King L Hung
@kinglhung.bsky.social
Biologist at Scripps, PhD at Stanford. Dynamics of genomes and cells.
https://kinglhung.org
https://kinglhung.org
So excited for you, Rose!
March 27, 2025 at 4:15 PM
So excited for you, Rose!
Thanks for highlighting our work!
November 19, 2024 at 10:22 PM
Thanks for highlighting our work!
Also recently published work from this month:
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Cancer cells often harbor oncogenes outside chromosomes on extrachromosomal DNA (ecDNA), which is unevenly inherited by dividing cells. We reported in Nature last week that collectives of ecDNAs are inherited together by dividing cancer cells. 1/
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Coordinated inheritance of extrachromosomal DNAs in cancer cells - Nature
Cooperative species of extrachromosomal DNAs are coordinately inherited through mitotic co-segregation.
www.nature.com
November 19, 2024 at 5:15 PM
Also recently published work from this month:
bsky.app/profile/king...
bsky.app/profile/king...
November 18, 2024 at 6:25 PM
Thanks to Cancer Grand Challenges for supporting this project. Thank you also to all other collaborators who made this study possible, including Joshua Lange, Britney He, Jens Luebeck, Rachel Schmargon, Elisa Scanu, Lotte Brückner, Ben Werner, Weini Huang, Ben Cravatt, and Anton Henssen. 9/
November 18, 2024 at 5:37 PM
Thanks to Cancer Grand Challenges for supporting this project. Thank you also to all other collaborators who made this study possible, including Joshua Lange, Britney He, Jens Luebeck, Rachel Schmargon, Elisa Scanu, Lotte Brückner, Ben Werner, Weini Huang, Ben Cravatt, and Anton Henssen. 9/
Overall, these results show unique distribution and evolution of extrachromosomal oncogene copies in cancer cells. Co-inheritance allows cancer cells to keep specific combinations of DNA sequences, allowing the winning combination to get amplified in cancer. 8/
November 18, 2024 at 5:37 PM
Overall, these results show unique distribution and evolution of extrachromosomal oncogene copies in cancer cells. Co-inheritance allows cancer cells to keep specific combinations of DNA sequences, allowing the winning combination to get amplified in cancer. 8/
Co-inheritance leads to coordinated dynamics of ecDNAs in cells under selective pressure. Treating cancer cells with a drug that inhibits one of the oncogene products leads to co-depletion of multiple ecDNAs, suggesting that they can have coupled responses to perturbations. 7/
November 18, 2024 at 5:37 PM
Co-inheritance leads to coordinated dynamics of ecDNAs in cells under selective pressure. Treating cancer cells with a drug that inhibits one of the oncogene products leads to co-depletion of multiple ecDNAs, suggesting that they can have coupled responses to perturbations. 7/
While evolutionary modeling suggested that cells harboring multiple ecDNA species could have been selected, the observed copy number correlation is mainly explained by co-inheritance rather than co-selection of ecDNAs. 6/
November 18, 2024 at 5:37 PM
While evolutionary modeling suggested that cells harboring multiple ecDNA species could have been selected, the observed copy number correlation is mainly explained by co-inheritance rather than co-selection of ecDNAs. 6/