King L Hung
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kinglhung.bsky.social
King L Hung
@kinglhung.bsky.social
230 followers 69 following 17 posts
Biologist at Scripps, PhD at Stanford. Dynamics of genomes and cells.
https://kinglhung.org
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kinglhung.bsky.social
King L Hung @kinglhung.bsky.social · Nov 18
Cancer cells often harbor oncogenes outside chromosomes on extrachromosomal DNA (ecDNA), which is unevenly inherited by dividing cells. We reported in Nature last week that collectives of ecDNAs are inherited together by dividing cancer cells. 1/
www.nature.com/articles/s41...
Coordinated inheritance of extrachromosomal DNAs in cancer cells - Nature
Cooperative species of extrachromosomal DNAs are coordinately inherited through mitotic co-segregation.
www.nature.com
Reposted by King L Hung
cancergrand.bsky.social
🎉 Congratulations to @kinglhung.bsky.social‬ from team eDyNAmiC for receiving the prestigious prize and for having his essay, “Oncogenes out of context: Cancer genes break free from the regulatory constraints of chromosomes”, published in
@science.org.

📖 Read more - lnkd.in/ekMqXC6J
kinglhung.bsky.social King L Hung @kinglhung.bsky.social · 4d
Honored to receive the Science & SciLifeLab Prize! Very grateful to all my mentors and colleagues. I wrote an article in @science.org about my PhD thesis research on extrachromosomal DNA at Stanford @stanfordmedicine.bsky.social. www.science.org/doi/10.1126/...
November 18, 2025 at 4:09 PM
Reposted by King L Hung
carolynbertozzi.bskyverified.social
Congrats King Hung, Science & SciLifeLabs award winner @stanfordmedicine.bsky.social, collaborating with @stanford-chemh.bsky.social institute scholar @paulmischel.bsky.social

www.science.org/doi/10.1126/...
Oncogenes out of context: Cancer genes break free from the regulatory constraints of chromosomes
Cancer genes break free from the regulatory constraints of chromosomes
www.science.org
November 14, 2025 at 5:49 PM
kinglhung.bsky.social
Honored to receive the Science & SciLifeLab Prize! Very grateful to all my mentors and colleagues. I wrote an article in @science.org about my PhD thesis research on extrachromosomal DNA at Stanford @stanfordmedicine.bsky.social. www.science.org/doi/10.1126/...
November 14, 2025 at 5:08 PM
Reposted by King L Hung
ardemp.bskyverified.social
And here is the story after peer review. This work highlights our current approach, which is to use Piezo channels to uncover new areas of biology that are shaped by mechanical forces: www.science.org/doi/10.1126/...
November 13, 2025 at 10:05 PM
Reposted by King L Hung
peiferlabunc.bsky.social
The community of Drosophila researchers is amazing, mutually supportive and collaborative. Right now a key resource for our community, @flybase.bsky.social , is threatened by the cancellation of its NIH grant and is seeking community help in raising short term funds 1/n 🧪 please share
Dear Fly Community, In May 2025, the NIH terminated all grant funding to Harvard University, including the NHGRI grant that supported FlyBase. This grant also funded FlyBase teams at Indiana University (IU) and the University of Cambridge (UK), and as a result, their subawards were also canceled. The Cambridge team has secured support for one to two years through generous donations from the European fly community, emergency funding from the Wellcome Trust, and support from the University of Cambridge. At IU, funding has been secured for one year thanks to reserve funds from Thom Kaufman and a supplement from ORIP/NIH to the Bloomington Drosophila Stock Center (BDSC). Unfortunately, the situation at Harvard is far more critical. Harvard University had supported FlyBase staff since May but recently denied a request for extended bridge funding. As a result, all eight employees (four full-time and four part-time) were abruptly laid off, with termination dates ranging from August to mid-October depending on their positions. In addition, our curator at the University of New Mexico will leave her position at the end of August. This decision came as a shock, and we are urgently pursuing all possible funding options. To put the need into perspective: although FlyBase is free to use, it is not free to make. It takes large teams of people and millions of dollars a year to create FlyBase to support fly research (the last NHGRI grant supported us with more than 2 million USD per annum). To help sustain FlyBase operations, we have been reaching out to you to ask for your support. We have set up a donation site in Cambridge, UK, to which European labs have and can continue to contribute, and a new donation site at IU to which labs in the US and the rest of the world can contribute. We urge researchers to work with their grant administrators to contribute to FlyBase via these sites if at all possible, as more of the money will go to FlyBase. However, we appreciate that some fu… https://wiki.flybase.org/wiki/FlyBase:Contribute_to_FlyBase Our immediate goals are: 1. To maintain core curation activities and keep the FlyBase website online 2. To complete integration with the Alliance of Genome Resources (The Alliance). Integration with the Alliance is essential for FlyBase’s long-term sustainability. For nearly a decade, NHGRI/NIH has supported the unification of Model Organism Databases (MODs) into the Alliance, which we aim to achieve by 2028. Therefore, securing bridge funding to sustain FlyBase over the next three years is crucial for successful integration and the long-term access to FlyBase data. At present, our remaining funds will allow us to keep the FlyBase website online for approximately one more year. Beyond that, its future is uncertain unless new funding is secured. We will, of course, continue pursuing additional grant opportunities as they arise. Given the uncertainty of future NIH or alternative funding sources, we are relying on the Fly community for support. Your contributions will directly help us retain the staff needed to complete this transition and to secure ongoing fly data curation into the Alliance beyond 2028. We at FlyBase are incredibly grateful for the outpouring of support from the community during this challenging time. Your encouragement has strengthened our resolve and underscores how vital this resource remains to Drosophila research worldwide. Sincerely, The FlyBase Team
August 23, 2025 at 12:18 PM
Reposted by King L Hung
ardemp.bskyverified.social
Published an op-ed for @cnn.com: “Nobel laureate: I owe America my success. Today, its scientific future is in danger.”
A personal reflection on what’s at stake as science funding gets slashed. I’d be grateful if you could amplify both in and beyond the science world.
www.cnn.com/2025/04/09/h...
Nobel laureate: I owe America my success. Today, its scientific future is in danger | CNN
Dr. Ardem Patapoutian says he watches “with deep sadness as the United States’ remarkable scientific enterprise, which took generations of hard work and national investment to build, faces a concerted...
www.cnn.com
April 9, 2025 at 11:30 AM
kinglhung.bsky.social
Cool approach to isolate extrachromosomal DNA: karyotyping by FACS! Wish I had thought of it. www.biorxiv.org/content/10.1...
March 28, 2025 at 4:28 AM
Reposted by King L Hung
mayavoichek.bsky.social
1/ Transposable elements are often called "jumping genes" because they mobilize within genomes. 🧬
But did you know they can also jump 𝘣𝘦𝘵𝘸𝘦𝘦𝘯 cells? 🤯
Our new study reveals how retrotransposons invade the germline directly from somatic cells.
www.biorxiv.org/content/10.1...
A short thread 🧵👇
Drosophila follicle showing retrotransposons (pink & yellow) expressed in somatic cells infecting the oocyte
March 17, 2025 at 11:56 AM
Reposted by King L Hung
katherinejwu.com
if you've had an NIH grant terminated, I want to hear about it. Signal: katherinejwu.12
March 7, 2025 at 2:17 PM
Reposted by King L Hung
ardemp.bskyverified.social
The Patapoutian lab started 25 years ago on March 1, 2000. A quarter-century of science with brilliant trainees, colleagues & collaborators. Cheers to my mentors & mentees! Excited to celebrate with past & present lab members in November. Here’s to more great science 🧪 and better times ahead!
a cat is laying on top of the number 25
ALT: a cat is laying on top of the number 25
media.tenor.com
March 1, 2025 at 3:14 PM
Reposted by King L Hung
neal-lab.bsky.social
Flooding BlueSky with good news today. Neal lab received a NoA! Grateful our NIH R35 MIRA renewal is funded to support our ongoing work on membrane protein quality! 🙏🙏
February 14, 2025 at 11:28 PM
kinglhung.bsky.social
Opportunity to work with an amazing scientist!
rose-hill.bsky.social Rose Z. Hill, Ph.D. @rose-hill.bsky.social · Jan 9
My group is hiring at Oregon Health & Science University. Come work with us in beautiful Portland to study interoception and physiology. Check out the lab view! 🌲👩‍🔬

Research Assistant 2: externalcareers-ohsu.icims.com/jobs/32602/r...

Postdoc applicants: please email me your CV and 3-4 references.
View of Portland from Marquam Hill campus at OHSU
January 10, 2025 at 1:52 AM
Reposted by King L Hung
ardemp.bskyverified.social
Join our lab! We're hiring a research technician—a great opportunity for individuals with a Bachelor's degree who want to gain valuable research experience before heading to medical or graduate school.
recruiting2.ultipro.com/SCR1003TSRI/...
recruiting2.ultipro.com
December 16, 2024 at 11:14 PM
kinglhung.bsky.social
Hi bluesky! A re-introduction: I am a cell biologist interested in cellular signaling logic and decision making. I worked on cancer genomes in my PhD at Stanford, and am now a postdoc working on how cells interpret force at Scripps in the Patapoutian lab. Excited to reconnect here!
November 19, 2024 at 5:15 PM
Reposted by King L Hung
susanmgasser.bsky.social
Two back-to-back papers in Nature comms from mylab explore the link between destabilization of the actin cytoskeleton and aberrant base excision repair - passing through nuclear actin and the actin-dependent nucleosome remodeler INO80C.
November 15, 2024 at 7:02 PM
Reposted by King L Hung
anton-henssen.bsky.social
First re-post on @bsky.app . Great collaboration between @kinglhung.bsky.social and team eDyNAmiC !! 🔥🔥👇🏻👇🏻
kinglhung.bsky.social King L Hung @kinglhung.bsky.social · Nov 18
Cancer cells often harbor oncogenes outside chromosomes on extrachromosomal DNA (ecDNA), which is unevenly inherited by dividing cells. We reported in Nature last week that collectives of ecDNAs are inherited together by dividing cancer cells. 1/
www.nature.com/articles/s41...
Coordinated inheritance of extrachromosomal DNAs in cancer cells - Nature
Cooperative species of extrachromosomal DNAs are coordinately inherited through mitotic co-segregation.
www.nature.com
November 18, 2024 at 7:40 PM
Reposted by King L Hung
trevorgraham.bsky.social
Lovely paper showing co-segregation and co-selection of multiple species of ecDNA within cancer cells. Nice computational modelling and inference of segregation and selection coefficients too @benjaminwerner.bsky.social and Weini Huang!
kinglhung.bsky.social King L Hung @kinglhung.bsky.social · Nov 18
Cancer cells often harbor oncogenes outside chromosomes on extrachromosomal DNA (ecDNA), which is unevenly inherited by dividing cells. We reported in Nature last week that collectives of ecDNAs are inherited together by dividing cancer cells. 1/
www.nature.com/articles/s41...
Coordinated inheritance of extrachromosomal DNAs in cancer cells - Nature
Cooperative species of extrachromosomal DNAs are coordinately inherited through mitotic co-segregation.
www.nature.com
November 18, 2024 at 7:41 PM
kinglhung.bsky.social
Cancer cells often harbor oncogenes outside chromosomes on extrachromosomal DNA (ecDNA), which is unevenly inherited by dividing cells. We reported in Nature last week that collectives of ecDNAs are inherited together by dividing cancer cells. 1/
www.nature.com/articles/s41...
Coordinated inheritance of extrachromosomal DNAs in cancer cells - Nature
Cooperative species of extrachromosomal DNAs are coordinately inherited through mitotic co-segregation.
www.nature.com
November 18, 2024 at 5:37 PM
Reposted by King L Hung
cagricevrim.bsky.social
Now we're all here; I think this paper need more attention!

journals.biologists.com/dev/article/...
The case against simplistic genetic explanations of evolution
Summary: Extreme traits in animals, from the origin of limbs to the loss of tails, capture public attention. This Review argues that scientists should not seek simple explanations for how they evolved...
journals.biologists.com
November 15, 2024 at 9:04 PM
Reposted by King L Hung
henrydebelly.bsky.social
Sharing my latest preprint as a re-introduction to bsky!

biorxiv.org/content/10.1...
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Everyday, cells like this crawl through your body to protect you. While we know that their front 🔴 and back 🔵 polarity programs work together, how exactly do these two processes communicate?
November 11, 2024 at 6:34 PM
Reposted by King L Hung
erictopol.bsky.social
High-resolution of cancer. Unprecedented. A brief review of what we've just learned from 17 new papers in the latest edition of Ground Truths.
It's free, open-access.
erictopol.substack.com/p/cancer-sci...
Cancer Science in On a Tear
New insights on evolution, resistance, and therapies
erictopol.substack.com
November 10, 2024 at 6:51 PM
Reposted by King L Hung
mjafreeman.bsky.social
Waves of new BlueSky arrivals in last few days!

I’ve been tracking starter packs relevant to molecular/mechanistic/genetic/cellular…etc biology

Hope it’s helpful but warning: now a v long thread!

Probably the last time I can do this...
November 12, 2024 at 3:03 PM
Reposted by King L Hung
theshanderson.bsky.social
Republicizing my preprint from earlier this year! We found that mitochondrial Raf1 upregulates glutamine catabolism in cancer cells.

www.biorxiv.org/content/10.1...
Mitochondrial Raf1 Regulates Glutamine Catabolism
Raf1 is present within the mitochondrial matrix, where it binds GLS to regulate glutamine catabolism and tumorigenesis. In cancer, Raf1 activation occurs via mechanisms that include mutation of upstr...
www.biorxiv.org
November 12, 2024 at 5:16 PM