM) les articles du journal où j’ai travaillé, ignorant l’actu chaude que je retrouvais sur l’appli du Monde où je suis abonné. J'avais testé en avril 2025 dix IA en préparation d’un Café IA du Conseil de l'intelligence artificielle et du numérique à Viva Technology avec Gilles Babinet. Perplexity est devenue la pire des IA (46% d’erreurs 🤯) car elle moissonne désormais aussi le web et ses usines à troll et malinfo dans un contexte de guerre hybride mondiale. Perplexity ne retrouve même pas dans le moteur du Monde les articles publiés la veille ! 🤪 La fabrique de l’info, c’est bien croiser comme à Combat ses sources et non produire du hachis pour temps de cerveau disponible Jean-Clément Texier ? Dites-moi... 😅 . Et c’est encore Google qui va plier le match avec Gemini, comme en 1998, quand nous avons créé Hachette.net au tout début de Club Internet (nous étions huit très à l’étroit sur un plateau encombré de modems bruyants 56K 🙃). Mon guide du web interactif a été enterré par Lagardère deux ans avant l’arrivée de Google et la disparition de ses moteurs concurrents, dont nous faisions partie avec Exalead... Je suis parti travailler au Routard, d’autres aux US à San Francisco... 😜 Donc je vais utiliser comme IA Gemini tant que l’UE ne sera pas unie pour en créer une, excepté pour mettre des amendes salées (justifiées mais illusoires) à ses brillants concurrents. Ceci risque d’être le dernier acte de l’enterrement des media déjà annoncé en 2011 par Bob Woodwards, après le print et la TV pour seniors où exercent de grands professionnels certes mais dépassés et écrasés par Youtube et ses Tubeurs, première chaine de France, désormais parrain des jeunes pousses du prix Albert Londres à l’initiative de Romain Cabrolier et #LaScam où je fus commissaire de l’écrit et qui a su dès 2000 s'adapter aux usages du digital... "First winner, second looser !", comme on disait avant la première bulle des TIC de 2000 bientôt engloutie par celle de l’IA selon Sam Altman fondateur d’OpenAI... La majorité des cadres aux US n’utilisent pas l’IA jugée défaillante. La majorité des jeunes français déclarent vouloir se passer d’internet jugé anxiogène, energivore, destructeur d’emplois et chronophage (cf Le Monde)... Bon je retourne sur FB, LI, X, Insta, Youtube, Google où je m’informe au quotidien 1h matin et soir selon mon smartphone. Je ne regarde plus la TV. Le reste est consacré aux itw IRL, à la lecture, l’écriture et aux flâneries créatives.... Ces instruments digitaux sont merveilleux quand on trie, qualifie et organise drastiquement ses contacts et ses journées de travail. Cela s’appelle du journalisme et j’ai été formé à la plus belle école : celle de mon ami et père de substitution Bernard Thomas, REC et critique du Canard Enchainé auquel je rends hommage. On s’est bien marrés et ce n’est pas près de s’arrêter... | 45 comments on LinkedIn

Researchers in a new #ScienceReview examine the influence that biological sex exerts on the immune system and immune-related diseases. Learn more: https://scim.ag/4fCsDyA | 19 commentaires sur LinkedIn

How often people use ChatGPT varies by country—India leads with 36% daily users, while Japan has the lowest daily adoption at 6%.

The distribution of ~ 2 trillion immune cells in the human body. Lymphocytes: ~ 40% of the number, and 15% of the mass Neutrophils: ~ 40% of the number, and 15% of the mass Macrophages: ~ 10% of the number, and 50% of the mass

Half a million genomes. 1.5 billion variants. One breakthrough: we are all truly unique. Twenty years ago, the Human Genome Project took 13 years and $2.7B to sequence a single genome. Today? We can sequence a genome in less than 24 hours for under $1,000. Last week, UK Biobank released 490,640 whole genomes — the largest genetic dataset ever (Nature, 2025). What did we learn? • Each person carries 4–5 million variants • 76% appear in fewer than 10 people — your genome is almost entirely yours • 1 in 10 carries clinically actionable mutations where doctors can intervene today (e.g., BRCA1/2 for cancer, LDLR for heart disease) Why it matters: • Previous genetic tests captured ~6% of human variation. This dataset reveals 40× more • In non-coding regions — the biological switches controlling genes — researchers found 63 new disease associations • Adding 31,785 non-European genomes uncovered 82 disease links invisible in Eurocentric studies From genetics to health impact This transforms medicine today: • Prevention - Polygenic risk scores flag disease decades before symptoms • Diagnosis - Rare disease patients waiting years for answers finally find them • Treatment - Pharmacogenomics matches the right drug, right dose, to your genome The next frontier: genetics + everything else Genetics is the hardware. Health is the software running in real time. Your DNA is fixed, but biology is dynamic, shaped by: • Epigenetics: how environment and lifestyle switch genes on/off • Proteomics & metabolomics: molecular signals revealing your current health state • Digital biomarkers: continuous data from stress, sleep, glucose, heart rate • Stress biology & neuroendocrine signaling: how cortisol and brain-body responses reshape your health trajectory Layer these dynamic signals onto genetic foundations, power them with AI, and you create living health models, not just predicting disease, but understanding when, why, and how it manifests in YOU. The critical question? We've spent decades treating the "average patient" — who doesn't exist. Now we can better see each person as they truly are: biologically unique, dynamically changing, infinitely complex. The healthcare winners of the next decade won't just collect data: they'll integrate genetics, epigenetics, molecular and phenotypic tests, lifestyle, stress biology, and digital signals to deliver truly personalized, preventive care at scale. There is no "normal" genome, only 8 billion unique experiments in being human. And we just decoded the first half million. 👉 Which excites you more: knowing your genetic blueprint, or understanding how your daily choices rewrite it? | 47 comments on LinkedIn

💉 14 Million Nigerian Girls Protected: A Giant Leap Toward Eliminating Cervical Cancer 💪🏽 Human papillomavirus (HPV) is a sexually transmitted infection that affects approximately 70% of individuals during their lifetime, with approximately 47 million women aged 15 years and older at risk of developing the disease in Nigeria. It is the leading cause of cervical cancer and cervical cancer remains one of the most preventable yet deadly threats to women and girls especially in Africa. But we are not powerless. The HPV vaccine is rewriting the story. We are proud to celebrate a historic milestone in Nigeria’s fight against cervical cancer: Over 14 million Nigerian girls have now received the HPV vaccine, according to the NPHCDA. This achievement represents not just a number. It is 14 million futures protected, 14 million girls given a chance to grow, thrive, and live free from a preventable disease. During a recent high-level panel session titled “Accelerating Cervical Cancer Elimination in Nigeria: From Policy to Practice”, experts reflected on this success while issuing a resounding call for more inclusive, innovative, and integrated efforts. 🌍 What’s needed now: ✅ Stronger community engagement ✅ Integration of HPV into ALL health and communication platforms ✅ Inclusive, gender-balanced stakeholder participation ✅ Better education of both girls and boys on HPV transmission and prevention ✅ Wider access to cervical screening and self-sampling technologies ✅ Increased research and innovation in diagnostics and vaccine accessibility Nigeria is setting the pace on the continent. But to truly eliminate cervical cancer, we must: ✅ Continue investing ✅ Continue educating ✅ Continue vaccinating ✅ Continue screening ✅ And continue the fight—together. “Let’s do it big and let’s do it together.” At Bloom Public Health, we remain committed to leading this charge through research, advocacy, partnership, and innovation. Because every girl matters. Every life counts. Saving lives should never depend on a ZIP code. Let’s unite for a future where every girl, everywhere, is protected. #BloomPublicHealth #HPVVaccine #CervicalCancerAwareness #ProtectOurGirls #ImmunizationSavesLives #EndCervicalCancer #Gavi #Unicef #PublicHealthNigeria #AfricaUnitedAgainstCancer #HealthEquity #VaccinesWork #VaccinateToEliminate #SaveHerFuture #WHO #HPV #GlobalHealth #Health #Africa #Nigeria #Lesotho #Rwanda #Zambia #Zimbabwe #Cameroon #Botswana #Ethiopia

💉 14 Million Nigerian Girls Protected: A Giant Leap Toward Eliminating Cervical Cancer 💪🏽 Human papillomavirus (HPV) is a sexually transmitted infection that affects approximately 70% of individuals during their lifetime, with approximately 47 million women aged 15 years and older at risk of developing the disease in Nigeria. It is the leading cause of cervical cancer and cervical cancer remains one of the most preventable yet deadly threats to women and girls especially in Africa. But we are not powerless. The HPV vaccine is rewriting the story. We are proud to celebrate a historic milestone in Nigeria’s fight against cervical cancer: Over 14 million Nigerian girls have now received the HPV vaccine, according to the NPHCDA. This achievement represents not just a number. It is 14 million futures protected, 14 million girls given a chance to grow, thrive, and live free from a preventable disease. During a recent high-level panel session titled “Accelerating Cervical Cancer Elimination in Nigeria: From Policy to Practice”, experts reflected on this success while issuing a resounding call for more inclusive, innovative, and integrated efforts. 🌍 What’s needed now: ✅ Stronger community engagement ✅ Integration of HPV into ALL health and communication platforms ✅ Inclusive, gender-balanced stakeholder participation ✅ Better education of both girls and boys on HPV transmission and prevention ✅ Wider access to cervical screening and self-sampling technologies ✅ Increased research and innovation in diagnostics and vaccine accessibility Nigeria is setting the pace on the continent. But to truly eliminate cervical cancer, we must: ✅ Continue investing ✅ Continue educating ✅ Continue vaccinating ✅ Continue screening ✅ And continue the fight—together. “Let’s do it big and let’s do it together.” At Bloom Public Health, we remain committed to leading this charge through research, advocacy, partnership, and innovation. Because every girl matters. Every life counts. Saving lives should never depend on a ZIP code. Let’s unite for a future where every girl, everywhere, is protected. #BloomPublicHealth #HPVVaccine #CervicalCancerAwareness #ProtectOurGirls #ImmunizationSavesLives #EndCervicalCancer #Gavi #Unicef #PublicHealthNigeria #AfricaUnitedAgainstCancer #HealthEquity #VaccinesWork #VaccinateToEliminate #SaveHerFuture #WHO #HPV #GlobalHealth #Health #Africa #Nigeria #Lesotho #Rwanda #Zambia #Zimbabwe #Cameroon #Botswana #Ethiopia

I keep staring at this video showing the movement of aerosols in the atmosphere. It's so mesmerizing! That and more of the best from Science Magazine and science in this edition of #ScienceAdviser: https://lnkd.in/gazjaRga

The immune system permeates and regulates organs and tissues across the body, and has diverse roles beyond pathogen control, including in development, tissue homeostasis and repair. The reshaping of the immune system that occurs during aging is therefore highly consequential. In this Focus issue, Nature Aging presents a collection of reviews of and opinions on recent advances in research into immune aging.