Haley Lab
@labohaley.bsky.social
We develop and apply advanced genetic manipulation technologies to make sense of biological complexity. Formerly @Genentech now @umontreal.ca. More about our lab and research here: labohaley.com
Pinned
Now in @natcomms.nature.com! Expanded well beyond the preprint, w/new experiments in iPSCs, kinetic analysis at the DNA & protein levels, & more. Kudos to the team (esp. Rajini Srinivasan, Tao Sun, and Andrew Ng) & the editor + reviewers for strengthening this work!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Haley Lab
McGill is recruiting top-tier researchers working abroad through the federally funded Canada Impact+ Research Chairs program, addressing global and national challenges. The first round is due in early 2026.
Learn more and submit your candidacy: https://mcgill.ca/x/5Zh
Learn more and submit your candidacy: https://mcgill.ca/x/5Zh
December 18, 2025 at 9:02 PM
McGill is recruiting top-tier researchers working abroad through the federally funded Canada Impact+ Research Chairs program, addressing global and national challenges. The first round is due in early 2026.
Learn more and submit your candidacy: https://mcgill.ca/x/5Zh
Learn more and submit your candidacy: https://mcgill.ca/x/5Zh
Reposted by Haley Lab
📢 NEW exciting opportunity!
Join Queen’s University as a tenure-track Assistant Professor in Cell Engineering and Biomanufacturing, with opportunities for interdisciplinary research across #ChemicalEngineering and #Biomedical and #MolecularSciences. 🔬
🔗 stemcellnetwork.ca/career-oppor...
Join Queen’s University as a tenure-track Assistant Professor in Cell Engineering and Biomanufacturing, with opportunities for interdisciplinary research across #ChemicalEngineering and #Biomedical and #MolecularSciences. 🔬
🔗 stemcellnetwork.ca/career-oppor...
December 17, 2025 at 7:16 PM
📢 NEW exciting opportunity!
Join Queen’s University as a tenure-track Assistant Professor in Cell Engineering and Biomanufacturing, with opportunities for interdisciplinary research across #ChemicalEngineering and #Biomedical and #MolecularSciences. 🔬
🔗 stemcellnetwork.ca/career-oppor...
Join Queen’s University as a tenure-track Assistant Professor in Cell Engineering and Biomanufacturing, with opportunities for interdisciplinary research across #ChemicalEngineering and #Biomedical and #MolecularSciences. 🔬
🔗 stemcellnetwork.ca/career-oppor...
Reposted by Haley Lab
Delivery of DLL1+FLT3L+IL-7 mRNA to hepatocytes boosted thymopoiesis to rejuvenate aged T cells & enhance DC abundance/function to restore immune function @nature.com @hhmi-science.bsky.social @broadinstitute.org @zhangf.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/d41...
www.nature.com/articles/s41...
www.nature.com/articles/d41...
December 17, 2025 at 5:29 PM
Delivery of DLL1+FLT3L+IL-7 mRNA to hepatocytes boosted thymopoiesis to rejuvenate aged T cells & enhance DC abundance/function to restore immune function @nature.com @hhmi-science.bsky.social @broadinstitute.org @zhangf.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/d41...
www.nature.com/articles/s41...
www.nature.com/articles/d41...
Now in @natcomms.nature.com! Expanded well beyond the preprint, w/new experiments in iPSCs, kinetic analysis at the DNA & protein levels, & more. Kudos to the team (esp. Rajini Srinivasan, Tao Sun, and Andrew Ng) & the editor + reviewers for strengthening this work!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
December 15, 2025 at 2:40 PM
Now in @natcomms.nature.com! Expanded well beyond the preprint, w/new experiments in iPSCs, kinetic analysis at the DNA & protein levels, & more. Kudos to the team (esp. Rajini Srinivasan, Tao Sun, and Andrew Ng) & the editor + reviewers for strengthening this work!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Haley Lab
In relapsed or refractory T-cell acute lymphoblastic leukemia, off-the-shelf allogeneic base-edited CAR7 T cells mediated responses in 11 patients, enabling stem-cell transplantation in 9 patients in deep remission. Full study results: nej.md/48wiyQL
#ASH25 | @ash.hematology.org
#ASH25 | @ash.hematology.org
December 8, 2025 at 9:35 PM
In relapsed or refractory T-cell acute lymphoblastic leukemia, off-the-shelf allogeneic base-edited CAR7 T cells mediated responses in 11 patients, enabling stem-cell transplantation in 9 patients in deep remission. Full study results: nej.md/48wiyQL
#ASH25 | @ash.hematology.org
#ASH25 | @ash.hematology.org
Reposted by Haley Lab
Announcing the 2026 edition of the EMBO workshop on RNA localization and local translation! This meeting will be held June 30 - July 4 near Porto, Portugal. Come for exciting updates in the field from both established investigators and trainees. See the link below for details!
December 8, 2025 at 4:40 PM
Announcing the 2026 edition of the EMBO workshop on RNA localization and local translation! This meeting will be held June 30 - July 4 near Porto, Portugal. Come for exciting updates in the field from both established investigators and trainees. See the link below for details!
Reposted by Haley Lab
🧪
@gingraslab.bsky.social
compared 10 enzymes used for proximity biotinylation proteomics experiments. UltraID is the winner.
www.biorxiv.org/content/10.1...
@gingraslab.bsky.social
compared 10 enzymes used for proximity biotinylation proteomics experiments. UltraID is the winner.
www.biorxiv.org/content/10.1...
Benchmarking of proximity-dependent biotinylation enzymes across cellular compartments and time windows
Proximity-dependent biotinylation has become a powerful approach for mapping protein interactions and subcellular organization in living cells. Although a growing number of engineered biotin ligases h...
www.biorxiv.org
November 26, 2025 at 1:31 PM
🧪
@gingraslab.bsky.social
compared 10 enzymes used for proximity biotinylation proteomics experiments. UltraID is the winner.
www.biorxiv.org/content/10.1...
@gingraslab.bsky.social
compared 10 enzymes used for proximity biotinylation proteomics experiments. UltraID is the winner.
www.biorxiv.org/content/10.1...
Grateful to the @src-crs.bsky.social for supporting our project using next-gen cell-based models + functional genomics to map how prostate cancer develops + how drug resistance arises! Many thanks to our collaborators + congrats to fellow awardees! cancerresearchsociety.ca/news/100-new...
100 news Operating Grants - Cancer Research Society
cancerresearchsociety.ca
November 22, 2025 at 5:39 PM
Grateful to the @src-crs.bsky.social for supporting our project using next-gen cell-based models + functional genomics to map how prostate cancer develops + how drug resistance arises! Many thanks to our collaborators + congrats to fellow awardees! cancerresearchsociety.ca/news/100-new...
Reposted by Haley Lab
🔊 Career opportunity: Professor / Associate Professor (Tenure) – Dr. Connie Eaves Chair in Cancer Stem Cell Research!
This position offers a unique opportunity to drive transformative research integrating cutting-edge technologies to improve patient outcomes. 🔬
🔗 stemcellnetwork.ca/wp-content/u...
This position offers a unique opportunity to drive transformative research integrating cutting-edge technologies to improve patient outcomes. 🔬
🔗 stemcellnetwork.ca/wp-content/u...
November 20, 2025 at 1:11 PM
🔊 Career opportunity: Professor / Associate Professor (Tenure) – Dr. Connie Eaves Chair in Cancer Stem Cell Research!
This position offers a unique opportunity to drive transformative research integrating cutting-edge technologies to improve patient outcomes. 🔬
🔗 stemcellnetwork.ca/wp-content/u...
This position offers a unique opportunity to drive transformative research integrating cutting-edge technologies to improve patient outcomes. 🔬
🔗 stemcellnetwork.ca/wp-content/u...
Reposted by Haley Lab
Influenza remains an important cause of illness and death. In a phase 3 trial, a nucleoside-modified mRNA (modRNA) quadrivalent vaccine was found to be superior to a standard quadrivalent vaccine in preventing influenza illness. Full trial results: nej.md/43udoTG
#MedSky #IDSky
#MedSky #IDSky
November 19, 2025 at 10:40 PM
Influenza remains an important cause of illness and death. In a phase 3 trial, a nucleoside-modified mRNA (modRNA) quadrivalent vaccine was found to be superior to a standard quadrivalent vaccine in preventing influenza illness. Full trial results: nej.md/43udoTG
#MedSky #IDSky
#MedSky #IDSky
Reposted by Haley Lab
Our new preprint is online! Viruses, bacteria and parasites use effector proteins to evade immunity and rewire host cell pathways. Together with @AlexanderStark8, we wondered if we could systematically map what these effectors, regardless of their origin, do in human cells. 1/8
www.biorxiv.org
November 18, 2025 at 3:57 PM
Our new preprint is online! Viruses, bacteria and parasites use effector proteins to evade immunity and rewire host cell pathways. Together with @AlexanderStark8, we wondered if we could systematically map what these effectors, regardless of their origin, do in human cells. 1/8
Reposted by Haley Lab
A parts list of promoters and gRNA scaffolds for mammalian genome engineering and molecular recording - @jshendure.bsky.social @troymcdiarmid.bsky.social @uwgenome.bsky.social go.nature.com/49eTPCu
A parts list of promoters and gRNA scaffolds for mammalian genome engineering and molecular recording - Nature Biotechnology
Prime editing in mammalian cells benefits from a comprehensive list of genetic parts.
go.nature.com
November 11, 2025 at 4:36 PM
A parts list of promoters and gRNA scaffolds for mammalian genome engineering and molecular recording - @jshendure.bsky.social @troymcdiarmid.bsky.social @uwgenome.bsky.social go.nature.com/49eTPCu
Reposted by Haley Lab
🌍Open call: Junior Group Leader positions!
Join a world-class biomedical research institute at the heart of the Vienna BioCenter, where curiosity drives discovery.
Lead your own lab, pursue bold ideas, and shape the future of science at the IMP: www.imp.ac.at/career/open-...
Join a world-class biomedical research institute at the heart of the Vienna BioCenter, where curiosity drives discovery.
Lead your own lab, pursue bold ideas, and shape the future of science at the IMP: www.imp.ac.at/career/open-...
November 10, 2025 at 1:26 PM
🌍Open call: Junior Group Leader positions!
Join a world-class biomedical research institute at the heart of the Vienna BioCenter, where curiosity drives discovery.
Lead your own lab, pursue bold ideas, and shape the future of science at the IMP: www.imp.ac.at/career/open-...
Join a world-class biomedical research institute at the heart of the Vienna BioCenter, where curiosity drives discovery.
Lead your own lab, pursue bold ideas, and shape the future of science at the IMP: www.imp.ac.at/career/open-...
Reposted by Haley Lab
I take this example from @ceronifranci.bsky.social to highlight that we, at CSH Protocols, are also always interested in review articles like this, centered around techniques.
So, if you have an idea, let's talk!
www.sciencedirect.com/science/arti...
So, if you have an idea, let's talk!
www.sciencedirect.com/science/arti...
Transgene integration in mammalian cells: The tools, the challenges, and the future
Robust and stable expression of genes of interest is crucial for studying and engineering biology. While expressing desired gene products in some micr…
www.sciencedirect.com
October 27, 2025 at 4:32 PM
I take this example from @ceronifranci.bsky.social to highlight that we, at CSH Protocols, are also always interested in review articles like this, centered around techniques.
So, if you have an idea, let's talk!
www.sciencedirect.com/science/arti...
So, if you have an idea, let's talk!
www.sciencedirect.com/science/arti...
Reposted by Haley Lab
Transcriptional interferences ensure one olfactory receptor per ant neuron
www.nature.com/articles/s41...
Caviar for RNA-Seq nerds! Check this out
www.nature.com/articles/s41...
Caviar for RNA-Seq nerds! Check this out
October 22, 2025 at 8:40 PM
Transcriptional interferences ensure one olfactory receptor per ant neuron
www.nature.com/articles/s41...
Caviar for RNA-Seq nerds! Check this out
www.nature.com/articles/s41...
Caviar for RNA-Seq nerds! Check this out
Reposted by Haley Lab
I am proud to be a member of the #ISSCR2026 Program Committee and to have helped develop the outstanding program, taking place in Montréal, Canada on 8-11 July 2026. Register to hear the excellent science presented! invt.io/1bxbi6gtbsl @isscr.org
I am a member of the ISSCR 2026 Program Committee
Register now
invt.io
October 19, 2025 at 8:13 AM
I am proud to be a member of the #ISSCR2026 Program Committee and to have helped develop the outstanding program, taking place in Montréal, Canada on 8-11 July 2026. Register to hear the excellent science presented! invt.io/1bxbi6gtbsl @isscr.org
Reposted by Haley Lab
I can't take any credit but I am still really excited about this LNP Review in @natbiomedeng.nature.com! Targeting and tracking mRNA lipid nanoparticles at the particle, transcript and protein level | Nature Biomedical Engineering share.google/vIhr3EOMUfke...
October 17, 2025 at 9:41 PM
I can't take any credit but I am still really excited about this LNP Review in @natbiomedeng.nature.com! Targeting and tracking mRNA lipid nanoparticles at the particle, transcript and protein level | Nature Biomedical Engineering share.google/vIhr3EOMUfke...
Reposted by Haley Lab
I’m very surprised that the frequently discussed topic of repeated adaptation through the same molecular pathways hadn’t been summarised in a review before. But that has now changed, and that’s a good thing. Thank you @siribirkeland.bsky.social
www.cell.com/trends/genet...
www.cell.com/trends/genet...
Pathway-level convergence: an underexplored aspect of convergent evolution
The extent to which evolution is repeatable at the genetic level remains a central
question in biology. Convergent adaptations can arise through mutations in homologous
genes, changes in different gen...
www.cell.com
October 16, 2025 at 8:58 PM
I’m very surprised that the frequently discussed topic of repeated adaptation through the same molecular pathways hadn’t been summarised in a review before. But that has now changed, and that’s a good thing. Thank you @siribirkeland.bsky.social
www.cell.com/trends/genet...
www.cell.com/trends/genet...
Reposted by Haley Lab
We are recuiting two new Associate Professors here in Oxford Biochemistry. Come join us! Reach out to me if you have any questions. Please repost! tinyurl.com/mr3m7bd3
October 17, 2025 at 2:56 PM
We are recuiting two new Associate Professors here in Oxford Biochemistry. Come join us! Reach out to me if you have any questions. Please repost! tinyurl.com/mr3m7bd3
Reposted by Haley Lab
Identification of optimal fluorophores for use in the Drosophila embryo by Timothy E Saunders and team: www.biorxiv.org/content/10.1...
September 30, 2025 at 2:43 PM
Identification of optimal fluorophores for use in the Drosophila embryo by Timothy E Saunders and team: www.biorxiv.org/content/10.1...
Reposted by Haley Lab
The @crick.ac.uk is recruiting Early Career Group Leaders
- Lab set-up, research costs, salaries for up to 5 researchers
- Support for up to 12 years
- Access to our core facilities
- Competitive salary
- Fantastic colleagues
- All areas of biology
Deadline 27 Nov
www.crick.ac.uk/careers-stud...
- Lab set-up, research costs, salaries for up to 5 researchers
- Support for up to 12 years
- Access to our core facilities
- Competitive salary
- Fantastic colleagues
- All areas of biology
Deadline 27 Nov
www.crick.ac.uk/careers-stud...
Early career group leaders
We appoint researchers from across biology and biomedicine to set up their first groups at the Crick.
www.crick.ac.uk
October 10, 2025 at 8:20 AM
The @crick.ac.uk is recruiting Early Career Group Leaders
- Lab set-up, research costs, salaries for up to 5 researchers
- Support for up to 12 years
- Access to our core facilities
- Competitive salary
- Fantastic colleagues
- All areas of biology
Deadline 27 Nov
www.crick.ac.uk/careers-stud...
- Lab set-up, research costs, salaries for up to 5 researchers
- Support for up to 12 years
- Access to our core facilities
- Competitive salary
- Fantastic colleagues
- All areas of biology
Deadline 27 Nov
www.crick.ac.uk/careers-stud...
Reposted by Haley Lab
**POSTDOC POSITION** My lab (www.goyallab.org) at Northwestern and CZ Biohub Chicago looking for a postdoctoc in quantitative biology. We work on a range of topics, including single-cell cancer plasticity, modeling single-cell perturbations, theory, and stem-embryo models. contact via email. Pls RT
Goyal Lab
www.goyallab.org
September 19, 2025 at 10:36 AM
**POSTDOC POSITION** My lab (www.goyallab.org) at Northwestern and CZ Biohub Chicago looking for a postdoctoc in quantitative biology. We work on a range of topics, including single-cell cancer plasticity, modeling single-cell perturbations, theory, and stem-embryo models. contact via email. Pls RT
Reposted by Haley Lab
Love RNA biology?
Join us to explore the piRNA pathway with structural and genetic approaches (see 👇👇).
PhD student/postdoc position co-supervised by Clemens Plaschka & myself.
DM or email us if you’d like to know more!
@vbcscitraining.bsky.social @imbavienna.bsky.social @impvienna.bsky.social
Join us to explore the piRNA pathway with structural and genetic approaches (see 👇👇).
PhD student/postdoc position co-supervised by Clemens Plaschka & myself.
DM or email us if you’d like to know more!
@vbcscitraining.bsky.social @imbavienna.bsky.social @impvienna.bsky.social
PIWI clade Argonautes are essential for transposon silencing. Without them, animals are sterile due to massive transposon activity.
But how does piRNA-guided target interaction translate into silencing?
PhD student Júlia Portell Montserrat has an intriguing answer
www.cell.com/molecular-ce...
But how does piRNA-guided target interaction translate into silencing?
PhD student Júlia Portell Montserrat has an intriguing answer
www.cell.com/molecular-ce...
September 18, 2025 at 2:34 PM
Love RNA biology?
Join us to explore the piRNA pathway with structural and genetic approaches (see 👇👇).
PhD student/postdoc position co-supervised by Clemens Plaschka & myself.
DM or email us if you’d like to know more!
@vbcscitraining.bsky.social @imbavienna.bsky.social @impvienna.bsky.social
Join us to explore the piRNA pathway with structural and genetic approaches (see 👇👇).
PhD student/postdoc position co-supervised by Clemens Plaschka & myself.
DM or email us if you’d like to know more!
@vbcscitraining.bsky.social @imbavienna.bsky.social @impvienna.bsky.social
Reposted by Haley Lab
Doomscrolling pause to chat CRISPR libraries! Preprint describes our new, data-driven approach to combine on-target and off-target predictions much more intelligently for *selecting* guides, which we use to develop our newest Cas9 knockout library, Jacquere. Thread: www.biorxiv.org/content/10.1...
Balancing off-target and on-target considerations for optimized Cas9 CRISPR knockout library design
The continued development of high-dimensional CRISPR screen readouts, such as single-cell RNA sequencing and high-content imaging, necessitates compact libraries to enable functional interrogation at ...
www.biorxiv.org
September 7, 2025 at 5:02 PM
Doomscrolling pause to chat CRISPR libraries! Preprint describes our new, data-driven approach to combine on-target and off-target predictions much more intelligently for *selecting* guides, which we use to develop our newest Cas9 knockout library, Jacquere. Thread: www.biorxiv.org/content/10.1...
Reposted by Haley Lab
JOB ALERT 🚨 We are hiring TWO principal investigators in cell, molecular, systems, or chemical biology in Toronto, Canada at @sinaihealth.bsky.social. We provide a generous startup, fully funded salary and academic appointment at U of Toronto.
www.nature.com/naturecareer...
Please repost!
www.nature.com/naturecareer...
Please repost!
August 28, 2025 at 6:34 AM
JOB ALERT 🚨 We are hiring TWO principal investigators in cell, molecular, systems, or chemical biology in Toronto, Canada at @sinaihealth.bsky.social. We provide a generous startup, fully funded salary and academic appointment at U of Toronto.
www.nature.com/naturecareer...
Please repost!
www.nature.com/naturecareer...
Please repost!