Nikos Margaritelis
@margaritelis.bsky.social
Associate Professor at Aristotle University of Thessaloniki, Greece
Pinned
Personalized redox biology: Designs and concepts
#redox #biology #antioxidants #ROS #free_radicals #personalized
pubmed.ncbi.nlm.nih.gov/37541453/
#redox #biology #antioxidants #ROS #free_radicals #personalized
pubmed.ncbi.nlm.nih.gov/37541453/
Our new paper with @mg-nikolaidis.bsky.social out in
@cp-trendsmolecmed.bsky.social
“Science captured by storytelling: the oxidative stress narrative”
DOI: authors.elsevier.com/a/1lt2w5Eb1B...
@cp-trendsmolecmed.bsky.social
“Science captured by storytelling: the oxidative stress narrative”
DOI: authors.elsevier.com/a/1lt2w5Eb1B...
October 3, 2025 at 4:03 PM
Our new paper with @mg-nikolaidis.bsky.social out in
@cp-trendsmolecmed.bsky.social
“Science captured by storytelling: the oxidative stress narrative”
DOI: authors.elsevier.com/a/1lt2w5Eb1B...
@cp-trendsmolecmed.bsky.social
“Science captured by storytelling: the oxidative stress narrative”
DOI: authors.elsevier.com/a/1lt2w5Eb1B...
Reposted by Nikos Margaritelis
🚨LEAD FEATURE ARTICLE🚨 November 2025✨
We are very excited to announce our lead feature article for the November 2025 by Lolli et al titled ‘Understanding Treatment Response Heterogeneity Using Crossover Randomized Controlled Trials: A Primer for Exercise and Nutrition Scientists’.
We are very excited to announce our lead feature article for the November 2025 by Lolli et al titled ‘Understanding Treatment Response Heterogeneity Using Crossover Randomized Controlled Trials: A Primer for Exercise and Nutrition Scientists’.
September 23, 2025 at 7:11 AM
🚨LEAD FEATURE ARTICLE🚨 November 2025✨
We are very excited to announce our lead feature article for the November 2025 by Lolli et al titled ‘Understanding Treatment Response Heterogeneity Using Crossover Randomized Controlled Trials: A Primer for Exercise and Nutrition Scientists’.
We are very excited to announce our lead feature article for the November 2025 by Lolli et al titled ‘Understanding Treatment Response Heterogeneity Using Crossover Randomized Controlled Trials: A Primer for Exercise and Nutrition Scientists’.
Reposted by Nikos Margaritelis
Reposted by Nikos Margaritelis
It was a rewarding labour of love to work on this paper with a fantastic team of authors, “Understanding Treatment Response Heterogeneity Using Crossover Randomized Controlled Trials: A Primer for Exercise and Nutrition Scientists”. @hk-ijsnem.bsky.social journals.humankinetics.com/view/journal...
journals.humankinetics.com
August 28, 2025 at 5:50 PM
It was a rewarding labour of love to work on this paper with a fantastic team of authors, “Understanding Treatment Response Heterogeneity Using Crossover Randomized Controlled Trials: A Primer for Exercise and Nutrition Scientists”. @hk-ijsnem.bsky.social journals.humankinetics.com/view/journal...
Reposted by Nikos Margaritelis
Your intuitions about individual responses to training are probably wrong 😉
👇🧵 1/11
👇🧵 1/11
August 11, 2025 at 10:16 AM
Your intuitions about individual responses to training are probably wrong 😉
👇🧵 1/11
👇🧵 1/11
Reposted by Nikos Margaritelis
This is a very interesting study comparing physiological variables between two phases of the menstrual cycle across two whole cycles. The design resembles a replicate crossover trial which enables proper study of individual responses. physoc.onlinelibrary.wiley.com/doi/10.1113/...
physoc.onlinelibrary.wiley.com
August 1, 2025 at 3:01 PM
This is a very interesting study comparing physiological variables between two phases of the menstrual cycle across two whole cycles. The design resembles a replicate crossover trial which enables proper study of individual responses. physoc.onlinelibrary.wiley.com/doi/10.1113/...
Reposted by Nikos Margaritelis
2nd Redox Medicine Workshop ... Meet the Speakers: More info: redoxmedicine2025.febsevents.org
Important dates: July 1 - SFRR-E and FEBS Fellowships Applications; July 20 - Abstract Submission (General Track)
@sfrre-ecr.bsky.social @ucoimbra.bsky.social @febsjuniorsection.bsky.social
Important dates: July 1 - SFRR-E and FEBS Fellowships Applications; July 20 - Abstract Submission (General Track)
@sfrre-ecr.bsky.social @ucoimbra.bsky.social @febsjuniorsection.bsky.social
June 26, 2025 at 6:27 PM
2nd Redox Medicine Workshop ... Meet the Speakers: More info: redoxmedicine2025.febsevents.org
Important dates: July 1 - SFRR-E and FEBS Fellowships Applications; July 20 - Abstract Submission (General Track)
@sfrre-ecr.bsky.social @ucoimbra.bsky.social @febsjuniorsection.bsky.social
Important dates: July 1 - SFRR-E and FEBS Fellowships Applications; July 20 - Abstract Submission (General Track)
@sfrre-ecr.bsky.social @ucoimbra.bsky.social @febsjuniorsection.bsky.social
I'm grateful to the SFRR-E for the ECR Fellowship (@sfrre-ecr.bsky.social) which made the RedoxOne project a reality. Otherwise, it would still be an idea saved in the “future studies” word file!
#redox #antioxidants #exercise #nutrition #Nof1 #interindividual_variability #galway
#redox #antioxidants #exercise #nutrition #Nof1 #interindividual_variability #galway
June 9, 2025 at 7:12 PM
I'm grateful to the SFRR-E for the ECR Fellowship (@sfrre-ecr.bsky.social) which made the RedoxOne project a reality. Otherwise, it would still be an idea saved in the “future studies” word file!
#redox #antioxidants #exercise #nutrition #Nof1 #interindividual_variability #galway
#redox #antioxidants #exercise #nutrition #Nof1 #interindividual_variability #galway
Reposted by Nikos Margaritelis
Vitamin C+E supplementation blunts molecular adaptations to sprint interval training but not performance gains.
Since performance wasn’t impaired, I wonder whether, and to what extent, the blunted molecular responses can truly be considered detrimental
physoc.onlinelibrary.wiley.com/doi/10.1113/...
Since performance wasn’t impaired, I wonder whether, and to what extent, the blunted molecular responses can truly be considered detrimental
physoc.onlinelibrary.wiley.com/doi/10.1113/...
Antioxidant supplementation blunts the proteome response to 3 weeks of sprint interval training preferentially in human type 2 muscle fibres
Abstract figure legend Sprint interval training (SIT) is a popular time-efficient type of endurance training. Healthy young men performed nine SIT sessions (4–6 × 30 s all-out cycling sprints) over 3...
physoc.onlinelibrary.wiley.com
May 29, 2025 at 1:57 PM
Vitamin C+E supplementation blunts molecular adaptations to sprint interval training but not performance gains.
Since performance wasn’t impaired, I wonder whether, and to what extent, the blunted molecular responses can truly be considered detrimental
physoc.onlinelibrary.wiley.com/doi/10.1113/...
Since performance wasn’t impaired, I wonder whether, and to what extent, the blunted molecular responses can truly be considered detrimental
physoc.onlinelibrary.wiley.com/doi/10.1113/...
Reposted by Nikos Margaritelis
After very valuable comments from referees, here's the revised preprint for our paper "Understanding treatment response heterogeneity using randomised crossover trials: A primer for exercise and nutrition scientists" (@lorenzololli.bsky.social @j-t-gonzalez.bsky.social et al) osf.io/preprints/os...
OSF
osf.io
May 27, 2025 at 7:04 PM
After very valuable comments from referees, here's the revised preprint for our paper "Understanding treatment response heterogeneity using randomised crossover trials: A primer for exercise and nutrition scientists" (@lorenzololli.bsky.social @j-t-gonzalez.bsky.social et al) osf.io/preprints/os...
Reposted by Nikos Margaritelis
Join us for a special ECR SFRR Webinar focused on Mental Health in Research by Amal Ibrahim.
Date: Tuesday 6th May 2025
Time: 15:00 CET
Where: Online (link in bio)
#MentalHealthInScience #ECRSFRR #WellbeingInResearch #FreeRadicalResearch #AcademicLife #PhDlife #PostdocLife #ScienceCommunity
Date: Tuesday 6th May 2025
Time: 15:00 CET
Where: Online (link in bio)
#MentalHealthInScience #ECRSFRR #WellbeingInResearch #FreeRadicalResearch #AcademicLife #PhDlife #PostdocLife #ScienceCommunity
May 5, 2025 at 2:10 PM
Join us for a special ECR SFRR Webinar focused on Mental Health in Research by Amal Ibrahim.
Date: Tuesday 6th May 2025
Time: 15:00 CET
Where: Online (link in bio)
#MentalHealthInScience #ECRSFRR #WellbeingInResearch #FreeRadicalResearch #AcademicLife #PhDlife #PostdocLife #ScienceCommunity
Date: Tuesday 6th May 2025
Time: 15:00 CET
Where: Online (link in bio)
#MentalHealthInScience #ECRSFRR #WellbeingInResearch #FreeRadicalResearch #AcademicLife #PhDlife #PostdocLife #ScienceCommunity
Reposted by Nikos Margaritelis
Hats off to them for publishing that paper without mentioning n-of-1 trials or person-by-treatment interactions 😬. We've this paper currently under review. It's frustratingly long-winded, but that's the complex nature of the precision nutrition beast I suppose, osf.io/preprints/os...
OSF
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osf.io
April 30, 2025 at 2:25 PM
Hats off to them for publishing that paper without mentioning n-of-1 trials or person-by-treatment interactions 😬. We've this paper currently under review. It's frustratingly long-winded, but that's the complex nature of the precision nutrition beast I suppose, osf.io/preprints/os...
Reposted by Nikos Margaritelis
James Imlay turns redox chaos into clockwork: his new paper shows how membrane permeability sets the tempo of oxidative stress, with straight-up back-of-the-envelope math in the appendix. Fundamental, elegant, causal.
onlinelibrary.wiley.com/doi/10.1111/...
onlinelibrary.wiley.com/doi/10.1111/...
The Barrier Properties of Biological Membranes Dictate How Cells Experience Oxidative Stress
Molecular oxygen diffuses across membranes with such speed that, despite respiration, the intracellular oxygen concentration does not differ significantly from that outside the cell. In contrast, mem...
onlinelibrary.wiley.com
April 23, 2025 at 4:15 PM
James Imlay turns redox chaos into clockwork: his new paper shows how membrane permeability sets the tempo of oxidative stress, with straight-up back-of-the-envelope math in the appendix. Fundamental, elegant, causal.
onlinelibrary.wiley.com/doi/10.1111/...
onlinelibrary.wiley.com/doi/10.1111/...
Reposted by Nikos Margaritelis
📢 Exciting Webinar Alert!
Join us tomorrow, April 1st, at 15:00 CET for an unmissable webinar on chaperones in redox biology, hosted by @sfrre-ecr.bsky.social! We’re thrilled to welcome two fantastic speakers: @ulrichlab.bsky.social and @rsutandy.bsky.social.
See you there!
Join us tomorrow, April 1st, at 15:00 CET for an unmissable webinar on chaperones in redox biology, hosted by @sfrre-ecr.bsky.social! We’re thrilled to welcome two fantastic speakers: @ulrichlab.bsky.social and @rsutandy.bsky.social.
See you there!
March 31, 2025 at 11:27 AM
📢 Exciting Webinar Alert!
Join us tomorrow, April 1st, at 15:00 CET for an unmissable webinar on chaperones in redox biology, hosted by @sfrre-ecr.bsky.social! We’re thrilled to welcome two fantastic speakers: @ulrichlab.bsky.social and @rsutandy.bsky.social.
See you there!
Join us tomorrow, April 1st, at 15:00 CET for an unmissable webinar on chaperones in redox biology, hosted by @sfrre-ecr.bsky.social! We’re thrilled to welcome two fantastic speakers: @ulrichlab.bsky.social and @rsutandy.bsky.social.
See you there!
Reposted by Nikos Margaritelis
Good to see this paper finally published in EJON, after a strange prior experience with another journal, "Inter-individual differences in the blood pressure lowering effects of dietary nitrate: a randomised double-blind placebo-controlled replicate crossover trial" link.springer.com/article/10.1...
Inter-individual differences in the blood pressure lowering effects of dietary nitrate: a randomised double-blind placebo-controlled replicate crossover trial - European Journal of Nutrition
Purpose Dietary nitrate supplementation increases nitric oxide (NO) bioavailability and reduces blood pressure (BP). Inter-individual differences in these responses are suspected but have not been inv...
link.springer.com
February 25, 2025 at 7:11 AM
Good to see this paper finally published in EJON, after a strange prior experience with another journal, "Inter-individual differences in the blood pressure lowering effects of dietary nitrate: a randomised double-blind placebo-controlled replicate crossover trial" link.springer.com/article/10.1...
Reposted by Nikos Margaritelis
Study shows that chronic antioxidant supplementation (VitC+VitE) blunted molecular adaptations to training, yet, no impact on any measure of exercise performance—considering that "antioxidant" is a vague term and that VitC+VitE may not always act as such.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
www.biorxiv.org
February 12, 2025 at 5:23 PM
Study shows that chronic antioxidant supplementation (VitC+VitE) blunted molecular adaptations to training, yet, no impact on any measure of exercise performance—considering that "antioxidant" is a vague term and that VitC+VitE may not always act as such.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Nikos Margaritelis
Great redox researcher to follow and excellent review in the redox biosensors field!
First Bluesky post! 👋 I work designing fluorescent indicators for redox biology. Last year, I published a review on genetically-encoded redox biosensors—DM me if you’d like a copy! Happy to connect with fluorescence enthusiasts and redox biologists. #FluorescenceFriday
doi.org/10.1016/j.ab...
doi.org/10.1016/j.ab...
January 31, 2025 at 3:08 PM
Great redox researcher to follow and excellent review in the redox biosensors field!
Reposted by Nikos Margaritelis
Important study highlighting plausible molecular links between redox metabolism and exercise performance—an area notoriously difficult to dissect. The findings challenge assumptions that G6PD deficiency decreases exercise performance. A human replication study would be invaluable.
G6PD deficiency affects 6% of humankind, predisposing RBCs to hemolysis after oxidant stress. Unexpectedly, humanized G6PD deficient mice do not hemolyze after oxidant stress post exercise, and tolerate exercise better! On the cover of @bloodadvances.bsky.social
ashpublications.org/bloodadvance...
ashpublications.org/bloodadvance...
Increased exercise tolerance in humanized G6PD-deficient mice
Key PointsG6PD-deficient mice maintain higher exercise speeds without increased red blood cell hemolysis, questioning assumed risks.Increased cardiac outpu
ashpublications.org
January 31, 2025 at 5:07 PM
Important study highlighting plausible molecular links between redox metabolism and exercise performance—an area notoriously difficult to dissect. The findings challenge assumptions that G6PD deficiency decreases exercise performance. A human replication study would be invaluable.
Reposted by Nikos Margaritelis
G6PD deficiency affects 6% of humankind, predisposing RBCs to hemolysis after oxidant stress. Unexpectedly, humanized G6PD deficient mice do not hemolyze after oxidant stress post exercise, and tolerate exercise better! On the cover of @bloodadvances.bsky.social
ashpublications.org/bloodadvance...
ashpublications.org/bloodadvance...
Increased exercise tolerance in humanized G6PD-deficient mice
Key PointsG6PD-deficient mice maintain higher exercise speeds without increased red blood cell hemolysis, questioning assumed risks.Increased cardiac outpu
ashpublications.org
January 30, 2025 at 2:45 PM
G6PD deficiency affects 6% of humankind, predisposing RBCs to hemolysis after oxidant stress. Unexpectedly, humanized G6PD deficient mice do not hemolyze after oxidant stress post exercise, and tolerate exercise better! On the cover of @bloodadvances.bsky.social
ashpublications.org/bloodadvance...
ashpublications.org/bloodadvance...
Our contribution to the Special Issue "Unlocking Athletic Potential: Exploring Exercise Physiology from Mechanisms to Performance" in FRBM, Guest-edited by Prof. Gomez-Cabrera & @c-handschin.bsky.social
#redox #supplements #sports #evidence
#redox #supplements #sports #evidence
“Evidence-based sports supplements: A redox analysis” by @margaritelis.bsky.social, @parikki.bsky.social, @mg-nikolaidis.bsky.social and colleagues.
www.sciencedirect.com/science/arti...
10/17
www.sciencedirect.com/science/arti...
10/17
Evidence-based sports supplements: A redox analysis
Despite the overwhelming number of sports supplements on the market, only seven are currently recognized as effective. Biological functions are largel…
www.sciencedirect.com
January 30, 2025 at 9:10 AM
Our contribution to the Special Issue "Unlocking Athletic Potential: Exploring Exercise Physiology from Mechanisms to Performance" in FRBM, Guest-edited by Prof. Gomez-Cabrera & @c-handschin.bsky.social
#redox #supplements #sports #evidence
#redox #supplements #sports #evidence
Reposted by Nikos Margaritelis
“Evidence-based sports supplements: A redox analysis” by @margaritelis.bsky.social, @parikki.bsky.social, @mg-nikolaidis.bsky.social and colleagues.
www.sciencedirect.com/science/arti...
10/17
www.sciencedirect.com/science/arti...
10/17
Evidence-based sports supplements: A redox analysis
Despite the overwhelming number of sports supplements on the market, only seven are currently recognized as effective. Biological functions are largel…
www.sciencedirect.com
January 30, 2025 at 7:33 AM
“Evidence-based sports supplements: A redox analysis” by @margaritelis.bsky.social, @parikki.bsky.social, @mg-nikolaidis.bsky.social and colleagues.
www.sciencedirect.com/science/arti...
10/17
www.sciencedirect.com/science/arti...
10/17
Reposted by Nikos Margaritelis
“Unlocking Athletic Potential: Exploring Exercise Physiology from Mechanisms to Performance” in FRBM is complete! Reviews on exercise physiology, muscle plasticity, molecular mechanisms and more! All #openaccess!
#myoblue #muscle #exercise
www.sciencedirect.com/special-issu...
A long🧵: 1/17
#myoblue #muscle #exercise
www.sciencedirect.com/special-issu...
A long🧵: 1/17
Free Radical Biology and Medicine | Unlocking Athletic Potential: Exploring Exercise Physiology from Mechanisms to Performance | ScienceDirect.com by ElsevierScienceDirect
Exercise training involves repeated exposure to increases in metabolic, thermal, mechanical, and oxidative stress. This exposure stimulates physiological adaptations that improve tolerance to similar ...
www.sciencedirect.com
January 30, 2025 at 7:33 AM
“Unlocking Athletic Potential: Exploring Exercise Physiology from Mechanisms to Performance” in FRBM is complete! Reviews on exercise physiology, muscle plasticity, molecular mechanisms and more! All #openaccess!
#myoblue #muscle #exercise
www.sciencedirect.com/special-issu...
A long🧵: 1/17
#myoblue #muscle #exercise
www.sciencedirect.com/special-issu...
A long🧵: 1/17
Reposted by Nikos Margaritelis
The editorial mentoring programme of the @sfrre-ecr.bsky.social is now running! Seeing initiatives we envisioned coming to fruition is always quite emotional! Wishing the best of success to the mentees for their journey ahead! Many thanks to senior editors of Redox Biology, FRBM and RBC, &elsevier!
January 24, 2025 at 7:37 PM
The editorial mentoring programme of the @sfrre-ecr.bsky.social is now running! Seeing initiatives we envisioned coming to fruition is always quite emotional! Wishing the best of success to the mentees for their journey ahead! Many thanks to senior editors of Redox Biology, FRBM and RBC, &elsevier!
Reposted by Nikos Margaritelis
New preprint: “Three-Sided Testing to Establish Practical Significance: A Tutorial” (osf.io/preprints/ps...) with @FitzgeraldJack_, proposing an upgraded version of the TOST equivalence test 🧵
OSF
osf.io
December 20, 2024 at 9:21 AM
New preprint: “Three-Sided Testing to Establish Practical Significance: A Tutorial” (osf.io/preprints/ps...) with @FitzgeraldJack_, proposing an upgraded version of the TOST equivalence test 🧵