Channelomics
@channelomics.bsky.social
Our Twitter feed lives on via an IFTTT rule, but this seems a nicer place.
Ion channel stuff, papers, jobs, Studentship and if you are still active at a rig; sympathy! Anyone that’s done electrophysiology knows it is the ”sharp” end of science.
Ion channel stuff, papers, jobs, Studentship and if you are still active at a rig; sympathy! Anyone that’s done electrophysiology knows it is the ”sharp” end of science.
Mechanism of conductance control and neurosteroid binding in NMDA #IonChannel receptors | Nature
Sorry it is paywalled…. But look at the beautiful channels 🥲
www.nature.com/articles/s41...
Sorry it is paywalled…. But look at the beautiful channels 🥲
www.nature.com/articles/s41...
November 6, 2025 at 9:08 AM
Mechanism of conductance control and neurosteroid binding in NMDA #IonChannel receptors | Nature
Sorry it is paywalled…. But look at the beautiful channels 🥲
www.nature.com/articles/s41...
Sorry it is paywalled…. But look at the beautiful channels 🥲
www.nature.com/articles/s41...
Deletion of the TRPV1 #Ionchannels attenuates afferent renal nerve responses to renal artery occlusion but not elevated renal pelvic pressure
physoc.onlinelibrary.wiley.com/doi/10.1113/...
physoc.onlinelibrary.wiley.com/doi/10.1113/...
November 5, 2025 at 11:39 AM
Deletion of the TRPV1 #Ionchannels attenuates afferent renal nerve responses to renal artery occlusion but not elevated renal pelvic pressure
physoc.onlinelibrary.wiley.com/doi/10.1113/...
physoc.onlinelibrary.wiley.com/doi/10.1113/...
Substrate stiffness attenuates cardiomyocyte depolarization slope via sodium channel modulation (Increased stiffness of the substrate causes the dysfunction of Nav1.5 #Ionchannel kinetics) www.sciencedirect.com/science/arti...
November 3, 2025 at 6:28 PM
Substrate stiffness attenuates cardiomyocyte depolarization slope via sodium channel modulation (Increased stiffness of the substrate causes the dysfunction of Nav1.5 #Ionchannel kinetics) www.sciencedirect.com/science/arti...
Sclareol and cinnarizine are non-selective inhibitors of voltage-gated Cav1.3 L-type Ca2+ #ionchannels Open access.
www.tandfonline.com/doi/full/10....
www.tandfonline.com/doi/full/10....
October 31, 2025 at 11:39 AM
Sclareol and cinnarizine are non-selective inhibitors of voltage-gated Cav1.3 L-type Ca2+ #ionchannels Open access.
www.tandfonline.com/doi/full/10....
www.tandfonline.com/doi/full/10....
Mouse retinal ganglion cells and night blindness |
TRPM1 #ionchannels, mGluR6 of retinal ON bipolar cells
J.General Physiol. rupress.org/jgp/article/...
TRPM1 #ionchannels, mGluR6 of retinal ON bipolar cells
J.General Physiol. rupress.org/jgp/article/...
October 22, 2025 at 10:39 AM
Mouse retinal ganglion cells and night blindness |
TRPM1 #ionchannels, mGluR6 of retinal ON bipolar cells
J.General Physiol. rupress.org/jgp/article/...
TRPM1 #ionchannels, mGluR6 of retinal ON bipolar cells
J.General Physiol. rupress.org/jgp/article/...
Aberrant HCN4 #ionchannel expression: Impacts on neuronal excitability and implications for epilepsy pathogenesis - Spyrou - British Journal of Pharmacology
Paywalled
bpspubs.onlinelibrary.wiley.com/doi/10.1111/...
Paywalled
bpspubs.onlinelibrary.wiley.com/doi/10.1111/...
October 21, 2025 at 10:39 AM
Aberrant HCN4 #ionchannel expression: Impacts on neuronal excitability and implications for epilepsy pathogenesis - Spyrou - British Journal of Pharmacology
Paywalled
bpspubs.onlinelibrary.wiley.com/doi/10.1111/...
Paywalled
bpspubs.onlinelibrary.wiley.com/doi/10.1111/...
Piezo1 #ionchannels regulate the mechanotransduction of soft matrix viscoelasticity | Nature Communications www.nature.com/articles/s41...
October 20, 2025 at 5:35 PM
Piezo1 #ionchannels regulate the mechanotransduction of soft matrix viscoelasticity | Nature Communications www.nature.com/articles/s41...
Massive reduction of RyR1 #Ionchannel in muscle spindles of mice carrying recessive Ryr1 mutations alters proprioception and causes scoliosis - Ruiz - The Journal of Physiology
physoc.onlinelibrary.wiley.com/doi/10.1113/...
physoc.onlinelibrary.wiley.com/doi/10.1113/...
October 17, 2025 at 10:39 AM
Massive reduction of RyR1 #Ionchannel in muscle spindles of mice carrying recessive Ryr1 mutations alters proprioception and causes scoliosis - Ruiz - The Journal of Physiology
physoc.onlinelibrary.wiley.com/doi/10.1113/...
physoc.onlinelibrary.wiley.com/doi/10.1113/...
Augmenting AMPA #IonChannel signaling after spinal cord injury increases ependymal-derived neural stem/progenitor cell migration and promotes functional recovery - Nature Neuroscience
www.nature.com/articles/s41...
www.nature.com/articles/s41...
October 14, 2025 at 10:39 AM
Augmenting AMPA #IonChannel signaling after spinal cord injury increases ependymal-derived neural stem/progenitor cell migration and promotes functional recovery - Nature Neuroscience
www.nature.com/articles/s41...
www.nature.com/articles/s41...
October 13, 2025 at 5:28 PM
Voltage-gated sodium #IonChannels: Mechanisms, disease, and a growing research community *Special Issue* Journal of General Physiology.
rupress.org/jgp/article/...
rupress.org/jgp/article/...
October 12, 2025 at 10:39 AM
Voltage-gated sodium #IonChannels: Mechanisms, disease, and a growing research community *Special Issue* Journal of General Physiology.
rupress.org/jgp/article/...
rupress.org/jgp/article/...
Fatigue arising from KATP SUR2 gain-of-function in Cantu syndrome mice Scala -> Nichols. £€$¥
rupress.org/jgp/article/...
TLDR: Cantu syndrome -> muscle fatigue via overactive KATP #Ionchannels. Reversed by glibenclamide, suggesting possible new treatment.
rupress.org/jgp/article/...
TLDR: Cantu syndrome -> muscle fatigue via overactive KATP #Ionchannels. Reversed by glibenclamide, suggesting possible new treatment.
October 11, 2025 at 5:28 PM
Fatigue arising from KATP SUR2 gain-of-function in Cantu syndrome mice Scala -> Nichols. £€$¥
rupress.org/jgp/article/...
TLDR: Cantu syndrome -> muscle fatigue via overactive KATP #Ionchannels. Reversed by glibenclamide, suggesting possible new treatment.
rupress.org/jgp/article/...
TLDR: Cantu syndrome -> muscle fatigue via overactive KATP #Ionchannels. Reversed by glibenclamide, suggesting possible new treatment.
A polycyclic scaffold identified by structure-based drug design effectively inhibits the human P2X7 #IonChannel receptor - Nature Communications
www.nature.com/articles/s41...
www.nature.com/articles/s41...
October 11, 2025 at 10:39 AM
A polycyclic scaffold identified by structure-based drug design effectively inhibits the human P2X7 #IonChannel receptor - Nature Communications
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Delta-type glutamate receptors are ligand-gated #ionchannels |Nature
£$¥€
www.nature.com/articles/s41...
£$¥€
www.nature.com/articles/s41...
October 10, 2025 at 10:39 AM
Delta-type glutamate receptors are ligand-gated #ionchannels |Nature
£$¥€
www.nature.com/articles/s41...
£$¥€
www.nature.com/articles/s41...
TLDR: CBD alone doesn’t stop drug-resistant epilepsy. But paired with GABAergic meds like phenobarbital or diazepam, it cuts mortality and resistance. But combining with sodium channel blockers may worsen seizures www.frontiersin.org/journals/pha...
#IonChannels
#IonChannels
October 9, 2025 at 8:08 AM
TLDR: CBD alone doesn’t stop drug-resistant epilepsy. But paired with GABAergic meds like phenobarbital or diazepam, it cuts mortality and resistance. But combining with sodium channel blockers may worsen seizures www.frontiersin.org/journals/pha...
#IonChannels
#IonChannels
Distinctive GABA A #Ionchannel receptor subunit expression modulates cell specific EMT and functional responses in glioblastoma breast and ovarian cancer - Scientific Reports
www.nature.com/articles/s41...
www.nature.com/articles/s41...
October 8, 2025 at 6:44 PM
Distinctive GABA A #Ionchannel receptor subunit expression modulates cell specific EMT and functional responses in glioblastoma breast and ovarian cancer - Scientific Reports
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Calmodulin binding is required for calcium mediated TRPA1 #IonChannel desensitization | Nature Communications
www.nature.com/articles/s41...
www.nature.com/articles/s41...
October 8, 2025 at 3:35 PM
Calmodulin binding is required for calcium mediated TRPA1 #IonChannel desensitization | Nature Communications
www.nature.com/articles/s41...
www.nature.com/articles/s41...
A conserved mechanism of LRRC8 #ionchannel inhibition by two structurally distinct drugs | Communications Biology www.nature.com/articles/s42...
Open access
Open access
October 8, 2025 at 10:39 AM
A conserved mechanism of LRRC8 #ionchannel inhibition by two structurally distinct drugs | Communications Biology www.nature.com/articles/s42...
Open access
Open access
TRPM7 Deficiency Accelerates Vascular Senescence by Inhibiting H3K18 Lactylation - Wang - Aging Cell - Wiley Online Library onlinelibrary.wiley.com/doi/10.1111/...
October 4, 2025 at 5:28 PM
TRPM7 Deficiency Accelerates Vascular Senescence by Inhibiting H3K18 Lactylation - Wang - Aging Cell - Wiley Online Library onlinelibrary.wiley.com/doi/10.1111/...
Twisting the Gate: How PIP2 Powers Kir #IonChannels
MD simulations reveal how PIP2 binding triggers conformational shifts that open Kir2, twisting cytoplasmic domains, reshaping gates, and enabling ion flow.
$$$
rupress.org/jgp/article/...
MD simulations reveal how PIP2 binding triggers conformational shifts that open Kir2, twisting cytoplasmic domains, reshaping gates, and enabling ion flow.
$$$
rupress.org/jgp/article/...
PIP2-driven cytoplasmic domain motions are coupled to Kir2 channel gating
Zangerl-Plessl et al. utilized MD simulations and revealed that PIP2 potentiated clockwise twisting motions in individual Kir2 channel cytoplasmic subunits
rupress.org
October 4, 2025 at 10:39 AM
Twisting the Gate: How PIP2 Powers Kir #IonChannels
MD simulations reveal how PIP2 binding triggers conformational shifts that open Kir2, twisting cytoplasmic domains, reshaping gates, and enabling ion flow.
$$$
rupress.org/jgp/article/...
MD simulations reveal how PIP2 binding triggers conformational shifts that open Kir2, twisting cytoplasmic domains, reshaping gates, and enabling ion flow.
$$$
rupress.org/jgp/article/...
Clinically relevant niclosamide concentrations modulate TMEM16A and CaV1.2 #ionchannels to control artery tone and capillary diameter - Kaye - British Journal of Pharmacology - Wiley Online Library bpspubs.onlinelibrary.wiley.com/doi/10.1111/...
June 13, 2025 at 10:39 AM
Clinically relevant niclosamide concentrations modulate TMEM16A and CaV1.2 #ionchannels to control artery tone and capillary diameter - Kaye - British Journal of Pharmacology - Wiley Online Library bpspubs.onlinelibrary.wiley.com/doi/10.1111/...
ASIC #ionchannel currents in cultured primate retinal amacrine/ganglion cells - Saafir - 2025 - Physiological Reports - Wiley Online Library physoc.onlinelibrary.wiley.com/doi/10.14814...
June 10, 2025 at 10:39 AM
ASIC #ionchannel currents in cultured primate retinal amacrine/ganglion cells - Saafir - 2025 - Physiological Reports - Wiley Online Library physoc.onlinelibrary.wiley.com/doi/10.14814...
Mmm… 🤔 Using metaphorical considerations to benefit research on the sodium channel fast inactivation mechanism | Journal of General Physiology | Rockefeller University Press rupress.org/jgp/article/...
June 8, 2025 at 10:39 AM
Mmm… 🤔 Using metaphorical considerations to benefit research on the sodium channel fast inactivation mechanism | Journal of General Physiology | Rockefeller University Press rupress.org/jgp/article/...
Functional expression of the T-type Cav3.2 calcium #ionchannel in female and male human dorsal root ganglion neurons | Brain | Oxford Academic academic.oup.com/brain/advanc...
June 7, 2025 at 5:28 PM
Functional expression of the T-type Cav3.2 calcium #ionchannel in female and male human dorsal root ganglion neurons | Brain | Oxford Academic academic.oup.com/brain/advanc...
The molecular transition that confers voltage dependence to muscle contraction | Nature Communications www.nature.com/articles/s41...
#ionchannels
#ionchannels
June 7, 2025 at 10:39 AM
The molecular transition that confers voltage dependence to muscle contraction | Nature Communications www.nature.com/articles/s41...
#ionchannels
#ionchannels