Lonnie Wollmuth
@lwollmuth.bsky.social
Professor. Stony Brook. Ion channels. Synaptic transmission. Membrane physiology. Zebrafish
Reposted by Lonnie Wollmuth
Happy about our new paper in Nature rdcu.be/eukUB
The GluA3 structure provides a framework for understanding this disease-prone glutamate receptor - novel interfaces will provide targets for modulator development
The GluA3 structure provides a framework for understanding this disease-prone glutamate receptor - novel interfaces will provide targets for modulator development
July 2, 2025 at 7:24 AM
Happy about our new paper in Nature rdcu.be/eukUB
The GluA3 structure provides a framework for understanding this disease-prone glutamate receptor - novel interfaces will provide targets for modulator development
The GluA3 structure provides a framework for understanding this disease-prone glutamate receptor - novel interfaces will provide targets for modulator development
Reposted by Lonnie Wollmuth
The 3rd Berlin Single Molecule Biophysics Course will run from 8th to 12th September at the HU-Berlin, Institute of Biology.
Learn about single channels, single molecule TIRF, theory and analysis. Apply by 7th July at bsmbc@icloud.com. Fee waivers and bursaries available.
! Please share widely !
Learn about single channels, single molecule TIRF, theory and analysis. Apply by 7th July at bsmbc@icloud.com. Fee waivers and bursaries available.
! Please share widely !
June 5, 2025 at 8:36 PM
The 3rd Berlin Single Molecule Biophysics Course will run from 8th to 12th September at the HU-Berlin, Institute of Biology.
Learn about single channels, single molecule TIRF, theory and analysis. Apply by 7th July at bsmbc@icloud.com. Fee waivers and bursaries available.
! Please share widely !
Learn about single channels, single molecule TIRF, theory and analysis. Apply by 7th July at bsmbc@icloud.com. Fee waivers and bursaries available.
! Please share widely !
Reposted by Lonnie Wollmuth
Hopkins researchers use cryoEM microscopy to advance understanding of glutamate AMPA receptor action. Article link: www.oneneurojhu.org/2025/04/02/b...
April 2, 2025 at 7:30 PM
Hopkins researchers use cryoEM microscopy to advance understanding of glutamate AMPA receptor action. Article link: www.oneneurojhu.org/2025/04/02/b...
Reposted by Lonnie Wollmuth
Today!!! Support our trainees!! Register here: us02web.zoom.us/webinar/regi...
March 26, 2025 at 2:49 PM
Today!!! Support our trainees!! Register here: us02web.zoom.us/webinar/regi...
Reposted by Lonnie Wollmuth
Here's our newest study: we reveal the molecular principles of neuronal excitation by glutamate, and how physiological temperatures influence this process.
www.nature.com/articles/s41...
www.nature.com/articles/d41...
Led by @anish-mondal07.bsky.social, published in @natureportfolio.nature.com
www.nature.com/articles/s41...
www.nature.com/articles/d41...
Led by @anish-mondal07.bsky.social, published in @natureportfolio.nature.com
March 26, 2025 at 4:29 PM
Here's our newest study: we reveal the molecular principles of neuronal excitation by glutamate, and how physiological temperatures influence this process.
www.nature.com/articles/s41...
www.nature.com/articles/d41...
Led by @anish-mondal07.bsky.social, published in @natureportfolio.nature.com
www.nature.com/articles/s41...
www.nature.com/articles/d41...
Led by @anish-mondal07.bsky.social, published in @natureportfolio.nature.com
Reposted by Lonnie Wollmuth
Nav1.7 structure and severe pain: join our next worldwide sodium channel seminar on March 25th by Goragot Wisedchaisri (Seattle, US) on the “Structural basis for severe pain caused by mutations in Nav1.7”
www.sodiumchannelseminars.org for link and infos. See you there!
#ionchannel #WSCS
www.sodiumchannelseminars.org for link and infos. See you there!
#ionchannel #WSCS
March 17, 2025 at 7:25 AM
Nav1.7 structure and severe pain: join our next worldwide sodium channel seminar on March 25th by Goragot Wisedchaisri (Seattle, US) on the “Structural basis for severe pain caused by mutations in Nav1.7”
www.sodiumchannelseminars.org for link and infos. See you there!
#ionchannel #WSCS
www.sodiumchannelseminars.org for link and infos. See you there!
#ionchannel #WSCS
Needed a break from the anti-science, anti-NIH administration. Dingle peninsula in Ireland.
March 19, 2025 at 2:35 PM
Needed a break from the anti-science, anti-NIH administration. Dingle peninsula in Ireland.
Reposted by Lonnie Wollmuth
The Channels, Receptors & Transporters Subgroup of the @biophysicalsoc.bsky.social is excited to announce the final program for our 2025 Symposium. Please join us on Feb 15 to hear from @willowcoyote.bsky.social @drcontrexin.bsky.social @corrylab.bsky.social and others 👇Thanks to our sponsors!
January 19, 2025 at 11:02 PM
The Channels, Receptors & Transporters Subgroup of the @biophysicalsoc.bsky.social is excited to announce the final program for our 2025 Symposium. Please join us on Feb 15 to hear from @willowcoyote.bsky.social @drcontrexin.bsky.social @corrylab.bsky.social and others 👇Thanks to our sponsors!
Reposted by Lonnie Wollmuth
Direct visualization of electric-field-stimulated ion conduction in a potassium #ionchannel - Cell https://buff.ly/3WfbsLe
January 12, 2025 at 11:39 AM
Direct visualization of electric-field-stimulated ion conduction in a potassium #ionchannel - Cell https://buff.ly/3WfbsLe
Reposted by Lonnie Wollmuth
Our January issue is here ✨ https://buff.ly/3DFIr4N The cover shows agonist-induced #ionchannel opening of human NMDA receptors assayed using single channel outside-out patches to detect varied activation delays and failures. From Miaomiao He & @lwollmuth.bsky.social (https://buff.ly/3W6IQ6J).
January 6, 2025 at 3:04 PM
Our January issue is here ✨ https://buff.ly/3DFIr4N The cover shows agonist-induced #ionchannel opening of human NMDA receptors assayed using single channel outside-out patches to detect varied activation delays and failures. From Miaomiao He & @lwollmuth.bsky.social (https://buff.ly/3W6IQ6J).
Reposted by Lonnie Wollmuth
The Neurobiology Division at the MRC LMB is looking for a new group leader:
www.nature.com/naturecareer...
www.nature.com/naturecareer...
Research Group Leader - Neurobiology - LMB 2531 - Cambridgeshire job with MRC Laboratory of Molecular Biology (LMB) | 12832855
Research Group Leader Starting Salary £50,608 - £58,919 per annum for appointment to Senior Investigator Scientist Salary £65,940 - £74,448 per ann...
www.nature.com
December 24, 2024 at 12:06 PM
The Neurobiology Division at the MRC LMB is looking for a new group leader:
www.nature.com/naturecareer...
www.nature.com/naturecareer...
Reposted by Lonnie Wollmuth
There is a postdoctoral position available in cryoET and FIB/SEM of Parkinson's disease available in at the Franklin!
See details here: opportunities.rfi.ac.uk/vacancy/post...
This work is in collaboration with our partners at MSD and their London Discovery Centre.
Please share!
See details here: opportunities.rfi.ac.uk/vacancy/post...
This work is in collaboration with our partners at MSD and their London Discovery Centre.
Please share!
December 20, 2024 at 3:28 PM
There is a postdoctoral position available in cryoET and FIB/SEM of Parkinson's disease available in at the Franklin!
See details here: opportunities.rfi.ac.uk/vacancy/post...
This work is in collaboration with our partners at MSD and their London Discovery Centre.
Please share!
See details here: opportunities.rfi.ac.uk/vacancy/post...
This work is in collaboration with our partners at MSD and their London Discovery Centre.
Please share!
Reposted by Lonnie Wollmuth
Grateful for having contributed to this work by the Isabelle Baconguis group, who solved eleven (!) new structures of hASIC1a to show that open states require linear transmembrane helices, while desensitized states display a dazzling structural diversity
www.biorxiv.org/content/10.1...
#ionchannels
www.biorxiv.org/content/10.1...
#ionchannels
December 13, 2024 at 1:47 PM
Grateful for having contributed to this work by the Isabelle Baconguis group, who solved eleven (!) new structures of hASIC1a to show that open states require linear transmembrane helices, while desensitized states display a dazzling structural diversity
www.biorxiv.org/content/10.1...
#ionchannels
www.biorxiv.org/content/10.1...
#ionchannels
Reposted by Lonnie Wollmuth
Dear ion channel community - come and join us for an exciting talk by @corrylab.bsky.social next Tuesday on sodium channel fast inactivation. Do you still believe in ball-and-chain? Or rather rings obliterating the pore? Something else? Then come and discuss with us at the #WSCS! #ionchannels #Nav
Nav computer modelling as tool to understand fast inactivation: join us for the next worldwide sodium channel seminar given by Ben Corry on December 17th. More info on www.sodiumchannelseminars.org. Mark your calendar and join in! #ionchannels #WSCS
December 14, 2024 at 3:15 PM
Dear ion channel community - come and join us for an exciting talk by @corrylab.bsky.social next Tuesday on sodium channel fast inactivation. Do you still believe in ball-and-chain? Or rather rings obliterating the pore? Something else? Then come and discuss with us at the #WSCS! #ionchannels #Nav
A good reason to bring out the brown alcohol. A former UG/MS student in the lab (far left. Now MD/PhD at Albert Einstein) stopped by for random visit. Others made the bad decision to work in my lab. Always fun.
December 14, 2024 at 1:30 AM
A good reason to bring out the brown alcohol. A former UG/MS student in the lab (far left. Now MD/PhD at Albert Einstein) stopped by for random visit. Others made the bad decision to work in my lab. Always fun.
Reposted by Lonnie Wollmuth
So receptors with only Glutamine (Q) present are permeable to potassium and sodium about equally well, and they actually prefer calcium. We show this in the preprint, others like @lwollmuth.bsky.social have shown this.
dx.doi.org/10.1113/jphy...
12/n
dx.doi.org/10.1113/jphy...
12/n
Voltage and concentration dependence of Ca2+ permeability in recombinant glutamate receptor subtypes
You have to enable JavaScript in your browser's settings in order to use the eReader.
dx.doi.org
December 6, 2024 at 11:05 AM
So receptors with only Glutamine (Q) present are permeable to potassium and sodium about equally well, and they actually prefer calcium. We show this in the preprint, others like @lwollmuth.bsky.social have shown this.
dx.doi.org/10.1113/jphy...
12/n
dx.doi.org/10.1113/jphy...
12/n
At McGill visiting Derek. Wonderful science here. Lots of synaptic physiology. Very elegant. #iglur. #ionchannels
December 5, 2024 at 2:05 PM
At McGill visiting Derek. Wonderful science here. Lots of synaptic physiology. Very elegant. #iglur. #ionchannels
Reposted by Lonnie Wollmuth
Book rec: Neanderthal Man by 2022 @nobelprize.bsky.social laureate Svante Pääbo. A fascinating dive into sequencing ancient 🧬. Captures the thrills, setbacks, and Pääbo’s personal vulnerabilities during groundbreaking science.
December 2, 2024 at 11:23 PM
Book rec: Neanderthal Man by 2022 @nobelprize.bsky.social laureate Svante Pääbo. A fascinating dive into sequencing ancient 🧬. Captures the thrills, setbacks, and Pääbo’s personal vulnerabilities during groundbreaking science.
Reposted by Lonnie Wollmuth
Important article that challenges the classic view of axons as simple tubes. To what extent they fluctuate in diameter is up for debate - see some thoughts in this commentary piece in @science.org. Exciting time for axon scientists!
December 2, 2024 at 10:33 AM
Important article that challenges the classic view of axons as simple tubes. To what extent they fluctuate in diameter is up for debate - see some thoughts in this commentary piece in @science.org. Exciting time for axon scientists!
Reposted by Lonnie Wollmuth
Happy to share our new review on the structural pharmacology of TRP channels!
Check out the supplementary table, which includes a list of all ligands, corresponding PDBs of complexes with TRP channels, and reported affinity values.
www.sciencedirect.com/science/arti... #ionchannel #TRPchannel (1/5)
Check out the supplementary table, which includes a list of all ligands, corresponding PDBs of complexes with TRP channels, and reported affinity values.
www.sciencedirect.com/science/arti... #ionchannel #TRPchannel (1/5)
December 1, 2024 at 3:00 AM
Happy to share our new review on the structural pharmacology of TRP channels!
Check out the supplementary table, which includes a list of all ligands, corresponding PDBs of complexes with TRP channels, and reported affinity values.
www.sciencedirect.com/science/arti... #ionchannel #TRPchannel (1/5)
Check out the supplementary table, which includes a list of all ligands, corresponding PDBs of complexes with TRP channels, and reported affinity values.
www.sciencedirect.com/science/arti... #ionchannel #TRPchannel (1/5)
Reposted by Lonnie Wollmuth
TRPM8 #ionchannel mutations Associated With Persistent Pain After Surgical Injury of Corneal Trigeminal Axons | Neurology Genetics
More from Waxman!
HT @rohacstibor.bsky.social
https://www.neurology.org/doi/10.1212/NXG.0000000000200206
More from Waxman!
HT @rohacstibor.bsky.social
https://www.neurology.org/doi/10.1212/NXG.0000000000200206
November 29, 2024 at 1:23 PM
TRPM8 #ionchannel mutations Associated With Persistent Pain After Surgical Injury of Corneal Trigeminal Axons | Neurology Genetics
More from Waxman!
HT @rohacstibor.bsky.social
https://www.neurology.org/doi/10.1212/NXG.0000000000200206
More from Waxman!
HT @rohacstibor.bsky.social
https://www.neurology.org/doi/10.1212/NXG.0000000000200206
Reposted by Lonnie Wollmuth
Nav computer modelling as tool to understand fast inactivation: join us for the next worldwide sodium channel seminar given by Ben Corry on December 17th. More info on www.sodiumchannelseminars.org. Mark your calendar and join in! #ionchannels #WSCS
November 29, 2024 at 5:43 PM
Nav computer modelling as tool to understand fast inactivation: join us for the next worldwide sodium channel seminar given by Ben Corry on December 17th. More info on www.sodiumchannelseminars.org. Mark your calendar and join in! #ionchannels #WSCS
Reposted by Lonnie Wollmuth
Considering a PhD in molecular biology?
There’s still time to apply to join the LMB in October 2024.
Applications close on 3rd DEC.
Visit our website for more info: www2.mrc-lmb.cam.ac.uk/students/int...
There’s still time to apply to join the LMB in October 2024.
Applications close on 3rd DEC.
Visit our website for more info: www2.mrc-lmb.cam.ac.uk/students/int...
November 22, 2024 at 4:01 PM
Considering a PhD in molecular biology?
There’s still time to apply to join the LMB in October 2024.
Applications close on 3rd DEC.
Visit our website for more info: www2.mrc-lmb.cam.ac.uk/students/int...
There’s still time to apply to join the LMB in October 2024.
Applications close on 3rd DEC.
Visit our website for more info: www2.mrc-lmb.cam.ac.uk/students/int...
Reposted by Lonnie Wollmuth
One for the Thanksgiving dinner table. 🦃
Faeces and vomit fossils from dinosaurs reveal how the animals evolved to rule Earth. 🦕🧪
www.nature.com/articles/d41...
Faeces and vomit fossils from dinosaurs reveal how the animals evolved to rule Earth. 🦕🧪
www.nature.com/articles/d41...
Fossilized poo and vomit show how dinosaurs rose to rule Earth
Analysis of 200-million-year-old digested foods reveals how the animals became dominant.
www.nature.com
November 28, 2024 at 3:20 PM
One for the Thanksgiving dinner table. 🦃
Faeces and vomit fossils from dinosaurs reveal how the animals evolved to rule Earth. 🦕🧪
www.nature.com/articles/d41...
Faeces and vomit fossils from dinosaurs reveal how the animals evolved to rule Earth. 🦕🧪
www.nature.com/articles/d41...
Reposted by Lonnie Wollmuth
This is a wonderful paper with a ton of difficult single channel measurements on NMDA receptors in non-equilibrium conditions. Fundamental information, presented without hype and with care.
November 27, 2024 at 8:08 PM
This is a wonderful paper with a ton of difficult single channel measurements on NMDA receptors in non-equilibrium conditions. Fundamental information, presented without hype and with care.