Brandán Pedre
@brandanium.bsky.social
I make fluorescent indicators that monitor metabolites and signaling molecules in the cell.
Now @KULeuven, previously in @DKFZ and @VIBLifeSciences.
Now @KULeuven, previously in @DKFZ and @VIBLifeSciences.
Reposted by Brandán Pedre
Excited to share our #BioSenSRRF preprint on bioRxiv! 🎉
We show how SRRF microscopy can be used with FRET-based biosensors to 🔬mitochondrial functions with high resolution 😍.
Code and test data are open (GitHub + Zenodo).
👏 to Nicolas, Pierre-Jean, and co-authors! www.biorxiv.org/content/10.1...
We show how SRRF microscopy can be used with FRET-based biosensors to 🔬mitochondrial functions with high resolution 😍.
Code and test data are open (GitHub + Zenodo).
👏 to Nicolas, Pierre-Jean, and co-authors! www.biorxiv.org/content/10.1...
Combining FRET and super-resolution microscopy reveals kinase activation and mitochondrial activity at the nanoscale
Protein kinases are key regulators of intracellular signaling, showing activities in specific subcellular compartments and in micro- or nano-domains. Genetically encoded biosensors based on Förster′s ...
www.biorxiv.org
October 13, 2025 at 11:37 AM
Excited to share our #BioSenSRRF preprint on bioRxiv! 🎉
We show how SRRF microscopy can be used with FRET-based biosensors to 🔬mitochondrial functions with high resolution 😍.
Code and test data are open (GitHub + Zenodo).
👏 to Nicolas, Pierre-Jean, and co-authors! www.biorxiv.org/content/10.1...
We show how SRRF microscopy can be used with FRET-based biosensors to 🔬mitochondrial functions with high resolution 😍.
Code and test data are open (GitHub + Zenodo).
👏 to Nicolas, Pierre-Jean, and co-authors! www.biorxiv.org/content/10.1...
Just wrapped up a fantastic week at the EMBO Workshop on Thiol-Based Redox Switches. Great science, great discussions, and a truly inspiring community. Huge thanks to the organizers @danareichmann.bsky.social and Tobias Dansen for their hard work in putting together such a memorable meeting!
September 22, 2025 at 7:10 PM
Just wrapped up a fantastic week at the EMBO Workshop on Thiol-Based Redox Switches. Great science, great discussions, and a truly inspiring community. Huge thanks to the organizers @danareichmann.bsky.social and Tobias Dansen for their hard work in putting together such a memorable meeting!
Reposted by Brandán Pedre
The @EMBO workshop #EMBOthiolSwitches is coming up soon, join us in beautiful Sant Feliu de Guíxols, Spain, 13–18 September 2025!
We have a fantastic speaker lineup, with a few spots still open for short talks. Abstract deadline extended to 31 May 2025.
meetings.embo.org/event/25-thi...
We have a fantastic speaker lineup, with a few spots still open for short talks. Abstract deadline extended to 31 May 2025.
meetings.embo.org/event/25-thi...
Thiol-based redox switches: From chemistry to physiology and pathology
Redox reactions have been essential for the emergence of life on Earth, and diverse strategies have evolved for responding to various cellular redox species. These mechanisms are still of vital impor…
meetings.embo.org
May 19, 2025 at 6:45 AM
The @EMBO workshop #EMBOthiolSwitches is coming up soon, join us in beautiful Sant Feliu de Guíxols, Spain, 13–18 September 2025!
We have a fantastic speaker lineup, with a few spots still open for short talks. Abstract deadline extended to 31 May 2025.
meetings.embo.org/event/25-thi...
We have a fantastic speaker lineup, with a few spots still open for short talks. Abstract deadline extended to 31 May 2025.
meetings.embo.org/event/25-thi...
Reposted by Brandán Pedre
James Imlay turns redox chaos into clockwork: his new paper shows how membrane permeability sets the tempo of oxidative stress, with straight-up back-of-the-envelope math in the appendix. Fundamental, elegant, causal.
onlinelibrary.wiley.com/doi/10.1111/...
onlinelibrary.wiley.com/doi/10.1111/...
The Barrier Properties of Biological Membranes Dictate How Cells Experience Oxidative Stress
Molecular oxygen diffuses across membranes with such speed that, despite respiration, the intracellular oxygen concentration does not differ significantly from that outside the cell. In contrast, mem...
onlinelibrary.wiley.com
April 23, 2025 at 4:15 PM
James Imlay turns redox chaos into clockwork: his new paper shows how membrane permeability sets the tempo of oxidative stress, with straight-up back-of-the-envelope math in the appendix. Fundamental, elegant, causal.
onlinelibrary.wiley.com/doi/10.1111/...
onlinelibrary.wiley.com/doi/10.1111/...
Reposted by Brandán Pedre
🧵 1/6
Just dropped in @naturecomms.bsky.social
We’ve engineered the most photostable yellow fluorescent proteins (YFPs) to date—mGold2s and mGold2t—with up to 25× greater photostability than mVenus and mCitrine, without compromising brightness.
👇
🔗 www.nature.com/articles/s41...
Just dropped in @naturecomms.bsky.social
We’ve engineered the most photostable yellow fluorescent proteins (YFPs) to date—mGold2s and mGold2t—with up to 25× greater photostability than mVenus and mCitrine, without compromising brightness.
👇
🔗 www.nature.com/articles/s41...
April 9, 2025 at 8:59 PM
🧵 1/6
Just dropped in @naturecomms.bsky.social
We’ve engineered the most photostable yellow fluorescent proteins (YFPs) to date—mGold2s and mGold2t—with up to 25× greater photostability than mVenus and mCitrine, without compromising brightness.
👇
🔗 www.nature.com/articles/s41...
Just dropped in @naturecomms.bsky.social
We’ve engineered the most photostable yellow fluorescent proteins (YFPs) to date—mGold2s and mGold2t—with up to 25× greater photostability than mVenus and mCitrine, without compromising brightness.
👇
🔗 www.nature.com/articles/s41...
Reposted by Brandán Pedre
A palette of bright and photostable monomeric fluorescent proteins for bacterial time-lapse imaging | Science Advances www.science.org/doi/10.1126/...
A palette of bright and photostable monomeric fluorescent proteins for bacterial time-lapse imaging
Bright and photostable monomeric fluorescent proteins enable long-term time-lapse imaging in E. coli.
www.science.org
April 18, 2025 at 1:01 PM
A palette of bright and photostable monomeric fluorescent proteins for bacterial time-lapse imaging | Science Advances www.science.org/doi/10.1126/...
Reposted by Brandán Pedre
The most-cited papers of the twenty-first century
...and the reflection of the capricious citation culture:
🤖
www.nature.com/articles/d41...
...and the reflection of the capricious citation culture:
🤖
www.nature.com/articles/d41...
Exclusive: the most-cited papers of the twenty-first century
A Nature analysis reveals the 25 highest-cited papers published this century and explores why they are breaking records.
www.nature.com
April 18, 2025 at 9:05 AM
The most-cited papers of the twenty-first century
...and the reflection of the capricious citation culture:
🤖
www.nature.com/articles/d41...
...and the reflection of the capricious citation culture:
🤖
www.nature.com/articles/d41...
Reposted by Brandán Pedre
A long but fruitful journey: from a roGFP2-based drug screen to reaching protein targets of the proton pump inhibitor rabeprazole. Congratulations to all the authors! @aubrykmiller.bsky.social
Site-specific activation of the proton pump inhibitor rabeprazole by tetrathiolate zinc centres, from Tobias P. Dick, Aubry K. Miller, and their team:
www.nature.com/articles/s41...
#chemsky
www.nature.com/articles/s41...
#chemsky
Site-specific activation of the proton pump inhibitor rabeprazole by tetrathiolate zinc centres - Nature Chemistry
Proton pump inhibitors (PPIs) are prodrugs that are activated by protonation in the highly acidic environment of the stomach lining. Now, coordination of PPIs to protein-bound zinc ions is revealed as...
www.nature.com
February 25, 2025 at 9:50 AM
A long but fruitful journey: from a roGFP2-based drug screen to reaching protein targets of the proton pump inhibitor rabeprazole. Congratulations to all the authors! @aubrykmiller.bsky.social
Reposted by Brandán Pedre
We are very excited to see the first orange flame lit up for our plasmid pHybrid-Electra2 on Addgene, which is designed for gene expression in E. coli and mammalian cells www.nature.com/articles/s41...
Dual-expression system for blue fluorescent protein optimization - Scientific Reports
Scientific Reports - Dual-expression system for blue fluorescent protein optimization
www.nature.com
February 18, 2025 at 5:11 AM
We are very excited to see the first orange flame lit up for our plasmid pHybrid-Electra2 on Addgene, which is designed for gene expression in E. coli and mammalian cells www.nature.com/articles/s41...
First Bluesky post! 👋 I work designing fluorescent indicators for redox biology. Last year, I published a review on genetically-encoded redox biosensors—DM me if you’d like a copy! Happy to connect with fluorescence enthusiasts and redox biologists. #FluorescenceFriday
doi.org/10.1016/j.ab...
doi.org/10.1016/j.ab...
January 31, 2025 at 8:51 AM
First Bluesky post! 👋 I work designing fluorescent indicators for redox biology. Last year, I published a review on genetically-encoded redox biosensors—DM me if you’d like a copy! Happy to connect with fluorescence enthusiasts and redox biologists. #FluorescenceFriday
doi.org/10.1016/j.ab...
doi.org/10.1016/j.ab...
Reposted by Brandán Pedre
Do you want to work as a #postdoc in our group in a Hospital Research Institute in Madrid?🏥🔬
Interested in how #mitochondria and #redox signalling/stress can influence #stroke outcome and #inflammation?🧠💊
Apply up to 26 December at n9.cl/iunkw (ref 72/2024)
Full call n9.cl/gijjd
Please repost 😉
Interested in how #mitochondria and #redox signalling/stress can influence #stroke outcome and #inflammation?🧠💊
Apply up to 26 December at n9.cl/iunkw (ref 72/2024)
Full call n9.cl/gijjd
Please repost 😉
December 16, 2024 at 10:23 AM
Do you want to work as a #postdoc in our group in a Hospital Research Institute in Madrid?🏥🔬
Interested in how #mitochondria and #redox signalling/stress can influence #stroke outcome and #inflammation?🧠💊
Apply up to 26 December at n9.cl/iunkw (ref 72/2024)
Full call n9.cl/gijjd
Please repost 😉
Interested in how #mitochondria and #redox signalling/stress can influence #stroke outcome and #inflammation?🧠💊
Apply up to 26 December at n9.cl/iunkw (ref 72/2024)
Full call n9.cl/gijjd
Please repost 😉