Lenny Teytelman
@lteytelman.bsky.social
Biologist. President and cofounder, protocols.io (he/him)
Reposted by Lenny Teytelman
Link for the full CRISPR Cas7-11 protocol: www.protocols.io/view/crispr-...
CRISPR/Cas7-11 tool for RNA targeting in Xenopus laevis
CRISPR/Cas systems are defense mechanisms in prokaryotic cells to induce the cleavage and degradation of nucleic acids derived from bacteriophages. Among the different classes,...
www.protocols.io
November 11, 2025 at 5:45 PM
Link for the full CRISPR Cas7-11 protocol: www.protocols.io/view/crispr-...
Reposted by Lenny Teytelman
Congratulations to @sofiram.bsky.social and @artemiskorovesi.bsky.social on our last paper about the role of Sox8 in #xenopus #gastrulation
A link to the whole paper is here www.embopress.org/doi/full/10....
A link to the whole paper is here www.embopress.org/doi/full/10....
Sox8 is essential for vertebrate gastrulation | EMBO reports
imageimageThe use of CRISPR Cas7-11 uncovers a role for sox8 in Xenopus gastrulation as a regulator of Wnt signaling. sox8 downregulation in the ventrolateral mesoderm disrupts blastopore closure and...
www.embopress.org
November 10, 2025 at 1:57 PM
Congratulations to @sofiram.bsky.social and @artemiskorovesi.bsky.social on our last paper about the role of Sox8 in #xenopus #gastrulation
A link to the whole paper is here www.embopress.org/doi/full/10....
A link to the whole paper is here www.embopress.org/doi/full/10....
Reposted by Lenny Teytelman
Excited to launch an openRxiv partnership with the scientist-run AI review service qed (@qedscience.bsky.social), the brainchild of @odedrechavi.bsky.social 1/n
openrxiv.org/enabling-rev...
openrxiv.org/enabling-rev...
Enabling options for review: from training and transparency to author-centered AI tools - openRxiv
Peer review is widely viewed as a critical aspect of biomedical communication. Ideally, it provides authors with feedback so they can improve manuscripts and gives readers, particularly nonspecialists...
openrxiv.org
November 6, 2025 at 2:32 PM
Excited to launch an openRxiv partnership with the scientist-run AI review service qed (@qedscience.bsky.social), the brainchild of @odedrechavi.bsky.social 1/n
openrxiv.org/enabling-rev...
openrxiv.org/enabling-rev...
Reposted by Lenny Teytelman
Our new preprint covering the improvements we made to our respiratory metagenomic assay is out now:
www.medrxiv.org/content/10.1...
✅ Now implemented in 6 NHS hospitals
✅ Increased sensitivity
✅ Increased pathogen genome coverage
(1/3)
www.medrxiv.org/content/10.1...
✅ Now implemented in 6 NHS hospitals
✅ Increased sensitivity
✅ Increased pathogen genome coverage
(1/3)
Optimisation of whole cell human depletion provides increased sensitivity and microbial genome coverage from respiratory metagenomic assays
Metagenomics is being adopted worldwide as a laboratory developed test. We have previously reported a unified metagenomic method for the direct detection of microorganisms from respiratory samples, de...
www.medrxiv.org
October 20, 2025 at 10:35 AM
Our new preprint covering the improvements we made to our respiratory metagenomic assay is out now:
www.medrxiv.org/content/10.1...
✅ Now implemented in 6 NHS hospitals
✅ Increased sensitivity
✅ Increased pathogen genome coverage
(1/3)
www.medrxiv.org/content/10.1...
✅ Now implemented in 6 NHS hospitals
✅ Increased sensitivity
✅ Increased pathogen genome coverage
(1/3)
Reposted by Lenny Teytelman
BIG ANNOUNCEMENT📣: I haven’t been this excited to be part of something new in 15 years… Thrilled to reveal the passion project I’ve been working on for the past year and a half!🙀🥳 (thread 👇)
October 15, 2025 at 12:22 PM
BIG ANNOUNCEMENT📣: I haven’t been this excited to be part of something new in 15 years… Thrilled to reveal the passion project I’ve been working on for the past year and a half!🙀🥳 (thread 👇)
Reposted by Lenny Teytelman
✨ Research assessment needs a rethink — and it finally feels like change might be possible.
At protocols.io (@protocolsio.bsky.social) and in my past life as a journal editor, I’ve had countless conversations about how we evaluate researchers. It’s a topic that keeps coming up — and for good reason.
At protocols.io (@protocolsio.bsky.social) and in my past life as a journal editor, I’ve had countless conversations about how we evaluate researchers. It’s a topic that keeps coming up — and for good reason.
October 9, 2025 at 10:40 AM
✨ Research assessment needs a rethink — and it finally feels like change might be possible.
At protocols.io (@protocolsio.bsky.social) and in my past life as a journal editor, I’ve had countless conversations about how we evaluate researchers. It’s a topic that keeps coming up — and for good reason.
At protocols.io (@protocolsio.bsky.social) and in my past life as a journal editor, I’ve had countless conversations about how we evaluate researchers. It’s a topic that keeps coming up — and for good reason.
Reposted by Lenny Teytelman
Explore our new featured protocols protocols.io/welcome
Bring structure to your research - protocols.io
A secure platform for developing and sharing reproducible methods.
protocols.io
October 6, 2025 at 6:31 PM
Explore our new featured protocols protocols.io/welcome
Reposted by Lenny Teytelman
In which I look at animal research for The New York Times and find some surprising answers.
Opinion | Can Trump End This Impossibly Cruel Practice?
www.nytimes.com
October 8, 2025 at 11:46 AM
In which I look at animal research for The New York Times and find some surprising answers.
Reposted by Lenny Teytelman
Listening to #WhatTheRef podcast on the train en route to Birmingham for The Festival of Hidden Ref tomorrow and Weds, perfect listening material, thanks @hiddenref.bsky.social,
I'm giving a lightning talk on Thurs - very much looking forward to this event :)
I'm giving a lightning talk on Thurs - very much looking forward to this event :)
October 6, 2025 at 11:55 AM
Listening to #WhatTheRef podcast on the train en route to Birmingham for The Festival of Hidden Ref tomorrow and Weds, perfect listening material, thanks @hiddenref.bsky.social,
I'm giving a lightning talk on Thurs - very much looking forward to this event :)
I'm giving a lightning talk on Thurs - very much looking forward to this event :)
I've been dreaming about this for a decade and it's now live!
"Global Collaboration Made Easier: Multilingual Protocols Now Available on protocols.io"
www.protocols.io/blog/global-...
"Global Collaboration Made Easier: Multilingual Protocols Now Available on protocols.io"
www.protocols.io/blog/global-...
Global Collaboration Made Easier: Multilingual Protocols Now Available on protocols.io
Research is a global endeavour, yet the expectation to communicate in English often creates barriers and an additional burden for non-native speakers. At the lab bench or in t...
www.protocols.io
October 2, 2025 at 6:45 PM
I've been dreaming about this for a decade and it's now live!
"Global Collaboration Made Easier: Multilingual Protocols Now Available on protocols.io"
www.protocols.io/blog/global-...
"Global Collaboration Made Easier: Multilingual Protocols Now Available on protocols.io"
www.protocols.io/blog/global-...
Reposted by Lenny Teytelman
Copy our protocols!
📝 Find many of our lab protocols and techniques on @protocolsio.bsky.social at www.protocols.io/search?q=%22...
🎥 Go deeper with recorded video tutorials of some of our most requested methods: alleninstitute.org/education/sc...
#OpenScienceWeek
📝 Find many of our lab protocols and techniques on @protocolsio.bsky.social at www.protocols.io/search?q=%22...
🎥 Go deeper with recorded video tutorials of some of our most requested methods: alleninstitute.org/education/sc...
#OpenScienceWeek
September 17, 2025 at 10:02 PM
Copy our protocols!
📝 Find many of our lab protocols and techniques on @protocolsio.bsky.social at www.protocols.io/search?q=%22...
🎥 Go deeper with recorded video tutorials of some of our most requested methods: alleninstitute.org/education/sc...
#OpenScienceWeek
📝 Find many of our lab protocols and techniques on @protocolsio.bsky.social at www.protocols.io/search?q=%22...
🎥 Go deeper with recorded video tutorials of some of our most requested methods: alleninstitute.org/education/sc...
#OpenScienceWeek
Reposted by Lenny Teytelman
We published a detailed protocol for our Plate-CUT&Tag method on @protocolsio.bsky.social to accompany our recent preprint (www.biorxiv.org/content/10.1...) give it a try! Feedback welcome! dx.doi.org/10.17504/protocols.io.n2bvjed5wgk5/v1
Plate CUT&Tag (Meers Lab version)
This protocol describes a method for carrying out CUT&Tag-Direct in 96 well microplates for high-throughput processing of samples by a single operator with only standard lab...
dx.doi.org
September 22, 2025 at 5:45 PM
We published a detailed protocol for our Plate-CUT&Tag method on @protocolsio.bsky.social to accompany our recent preprint (www.biorxiv.org/content/10.1...) give it a try! Feedback welcome! dx.doi.org/10.17504/protocols.io.n2bvjed5wgk5/v1
Reposted by Lenny Teytelman
Why hasn't Preprint Peer Review caught on more?
I discovered a small, but simple reason - authors are missing out on the JOY of getting feedback because they aren't notified when feedback occurs.
more in thread below!
I discovered a small, but simple reason - authors are missing out on the JOY of getting feedback because they aren't notified when feedback occurs.
more in thread below!
September 8, 2025 at 3:59 PM
Why hasn't Preprint Peer Review caught on more?
I discovered a small, but simple reason - authors are missing out on the JOY of getting feedback because they aren't notified when feedback occurs.
more in thread below!
I discovered a small, but simple reason - authors are missing out on the JOY of getting feedback because they aren't notified when feedback occurs.
more in thread below!
Reposted by Lenny Teytelman
We're hiring at protocols.io (@protocolsio.bsky.social) in NY or Jersey City - Associate Scientific Engagement Manager
See LinkedIn post for more info & feel free to message me: www.linkedin.com/posts/eganle...
See LinkedIn post for more info & feel free to message me: www.linkedin.com/posts/eganle...
August 14, 2025 at 10:09 AM
We're hiring at protocols.io (@protocolsio.bsky.social) in NY or Jersey City - Associate Scientific Engagement Manager
See LinkedIn post for more info & feel free to message me: www.linkedin.com/posts/eganle...
See LinkedIn post for more info & feel free to message me: www.linkedin.com/posts/eganle...
Reposted by Lenny Teytelman
"proliferation of LLMs has prompted many people without experience to start creating [screening] tools...Simpler approaches often perform better [and] LLM results may not be reproducible...The fact that you can use an LLM doesn’t mean that you should." www.arxiv.org/abs/2507.17991
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Use as Directed? A Comparison of Software Tools Intended to Check Rigor and Transparency of Published Work
The causes of the reproducibility crisis include lack of standardization and transparency in scientific reporting. Checklists such as ARRIVE and CONSORT seek to improve transparency, but they are not ...
www.arxiv.org
August 11, 2025 at 5:35 PM
"proliferation of LLMs has prompted many people without experience to start creating [screening] tools...Simpler approaches often perform better [and] LLM results may not be reproducible...The fact that you can use an LLM doesn’t mean that you should." www.arxiv.org/abs/2507.17991
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•
Reposted by Lenny Teytelman
We just published: Why you should sequence your plasmids (and how to do it for free)
Through @GetGenome scientists in 100 countries can access free whole-plasmid sequencing —giving researchers the confidence to move their experiments forward.
medium.com/p/why-you-sh...
Through @GetGenome scientists in 100 countries can access free whole-plasmid sequencing —giving researchers the confidence to move their experiments forward.
medium.com/p/why-you-sh...
Why you should sequence your plasmids (and how to do it for free)
Through GetGenome, scientists in 100 countries can access free whole-plasmid sequencing — removing barriers, improving quality control…
medium.com
August 11, 2025 at 12:14 PM
We just published: Why you should sequence your plasmids (and how to do it for free)
Through @GetGenome scientists in 100 countries can access free whole-plasmid sequencing —giving researchers the confidence to move their experiments forward.
medium.com/p/why-you-sh...
Through @GetGenome scientists in 100 countries can access free whole-plasmid sequencing —giving researchers the confidence to move their experiments forward.
medium.com/p/why-you-sh...
There's no evidence that opossums eat any ticks, but it's a common myth (www.sciencedirect.com/science/arti...).
I asked ChatGPT & Copilot, "Do opossums eat ticks?"
Both confidently: "yes, thousands per week!". I then prompted, "Isn't it a myth?" And both answered: "yes, it's been debunked!"
I asked ChatGPT & Copilot, "Do opossums eat ticks?"
Both confidently: "yes, thousands per week!". I then prompted, "Isn't it a myth?" And both answered: "yes, it's been debunked!"
August 6, 2025 at 10:36 PM
There's no evidence that opossums eat any ticks, but it's a common myth (www.sciencedirect.com/science/arti...).
I asked ChatGPT & Copilot, "Do opossums eat ticks?"
Both confidently: "yes, thousands per week!". I then prompted, "Isn't it a myth?" And both answered: "yes, it's been debunked!"
I asked ChatGPT & Copilot, "Do opossums eat ticks?"
Both confidently: "yes, thousands per week!". I then prompted, "Isn't it a myth?" And both answered: "yes, it's been debunked!"
Reposted by Lenny Teytelman
Protocols @nmrfam.bsky.social Alex Paterson, Network for Advanced NMR Materials (NAN) Solid-State NMR Data Acquisition Protocols V.2 www.protocols.io/view/network... #NMRchat #NMR 🧲
Network for Advanced NMR Materials SSNMR Data Acquisition Protocols
The NAN Materials SSNMR Data Acquisition Protocols collection is part of the NAN Materials SSNMR Knowledgebase; a collection of resources, training and educational material, pul...
www.protocols.io
July 31, 2025 at 5:18 PM
Protocols @nmrfam.bsky.social Alex Paterson, Network for Advanced NMR Materials (NAN) Solid-State NMR Data Acquisition Protocols V.2 www.protocols.io/view/network... #NMRchat #NMR 🧲
Reposted by Lenny Teytelman
How do we correct preprints? Caveat emptor, revisions & withdrawals - what this means for the scientific record. My presentation to the National Academies 1/n vimeo.com/1102568612?s...
Day 2-Corrections and Retractions: Upgrading the Scientific Record
This is "Day 2-Corrections and Retractions: Upgrading the Scientific Record" by The National Academies on Vimeo, the home for high quality videos and the…
vimeo.com
August 1, 2025 at 3:11 PM
How do we correct preprints? Caveat emptor, revisions & withdrawals - what this means for the scientific record. My presentation to the National Academies 1/n vimeo.com/1102568612?s...
So, Elon Musk, a Silicon Valley technocrat, created DOGE with the supposed goal of increased government efficiency.
But what we got instead is an extra government entity that has inserted senseless chaos and waste and worsened the existing bureaucracy?
But what we got instead is an extra government entity that has inserted senseless chaos and waste and worsened the existing bureaucracy?
July 30, 2025 at 4:46 PM
So, Elon Musk, a Silicon Valley technocrat, created DOGE with the supposed goal of increased government efficiency.
But what we got instead is an extra government entity that has inserted senseless chaos and waste and worsened the existing bureaucracy?
But what we got instead is an extra government entity that has inserted senseless chaos and waste and worsened the existing bureaucracy?
Reposted by Lenny Teytelman
Author here to answer any questions. The full protocol is online at protocols.io and all codebooks on github
Bring structure to your research - protocols.io
A secure platform for developing and sharing reproducible methods.
protocols.io
July 29, 2025 at 7:48 PM
Author here to answer any questions. The full protocol is online at protocols.io and all codebooks on github
Reposted by Lenny Teytelman
The U.S. has led the world in science since the mid-20th century for two reasons: funding & welcoming students and researchers from around the world. The Trump administration is destroying both advantages (1/2)
Science is the most international endeavor in human history.
This flagrantly racist administration is destroying the U.S.'s lucrative and life-saving leadership. www.thetransmitter.org/policy/what-... on @thetransmitter.bsky.social
This flagrantly racist administration is destroying the U.S.'s lucrative and life-saving leadership. www.thetransmitter.org/policy/what-... on @thetransmitter.bsky.social
What U.S. science stands to lose without international graduate students and postdoctoral researchers
Neuroscience in other countries will strengthen—at the United States’ expense—as rising visa restrictions and rejections block many international students from enrolling at U.S.
www.thetransmitter.org
July 28, 2025 at 5:52 PM
The U.S. has led the world in science since the mid-20th century for two reasons: funding & welcoming students and researchers from around the world. The Trump administration is destroying both advantages (1/2)
Reposted by Lenny Teytelman
Comparative Analysis of Phage Profiles in Environmental Samples: Metagenomic Sequencing Versus Culture-Based Isolation www.protocols.io/view/compara...
Comparative Analysis of Phage Profiles in Environmental Samples: Metagenomic Sequencing Versus Culture-Bas...
Culture-based isolation of bacteriophages from wastewater relies on a limited set of laboratory‐cultivable host strains, causing it to recover only a small fraction of the tru...
www.protocols.io
July 22, 2025 at 6:26 PM
Comparative Analysis of Phage Profiles in Environmental Samples: Metagenomic Sequencing Versus Culture-Based Isolation www.protocols.io/view/compara...
Reposted by Lenny Teytelman
Happy to answer any and all questions about this work. We'd love to see more people try it.
Full protocol: www.protocols.io/view/craftse...
Full analysis: github.com/immunogenomi...
Full protocol: www.protocols.io/view/craftse...
Full analysis: github.com/immunogenomi...
CRAFTseq
Genetic studies have identified thousands of individual disease-associated non-coding alleles, but identification of the causal alleles and their functions remain critical bottl...
www.protocols.io
July 23, 2025 at 3:22 PM
Happy to answer any and all questions about this work. We'd love to see more people try it.
Full protocol: www.protocols.io/view/craftse...
Full analysis: github.com/immunogenomi...
Full protocol: www.protocols.io/view/craftse...
Full analysis: github.com/immunogenomi...
Reposted by Lenny Teytelman
Load gels? Use #zebrafish 🐟? Want to do more sustainable research w/out compromising science? We-G Gestri, K Turner, G Powell @stevewilsonlab.bsky.social-made these protocols. Yes, we use these in our @science.org+@nature.com papers.
www.protocols.io/view/re-usin...
www.protocols.io/view/washing...
www.protocols.io/view/re-usin...
www.protocols.io/view/washing...
Re-using pipette tips for gel loading
Gel loading tips can be reused for most applications; there’s REALLY no need to throw them away after a single use. In
our labs, we routinely reuse tips when loading gels, onl...
www.protocols.io
July 22, 2025 at 4:02 PM
Load gels? Use #zebrafish 🐟? Want to do more sustainable research w/out compromising science? We-G Gestri, K Turner, G Powell @stevewilsonlab.bsky.social-made these protocols. Yes, we use these in our @science.org+@nature.com papers.
www.protocols.io/view/re-usin...
www.protocols.io/view/washing...
www.protocols.io/view/re-usin...
www.protocols.io/view/washing...