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In a recent study in cell lines, Omachi et al demonstrate that engineered anticodon-edited tRNAs promote translational readthrough of COL4A5 premature stop codons, offering a potential strategy to restore full-length type IV collagen in Alport syndrome.
Anticodon-edited tRNA enables translational readthrough of COL4A5 premature termination codons
Alport syndrome is caused by variants in COL4A3, COL4A4, or COL4A5, which encode the α3α4α5 chains of type IV collagen. These variants result in defects in the glomerular basement membrane (GBM) and…
plos.io
December 29, 2025 at 2:01 PM
In a recent study in cell lines, Omachi et al demonstrate that engineered anticodon-edited tRNAs promote translational readthrough of COL4A5 premature stop codons, offering a potential strategy to restore full-length type IV collagen in Alport syndrome.
A new study by Guo et al predicts climate-driven habitat shifts for a desert shrub and its parasitic plant using a dual niche modeling framework that integrates climate and soil suitability layers with interpretable machine-learning.
plos.io/4pazUch
plos.io/4pazUch
Dual niche modeling with GEE and SHAP for predicting habitat shifts of Haloxylon ammodendron and Cistanche deserticola under climate change
Haloxylon ammodendron, a keystone woody species, and its parasitic plant, Cistanche deserticola, play critical roles in sustaining arid ecosystems and supporting regional economies. However, their…
journals.plos.org
December 24, 2025 at 10:00 AM
A new study by Guo et al predicts climate-driven habitat shifts for a desert shrub and its parasitic plant using a dual niche modeling framework that integrates climate and soil suitability layers with interpretable machine-learning.
plos.io/4pazUch
plos.io/4pazUch
Reposted by PLOS One
📢 In a new Editorial, PLOS Climate Section Editors for Adaptation Jeff Birchall and Desiree Rose share their vision for the section and key priorities for the adaptation research community 👇
🔗 journals.plos.org/climate/arti...
🔗 journals.plos.org/climate/arti...
December 23, 2025 at 11:00 AM
📢 In a new Editorial, PLOS Climate Section Editors for Adaptation Jeff Birchall and Desiree Rose share their vision for the section and key priorities for the adaptation research community 👇
🔗 journals.plos.org/climate/arti...
🔗 journals.plos.org/climate/arti...
A new study by Nicole Pauli and colleagues finds that while Old World camelids follow expected long-day breeding patterns, South American camelids show a surprising short-day seasonality, possibly a result of climatic conditions and vegetational growth patterns.
journals.plos.org/plosone/arti...
journals.plos.org/plosone/arti...
Breeding seasonality of Tylopoda: Expected patterns in Old World camelids but an exceptional pattern in South American camelids
Seasonal breeding is a common adaptation among mammals in seasonal environments, ensuring offspring is born under favourable conditions. As only conception can be controlled but not birth itself, a pr...
journals.plos.org
December 23, 2025 at 1:43 PM
A new study by Nicole Pauli and colleagues finds that while Old World camelids follow expected long-day breeding patterns, South American camelids show a surprising short-day seasonality, possibly a result of climatic conditions and vegetational growth patterns.
journals.plos.org/plosone/arti...
journals.plos.org/plosone/arti...
A study by @auersperga.bsky.social and colleagues shows that Goffin’s cockatoos do not perform better than chance in a conditional discrimination task, in line with a similar previous study of chimpanzees, and contrary to earlier suggestions that cockatoos might perform better.
Testing weight-based conditional discrimination in Goffin’s cockatoos, Cacatua goffiniana
Discrimination learning tasks are a method for investigating species’ perception of and associative learning with a particular stimulus. Goffin’s cockatoos previously required surprisingly few trials…
plos.io
December 23, 2025 at 10:30 AM
A study by @auersperga.bsky.social and colleagues shows that Goffin’s cockatoos do not perform better than chance in a conditional discrimination task, in line with a similar previous study of chimpanzees, and contrary to earlier suggestions that cockatoos might perform better.
Reposted by PLOS One
A new study from Rashedul Hoque and colleagues shows distinct electrical signatures of clinically-derived primary cervical epithelial cells vs HeLa cells, providing a “fingerprint” to discriminate healthy and malignant cells in a label-free, rapid manner.
plos.io/4pZRJfh
plos.io/4pZRJfh
Electrophysiological fingerprints of healthy cervical epithelial and HeLa cells: Membrane potential, zeta potential and passive electrical properties
There is a growing appreciation that cellular electrical mechanisms play an important role both in cell regulation, and in cell dysregulation in diseases such as cancer. These electrical mechanisms…
journals.plos.org
December 22, 2025 at 12:01 PM
A new study from Rashedul Hoque and colleagues shows distinct electrical signatures of clinically-derived primary cervical epithelial cells vs HeLa cells, providing a “fingerprint” to discriminate healthy and malignant cells in a label-free, rapid manner.
plos.io/4pZRJfh
plos.io/4pZRJfh
Reposted by PLOS One
Nice to see this out! Open access @plosone.org journals.plos.org/plosone/arti...
Treating a friend to voter registration in a Divided America
As partisanship strengthens in the United States, unaffiliated voter registration is also increasing. We conducted an original survey experiment to understand voter registration choices among register...
journals.plos.org
December 22, 2025 at 3:42 PM
Nice to see this out! Open access @plosone.org journals.plos.org/plosone/arti...
Reposted by PLOS One
Mahtab Dastpak, @camimoso.bsky.social, @adelmanlab.bsky.social and colleagues report that a SF3B1 mutation in human embryonic stem cells alters splicing and dysregulates immune-related gene expression, providing new insights into the role of SF3B1 in haematologic malignancies.
SF3B1K700E mutation in human embryonic stem cells causes aberrant expression of immune-related genes
SF3B1, a component of the U2 snRNP pre-mRNA splicing factor, plays a critical role in splicing and is frequently mutated in cancer, particularly hematologic malignancies. We investigated the effects…
plos.io
December 19, 2025 at 3:01 PM
Mahtab Dastpak, @camimoso.bsky.social, @adelmanlab.bsky.social and colleagues report that a SF3B1 mutation in human embryonic stem cells alters splicing and dysregulates immune-related gene expression, providing new insights into the role of SF3B1 in haematologic malignancies.
Reposted by PLOS One
Obley et al show that grading hatchery steelhead by size before rearing significantly reduces size variance and may limit unintended domestication selection, which can cause hatchery fish to produce fewer surviving adult offspring when they spawn in the wild.
journals.plos.org/plosone/arti...
journals.plos.org/plosone/arti...
Grading by size to reduce the opportunity for domestication selection in hatchery-reared steelhead (Oncorhynchus mykiss)
Fish that are produced in hatcheries often produce fewer surviving adult offspring than do wild fish when both spawn in the wild. This difference in fitness is likely due to inadvertent selection for ...
journals.plos.org
December 18, 2025 at 3:06 PM
Obley et al show that grading hatchery steelhead by size before rearing significantly reduces size variance and may limit unintended domestication selection, which can cause hatchery fish to produce fewer surviving adult offspring when they spawn in the wild.
journals.plos.org/plosone/arti...
journals.plos.org/plosone/arti...
A new study from Rashedul Hoque and colleagues shows distinct electrical signatures of clinically-derived primary cervical epithelial cells vs HeLa cells, providing a “fingerprint” to discriminate healthy and malignant cells in a label-free, rapid manner.
plos.io/4pZRJfh
plos.io/4pZRJfh
Electrophysiological fingerprints of healthy cervical epithelial and HeLa cells: Membrane potential, zeta potential and passive electrical properties
There is a growing appreciation that cellular electrical mechanisms play an important role both in cell regulation, and in cell dysregulation in diseases such as cancer. These electrical mechanisms…
journals.plos.org
December 22, 2025 at 12:01 PM
A new study from Rashedul Hoque and colleagues shows distinct electrical signatures of clinically-derived primary cervical epithelial cells vs HeLa cells, providing a “fingerprint” to discriminate healthy and malignant cells in a label-free, rapid manner.
plos.io/4pZRJfh
plos.io/4pZRJfh
Reposted by PLOS One
A study by @tastrobiologist.bsky.social and Charles Cockell uses high-pressure differential scanning calorimetry to show that bacterial cells in subzero high-pressure environments can remain liquidous, and potentially metabolically active, and not merely vitrified and preserved.
plos.io/3Y3QGP6
plos.io/3Y3QGP6
High pressures depress the onset of intracellular vitrification
The low temperature limit for life remains elusive and poorly understood. This ignorance is further compounded when applied to life in multi-extreme environments where low temperatures combine with…
doi.org
December 19, 2025 at 11:34 AM
A study by @tastrobiologist.bsky.social and Charles Cockell uses high-pressure differential scanning calorimetry to show that bacterial cells in subzero high-pressure environments can remain liquidous, and potentially metabolically active, and not merely vitrified and preserved.
plos.io/3Y3QGP6
plos.io/3Y3QGP6
Mahtab Dastpak, @camimoso.bsky.social, @adelmanlab.bsky.social and colleagues report that a SF3B1 mutation in human embryonic stem cells alters splicing and dysregulates immune-related gene expression, providing new insights into the role of SF3B1 in haematologic malignancies.
SF3B1K700E mutation in human embryonic stem cells causes aberrant expression of immune-related genes
SF3B1, a component of the U2 snRNP pre-mRNA splicing factor, plays a critical role in splicing and is frequently mutated in cancer, particularly hematologic malignancies. We investigated the effects…
plos.io
December 19, 2025 at 3:01 PM
Mahtab Dastpak, @camimoso.bsky.social, @adelmanlab.bsky.social and colleagues report that a SF3B1 mutation in human embryonic stem cells alters splicing and dysregulates immune-related gene expression, providing new insights into the role of SF3B1 in haematologic malignancies.
Reposted by PLOS One
Happy to share my latest paper in @plosone.org, we looked at how high presssures affect the intracellular vitrification (Tg') of microbial cells and how this informs our understanding of the habitability of multi-extreme environments.
journals.plos.org/plosone/arti...
#astrobiology #cryobiology
journals.plos.org/plosone/arti...
#astrobiology #cryobiology
High pressures depress the onset of intracellular vitrification
The low temperature limit for life remains elusive and poorly understood. This ignorance is further compounded when applied to life in multi-extreme environments where low temperatures combine with fa...
journals.plos.org
December 19, 2025 at 11:36 AM
Happy to share my latest paper in @plosone.org, we looked at how high presssures affect the intracellular vitrification (Tg') of microbial cells and how this informs our understanding of the habitability of multi-extreme environments.
journals.plos.org/plosone/arti...
#astrobiology #cryobiology
journals.plos.org/plosone/arti...
#astrobiology #cryobiology
A study by @tastrobiologist.bsky.social and Charles Cockell uses high-pressure differential scanning calorimetry to show that bacterial cells in subzero high-pressure environments can remain liquidous, and potentially metabolically active, and not merely vitrified and preserved.
plos.io/3Y3QGP6
plos.io/3Y3QGP6
High pressures depress the onset of intracellular vitrification
The low temperature limit for life remains elusive and poorly understood. This ignorance is further compounded when applied to life in multi-extreme environments where low temperatures combine with…
doi.org
December 19, 2025 at 11:34 AM
A study by @tastrobiologist.bsky.social and Charles Cockell uses high-pressure differential scanning calorimetry to show that bacterial cells in subzero high-pressure environments can remain liquidous, and potentially metabolically active, and not merely vitrified and preserved.
plos.io/3Y3QGP6
plos.io/3Y3QGP6
Reposted by PLOS One
Jennings et al identify 54 genes involved in E. coli carbonate mineral precipitation. This knowledge could increase the volume of CO2 fixed using this pathway and yield products to replace CO2 intensive products, such as precipitated calcium carbonates for industry.
journals.plos.org/plosone/arti...
journals.plos.org/plosone/arti...
The diversity of cellular systems involved in carbonate precipitation by Escherichia coli
Climate change is increasing the need to limit levels of anthropogenic CO2 released into the atmosphere. One approach being investigated is to generate products based on microbially induced carbonate ...
journals.plos.org
December 18, 2025 at 1:36 PM
Jennings et al identify 54 genes involved in E. coli carbonate mineral precipitation. This knowledge could increase the volume of CO2 fixed using this pathway and yield products to replace CO2 intensive products, such as precipitated calcium carbonates for industry.
journals.plos.org/plosone/arti...
journals.plos.org/plosone/arti...
Reposted by PLOS One
“The only way an organization from the Global North can really make an impact and to be inclusive is to collaborate.”
Read key takeaways from our event with TCC Africa in Nairobi, exploring new models for open science: plos.io/48QqFrm
#OpenScience #OpenInfrastructure
Read key takeaways from our event with TCC Africa in Nairobi, exploring new models for open science: plos.io/48QqFrm
#OpenScience #OpenInfrastructure
Understanding needs and opportunities for open science in Africa and LMICs
Explore how PLOS is working with regional partners to advance open science in Africa and LMICs through local collaboration and inclusive publishing models.
plos.io
December 18, 2025 at 5:06 PM
“The only way an organization from the Global North can really make an impact and to be inclusive is to collaborate.”
Read key takeaways from our event with TCC Africa in Nairobi, exploring new models for open science: plos.io/48QqFrm
#OpenScience #OpenInfrastructure
Read key takeaways from our event with TCC Africa in Nairobi, exploring new models for open science: plos.io/48QqFrm
#OpenScience #OpenInfrastructure
Reposted by PLOS One
Some thoughts from Executive Editor @juliarobinson.bsky.social on the past year of Front Matter (Reviews, Essays, and Opinion articles) in PLOS Global Public Health.
speakingofmedicine.plos.org/2025/12/18/r...
speakingofmedicine.plos.org/2025/12/18/r...
December 18, 2025 at 8:58 PM
Some thoughts from Executive Editor @juliarobinson.bsky.social on the past year of Front Matter (Reviews, Essays, and Opinion articles) in PLOS Global Public Health.
speakingofmedicine.plos.org/2025/12/18/r...
speakingofmedicine.plos.org/2025/12/18/r...
Reposted by PLOS One
2025 was marked by upheaval and uncertainty for many within the life science community. In this Editorial, we reflect on the past year and highlight some of the many research achievements that give us reasons to be thankful.
🧪 #AcademicSky #biology #EOY #science #roundup
plos.io/4j5T3uh
🧪 #AcademicSky #biology #EOY #science #roundup
plos.io/4j5T3uh
December 19, 2025 at 10:13 AM
2025 was marked by upheaval and uncertainty for many within the life science community. In this Editorial, we reflect on the past year and highlight some of the many research achievements that give us reasons to be thankful.
🧪 #AcademicSky #biology #EOY #science #roundup
plos.io/4j5T3uh
🧪 #AcademicSky #biology #EOY #science #roundup
plos.io/4j5T3uh
Obley et al show that grading hatchery steelhead by size before rearing significantly reduces size variance and may limit unintended domestication selection, which can cause hatchery fish to produce fewer surviving adult offspring when they spawn in the wild.
journals.plos.org/plosone/arti...
journals.plos.org/plosone/arti...
Grading by size to reduce the opportunity for domestication selection in hatchery-reared steelhead (Oncorhynchus mykiss)
Fish that are produced in hatcheries often produce fewer surviving adult offspring than do wild fish when both spawn in the wild. This difference in fitness is likely due to inadvertent selection for ...
journals.plos.org
December 18, 2025 at 3:06 PM
Obley et al show that grading hatchery steelhead by size before rearing significantly reduces size variance and may limit unintended domestication selection, which can cause hatchery fish to produce fewer surviving adult offspring when they spawn in the wild.
journals.plos.org/plosone/arti...
journals.plos.org/plosone/arti...
Reposted by PLOS One
Are authors fairly judged by assessing the #journals in which their work is published? @bihutchins.bsky.social &co reveal that most influential papers are published in lower tier journals, and more authors would be better recognized with #ArticleLevelMetrics #ALMs @plosbiology.org 🧪 plos.io/4oV58Ed
December 18, 2025 at 9:01 AM
Are authors fairly judged by assessing the #journals in which their work is published? @bihutchins.bsky.social &co reveal that most influential papers are published in lower tier journals, and more authors would be better recognized with #ArticleLevelMetrics #ALMs @plosbiology.org 🧪 plos.io/4oV58Ed
Jennings et al identify 54 genes involved in E. coli carbonate mineral precipitation. This knowledge could increase the volume of CO2 fixed using this pathway and yield products to replace CO2 intensive products, such as precipitated calcium carbonates for industry.
journals.plos.org/plosone/arti...
journals.plos.org/plosone/arti...
The diversity of cellular systems involved in carbonate precipitation by Escherichia coli
Climate change is increasing the need to limit levels of anthropogenic CO2 released into the atmosphere. One approach being investigated is to generate products based on microbially induced carbonate ...
journals.plos.org
December 18, 2025 at 1:36 PM
Jennings et al identify 54 genes involved in E. coli carbonate mineral precipitation. This knowledge could increase the volume of CO2 fixed using this pathway and yield products to replace CO2 intensive products, such as precipitated calcium carbonates for industry.
journals.plos.org/plosone/arti...
journals.plos.org/plosone/arti...
Reposted by PLOS One
A new study by Anne-Fleur Griffon and colleagues presents an optimized qRT-PCR-based competition assay that quantifies differential replicative fitness among dengue virus serotypes in vitro, aiding comparative viral fitness research.
plos.io/48J0G6D
plos.io/48J0G6D
Development of a competition assay to assess the in vitro fitness of dengue virus serotypes using an optimized serotype-specific qRT-PCR
Background Comparing the in vitro fitness of dengue virus (DENV) isolates is a pivotal approach to assess the contribution of DENV strains’ replicative fitness to epidemiological contexts, including…
journals.plos.org
December 17, 2025 at 3:21 PM
A new study by Anne-Fleur Griffon and colleagues presents an optimized qRT-PCR-based competition assay that quantifies differential replicative fitness among dengue virus serotypes in vitro, aiding comparative viral fitness research.
plos.io/48J0G6D
plos.io/48J0G6D
Reposted by PLOS One
A new study by Hens et al reports generation of floxed Gabbr2 mice that, when bred with mice expressing Cre-recombinase, mirror global GABBR2 loss and show neurological deficits, providing a tool for studying cell type-specific loss of GABBR2 function in the brain and other organs.
plos.io/4iYVIpA
plos.io/4iYVIpA
Development of a floxed Gabbr2 gene allows for widespread conditional disruption of GABBR2 and recapitulates the phenotype of germline Gabbr2 knockout mice
GABBR1 and GABBR2 are widely expressed in the brain and genetic inhibition of their function leads to neurologic dysfunction and premature death in mice. Given that GABBR1 and GABBR2 heterodimerize…
journals.plos.org
December 17, 2025 at 4:03 PM
A new study by Hens et al reports generation of floxed Gabbr2 mice that, when bred with mice expressing Cre-recombinase, mirror global GABBR2 loss and show neurological deficits, providing a tool for studying cell type-specific loss of GABBR2 function in the brain and other organs.
plos.io/4iYVIpA
plos.io/4iYVIpA
A new study by Hens et al reports generation of floxed Gabbr2 mice that, when bred with mice expressing Cre-recombinase, mirror global GABBR2 loss and show neurological deficits, providing a tool for studying cell type-specific loss of GABBR2 function in the brain and other organs.
plos.io/4iYVIpA
plos.io/4iYVIpA
Development of a floxed Gabbr2 gene allows for widespread conditional disruption of GABBR2 and recapitulates the phenotype of germline Gabbr2 knockout mice
GABBR1 and GABBR2 are widely expressed in the brain and genetic inhibition of their function leads to neurologic dysfunction and premature death in mice. Given that GABBR1 and GABBR2 heterodimerize…
journals.plos.org
December 17, 2025 at 4:03 PM
A new study by Hens et al reports generation of floxed Gabbr2 mice that, when bred with mice expressing Cre-recombinase, mirror global GABBR2 loss and show neurological deficits, providing a tool for studying cell type-specific loss of GABBR2 function in the brain and other organs.
plos.io/4iYVIpA
plos.io/4iYVIpA
A new study by Anne-Fleur Griffon and colleagues presents an optimized qRT-PCR-based competition assay that quantifies differential replicative fitness among dengue virus serotypes in vitro, aiding comparative viral fitness research.
plos.io/48J0G6D
plos.io/48J0G6D
Development of a competition assay to assess the in vitro fitness of dengue virus serotypes using an optimized serotype-specific qRT-PCR
Background Comparing the in vitro fitness of dengue virus (DENV) isolates is a pivotal approach to assess the contribution of DENV strains’ replicative fitness to epidemiological contexts, including…
journals.plos.org
December 17, 2025 at 3:21 PM
A new study by Anne-Fleur Griffon and colleagues presents an optimized qRT-PCR-based competition assay that quantifies differential replicative fitness among dengue virus serotypes in vitro, aiding comparative viral fitness research.
plos.io/48J0G6D
plos.io/48J0G6D