Kamphorst LAB
@kamphorstlab.bsky.social
Immunologist - T cell biologist
Opinions are my own
https://kamphorstlab.org/
From Brazil, adopted by NYC
Opinions are my own
https://kamphorstlab.org/
From Brazil, adopted by NYC
Reposted by Kamphorst LAB
🚀 NY-CURES Launch — Championing State-Wide Investment in Science! 🚀
Our new coalition advocates for sustained public support of New York’s vibrant biomedical research ecosystem — creating cures, economic gains & strengthening communities.
Sign up. Stay informed. Join the movement: www.nycures.org/
Our new coalition advocates for sustained public support of New York’s vibrant biomedical research ecosystem — creating cures, economic gains & strengthening communities.
Sign up. Stay informed. Join the movement: www.nycures.org/
September 4, 2025 at 4:32 PM
🚀 NY-CURES Launch — Championing State-Wide Investment in Science! 🚀
Our new coalition advocates for sustained public support of New York’s vibrant biomedical research ecosystem — creating cures, economic gains & strengthening communities.
Sign up. Stay informed. Join the movement: www.nycures.org/
Our new coalition advocates for sustained public support of New York’s vibrant biomedical research ecosystem — creating cures, economic gains & strengthening communities.
Sign up. Stay informed. Join the movement: www.nycures.org/
Excited to head to Japan in November to present at the CSHA meeting on Immunoreceptor Signaling and Therapeutic Applications.
Abstract deadline is next week!
www.csh-asia.org?content/1343
Abstract deadline is next week!
www.csh-asia.org?content/1343
WELCOME-Meetings-Cold Spring Harbor Asia
www.csh-asia.org
August 27, 2025 at 8:06 PM
Excited to head to Japan in November to present at the CSHA meeting on Immunoreceptor Signaling and Therapeutic Applications.
Abstract deadline is next week!
www.csh-asia.org?content/1343
Abstract deadline is next week!
www.csh-asia.org?content/1343
Reposted by Kamphorst LAB
It was a privilege and a pleasure for both myself and @menezesnmaria.bsky.social to preview a great upcoming article in @cp-immunity.bsky.social by @kamphorstlab.bsky.social showing an unexpected inhibitory role for ICOS in exhausted CD8+ T cells.
www.cell.com/immunity/abs...
www.cell.com/immunity/abs...
The high (I)COSt of costimulation for exhausted T cells
ICOS agonists are being investigated for cancer immunotherapy based on the idea that
they will reinvigorate exhausted CD8+ T cell anti-cancer immunity. Humblin et al.
unexpectedly find the opposite—th...
www.cell.com
August 13, 2025 at 11:33 AM
It was a privilege and a pleasure for both myself and @menezesnmaria.bsky.social to preview a great upcoming article in @cp-immunity.bsky.social by @kamphorstlab.bsky.social showing an unexpected inhibitory role for ICOS in exhausted CD8+ T cells.
www.cell.com/immunity/abs...
www.cell.com/immunity/abs...
Reposted by Kamphorst LAB
BREAKING NEWS: a government watchdog confirmed the Trump administration is breaking the law by blocking NIH funds.
How many kids with cancer or grandmas with Alzheimer’s have to get closer to death while crucial research is stalled?
Trump must end this illegal funding freeze.
How many kids with cancer or grandmas with Alzheimer’s have to get closer to death while crucial research is stalled?
Trump must end this illegal funding freeze.
August 5, 2025 at 10:46 PM
BREAKING NEWS: a government watchdog confirmed the Trump administration is breaking the law by blocking NIH funds.
How many kids with cancer or grandmas with Alzheimer’s have to get closer to death while crucial research is stalled?
Trump must end this illegal funding freeze.
How many kids with cancer or grandmas with Alzheimer’s have to get closer to death while crucial research is stalled?
Trump must end this illegal funding freeze.
Hopefully a nudge in the right direction
thehill.com/homenews/543...
thehill.com/homenews/543...
NIH broke law by withholding funding: GAO
A congressional watchdog determined Tuesday that the Trump administration broke the law when it directed the National Institutes of Health (NIH) to cancel hundreds of research grants earlier this y…
thehill.com
August 6, 2025 at 2:47 AM
Hopefully a nudge in the right direction
thehill.com/homenews/543...
thehill.com/homenews/543...
Our paper is out! Check out this beautiful story where we uncovered that the costimulatory molecule ICOS is detrimental for PD-1+ CD8 T cells.
Sustained ICOS signaling reduces memory-like features of progenitor exhausted CD8 T cells in chronic viral infection and liver cancer.
Sustained ICOS signaling reduces memory-like features of progenitor exhausted CD8 T cells in chronic viral infection and liver cancer.
July 8, 2025 at 1:05 PM
Our paper is out! Check out this beautiful story where we uncovered that the costimulatory molecule ICOS is detrimental for PD-1+ CD8 T cells.
Sustained ICOS signaling reduces memory-like features of progenitor exhausted CD8 T cells in chronic viral infection and liver cancer.
Sustained ICOS signaling reduces memory-like features of progenitor exhausted CD8 T cells in chronic viral infection and liver cancer.
Reposted by Kamphorst LAB
These are extremely challenging times for early-career faculty. Here is my office's small contribution to make their hard and important work a bit easier:
Download our curated and comprehensive database of funding opportunities for early-career faculty.
Here: research.jhu.edu/rdt/funding-...
Download our curated and comprehensive database of funding opportunities for early-career faculty.
Here: research.jhu.edu/rdt/funding-...
March 6, 2025 at 8:28 PM
These are extremely challenging times for early-career faculty. Here is my office's small contribution to make their hard and important work a bit easier:
Download our curated and comprehensive database of funding opportunities for early-career faculty.
Here: research.jhu.edu/rdt/funding-...
Download our curated and comprehensive database of funding opportunities for early-career faculty.
Here: research.jhu.edu/rdt/funding-...
Reposted by Kamphorst LAB
By itself, this is certainly not the most important issue we're confronting right now. But it's emblematic of the pervasive, destructive, anti-science efforts.
Gift link
www.nytimes.com/2025/02/26/c...
Gift link
www.nytimes.com/2025/02/26/c...
She Lobbied for a Carcinogen. Now She’s at the E.P.A., Approving New Chemicals. (Gift Article)
Lynn Dekleva, who recently took a senior role at the agency, once led an aggressive effort by industry to block regulations on formaldehyde.
www.nytimes.com
March 2, 2025 at 4:04 PM
By itself, this is certainly not the most important issue we're confronting right now. But it's emblematic of the pervasive, destructive, anti-science efforts.
Gift link
www.nytimes.com/2025/02/26/c...
Gift link
www.nytimes.com/2025/02/26/c...
I am sure a lot more science programs will have to make these tough decisions
BREAKING:
The NIH summer internship program (SIP) has been officially cancelled, across all institutes.
It’s a sad loss for the brightest science students in America, for American science, and for future cures for diseases like cancer and Alzheimer’s. 🧪 1/
The NIH summer internship program (SIP) has been officially cancelled, across all institutes.
It’s a sad loss for the brightest science students in America, for American science, and for future cures for diseases like cancer and Alzheimer’s. 🧪 1/
NIDA has announced it, but all the NIH summer internship programs are likely cancelled.
Sorry college students interested in STEM jobs, sorry high school students looking at science 🧪 careers. Trump and Musk are cancelling your futures.
Sorry college students interested in STEM jobs, sorry high school students looking at science 🧪 careers. Trump and Musk are cancelling your futures.
February 26, 2025 at 10:33 PM
I am sure a lot more science programs will have to make these tough decisions
Reposted by Kamphorst LAB
'In 2024, a budget cut of €900m shocked the scientific community. More recently, additional amendments to this budget proposed further cuts of €630m, along with an extra €534m reduction to the France 2030 program. These cuts threaten not only basic research but also higher education'
The importance of delivering Recherche d'Avenir – research for the future
In recent years, several European countries, including France, have reduced their investment in scientific research, with biomedical research taking a significant hit. The primary casualty is basic re...
journals.biologists.com
February 26, 2025 at 6:16 PM
'In 2024, a budget cut of €900m shocked the scientific community. More recently, additional amendments to this budget proposed further cuts of €630m, along with an extra €534m reduction to the France 2030 program. These cuts threaten not only basic research but also higher education'
Reposted by Kamphorst LAB
We are too! DM me or find me on Signal at zacharybrennan.20
ATTENTION
The Washington Post is collecting data about funding issues. Please consider contributing.
thewashingtonpost.formstack.com/forms/scient...
The Washington Post is collecting data about funding issues. Please consider contributing.
thewashingtonpost.formstack.com/forms/scient...
Are you a scientist who has lost funding or grants in recent weeks? - Formstack
thewashingtonpost.formstack.com
February 26, 2025 at 6:21 PM
We are too! DM me or find me on Signal at zacharybrennan.20
Reposted by Kamphorst LAB
Donald Trump and Elon Musk’s idea of efficiency is stopping research on curing cancer.
February 14, 2025 at 1:59 AM
Donald Trump and Elon Musk’s idea of efficiency is stopping research on curing cancer.
March is still a long time from now. We need to stop the bleeding. Talk to your patients. Reach out to your patient advocates and community scientist - call your representatives! Make some noise.
We want you to help us #standupforscience2025 📣
We’re currently recruiting local leads and volunteers across all state capitals and other major cities across the US!
If you’re interested in helping us organize, please fill out this form: airtable.com/app4h5wUssMG...
We’re currently recruiting local leads and volunteers across all state capitals and other major cities across the US!
If you’re interested in helping us organize, please fill out this form: airtable.com/app4h5wUssMG...
February 13, 2025 at 2:09 PM
March is still a long time from now. We need to stop the bleeding. Talk to your patients. Reach out to your patient advocates and community scientist - call your representatives! Make some noise.
Reposted by Kamphorst LAB
Use this form to tell us how the new US administration is affecting your research, or suggest future coverage
https://go.nature.com/42SyoUu
https://go.nature.com/42SyoUu
Are the Trump team’s actions affecting your research? How to contact Nature
Use this form to share information with Nature’s news team, or to make suggestions for future coverage.
go.nature.com
February 13, 2025 at 1:12 PM
Use this form to tell us how the new US administration is affecting your research, or suggest future coverage
https://go.nature.com/42SyoUu
https://go.nature.com/42SyoUu
In my lab, we analyze patient samples and develop preclinical models to understand why some patients respond to immunotherpies and others don't. We write grants to support our research. Only 9%, really the top, are funded. But now, NCI/NIH tare not awarding grants even to top scores.
Welcome to the Bluesky account for Stand Up for Science 2025!
Keep an eye on this space for updates, event information, and ways to get involved. We can't wait to see everyone #standupforscience2025 on March 7th, both in DC and locations nationwide!
#scienceforall #sciencenotsilence
Keep an eye on this space for updates, event information, and ways to get involved. We can't wait to see everyone #standupforscience2025 on March 7th, both in DC and locations nationwide!
#scienceforall #sciencenotsilence
February 12, 2025 at 8:02 PM
In my lab, we analyze patient samples and develop preclinical models to understand why some patients respond to immunotherpies and others don't. We write grants to support our research. Only 9%, really the top, are funded. But now, NCI/NIH tare not awarding grants even to top scores.
Reposted by Kamphorst LAB
Internal NIH guidance updated yesterday. Just canceling stuff each day from here on out I guess, pending new guidance. Killing science off both slowly and incredibly rapidly.
February 12, 2025 at 6:11 PM
Internal NIH guidance updated yesterday. Just canceling stuff each day from here on out I guess, pending new guidance. Killing science off both slowly and incredibly rapidly.
Reposted by Kamphorst LAB
ATTENTION
If anyone has received a NoA after the "pause", please DM me with information about the mechanism and institute or center.
THANK YOU
If anyone has received a NoA after the "pause", please DM me with information about the mechanism and institute or center.
THANK YOU
a cartoon character says " just let me know "
ALT: a cartoon character says " just let me know "
media.tenor.com
February 11, 2025 at 2:07 PM
ATTENTION
If anyone has received a NoA after the "pause", please DM me with information about the mechanism and institute or center.
THANK YOU
If anyone has received a NoA after the "pause", please DM me with information about the mechanism and institute or center.
THANK YOU
Reposted by Kamphorst LAB
The deadline to submit an abstract for a poster presentation is Feb 20. Register now 👉 hubs.la/Q034zC0H0 #KSCancerImmune25
February 11, 2025 at 10:00 PM
The deadline to submit an abstract for a poster presentation is Feb 20. Register now 👉 hubs.la/Q034zC0H0 #KSCancerImmune25
Reposted by Kamphorst LAB
So the first year of one our #NIH grants ended on 1/31 and we have not received the Notice of Award for year 2. I'm so confused now--is there an NIH freeze or not? Wasn't it blocked by a judge? Has anyone else received a NOA since this debacle? #academicsky #medsky
February 2, 2025 at 4:33 PM
So the first year of one our #NIH grants ended on 1/31 and we have not received the Notice of Award for year 2. I'm so confused now--is there an NIH freeze or not? Wasn't it blocked by a judge? Has anyone else received a NOA since this debacle? #academicsky #medsky
Reposted by Kamphorst LAB
Absolutely. Dozens of them. See also www.chronicle.com/article/were...
February 9, 2025 at 6:05 PM
Absolutely. Dozens of them. See also www.chronicle.com/article/were...
Reposted by Kamphorst LAB
Press release by the appropriations subcommittee on NIH budget slashing by @delauro.house.gov 🙏
Trump Team Dismantles Efforts to Find a Cure for Cancer and Other Deadly Disorders and Diseases
President Trump’s Administration is imposing a new policy to cap indirect costs for National Institutes of Health (NIH) research grants at 15 percent, which would cut billions of dollars in funding fo...
democrats-appropriations.house.gov
February 10, 2025 at 4:59 AM
Press release by the appropriations subcommittee on NIH budget slashing by @delauro.house.gov 🙏
awful
@jeremymberg.bsky.social Have you or anyone else heard about any Admin supplements to Promote Research Continuity (“Maternity Leave Supplements”) being discontinued? A new Asst. Prof. at home with a tiny baby just had hers disappear from her ERA commons account while waiting for her NOA. Awful.
February 10, 2025 at 12:29 AM
awful
Reposted by Kamphorst LAB
YES. Need to say this loudly and often! This 2.46x is also the short-term ROI. Long-term ROI (more difficult to estimate) may ~10x. Highest for any gov't spending. And the source of discoveries necessary for all new drugs (industry important too but without NIH funded science there's no foundation)
February 8, 2025 at 3:54 PM
YES. Need to say this loudly and often! This 2.46x is also the short-term ROI. Long-term ROI (more difficult to estimate) may ~10x. Highest for any gov't spending. And the source of discoveries necessary for all new drugs (industry important too but without NIH funded science there's no foundation)
Reposted by Kamphorst LAB
First time calling politicians - it felt GOOD! Empowering - might call them again tomorrow, and the day after - get out there! this 5calls website will tell you who to call and provide a draft script #science will #prevail. 5calls.org/issue/nih-ns...
Save NIH and NSF Research Funding ⭑ 5 Calls
On February 7, the Trump administration moved to cut billions of dollars in funding from the National Institutes of Health (NIH) and National Science …
5calls.org
February 9, 2025 at 2:18 AM
First time calling politicians - it felt GOOD! Empowering - might call them again tomorrow, and the day after - get out there! this 5calls website will tell you who to call and provide a draft script #science will #prevail. 5calls.org/issue/nih-ns...
Reposted by Kamphorst LAB
The loss of AMERICAN science will have ripple effects on jobs and economic growth. At the same time China and other countries are investing heavily in science @schumer.senate.gov @nadler.house.gov
The NIH overhead cut doesn't just hurt universities.
It's deadly to the US economy.
The US is a world leader in tech due to the ecosystem that NIH and NSF propel. It drives innovation for tech transfer, creates a highly-skilled sci/tech workforce, and fosters academic/industry crossfertilization.
It's deadly to the US economy.
The US is a world leader in tech due to the ecosystem that NIH and NSF propel. It drives innovation for tech transfer, creates a highly-skilled sci/tech workforce, and fosters academic/industry crossfertilization.
2. While NSF and NIH indeed have a mission to fund specific research innovations via grantmaking, they do a lot more than that.
Their principal role is support a scientific ecosystem in the United States, that includes everything from education and training to infrastructure and communication.
Their principal role is support a scientific ecosystem in the United States, that includes everything from education and training to infrastructure and communication.
February 8, 2025 at 3:18 PM
The loss of AMERICAN science will have ripple effects on jobs and economic growth. At the same time China and other countries are investing heavily in science @schumer.senate.gov @nadler.house.gov