Kristina Micheva
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kdmicheva.bsky.social
Kristina Micheva
@kdmicheva.bsky.social
890 followers 240 following 41 posts
Neuroscientist, array tomographist, learner of languages and martial arts
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Reposted by Kristina Micheva
wormsense.bsky.social
It is with a heavy heart that I share the unexpected news that our colleague, friend, and mentor Daniel Madison passed away on Thursday, October 9.
Portrait of Dan V. Madison at an electrophysiology rig, overlayed on pairs of pyramidal neurons filled and reconstructed.
October 19, 2025 at 8:49 PM
Reposted by Kristina Micheva
andrewcpayne.bsky.social
E11 Bio is excited to unveil PRISM technology for mapping brain wiring with simple light microscopes. Today, brain mapping in humans and other mammals is bottlenecked by accurate neuron tracing. PRISM uses molecular ID codes and AI to help neurons trace themselves.

Read more: e11.bio/blog/prism
October 1, 2025 at 2:16 PM
kdmicheva.bsky.social
Back from a trip and I found this unintentional present I left myself
A sprouted sweet potato puts a gorgeous display of delicate pinkish-purpelish stems and leaves
September 28, 2025 at 7:45 PM
Reposted by Kristina Micheva
dddavi.bsky.social
It was a good experience to step back and briefly take stock of the amazing progress in connectomics since I started working on this stuff (20 years ago!)

thanks as well to @natrevneuro.nature.com for the constructive editorial interactions.
August 14, 2025 at 7:40 PM
kdmicheva.bsky.social
Ultramicrotomy escapism: trimming blocks and enjoying the shapes and colors 💕
August 12, 2025 at 8:52 PM
kdmicheva.bsky.social
Our 2nd Array Tomography Workshop will be in November in Buenos Aires and there is still time to apply! Five days of hands-on learning, discussions and talks + gorgeous electron microscopy and immunofluorescence. Focus on simple and affordable workflows.
www.arraytomography.org/workshop-202...
Workshop 2025
About the workshop This workshop will cover array tomography (AT) technology with a focus on “simple and affordable” workflows based on serial ultramicrotomy and imaging. The practicals include...
www.arraytomography.org
August 1, 2025 at 12:42 AM
Reposted by Kristina Micheva
mblscience.bsky.social
We're thrilled to announce the largest private gift in our 137-year history: a $25 million unrestricted donation from MBL Whitman Scientist Mark Terasaki.

His extraordinary generosity will bolster our renowned research and education programs. 🔬

Learn more: bit.ly/452WL1m
MBL Announces Largest Ever Gift for Its Renowned Biological Education and Research Programs | Marine Biological Laboratory
Cell Biology Researcher Mark Terasaki’s $25 Million Unrestricted Gift Will Support Operations and Infrastructure Contact: Samantha Cummis scummis@mbl.edu; 973.800.4119
bit.ly
July 28, 2025 at 6:46 PM
Reposted by Kristina Micheva
jemimaburden.bsky.social
Excited to announce registration to the next Array Tomography workshop in Buenos Aires is now open!

#volumeEM

See our AT website page for more information ⬇
www.arraytomography.org/workshop-202...
July 3, 2025 at 6:00 PM
Reposted by Kristina Micheva
lyons-lab.bsky.social
For those who want a distraction and/ or are interested, here's the latest from the group, led by Phil Braaker

www.nature.com/articles/s41...
Activity-driven myelin sheath growth is mediated by mGluR5 - Nature Neuroscience
Employing pharmacology, genetics and all-optical approaches in zebrafish, Braaker et al. find that neuronal activity influences the growth of myelin sheaths along axons by signaling through metabotrop...
www.nature.com
May 14, 2025 at 11:45 AM
Reposted by Kristina Micheva
christlet.bsky.social
Reminder that @europepmc.org is a mirror of Pubmed with better search and that it indexes *all* bioRxiv preprints (as well as ResearchSquare), not just the ones funded by NIH like chauvinist Pubmed
prasad.bsky.social Prasad Jallepalli, MD, PhD @prasad.bsky.social · Jan 31
I’m very scared to see what happens to PubMed
January 31, 2025 at 8:44 PM
Reposted by Kristina Micheva
wiringthebrain.bsky.social
What happened to the pursuit of truth? rupress.org/jgp/article/... - Eve Marder, on point...
What happened to the pursuit of truth? | Journal of General Physiology | Rockefeller University Press
The knowledge in our brains, not in our phones, is necessary for creative thinking and the pursuit of truth.
rupress.org
January 20, 2025 at 10:03 AM
kdmicheva.bsky.social
Happy to share a new biorxiv manuscript with @owen-lab.bsky.social where we “slice and dice” synapses with array tomography and find subclasses with different glutamate receptor composition 🧪
biorxiv-neursci.bsky.social bioRxiv Neuroscience @biorxiv-neursci.bsky.social · Dec 14
Data-driven synapse classification reveals a logic of glutamate receptor composition https://www.biorxiv.org/content/10.1101/2024.12.11.628056v1
December 18, 2024 at 11:33 PM
Reposted by Kristina Micheva
haniehfalahati.bsky.social
Our paper is out just in time for #EM_Monday! It is about a specialized neuron-specific ER, called the spine apparatus, which is found close to synapses and has a very peculiar shape. If you think neurons are special, the spine apparatus is their🦄 horn! But how does it form?!
doi.org/10.1016/j.cu...
Gif showing a spine containing spine apparatus, reconstructed from FIB-SEM images. ER: red, synapse: yellow, plasma membrane: blue
December 2, 2024 at 5:52 PM
Reposted by Kristina Micheva
bwjones.bsky.social
Layers Upon Layers

bryanwjones.com/2020/06/laye...

#SciArt #retina
A section of retina through the optic fiber layer, ganglion cell layer, inner plexiform layer, inner nuclear layer with amacrine and bipolar cells, the outer plexiform layer and the outer nuclear layers of retina. This has been labeled with antibodies against small molecules to visualize the metabolism using Computational Molecular Phenotyping (CMP) strategies.
November 28, 2024 at 5:45 PM
Reposted by Kristina Micheva
crozell.bsky.social
Get a free NIH BRAIN Initiative art calendar to prep for 2025: catalog.ninds.nih.gov/publications... .

I'm proud to say that the cover is a piece we created from the DTI imaging of a subject in the BRAIN funded depression DBS study we reported last year: go.nature.com/48lmlzC

🧪🧠
November 25, 2024 at 1:13 PM
Reposted by Kristina Micheva
gordfishell.bsky.social
Cortical interneurons learn on the job! Speculated this was true a decade ago! Sherry Wu and Min Dai finally provide evidence! www.biorxiv.org/content/10.1...
Pyramidal neurons proportionately alter the identity and survival of specific cortical interneuron subtypes
The mammalian cerebral cortex comprises a complex neuronal network that maintains a delicate balance between excitatory neurons and inhibitory interneurons. Previous studies, including our own researc...
www.biorxiv.org
November 24, 2024 at 3:05 AM
kdmicheva.bsky.social
This is fun 🦋 With help from Scholar Goggler scholargoggler.com
my word cloud, prominently featuring array tomography in big yellow letters, all things synaptic in blue and red, and a colorful cloud of other brain and imaging keywords
November 22, 2024 at 11:10 PM
Reposted by Kristina Micheva
christlet.bsky.social
Best thing you could watch in 2016 and best thing you can watch today. RIP Thomas Reese
November 19, 2024 at 12:45 PM
kdmicheva.bsky.social
Celebrating the small (70 nm) victories today - look at these perfect serial sections that I cut!
🧪 the joys of #arraytomography
A shiny, perfectly straight ribbon of serial trapezoid sections floating in the water bath of a diamond knife. These are sections from a mouse brain embedded in plastic, each section is 70 nm thin! A closeup of an ultramicrotome and the diamond knife used for cutting the ultrathin sections. There's a beautiful long ribbon of sections floating in the middle of the diamond knife boat and a coverslip is propped in, ready to pick the ribbon.
November 19, 2024 at 2:51 AM
kdmicheva.bsky.social
I'm here, who else?
andrewhires.bsky.social Andrew Hires @andrewhires.bsky.social · Nov 12
Who’s heading to Austin for CZI?

🙋‍♂️
November 13, 2024 at 4:47 PM
kdmicheva.bsky.social
Time for some of my favorite images with immunofluorescence array tomography: this one is human cortex, and the yellow fluff around the blue nuclei are lipofuscin granules that accumulate with aging. Lipofuscin in this image comes for free - no label needed because it is autofluorescent!
Immunofluorescence array tomography image from human cortex. Several colorful neurons can be seen.This is a volume reconstruction from ~30 serial sections, 70 nm each, that were labeled with three different antibodies. Yellow lipofuscin granules surround the blue nuclei of some of the neurons.
November 12, 2024 at 10:20 PM
kdmicheva.bsky.social
Delicious & unique array tomography cake from the Array Tomography Workshop in Munich 2024. Thank you!
November 8, 2024 at 9:18 PM
kdmicheva.bsky.social
Color-coordinated EM. Chapter 2. Autumn synapses with #webknossos
Computer screens showing electron microscopy of brain tissue overlaid with immunofluorescence for synaptic markers; the color palette inspired by the beautiful autumn colors of the trees outside the window.
November 17, 2023 at 7:53 PM
kdmicheva.bsky.social
There are places / communities / ecosystems that are so difficult to leave and keep pulling you back
Woods Hole, MBL
August 24, 2023 at 10:08 PM
kdmicheva.bsky.social
Found in the Lillie library, MBL - interesting dynamics of the languages used in early zoological literature
and here's the actual reference: doi: 10.3897/zookeys.550.10041
August 16, 2023 at 8:48 PM