Matthias Soller
@matthiassoller.bsky.social
Professor of RNA Biology FBMH University of Manchester
Molecular geneticist interested in RNA regulation in the brain using mighty Drosophila fruit flies
Epitranscriptomics Phylogenomics Neuro-connectomics ELAV Dscam Sex-peptide Synapse
www.sollerlab.org
Molecular geneticist interested in RNA regulation in the brain using mighty Drosophila fruit flies
Epitranscriptomics Phylogenomics Neuro-connectomics ELAV Dscam Sex-peptide Synapse
www.sollerlab.org
Reposted by Matthias Soller
Make your gene knockouts more efficient with multiplexed Cas12a sgRNAs. Our new paper is out now, with tools available from @addgene.bsky.social , www.plasmids.eu and @vdrc-flies.bsky.social.
www.nature.com/articles/s41...
#CRISPR #geneediting #Drosophila 🧪🧬✂️🔬🪰
Summary 🧵 below.
www.nature.com/articles/s41...
#CRISPR #geneediting #Drosophila 🧪🧬✂️🔬🪰
Summary 🧵 below.
January 29, 2026 at 9:26 AM
Make your gene knockouts more efficient with multiplexed Cas12a sgRNAs. Our new paper is out now, with tools available from @addgene.bsky.social , www.plasmids.eu and @vdrc-flies.bsky.social.
www.nature.com/articles/s41...
#CRISPR #geneediting #Drosophila 🧪🧬✂️🔬🪰
Summary 🧵 below.
www.nature.com/articles/s41...
#CRISPR #geneediting #Drosophila 🧪🧬✂️🔬🪰
Summary 🧵 below.
Reposted by Matthias Soller
Online Now: Why m⁶A? An RNA surveillance model Online now:
Why m⁶A? An RNA surveillance model
Dierks and Schwartz discuss the m6A surveillance model, proposing that m6A flags “undesirable” intron-less RNAs (e.g., transposons) for decay. This provides a mechanism to distinguish “legitimate” spliced mRNAs and potentially suppress harmful RNA.
dlvr.it
January 28, 2026 at 12:32 PM
Online Now: Why m⁶A? An RNA surveillance model Online now:
This is MRC - what a nightmare!
January 28, 2026 at 10:26 AM
This is MRC - what a nightmare!
January 28, 2026 at 10:21 AM
Reposted by Matthias Soller
Excited to share our latest preprint: "SWARM: A Single-Molecule Workflow for High-Precision Profiling of RNA Modifications" www.biorxiv.org/content/10.6...
Led by Stefan Prodic #RNA #Epitranscriptomics #Nanopore 1/6
Led by Stefan Prodic #RNA #Epitranscriptomics #Nanopore 1/6
www.biorxiv.org
January 28, 2026 at 1:24 AM
Excited to share our latest preprint: "SWARM: A Single-Molecule Workflow for High-Precision Profiling of RNA Modifications" www.biorxiv.org/content/10.6...
Led by Stefan Prodic #RNA #Epitranscriptomics #Nanopore 1/6
Led by Stefan Prodic #RNA #Epitranscriptomics #Nanopore 1/6
Reposted by Matthias Soller
Just out @natrevimmunol.nature.com
RNA-binding proteins and ribonucleoproteins as determinants of immunity
www.nature.com/articles/s41...
gives our perspective on this growing area of research. Special thanks to the editor Alexandra, for streamlining the manuscript.
RNA-binding proteins and ribonucleoproteins as determinants of immunity
www.nature.com/articles/s41...
gives our perspective on this growing area of research. Special thanks to the editor Alexandra, for streamlining the manuscript.
RNA-binding proteins and ribonucleoproteins as determinants of immunity - Nature Reviews Immunology
RNA-binding proteins (RBPs) considerably expand the information content of the genome and can determine the lifespan, localization and function of RNA, thereby controlling when, where and how much pro...
www.nature.com
January 27, 2026 at 7:32 AM
Just out @natrevimmunol.nature.com
RNA-binding proteins and ribonucleoproteins as determinants of immunity
www.nature.com/articles/s41...
gives our perspective on this growing area of research. Special thanks to the editor Alexandra, for streamlining the manuscript.
RNA-binding proteins and ribonucleoproteins as determinants of immunity
www.nature.com/articles/s41...
gives our perspective on this growing area of research. Special thanks to the editor Alexandra, for streamlining the manuscript.
Reposted by Matthias Soller
new paper from the Lai lab! Renfu Shang performs careful mechanistic dissection of miRNA cluster assistance and reveals many insights and surprises to this enigmatic regulatory strategy that gives suboptimal miRNAs a boost. if you love Northerns, you'll ♥️ this! 🧬
genesdev.cshlp.org/content/earl...
genesdev.cshlp.org/content/earl...
Separable roles for Microprocessor and its cofactors, ERH and SAFB1/2, during microRNA cluster assistance
A biweekly scientific journal publishing high-quality research in molecular biology and genetics, cancer biology, biochemistry, and related fields
genesdev.cshlp.org
January 23, 2026 at 8:21 PM
new paper from the Lai lab! Renfu Shang performs careful mechanistic dissection of miRNA cluster assistance and reveals many insights and surprises to this enigmatic regulatory strategy that gives suboptimal miRNAs a boost. if you love Northerns, you'll ♥️ this! 🧬
genesdev.cshlp.org/content/earl...
genesdev.cshlp.org/content/earl...
Reposted by Matthias Soller
Reposted by Matthias Soller
A new study in Nature Communications has challenged 50-year-old dogma by revealing that vaccinia virus mRNAs with 5'-poly(A) leaders lack the 5' m7G caps. This unexpected finding reshapes our understanding of poxvirus RNA polymerase function and viral gene expression.
More: rdcu.be/eXksT
More: rdcu.be/eXksT
Vaccinia virus mRNAs containing long 5′-poly(A)-leaders lack a canonical 5′-methylguanosine cap
Nature Communications - The vaccinia virus produces mRNA lacking the 5′ m7G cap structure. These uncapped mRNAs have long poly(A) leaders and dominate late in infection, suggesting a novel...
rdcu.be
January 5, 2026 at 8:41 AM
A new study in Nature Communications has challenged 50-year-old dogma by revealing that vaccinia virus mRNAs with 5'-poly(A) leaders lack the 5' m7G caps. This unexpected finding reshapes our understanding of poxvirus RNA polymerase function and viral gene expression.
More: rdcu.be/eXksT
More: rdcu.be/eXksT
Reposted by Matthias Soller
Clever new method for assembling DNA oligos into larger sequences without the need for unique overlap sequences. Can't wait for those 'this sequence is too complex' rejection messages from DNA suppliers to become a thing of the past. 🧬🧪
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Construction of complex and diverse DNA sequences using DNA three-way junctions - Nature
Sidewinder enables high-fidelity DNA assembly by separating the information that guides assembly from the final assembled sequence.
www.nature.com
January 22, 2026 at 8:29 AM
Clever new method for assembling DNA oligos into larger sequences without the need for unique overlap sequences. Can't wait for those 'this sequence is too complex' rejection messages from DNA suppliers to become a thing of the past. 🧬🧪
www.nature.com/articles/s41...
www.nature.com/articles/s41...
RNA in Davos - everybody seems to know hence the low turnaround to excellent displays by Tom Cech and Victor Ambros.
Tom Cech on RNA research in Davos (video): www.weforum.org/meetings/wor...
January 21, 2026 at 9:56 PM
RNA in Davos - everybody seems to know hence the low turnaround to excellent displays by Tom Cech and Victor Ambros.
Reposted by Matthias Soller
Discuss #RNA 3' ends and their regulation at the EMBO Workshop "RNA 3' ends and beyond" in #Oxford, United Kingdom, 7–11 September 2026.
Deadline: 4 May 2026
https://meetings.embo.org/event/26-rna3
#EMBORNA3EndsBeyond #RNAsky #LifeSciences #meeting #EMBOevents 🧪
Deadline: 4 May 2026
https://meetings.embo.org/event/26-rna3
#EMBORNA3EndsBeyond #RNAsky #LifeSciences #meeting #EMBOevents 🧪
January 20, 2026 at 3:30 PM
Discuss #RNA 3' ends and their regulation at the EMBO Workshop "RNA 3' ends and beyond" in #Oxford, United Kingdom, 7–11 September 2026.
Deadline: 4 May 2026
https://meetings.embo.org/event/26-rna3
#EMBORNA3EndsBeyond #RNAsky #LifeSciences #meeting #EMBOevents 🧪
Deadline: 4 May 2026
https://meetings.embo.org/event/26-rna3
#EMBORNA3EndsBeyond #RNAsky #LifeSciences #meeting #EMBOevents 🧪
Very nice paper showing how a virus induces aggressive behaviour in the host.
www.pnas.org/doi/abs/10.1...
www.pnas.org/doi/abs/10.1...
January 21, 2026 at 12:53 PM
Very nice paper showing how a virus induces aggressive behaviour in the host.
www.pnas.org/doi/abs/10.1...
www.pnas.org/doi/abs/10.1...
Reposted by Matthias Soller
Your gut has a sex, and it matters! 🔥
In females, the ovary sends a relaxin hormone signal to enteric neurons, switching on gut enlargement and increased feeding after mating.
So excited my postdoc work is finally out as a preprint 🥳
www.biorxiv.org/content/10.6...
In females, the ovary sends a relaxin hormone signal to enteric neurons, switching on gut enlargement and increased feeding after mating.
So excited my postdoc work is finally out as a preprint 🥳
www.biorxiv.org/content/10.6...
📣First preprint of the lab📣 Did that really happen?😅
Enteric neurons, aka somatic postmitotic cells, must hold on to their sex identity tight, to deliver a tuned response to signals from the ovary that instruct the animal to engage sex-matched behavioural programmes.
www.biorxiv.org/content/10.6...
Enteric neurons, aka somatic postmitotic cells, must hold on to their sex identity tight, to deliver a tuned response to signals from the ovary that instruct the animal to engage sex-matched behavioural programmes.
www.biorxiv.org/content/10.6...
Genetic sex of enteric neurons enables ovarian relaxin to gate maternal gut plasticity
Animals must align intestinal plasticity and feeding with reproductive state, yet the checkpoint that gates these adaptations is unknown. Here we show that an ovary-to-enteric-neuron axis gates the on...
www.biorxiv.org
January 11, 2026 at 5:19 PM
Your gut has a sex, and it matters! 🔥
In females, the ovary sends a relaxin hormone signal to enteric neurons, switching on gut enlargement and increased feeding after mating.
So excited my postdoc work is finally out as a preprint 🥳
www.biorxiv.org/content/10.6...
In females, the ovary sends a relaxin hormone signal to enteric neurons, switching on gut enlargement and increased feeding after mating.
So excited my postdoc work is finally out as a preprint 🥳
www.biorxiv.org/content/10.6...
Not the times we dreamt off requiring a FARADAY BAG FOR PHONES and your car key.
We've removed the paywall from this guide so everyone can access it. 👇 Stay safe.
Just days into 2026, the killing of 37-year-old Renee Nicole Good by a federal immigration officer in Minneapolis, Minnesota, has sparked protests around the US.
If you’re planning to protest, here’s how to safeguard your digital security.
If you’re planning to protest, here’s how to safeguard your digital security.
January 9, 2026 at 8:14 AM
Not the times we dreamt off requiring a FARADAY BAG FOR PHONES and your car key.
Excited to share our first publication of the year @mcf-uom.bsky.social . Here is a very detailed protocol how to do band-shift assays thanks to @davidmcquarrie.bsky.social and for the invitation @kifla.bsky.social
bio-protocol.org/en/bpdetail?...
bio-protocol.org/en/bpdetail?...
January 8, 2026 at 10:22 AM
Excited to share our first publication of the year @mcf-uom.bsky.social . Here is a very detailed protocol how to do band-shift assays thanks to @davidmcquarrie.bsky.social and for the invitation @kifla.bsky.social
bio-protocol.org/en/bpdetail?...
bio-protocol.org/en/bpdetail?...
Reposted by Matthias Soller
New work from @miyapan.bsky.social and our team, bringing ant, bee, and wasp labs together. @chuanxinyu.bsky.social shows that the ANTSR locus we discovered in ants has determined sex for 150+ My across bees and stinging wasps 🐜🐝, despite virtually no sequence conservation 😮 doi.org/10.1073/pnas...
January 6, 2026 at 3:01 AM
New work from @miyapan.bsky.social and our team, bringing ant, bee, and wasp labs together. @chuanxinyu.bsky.social shows that the ANTSR locus we discovered in ants has determined sex for 150+ My across bees and stinging wasps 🐜🐝, despite virtually no sequence conservation 😮 doi.org/10.1073/pnas...
Life before getting stuck at the junction. Nice paper from @karlaneugebauer.bsky.social lab about roles of EJC components in splicing.
genesdev.cshlp.org/content/40/1...
genesdev.cshlp.org/content/40/1...
The exon junction complex coordinates the cotranscriptional inclusion of blocks of neighboring exons
A biweekly scientific journal publishing high-quality research in molecular biology and genetics, cancer biology, biochemistry, and related fields
genesdev.cshlp.org
January 5, 2026 at 6:10 PM
Life before getting stuck at the junction. Nice paper from @karlaneugebauer.bsky.social lab about roles of EJC components in splicing.
genesdev.cshlp.org/content/40/1...
genesdev.cshlp.org/content/40/1...
Interesting insights into m6A complex assembly
pubmed.ncbi.nlm.nih.gov/41481436/
pubmed.ncbi.nlm.nih.gov/41481436/
January 5, 2026 at 5:58 PM
Interesting insights into m6A complex assembly
pubmed.ncbi.nlm.nih.gov/41481436/
pubmed.ncbi.nlm.nih.gov/41481436/
Reposted by Matthias Soller
Not that long ago, in vivo mouse enhancer design was a dream. Today, it's a reality! Using transfer deep learning to design de novo synthetic embryonic enhancers active in the heart, limb, and CNS. Great collab with @alex-stark.bsky.social lab! @ucibiosci.bsky.social @impvienna.bsky.social
December 24, 2025 at 3:51 PM
Not that long ago, in vivo mouse enhancer design was a dream. Today, it's a reality! Using transfer deep learning to design de novo synthetic embryonic enhancers active in the heart, limb, and CNS. Great collab with @alex-stark.bsky.social lab! @ucibiosci.bsky.social @impvienna.bsky.social
Reposted by Matthias Soller
Happy to share another story by Annesha Ghosh. Here, we show that inhibition of the mRNA cap methyltransferase CMTR-1 activates a protective immune response via the GATA transcription factor ELT-2.
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
RNA methyltransferase CMTR-1 inhibition activates a GATA transcription factor-mediated protective immune response
Organisms can activate innate immunity not only by detecting pathogens but also by sensing disturbances to essential cellular processes. Such damage-based surveillance provides a means to identify cel...
www.biorxiv.org
December 13, 2025 at 4:39 AM
Happy to share another story by Annesha Ghosh. Here, we show that inhibition of the mRNA cap methyltransferase CMTR-1 activates a protective immune response via the GATA transcription factor ELT-2.
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
Glad to see @davidmcquarrie.bsky.social paper #genetics showing that core promoters of Drosophila "prostata" genes evolve fast which can leading to allelic dominance.
Latest research in #GENETICS from @davidmcquarrie.bsky.social, @matthiassoller.bsky.social, and colleagues shows that regulatory evolution, and not genome background variation, drives accessory gland protein expression changes in #Drosophila males. buff.ly/ZudjASk
December 24, 2025 at 9:13 AM
Glad to see @davidmcquarrie.bsky.social paper #genetics showing that core promoters of Drosophila "prostata" genes evolve fast which can leading to allelic dominance.
Good to be true?
this is amazing
they show some compelling evidence for 3' to 5' translation
#RNASky #RNABiology 🧪
www.biorxiv.org/content/10.6...
they show some compelling evidence for 3' to 5' translation
#RNASky #RNABiology 🧪
www.biorxiv.org/content/10.6...
3' to 5' Translation of Circular RNAs?
For decades, the 5' to 3' direction of translation has been a central dogma of molecular biology. Here we present evidence that eukaryotic circular RNAs (circRNAs) can serve as templates for 3' to 5' ...
www.biorxiv.org
December 23, 2025 at 8:29 AM
Good to be true?
Reposted by Matthias Soller
Selective vulnerability of certain cell types to loss of dosage compensation. Post-embryonically, most tissues can do without it - except for a subset of adult progenitors. Congrats Océane, Bruno and Lucie!
Have you ever wondered what difference it makes to have 1 or 2 X chromosomes in your cells?
✨ I’m excited to share that our paper is now out!
Looking for some X-mas content featuring an actual X? 🎄 Here’s the paper: 👉 www.cell.com/current-biol...
✨ I’m excited to share that our paper is now out!
Looking for some X-mas content featuring an actual X? 🎄 Here’s the paper: 👉 www.cell.com/current-biol...
X chromosome dosage in respiratory stem cells is critical for post-embryonic development and survival
Tournière et al. uncover the biological roles of sex chromosome dosage compensation,
showing it is broadly dispensable except in the respiratory system during metamorphosis,
where X chromosome dose de...
www.cell.com
December 22, 2025 at 4:25 PM
Selective vulnerability of certain cell types to loss of dosage compensation. Post-embryonically, most tissues can do without it - except for a subset of adult progenitors. Congrats Océane, Bruno and Lucie!
Reposted by Matthias Soller
A high-resolution atlas of the brain predicts lineage and birth order underlying neuronal identity: Cell Genomics www.cell.com/cell-genomic... Follow-up paper on sex, online in the New year
A high-resolution atlas of the brain predicts lineage and birth order underlying neuronal identity
Using an integrated single-cell transcriptomic atlas of the adult Drosophila central
brain, Allen et al. uncover over 4,000 transcriptionally distinct neuronal subtypes.
The authors show that adult ne...
www.cell.com
December 20, 2025 at 1:22 PM
A high-resolution atlas of the brain predicts lineage and birth order underlying neuronal identity: Cell Genomics www.cell.com/cell-genomic... Follow-up paper on sex, online in the New year