Matthias Soller
@matthiassoller.bsky.social
Professor of RNA Biology FBMH University of Manchester
Molecular geneticist interested in RNA regulation in the brain using mighty Drosophila fruit flies
Epitranscriptomics Phylogenomics Neuro-connectomics ELAV Dscam Sex-peptide Synapse
www.sollerlab.org
Molecular geneticist interested in RNA regulation in the brain using mighty Drosophila fruit flies
Epitranscriptomics Phylogenomics Neuro-connectomics ELAV Dscam Sex-peptide Synapse
www.sollerlab.org
In memory every summer!
November 12, 2025 at 11:23 PM
In memory every summer!
Reposted by Matthias Soller
Preprint: Bacteria sense virus-induced genome degradation via methylated mononucleotides
tinyurl.com/ch3damp
We show how molecular byproducts released during virus-induced cell exploitation are used as signals to trigger host immunity
Revealed by the amazing Ilya Osterman. See his thread below👇
tinyurl.com/ch3damp
We show how molecular byproducts released during virus-induced cell exploitation are used as signals to trigger host immunity
Revealed by the amazing Ilya Osterman. See his thread below👇
November 6, 2025 at 10:39 AM
Preprint: Bacteria sense virus-induced genome degradation via methylated mononucleotides
tinyurl.com/ch3damp
We show how molecular byproducts released during virus-induced cell exploitation are used as signals to trigger host immunity
Revealed by the amazing Ilya Osterman. See his thread below👇
tinyurl.com/ch3damp
We show how molecular byproducts released during virus-induced cell exploitation are used as signals to trigger host immunity
Revealed by the amazing Ilya Osterman. See his thread below👇
Reposted by Matthias Soller
🦖 Something HUGE just hatched.
Plasmidsaurus now offers RNA sequencing for gene expression analysis:
• As fast as 3 day turnaround
• $50/sample for academia, $80 for industry
• Up to ~10M unique transcript 3’ end reads per sample
• Interactive results
Explore Plasmidsaurus RNA-Seq today.
Plasmidsaurus now offers RNA sequencing for gene expression analysis:
• As fast as 3 day turnaround
• $50/sample for academia, $80 for industry
• Up to ~10M unique transcript 3’ end reads per sample
• Interactive results
Explore Plasmidsaurus RNA-Seq today.
October 15, 2025 at 4:02 PM
🦖 Something HUGE just hatched.
Plasmidsaurus now offers RNA sequencing for gene expression analysis:
• As fast as 3 day turnaround
• $50/sample for academia, $80 for industry
• Up to ~10M unique transcript 3’ end reads per sample
• Interactive results
Explore Plasmidsaurus RNA-Seq today.
Plasmidsaurus now offers RNA sequencing for gene expression analysis:
• As fast as 3 day turnaround
• $50/sample for academia, $80 for industry
• Up to ~10M unique transcript 3’ end reads per sample
• Interactive results
Explore Plasmidsaurus RNA-Seq today.
Cold-inducible RNA-binding protein CIRBP: A whales secret to long life?
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Evidence for improved DNA repair in long-lived bowhead whale - Nature
Analysis of the longest-lived mammal, the bowhead whale, reveals an improved ability to repair DNA breaks, mediated by high levels of cold-inducible RNA-binding protein. &nbs...
www.nature.com
November 3, 2025 at 7:42 AM
Cold-inducible RNA-binding protein CIRBP: A whales secret to long life?
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Well represented #EMBO epitranscriptomics 2025
📢 Our scientists are among the initiators and participants of the Human RNome Project - a global initiative aimed at fully characterizing all human RNA molecules and their chemical modifications. 🧬
👉Read the story: tinyurl.com/Human-RNome-...
#RNome #RNA
👉Read the story: tinyurl.com/Human-RNome-...
#RNome #RNA
October 29, 2025 at 10:38 PM
Well represented #EMBO epitranscriptomics 2025
Reposted by Matthias Soller
We have a new academic post opening for a Lecture/Senior-Lecturer in Structural Biology @mcf-uom.bsky.social @fbmh-uom.bsky.social @manchester.ac.uk The University of Manchester is ranked among the top Universities worldwide. QS world rankings: 34th (2025)
www.jobs.manchester.ac.uk/Job/JobDetai...
www.jobs.manchester.ac.uk/Job/JobDetai...
Lecturer / Senior Lecturer in Structural Biology:Oxford Road
The purpose of this post is to undertake high quality research and also excellent teaching. Hence, the ability to enhance teaching activities within our UG/PG programmes will also be expected.
www.jobs.manchester.ac.uk
October 28, 2025 at 11:07 AM
We have a new academic post opening for a Lecture/Senior-Lecturer in Structural Biology @mcf-uom.bsky.social @fbmh-uom.bsky.social @manchester.ac.uk The University of Manchester is ranked among the top Universities worldwide. QS world rankings: 34th (2025)
www.jobs.manchester.ac.uk/Job/JobDetai...
www.jobs.manchester.ac.uk/Job/JobDetai...
Reposted by Matthias Soller
Exciting news for the RNA research community!
The Human RNome Project has been launched: a global effort to map all human RNAs and their chemical modifications. Proud to support it and contribute to the article in Genome Biology doi.org/10.1186/s130...
#RNA #bioinformatics #RNAstructure #modomics
The Human RNome Project has been launched: a global effort to map all human RNAs and their chemical modifications. Proud to support it and contribute to the article in Genome Biology doi.org/10.1186/s130...
#RNA #bioinformatics #RNAstructure #modomics
Unlocking the regulatory code of RNA: launching the Human RNome Project - Genome Biology
The human RNome, the complete set of RNA molecules in human cells, arises through complex processing and includes diverse molecular species. While research traditionally focuses on four canonical nucl...
genomebiology.biomedcentral.com
October 25, 2025 at 10:27 PM
Exciting news for the RNA research community!
The Human RNome Project has been launched: a global effort to map all human RNAs and their chemical modifications. Proud to support it and contribute to the article in Genome Biology doi.org/10.1186/s130...
#RNA #bioinformatics #RNAstructure #modomics
The Human RNome Project has been launched: a global effort to map all human RNAs and their chemical modifications. Proud to support it and contribute to the article in Genome Biology doi.org/10.1186/s130...
#RNA #bioinformatics #RNAstructure #modomics
Why?
Water companies are paid to deal with waste water, like coffee.
Unbelievable how deteriorated this has become. On the cost of tax payers.
Water companies are paid to deal with waste water, like coffee.
Unbelievable how deteriorated this has become. On the cost of tax payers.
October 22, 2025 at 10:39 PM
Why?
Water companies are paid to deal with waste water, like coffee.
Unbelievable how deteriorated this has become. On the cost of tax payers.
Water companies are paid to deal with waste water, like coffee.
Unbelievable how deteriorated this has become. On the cost of tax payers.
Reposted by Matthias Soller
Excited to share our paper, led by Naoki Okamoto in our group, just out in Nature!
Neuroendocrine control of calcium mobilization in the fruit fly
www.nature.com/articles/s41...
We “re”-discovered the calcium storage site in “boneless” Drosophila and revealed how calcium mobilization is regulated.
Neuroendocrine control of calcium mobilization in the fruit fly
www.nature.com/articles/s41...
We “re”-discovered the calcium storage site in “boneless” Drosophila and revealed how calcium mobilization is regulated.
Neuroendocrine control of calcium mobilization in the fruit fly - Nature
The peptide hormone Capa is responsible for regulating extracellular fluid Ca2+ levels in the fruit fly Drosophila melanogaster.
www.nature.com
October 22, 2025 at 3:04 PM
Excited to share our paper, led by Naoki Okamoto in our group, just out in Nature!
Neuroendocrine control of calcium mobilization in the fruit fly
www.nature.com/articles/s41...
We “re”-discovered the calcium storage site in “boneless” Drosophila and revealed how calcium mobilization is regulated.
Neuroendocrine control of calcium mobilization in the fruit fly
www.nature.com/articles/s41...
We “re”-discovered the calcium storage site in “boneless” Drosophila and revealed how calcium mobilization is regulated.
Reposted by Matthias Soller
We’ve not given up trying to work out what is killing the bees, with @matthiassoller.bsky.social @annalassota.bsky.social www.nature.com/articles/s41... Assessing species-specific neonicotinoid toxicity using cross-species chimeric nicotinic acetylcholine receptors in a Drosophila model
Assessing species-specific neonicotinoid toxicity using cross-species chimeric nicotinic acetylcholine receptors in a Drosophila model - Scientific Reports
Scientific Reports - Assessing species-specific neonicotinoid toxicity using cross-species chimeric nicotinic acetylcholine receptors in a Drosophila model
www.nature.com
October 21, 2025 at 4:28 PM
We’ve not given up trying to work out what is killing the bees, with @matthiassoller.bsky.social @annalassota.bsky.social www.nature.com/articles/s41... Assessing species-specific neonicotinoid toxicity using cross-species chimeric nicotinic acetylcholine receptors in a Drosophila model
Reposted by Matthias Soller
This is a super interesting paper by @conradlab.bsky.social lab on METTL16. They separate METTL16 function on U6 and MAT2A allowing more accurate analysis. Their results cast serious doubt on hundreds of papers claiming METTL16 methylates vast number of mRNAs. www.cell.com/cell-reports...
The catalytic efficiency of METTL16 affects cellular processes by governing the intracellular S-adenosylmethionine setpoint
Flaherty et al. demonstrate that the catalytic efficiency of METTL16 regulates expression
of MAT2A to determine the intracellular SAM setpoint. Their data indicate that this
is required for several SA...
www.cell.com
October 21, 2025 at 1:38 PM
This is a super interesting paper by @conradlab.bsky.social lab on METTL16. They separate METTL16 function on U6 and MAT2A allowing more accurate analysis. Their results cast serious doubt on hundreds of papers claiming METTL16 methylates vast number of mRNAs. www.cell.com/cell-reports...
Reposted by Matthias Soller
Our paper describing enhanced hybridization-proximity labeling technology is finally out! Enhanced HyPro can identify proteins associated with small RNA compartments and even some individual transcripts, such as pathological C9orf72 transcripts: www.nature.com/articles/s41...
Enhanced hybridization-proximity labeling discovers protein interactomes of single RNA molecules - Nature Communications
Systematic discovery of proteins interacting with low-abundance RNAs is challenging. Here, the authors develop an enhanced HyPro technology to identify proteins associated with compact RNA compartment...
www.nature.com
October 21, 2025 at 8:46 AM
Our paper describing enhanced hybridization-proximity labeling technology is finally out! Enhanced HyPro can identify proteins associated with small RNA compartments and even some individual transcripts, such as pathological C9orf72 transcripts: www.nature.com/articles/s41...
Reposted by Matthias Soller
Future thinking.
For obvious reasons, I've become fascinated with retrotransposons. So we ( @alexwhiteley.bsky.social and I) wrote an article now out in Neuron @cellpress.bsky.social on how we think retrotransposons influence brain function and health! kwnsfk27.r.eu-west-1.awstrack.me/L0/https:%2F...
October 21, 2025 at 2:06 AM
Future thinking.
Last of the trilogy about core promoter evolution thanks to @davidmcquarrie.bsky.social
academic.oup.com/genetics/adv...
academic.oup.com/genetics/adv...
Rapid promoter evolution of male accessory gland genes is accompanied by divergent expression in closely related Drosophila species
Abstract. Seminal fluid proteins (Sfps) are essential for reproductive success and evolve fast on average, possibly driven by post-copulatory sexual select
academic.oup.com
October 20, 2025 at 7:04 AM
Last of the trilogy about core promoter evolution thanks to @davidmcquarrie.bsky.social
academic.oup.com/genetics/adv...
academic.oup.com/genetics/adv...
Reposted by Matthias Soller
Rapid promoter evolution of male accessory gland genes is accompanied by divergent expression in closely related Drosophila species
#Drosophila
#Drosophila
Rapid promoter evolution of male accessory gland genes is accompanied by divergent expression in closely related Drosophila species
#Drosophila
PubMed link
pubmed.ncbi.nlm.nih.gov
October 18, 2025 at 5:23 PM
Rapid promoter evolution of male accessory gland genes is accompanied by divergent expression in closely related Drosophila species
#Drosophila
#Drosophila
Reposted by Matthias Soller
Interested in what happens when a fly gets a bee receptor? 🐝➡️🪰
Check out our new paper!
Many thanks to @matthiassoller.bsky.social and @docfly.bsky.social
Check out our new paper!
Many thanks to @matthiassoller.bsky.social and @docfly.bsky.social
Making beta to alpha - see our latest work here pinning honey bee nicotinic acetylcholine receptor alpha8 gene into flies to test neonicotinoid sensitivity thanks to @annalassota.bsky.social and @docfly.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Assessing species-specific neonicotinoid toxicity using cross-species chimeric nicotinic acetylcholine receptors in a Drosophila model - Scientific Reports
Scientific Reports - Assessing species-specific neonicotinoid toxicity using cross-species chimeric nicotinic acetylcholine receptors in a Drosophila model
www.nature.com
October 17, 2025 at 10:08 AM
Interested in what happens when a fly gets a bee receptor? 🐝➡️🪰
Check out our new paper!
Many thanks to @matthiassoller.bsky.social and @docfly.bsky.social
Check out our new paper!
Many thanks to @matthiassoller.bsky.social and @docfly.bsky.social
Making beta to alpha - see our latest work here pinning honey bee nicotinic acetylcholine receptor alpha8 gene into flies to test neonicotinoid sensitivity thanks to @annalassota.bsky.social and @docfly.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Assessing species-specific neonicotinoid toxicity using cross-species chimeric nicotinic acetylcholine receptors in a Drosophila model - Scientific Reports
Scientific Reports - Assessing species-specific neonicotinoid toxicity using cross-species chimeric nicotinic acetylcholine receptors in a Drosophila model
www.nature.com
October 17, 2025 at 7:26 AM
Making beta to alpha - see our latest work here pinning honey bee nicotinic acetylcholine receptor alpha8 gene into flies to test neonicotinoid sensitivity thanks to @annalassota.bsky.social and @docfly.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Great day in Lancaster, thanks to
@agatsiou.bsky.social for the invitation.
@agatsiou.bsky.social for the invitation.
We were delighted to welcome Professor Matthias Soller from the University of Manchester for this week’s departmental seminar “Keeping RNA regulation in shape for health,” generously sponsored by BGI Genomics. @matthiassoller.bsky.social
October 16, 2025 at 5:16 PM
Great day in Lancaster, thanks to
@agatsiou.bsky.social for the invitation.
@agatsiou.bsky.social for the invitation.
Reposted by Matthias Soller
Still time to apply for this post!!!
3-year technician position with a possibility of doing a PhD available to study chromatin replication and ubiquitylation using cell free system of Xenopus laevis egg extract. Closing date 28/10/25. Get in touch @agagambus.bsky.social or @m-saponaro.bsky.social for informal inquiries
lnkd.in/etU3yydb
lnkd.in/etU3yydb
LinkedIn
This link will take you to a page that’s not on LinkedIn
lnkd.in
October 15, 2025 at 4:20 PM
Still time to apply for this post!!!
Reposted by Matthias Soller
New BBSRC funded PhD opportunity in my group with Inspiralis Ltd and @conradn.bsky.social. If you are interested in RNA - protein interactions and RNA modifications check the details below for how to apply. @nrpdtp.bsky.social @biouea.bsky.social @earlhaminst.bsky.social tinyurl.com/bdzvn4dr
How do RNA molecules shape genome regulation in the nervous system? (AKAY_U26CASE) | Doctoral Training Partnership
This PhD project will investigate how RNA modifications influence the activity of topoisomerase I (TOP1), a crucial enzyme that regulates DNA supercoiling during replication and transcription. Using C...
biodtp.norwichresearchpark.ac.uk
October 12, 2025 at 7:43 PM
New BBSRC funded PhD opportunity in my group with Inspiralis Ltd and @conradn.bsky.social. If you are interested in RNA - protein interactions and RNA modifications check the details below for how to apply. @nrpdtp.bsky.social @biouea.bsky.social @earlhaminst.bsky.social tinyurl.com/bdzvn4dr
Reposted by Matthias Soller
Reposted by Matthias Soller
Some fly neurons are “dimorphic”, existing in both males and females but connecting to different neighboring neurons. Neighbors may be “isomorphic”, the same in both male and female; or sex specific; or dimorphic themselves. Here's an example, the type AOTU012, present in left and right instances.
October 8, 2025 at 9:11 AM
Some fly neurons are “dimorphic”, existing in both males and females but connecting to different neighboring neurons. Neighbors may be “isomorphic”, the same in both male and female; or sex specific; or dimorphic themselves. Here's an example, the type AOTU012, present in left and right instances.
Reposted by Matthias Soller
RNA journal increases to over 5.0! Publish your research in RNA today!
October 6, 2025 at 5:00 AM
RNA journal increases to over 5.0! Publish your research in RNA today!
Reposted by Matthias Soller
If you want to know more about the science behind the latest @nobelprize.bsky.social in Physiology and Medecine awarded to the "FoxP3-Tregs" field have a look at this:
www.nobelprize.org/prizes/medic...
A very detailed account!
www.nobelprize.org/prizes/medic...
A very detailed account!
Nobel Prize in Physiology or Medicine 2025
The Nobel Prize in Physiology or Medicine 2025 was awarded to Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi “for their discoveries concerning peripheral immune tolerance.”
www.nobelprize.org
October 6, 2025 at 2:50 PM
If you want to know more about the science behind the latest @nobelprize.bsky.social in Physiology and Medecine awarded to the "FoxP3-Tregs" field have a look at this:
www.nobelprize.org/prizes/medic...
A very detailed account!
www.nobelprize.org/prizes/medic...
A very detailed account!
Reposted by Matthias Soller
Having personally sworn for years that insects don’t use GPCRs for odour detection, Suguru Takagi (@sugurutakagi.bsky.social) discovers that, in fact, they sometimes do …
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
A GPCR signaling pathway in insect odor detection
Odor detection differs fundamentally in vertebrates, which use G protein-coupled receptors (GPCRs), and insects, which employ ion channels. Here, we report the first evidence for a GPCR defining tunin...
www.biorxiv.org
October 6, 2025 at 4:17 AM
Having personally sworn for years that insects don’t use GPCRs for odour detection, Suguru Takagi (@sugurutakagi.bsky.social) discovers that, in fact, they sometimes do …
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...