Paraskevi Kritsiligkou
@parikki.bsky.social
Tenure Track Fellow at the University of Liverpool. In my lab we study #redox heterogeneity in intracellular nanodomains, gene expression regulation and metabolism in yeast and cancer models. https://www.kritsiligkou.com
Reposted by Paraskevi Kritsiligkou
📢 Fully funded PhD opportunity in my group!
Project title: Unravelling the origins, mechanisms and implications of species differences in cellular stress response pathway capacities.
Application deadline: 7 December 2025.
Details/apply: tinyurl.com/2jcp9jfz
Questions: Get in touch!
Project title: Unravelling the origins, mechanisms and implications of species differences in cellular stress response pathway capacities.
Application deadline: 7 December 2025.
Details/apply: tinyurl.com/2jcp9jfz
Questions: Get in touch!
(BBSRC NWD CASE) Unravelling the origins, mechanisms and implications of species differences in cellular stress response pathway capacities at University of Liverpool on FindAPhD.com
PhD Project - (BBSRC NWD CASE) Unravelling the origins, mechanisms and implications of species differences in cellular stress response pathway capacities at University of Liverpool, listed on FindAPhD...
tinyurl.com
November 11, 2025 at 9:37 PM
📢 Fully funded PhD opportunity in my group!
Project title: Unravelling the origins, mechanisms and implications of species differences in cellular stress response pathway capacities.
Application deadline: 7 December 2025.
Details/apply: tinyurl.com/2jcp9jfz
Questions: Get in touch!
Project title: Unravelling the origins, mechanisms and implications of species differences in cellular stress response pathway capacities.
Application deadline: 7 December 2025.
Details/apply: tinyurl.com/2jcp9jfz
Questions: Get in touch!
🌍🌎🌏Open to students worldwide! I m super excited for this project 🎉
🧠 Fully funded 4-year PhD studentship 🧠 Please repost
BBSRC NWD project with @parikki.bsky.social and @iamabyron.bsky.social
Come join us to look at how mechanical and oxidative stress signalling pathways converge on the synaptic scaffold protein talin.
www.findaphd.com/phds/project...
BBSRC NWD project with @parikki.bsky.social and @iamabyron.bsky.social
Come join us to look at how mechanical and oxidative stress signalling pathways converge on the synaptic scaffold protein talin.
www.findaphd.com/phds/project...
(BBSRC NWD) A novel redox mechanosignalling nexus in the synapse that is misregulated in neurodegeneration at University of Liverpool on FindAPhD.com
PhD Project - (BBSRC NWD) A novel redox mechanosignalling nexus in the synapse that is misregulated in neurodegeneration at University of Liverpool, listed on FindAPhD.com
www.findaphd.com
November 11, 2025 at 11:07 AM
🌍🌎🌏Open to students worldwide! I m super excited for this project 🎉
Congratulations Colin!!! ❤️🎉 Can’t wait to see the super cool data will you generate!
Very excited to receive this Spatial Biology in Neuro-Oncology Grant to pump-prime our studies into histone supply biology in high grade glioma patient samples!
Thanks to @standardbiotools.bsky.social and @eanoassociation.bsky.social for your generous support!🙂
🥳🧬🙌Exciting times ahead!! 🤸🧬🥳
Thanks to @standardbiotools.bsky.social and @eanoassociation.bsky.social for your generous support!🙂
🥳🧬🙌Exciting times ahead!! 🤸🧬🥳
October 31, 2025 at 12:57 PM
Congratulations Colin!!! ❤️🎉 Can’t wait to see the super cool data will you generate!
Reposted by Paraskevi Kritsiligkou
This was a fun new collaboration using selective ribosome profiling to understand how the subunit composition of the ER translocon is tailored by the nascent chain. Congratulations to everyone involved!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Global analysis of translocon remodeling during protein synthesis at the ER - Nature Structural & Molecular Biology
The authors use selective ribosome profiling to define how and when factors for N-glycosylation and membrane insertion engage and disengage from the core Sec61 translocation channel during biogenesis ...
www.nature.com
October 20, 2025 at 8:08 PM
This was a fun new collaboration using selective ribosome profiling to understand how the subunit composition of the ER translocon is tailored by the nascent chain. Congratulations to everyone involved!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Paraskevi Kritsiligkou
Want to apply for an EMBO Postdoctoral #Fellowship? 🧪
Here are tips from the EMBO Fellowship Committee:
www.youtube.com/watch?v=xY7c...
#LifeSciences #grant #funding
Here are tips from the EMBO Fellowship Committee:
www.youtube.com/watch?v=xY7c...
#LifeSciences #grant #funding
How to apply for an EMBO Postdoctoral Fellowship: Tips from the Committee
YouTube video by EMBO - excellence in life sciences
www.youtube.com
October 7, 2025 at 2:10 PM
Want to apply for an EMBO Postdoctoral #Fellowship? 🧪
Here are tips from the EMBO Fellowship Committee:
www.youtube.com/watch?v=xY7c...
#LifeSciences #grant #funding
Here are tips from the EMBO Fellowship Committee:
www.youtube.com/watch?v=xY7c...
#LifeSciences #grant #funding
Reposted by Paraskevi Kritsiligkou
What's the role of stress granules in translation? Here we provide a clue: we characterized the distribution of ribosomal complexes within SGs and reproduced this landscape with a phase-field model, pointing to a new regulatory mechanism. #TEAMTOMO www.science.org/doi/10.1126/...
Translation landscape of stress granules
Cryo–electron tomography visualizes stress granules in situ, revealing their spatial interplay with translation machinery.
www.science.org
October 5, 2025 at 5:22 AM
What's the role of stress granules in translation? Here we provide a clue: we characterized the distribution of ribosomal complexes within SGs and reproduced this landscape with a phase-field model, pointing to a new regulatory mechanism. #TEAMTOMO www.science.org/doi/10.1126/...
Reposted by Paraskevi Kritsiligkou
🚀 Our new paper is out @natmethods.nature.com!
Kuffer & Marzilli engineered conditionally stable MS2 & PP7 coat proteins (dMCP & dPCP) that degrade unless bound to RNA, enabling ultra–low-background, single-mRNA imaging in live cells.
🔗 www.nature.com/articles/s41...
🧬 www.addgene.org/John_Ngo/
Kuffer & Marzilli engineered conditionally stable MS2 & PP7 coat proteins (dMCP & dPCP) that degrade unless bound to RNA, enabling ultra–low-background, single-mRNA imaging in live cells.
🔗 www.nature.com/articles/s41...
🧬 www.addgene.org/John_Ngo/
September 22, 2025 at 6:27 PM
🚀 Our new paper is out @natmethods.nature.com!
Kuffer & Marzilli engineered conditionally stable MS2 & PP7 coat proteins (dMCP & dPCP) that degrade unless bound to RNA, enabling ultra–low-background, single-mRNA imaging in live cells.
🔗 www.nature.com/articles/s41...
🧬 www.addgene.org/John_Ngo/
Kuffer & Marzilli engineered conditionally stable MS2 & PP7 coat proteins (dMCP & dPCP) that degrade unless bound to RNA, enabling ultra–low-background, single-mRNA imaging in live cells.
🔗 www.nature.com/articles/s41...
🧬 www.addgene.org/John_Ngo/
Reposted by Paraskevi Kritsiligkou
Happy to share latest work from the lab. Led by talented first author @awmartinelli.bsky.social. Mapping the genetic landscape of iron metabolism uncovers the SETD2 methyltransferase as a modulator of iron flux | Science Advances www.science.org/doi/10.1126/... Congratulations to all the team.
Mapping the genetic landscape of iron metabolism uncovers the SETD2 methyltransferase as a modulator of iron flux
Genetic screens using endogenous reporters map key modulators of cellular iron, including the transcriptional regulator SETD2.
www.science.org
September 18, 2025 at 7:02 PM
Happy to share latest work from the lab. Led by talented first author @awmartinelli.bsky.social. Mapping the genetic landscape of iron metabolism uncovers the SETD2 methyltransferase as a modulator of iron flux | Science Advances www.science.org/doi/10.1126/... Congratulations to all the team.
Reposted by Paraskevi Kritsiligkou
Reposted by Paraskevi Kritsiligkou
#RNAsky
💜💜💜💜💜💜💜
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RNA can control cell migration by acting at focal adhesions www.lifescienceeditors.com/2025/06/24/r...
RNA can control cell migration by acting at focal adhesions - Scientific editing and writing experts - Life Science Editors
Scientific editing and writing experts for manuscripts and grants
www.lifescienceeditors.com
July 27, 2025 at 7:38 AM
#RNAsky
💜💜💜💜💜💜💜
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On my way back from a truly brilliant yeast meeting! With more than 500 participants, so much cool science and loads of fruitful discussions, this week was remarkable! #yeast2025
July 25, 2025 at 10:48 AM
On my way back from a truly brilliant yeast meeting! With more than 500 participants, so much cool science and loads of fruitful discussions, this week was remarkable! #yeast2025
I am in Paris this week for #yeast2025!
July 21, 2025 at 8:33 AM
I am in Paris this week for #yeast2025!
Reposted by Paraskevi Kritsiligkou
Delighted to share our latest work on ABHD11 as a novel deglutarylating enzyme, and its role in T cell metabolism @natchembio.nature.com rdcu.be/ewiYZ. Many congratulations to co-first authors Guine Grice, Eleanor Minogue and @hudsonwilco.bsky.social! Great team effort with Randall Johnson's lab.
Lipoyl deglutarylation by ABHD11 regulates mitochondrial and T cell metabolism
Nature Chemical Biology - Glutarate rewires cell metabolism through conjugation to proteins or fatty acids, but how glutarylation is regulated is unclear. ABHD11 was identified as a...
rdcu.be
July 15, 2025 at 4:12 PM
Delighted to share our latest work on ABHD11 as a novel deglutarylating enzyme, and its role in T cell metabolism @natchembio.nature.com rdcu.be/ewiYZ. Many congratulations to co-first authors Guine Grice, Eleanor Minogue and @hudsonwilco.bsky.social! Great team effort with Randall Johnson's lab.
Reposted by Paraskevi Kritsiligkou
Our new preprint: how photoprotection is spatially coordinated with energy metabolism. Photosystem I is major source of radicals. We report EM structure of PSI in complex with superoxide dismutase SOD: direct link between energy conversion & oxidative stress defence
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
July 7, 2025 at 6:03 AM
Our new preprint: how photoprotection is spatially coordinated with energy metabolism. Photosystem I is major source of radicals. We report EM structure of PSI in complex with superoxide dismutase SOD: direct link between energy conversion & oxidative stress defence
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Paraskevi Kritsiligkou
🎉Excited to share our latest paper, published in Nature Communications!🎉
"Enhancing autophagy by redox regulation extends lifespan in Drosophila"
#redox #metabolism #ageing #Drosophila
@natcomms.nature.com @mrc-lms.bsky.social
doi.org/10.1038/s414...
"Enhancing autophagy by redox regulation extends lifespan in Drosophila"
#redox #metabolism #ageing #Drosophila
@natcomms.nature.com @mrc-lms.bsky.social
doi.org/10.1038/s414...
Enhancing autophagy by redox regulation extends lifespan in Drosophila - Nature Communications
Redox signalling is emerging as an important regulator of metabolism and physiology, which is dysregulated in ageing and disease. Here, the authors show that redox regulation of a key redox sensitive ...
doi.org
June 27, 2025 at 11:21 AM
🎉Excited to share our latest paper, published in Nature Communications!🎉
"Enhancing autophagy by redox regulation extends lifespan in Drosophila"
#redox #metabolism #ageing #Drosophila
@natcomms.nature.com @mrc-lms.bsky.social
doi.org/10.1038/s414...
"Enhancing autophagy by redox regulation extends lifespan in Drosophila"
#redox #metabolism #ageing #Drosophila
@natcomms.nature.com @mrc-lms.bsky.social
doi.org/10.1038/s414...
Reposted by Paraskevi Kritsiligkou
New tools! GreenPy and ApplePy are fluorescent biosensors for pyruvate with huge responses (20–40x in vitro) and a range of affinities (10s of μM to mM). These should be game changers for imaging of metabolism! Great work by Shosei Imai @sikmys.bsky.social and team 👏. www.biorxiv.org/content/10.1...
High-performance genetically-encoded green and red fluorescent biosensors for pyruvate
Pyruvate is the end-product of glycolysis and a central metabolite involved in many biochemical pathways. However, a lack of high-performance (i.e., Δ F / F > 10) single fluorescent protein (FP)-base...
www.biorxiv.org
April 19, 2025 at 6:42 AM
New tools! GreenPy and ApplePy are fluorescent biosensors for pyruvate with huge responses (20–40x in vitro) and a range of affinities (10s of μM to mM). These should be game changers for imaging of metabolism! Great work by Shosei Imai @sikmys.bsky.social and team 👏. www.biorxiv.org/content/10.1...
Reposted by Paraskevi Kritsiligkou
How do cells switch on the actin assembly at endocytic sites? How can this on-switch evolve? Check out our new preprint!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
June 24, 2025 at 7:22 PM
How do cells switch on the actin assembly at endocytic sites? How can this on-switch evolve? Check out our new preprint!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Paraskevi Kritsiligkou
1/27 We have a new paper out! Turns out that snowflake yeast have been hiding a secret from us - they've evolved a (very!) crude circulatory system. Not with blood vessels or a heart, but through spontaneous fluid flows powered by their metabolism. 🧪🔬
www.science.org/doi/full/10....
www.science.org/doi/full/10....
June 24, 2025 at 4:52 PM
1/27 We have a new paper out! Turns out that snowflake yeast have been hiding a secret from us - they've evolved a (very!) crude circulatory system. Not with blood vessels or a heart, but through spontaneous fluid flows powered by their metabolism. 🧪🔬
www.science.org/doi/full/10....
www.science.org/doi/full/10....
Reposted by Paraskevi Kritsiligkou
Are you looking for a postdoc?
I will be looking for 2-4 people after the summer to join the lab !!
Do not hesitate to reach out and disseminate !!
I will be looking for 2-4 people after the summer to join the lab !!
Do not hesitate to reach out and disseminate !!
June 23, 2025 at 2:29 PM
Are you looking for a postdoc?
I will be looking for 2-4 people after the summer to join the lab !!
Do not hesitate to reach out and disseminate !!
I will be looking for 2-4 people after the summer to join the lab !!
Do not hesitate to reach out and disseminate !!
Reposted by Paraskevi Kritsiligkou
Congratulations to Dr Aphrodite Vasilaki and Dr Paraskevi Kritsiligkou @parikki.bsky.social who won the Leopold Flohé Redox Pioneer Young Investigator Award and Catherine Pasquier Award respectively at the 2025 Society for Free Radical Research International meeting
▶️ bit.ly/4ebZ9XN
▶️ bit.ly/4ebZ9XN
June 20, 2025 at 3:32 PM
Congratulations to Dr Aphrodite Vasilaki and Dr Paraskevi Kritsiligkou @parikki.bsky.social who won the Leopold Flohé Redox Pioneer Young Investigator Award and Catherine Pasquier Award respectively at the 2025 Society for Free Radical Research International meeting
▶️ bit.ly/4ebZ9XN
▶️ bit.ly/4ebZ9XN
Spent the day listening to some amazing talks from first and second year PhD students in our Biochemistry, Cell and Systems Biology Department! I loved how confident and knowledgeable our students are! Can’t wait for my students to give their talks next year 🥹
June 18, 2025 at 4:14 PM
Spent the day listening to some amazing talks from first and second year PhD students in our Biochemistry, Cell and Systems Biology Department! I loved how confident and knowledgeable our students are! Can’t wait for my students to give their talks next year 🥹
Had a great time at the SFRR-I meeting! I listened to some exciting new science, spent time with my friends that live far away and met my fellow @sfrre-ecr.bsky.social in person!❤️ We successfully organised networking events and a sunrise seminar and it is clear we are building a great community 🎉
June 7, 2025 at 3:36 PM
Had a great time at the SFRR-I meeting! I listened to some exciting new science, spent time with my friends that live far away and met my fellow @sfrre-ecr.bsky.social in person!❤️ We successfully organised networking events and a sunrise seminar and it is clear we are building a great community 🎉
Reposted by Paraskevi Kritsiligkou
Outstanding talk by @parikki.bsky.social , recipient of the CATHERINE PASQUIER AWARD LECTURE at SFFR-I Biennial Meeting in Galway @uniofgalway.bsky.social.
Are ROS generated in nanodomains / condensates in cells?
Want to know more, please read her paper
lnkd.in/dq_6Rnaw
@sfrre-ecr.bsky.social
Are ROS generated in nanodomains / condensates in cells?
Want to know more, please read her paper
lnkd.in/dq_6Rnaw
@sfrre-ecr.bsky.social
June 6, 2025 at 11:11 AM
Outstanding talk by @parikki.bsky.social , recipient of the CATHERINE PASQUIER AWARD LECTURE at SFFR-I Biennial Meeting in Galway @uniofgalway.bsky.social.
Are ROS generated in nanodomains / condensates in cells?
Want to know more, please read her paper
lnkd.in/dq_6Rnaw
@sfrre-ecr.bsky.social
Are ROS generated in nanodomains / condensates in cells?
Want to know more, please read her paper
lnkd.in/dq_6Rnaw
@sfrre-ecr.bsky.social