Marta Lourenço
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martalourenco21.bsky.social
Marta Lourenço
@martalourenco21.bsky.social
Microbiologist |microbial ecology | microbiome | phage-bacteria interactions
phages rule the world👀
Postdoc at Evolutionary Biology lab, Gulbenkian Institute for Molecular Medicine - Oeiras
Reposted by Marta Lourenço
🚀New preprint from our lab!
I am very excited to finally share what has been the main focus of my PhD for the past almost 3 years! It is about viral dark matter and a powerful tool we built to shed light on it. 🧬💡
Continue reading (🧵)
November 20, 2025 at 6:52 PM
Podcast com Isabel Gordo, Group Leader no Gulbenkian Institute for Molecular Medicine (@gimmfoundation.bsky.social):

"Como é que um medicamento mata bactérias?"
YouTube: youtu.be/wRyYYa2D5i0
Spotify: open.spotify.com/episode/1AqQ...
Ep 4: Como é que um medicamento mata bactérias? (com Isabel Gordo)
YouTube video by GIMM Gulbenkian Institute for Molecular Medicine
youtu.be
November 19, 2025 at 11:27 AM
Reposted by Marta Lourenço
Our new paper is out in @narjournal.bsky.social We show that natural transformation enables bacteria to shuffle integron cassettes, boosting their phenotypic diversity.
academic.oup.com/nar/article/... 1/5
Bacterial natural transformation drives cassette shuffling and simplifies recombination in chromosomal integrons
Abstract. Integrons act as biobanks of gene cassettes conferring functions crucial for bacterial defense, including protection against phages and antibioti
academic.oup.com
November 17, 2025 at 3:44 PM
Reposted by Marta Lourenço
🚨 Excited to share our new paper is out! 🎉
We show how interactions within gut microbiomes allow certain antibiotic-resistant E. coli strains to persist even without antibiotics, helping explain how resistance is maintained in the human gut.

Now published in @natcomms.nature.com rdcu.be/eOf63
Multi-layered ecological interactions determine growth of clinical antibiotic-resistant strains within human microbiomes
Nature Communications - The role of ecological factors in modulating the spread of antibiotic-resistance bacteria in the gut remains unclear. Here, the authors use anaerobic microcosms to study the...
rdcu.be
November 7, 2025 at 9:15 AM
Reposted by Marta Lourenço
🚨New preprint out!
We present a foundational genomic resource of human gut microbiome viruses. It delivers high-quality, deeply curated data spanning taxonomy, predicted hosts, structures, and functions, providing a reference for gut virome research. (1/8)
www.biorxiv.org/content/10.1...
November 6, 2025 at 5:26 PM
Reposted by Marta Lourenço
👉 Host-targeted immunity meets antibiotic synergy!

We show that OM-89 reprograms bladder epithelial cells to boost their lysosomal activity and antibiotic uptake, helping clear intracellular UPEC.

📖 Read more: www.biorxiv.org/content/10.1...

#UTI #InfectiousDisease #HostDefense #Organoids #UTIsky
doi.org
October 23, 2025 at 7:25 AM
Reposted by Marta Lourenço
📣 We are moving to Barcelona to join the amazing @crg.eu and explore how centrosomes & cilia work, evolve & respond to the environment. We are looking for
PhD students www.crg.eu/en/content/t...
Postdocs gimm.pt/jobs/postdoc...
Other calls to open, also for an experienced lab manager.
Get in touch!
October 30, 2025 at 1:15 PM
Reposted by Marta Lourenço
Do you like microbes and insects, and would like to get your favourites printed on articles or clothing? check out my art prints on Redbubble: www.redbubble.com/people/Chaii...
Happy to take requests to add to this collection too :)

#sciart #art #symbiosis #microbes #insects
Chai_ntist Shop | Redbubble
Chai_ntist is an independent artist creating amazing designs for great products such as t-shirts, stickers, posters, and phone cases.
www.redbubble.com
October 23, 2025 at 9:05 AM
Reposted by Marta Lourenço
JOB OFFER #PhageSky

We have a postdoc position opening in my group to investigate phage-MGE interactions !

We're based in the very nice city of Lyon, France @mmsb-lyon.bsky.social

Contact me for more info !

>> Apply on the CNRS webpage emploi.cnrs.fr/Offres/CDD/U...
Portail Emploi CNRS - Offre d'emploi - Postdoctoral researcher Microbiology (M/F)
emploi.cnrs.fr
October 22, 2025 at 9:35 AM
Reposted by Marta Lourenço
Excited to share our preprint led by Carlos Voogdt et al

We developed new genetic tools & genome-wide libraries for species of the Bacteroidales order; constructed saturated barcoded transposon libraries in key representatives of three genera.
www.biorxiv.org/content/10.1...
October 13, 2025 at 7:48 AM
Reposted by Marta Lourenço
New pre-print www.biorxiv.org/content/10.1...
Plasmid-dependent phage (PDPs) are ubiquitous, but the selective pressures that they impose on plasmids are not well understood. Project led by Daniel Cazares in collaboration with @brockhurstlab.bsky.social!
#phagesky#microsky
Trade-offs between phage resistance and conjugative ability shape the ecological and evolutionary response of a multidrug resistance plasmid to plasmid-dependent phage
Phage therapy is a promising alternative to antibiotics to treat multidrug resistant infections. Plasmid dependent phages (PDPs) are particularly attractive as therapeutics because they can both kill ...
www.biorxiv.org
October 9, 2025 at 10:07 AM
Reposted by Marta Lourenço
🚨 Microbiologists! We are recruiting Assistant / Associate Professors in 3 collaborative areas of our U. Pittsburgh School of Medicine.
1) MMG (my dept): fundamental research in med micro
2) Peds ID / I4Kids institute
3) Center for Vaccine Research
🔗 to all 3 w/info: www.linkedin.com/posts/vaughn...
Faculty Professor Associate - Full-Time | Vaughn Cooper
We are recruiting Faculty microbiologists in three (3) different, complementary, and collaborative areas at the University of Pittsburgh associated with the School of Medicine. 1) Fundamental researc...
www.linkedin.com
September 23, 2025 at 10:31 PM
Reposted by Marta Lourenço
Excited to annouce the latest research published by our lab, which is led by Dinesh Subedi and is out today in Nature Microbiology.

www.nature.com/articles/s41...
Rational design of a hospital-specific phage cocktail to treat Enterobacter cloacae complex infections - Nature Microbiology
The Entelli-02 phage product containing five phages has frontline potential to address infections caused by the multidrug-resistant Enterobacter cloacae complex.
www.nature.com
September 24, 2025 at 12:20 PM
Reposted by Marta Lourenço
www.biorxiv.org/content/10.1...

#phagesky #phage
Anecdotally, a few years ago a very trigger-happy temperate had infected a strain of E. coli of mine and caused significant lysis. The release of enzymes in the medium degraded a sugar into a different form which could be used by the other cells.
Phage-mediated lysis increases growth rate of surviving bacterial cells
Bacterial phage infection and subsequent lysis are traditionally considered mechanisms of bacterial mortality and viral propagation; additionally, emerging evidence indicates that they may also contri...
www.biorxiv.org
September 19, 2025 at 7:57 AM
Reposted by Marta Lourenço
Happy to share that our story on the bacterial archaellum was published today in @natmicrobiol.nature.com
www.nature.com/articles/s41...

Congrats to the authors: @sshamphavi.bsky.social @loumollat.bsky.social @mariejoest.bsky.social Najwa Taib and @sgribaldo.bsky.social
September 17, 2025 at 5:41 PM
Reposted by Marta Lourenço
In our new article, we show how P. aeruginosa, a major cause of chronic respiratory infections in #cysticfibrosis (CF), uses the Type VI Secretion System #T6SS and specific #toxins to eliminate competing bacteria
www.cell.com/cell-reports...
#cryoEM @dshatskiy.bsky.social @jakecolautti.bsky.social
September 14, 2025 at 8:52 AM
Reposted by Marta Lourenço
Thrilled to share our two latest papers with the @tcostalab.bsky.social
lab! In the first, we uncover a new mechanism of satellite transfer: cf-PICIs hijack tails from diverse phages to spread across species.
@imperialcollegeldn.bsky.social
www.cell.com/cell/fulltex...
Chimeric infective particles expand species boundaries in phage-inducible chromosomal island mobilization
Capsid-forming PICIs (cf-PICIs) produce their own capsids and exploit phage tails from unrelated species to transfer their DNA across bacterial hosts. This tail piracy enables broad dissemination and ...
www.cell.com
September 9, 2025 at 5:05 PM
Reposted by Marta Lourenço
How complex functions, with important physiological and evolutionary impacts get repeatedly and efficiently transferred across genomes?
That’s what we explored using one of the fastest-evolving loci in Bacteria: the capsule locus.
The paper: www.biorxiv.org/content/10.1...
Thread👇
Serotype swapping in Klebsiella spp. by plug-and-play
Understanding how complex, multi-gene systems evolve and function across genetic backgrounds is a central question in molecular evolution. While such systems often impose costs through epistatic inter...
www.biorxiv.org
September 10, 2025 at 8:17 AM
Reposted by Marta Lourenço
Delighted to share our recently published work!
Ever wondered how Klebsiella (and others) deals with capsule production’s costs ?
The paper: journals.asm.org/doi/10.1128/...
Thread👇
Phenotypic heterogeneity of capsule production across opportunistic pathogens | mBio
The polysaccharidic capsule is present in ~50% of species across the bacterial phylogeny, including all ESKAPE microorganisms, the six most significant multidrug-resistant (MDR) nosocomial pathogens. It is also an important virulence factor and a major ...
journals.asm.org
September 5, 2025 at 1:49 PM
Reposted by Marta Lourenço
Happy to see our paper out!

Functional assessment of anti-phage defence systems in their native clinical E. coli host
royalsocietypublishing.org/doi/10.1098/...

Thread in previous post 👇
September 5, 2025 at 10:44 AM
Reposted by Marta Lourenço
Assistant Professor position in the Microbiome Engineering group (Prof Sahar El Aidy) at University of Amsterdam

Assistant Professor in Microbiome Imaging and Functional Analysis
werkenbij.uva.nl/en/vacancies...
Vacancy — Assistant Professor in Microbiome Imaging and Functional Analysis
Are you pioneering molecular tools and applying advanced imaging strategies to uncover how microbial communities are organized and interact in space and time? If so, we invite you to join The Swammerd...
werkenbij.uva.nl
September 5, 2025 at 9:18 AM
Reposted by Marta Lourenço
How do bacteria choose what type of defences to use against phages? We explored that question in the last paper I worked on as a postdoc at the Uni of Exeter @uniofexeteresi.bsky.social with Stineke van Houte, Stefano Pagliara and Edze Westra (not on Bluesky)
doi.org/10.1098/rstb...
Phage provoke growth delays and SOS response induction despite CRISPR-Cas protection | Philosophical Transactions of the Royal Society B: Biological Sciences
Bacteria evolve resistance against their phage foes with a wide range of resistance strategies whose costs and benefits depend on the level of protection they confer and on the costs for maintainance....
doi.org
September 4, 2025 at 4:02 PM
Reposted by Marta Lourenço
Can CRISPR-Cas systems target any phage? Yes, no, it depends? What does it depend on? The second paper from my PhD came out today in a special issue of Phil Trans B on the ecology and evolution of bacterial immune systems
doi.org/10.1098/rstb...
Phage susceptibility to a minimal, modular synthetic CRISPR-Cas system in Pseudomonas aeruginosa is nutrient dependent | Philosophical Transactions of the Royal Society B: Biological Sciences
CRISPR-Cas systems can provide adaptive, heritable immunity to their prokaryotic hosts against invading genetic material such as phages. It is clear that the importance of acquiring CRISPR-Cas immunit...
doi.org
September 4, 2025 at 11:32 AM
Reposted by Marta Lourenço
🚨 New preprint! 🧬

𝐏𝐡𝐚𝐠𝐞-𝐩𝐥𝐚𝐬𝐦𝐢𝐝𝐬 (𝐏-𝐏𝐬) are fascinating elements: both 𝐭𝐞𝐦𝐩𝐞𝐫𝐚𝐭𝐞 𝐩𝐡𝐚𝐠𝐞𝐬 and 𝐩𝐥𝐚𝐬𝐦𝐢𝐝𝐬 ➡️ tricky to detect.

We present 𝐭𝐲𝐏𝐏𝐢𝐧𝐠 — the first 𝐢𝐝𝐞𝐧𝐭𝐢𝐟𝐢𝐜𝐚𝐭𝐢𝐨𝐧 𝐚𝐧𝐝 𝐜𝐥𝐚𝐬𝐬𝐢𝐟𝐢𝐜𝐚𝐭𝐢𝐨𝐧 𝐭𝐨𝐨𝐥 🛠️designed specifically for P-Ps:
✅ Accurate
✅ Sensitive
✅ Easy to use

📖 www.biorxiv.org/content/10.1...
Efficient detection and typing of phage-plasmids
Phage-plasmids are temperate phages that replicate as plasmids during lysogeny. Despite their high diversity, they carry genes similar to phages and plasmids. This leads to gene exchanges, and to the ...
www.biorxiv.org
September 3, 2025 at 1:03 PM