Ian Parish
@ianparish.bsky.social
Immunologist & Group Leader at the Peter MacCallum Cancer Centre. Views are my own.
https://www.petermac.org/research/research-programs-and-labs/cancer-immunology-program/ian-parish-lab
https://www.petermac.org/research/research-programs-and-labs/cancer-immunology-program/ian-parish-lab
Reposted by Ian Parish
OBS Immunology | Young Investigator Seminar
'Understanding CD8+ T cell Tolerance'
Ian Parish, PhD
Assoc. Professor & Group Leader,
Peter MacCallum Cancer Centre
tinyurl.com/Parish-Lab
@ianparish.bsky.social
🎙️@danmcmanus123.bsky.social
Thursday, Feb 19th, 2026
5pm ET | 4pm CT | 2pm PT
Zoom👇️
'Understanding CD8+ T cell Tolerance'
Ian Parish, PhD
Assoc. Professor & Group Leader,
Peter MacCallum Cancer Centre
tinyurl.com/Parish-Lab
@ianparish.bsky.social
🎙️@danmcmanus123.bsky.social
Thursday, Feb 19th, 2026
5pm ET | 4pm CT | 2pm PT
Zoom👇️
February 13, 2026 at 4:35 PM
OBS Immunology | Young Investigator Seminar
'Understanding CD8+ T cell Tolerance'
Ian Parish, PhD
Assoc. Professor & Group Leader,
Peter MacCallum Cancer Centre
tinyurl.com/Parish-Lab
@ianparish.bsky.social
🎙️@danmcmanus123.bsky.social
Thursday, Feb 19th, 2026
5pm ET | 4pm CT | 2pm PT
Zoom👇️
'Understanding CD8+ T cell Tolerance'
Ian Parish, PhD
Assoc. Professor & Group Leader,
Peter MacCallum Cancer Centre
tinyurl.com/Parish-Lab
@ianparish.bsky.social
🎙️@danmcmanus123.bsky.social
Thursday, Feb 19th, 2026
5pm ET | 4pm CT | 2pm PT
Zoom👇️
Reposted by Ian Parish
New study—and exciting collaboration with Wei Wang, Cong Liu (UCSD), and Kay Chung (new lab at UNC)—that provides a platform for designing T cells into specific states. We identified state-selective TFs for CD8 T cell states that enable “recipes” for cell engineering! www.nature.com/articles/s41...
Atlas-guided discovery of transcription factors for T cell programming - Nature
A comprehensive atlas platform integrating transcriptional and epigenetic data enables more precise engineering of T cell states, accelerating the rational design of more effective cellular immunother...
www.nature.com
February 6, 2026 at 4:40 PM
New study—and exciting collaboration with Wei Wang, Cong Liu (UCSD), and Kay Chung (new lab at UNC)—that provides a platform for designing T cells into specific states. We identified state-selective TFs for CD8 T cell states that enable “recipes” for cell engineering! www.nature.com/articles/s41...
Reposted by Ian Parish
A great piece in ACIR discussing the there papers on #BACH2 dosing for T cell therapy of cancer recently out in
@NatImmunol
bit.ly/3atHQyV
@NatImmunol
bit.ly/3atHQyV
February 4, 2026 at 9:26 PM
A great piece in ACIR discussing the there papers on #BACH2 dosing for T cell therapy of cancer recently out in
@NatImmunol
bit.ly/3atHQyV
@NatImmunol
bit.ly/3atHQyV
Reposted by Ian Parish
We have an active search for tenure-track faculty interested in #ImmuneEngineering #ProteinEngineering #GenomeEngineering & #CancerImmunology. Join the newly formed Center for Cellular Therapies and Cancer Immunology #CCTCI. Learn more at apply.interfolio.com/173562. #facultyjobs
Apply - Interfolio
{{$ctrl.$state.data.pageTitle}} - Apply - Interfolio
apply.interfolio.com
September 20, 2025 at 12:48 AM
We have an active search for tenure-track faculty interested in #ImmuneEngineering #ProteinEngineering #GenomeEngineering & #CancerImmunology. Join the newly formed Center for Cellular Therapies and Cancer Immunology #CCTCI. Learn more at apply.interfolio.com/173562. #facultyjobs
Great to see this out, it was fun to work with Roychoudhuri lab on this really nice story. A good illustration that too much "stemness" in T cells can be a bad thing.
Thrilled to share our latest work: Fine-tuning BACH2 dosage balances stemness and effector function to enhance antitumor T cell therapy - now online in Nature Immunology. Led by Alberto Conti, Alex Evans and Teresa von Linde in the lab. www.nature.com/articles/s41...
January 17, 2026 at 10:46 AM
Great to see this out, it was fun to work with Roychoudhuri lab on this really nice story. A good illustration that too much "stemness" in T cells can be a bad thing.
Reposted by Ian Parish
Peter Mac has been awarded $7.5M+ in @nhmrc.bsky.social Ideas Grant funding for five innovative projects tackling cancer metastasis, treatment resistance and immunotherapy.
An outstanding result in a highly competitive scheme!
Read more: www.petermac.org/about-us/new...
An outstanding result in a highly competitive scheme!
Read more: www.petermac.org/about-us/new...
January 12, 2026 at 5:37 AM
Peter Mac has been awarded $7.5M+ in @nhmrc.bsky.social Ideas Grant funding for five innovative projects tackling cancer metastasis, treatment resistance and immunotherapy.
An outstanding result in a highly competitive scheme!
Read more: www.petermac.org/about-us/new...
An outstanding result in a highly competitive scheme!
Read more: www.petermac.org/about-us/new...
Reposted by Ian Parish
A $5 million @nhmrc grant will help Peter Mac researchers tackle one of cancer’s toughest challenges: advanced, metastatic disease.
The project, led by @belindaparker.bsky.social, will focus on understanding how metastatic cancers evade the immune system.
More: www.petermac.org/about-us/new...
The project, led by @belindaparker.bsky.social, will focus on understanding how metastatic cancers evade the immune system.
More: www.petermac.org/about-us/new...
January 7, 2026 at 11:05 PM
A $5 million @nhmrc grant will help Peter Mac researchers tackle one of cancer’s toughest challenges: advanced, metastatic disease.
The project, led by @belindaparker.bsky.social, will focus on understanding how metastatic cancers evade the immune system.
More: www.petermac.org/about-us/new...
The project, led by @belindaparker.bsky.social, will focus on understanding how metastatic cancers evade the immune system.
More: www.petermac.org/about-us/new...
Reposted by Ian Parish
👇See our newest study:
What was supposed to be a control experiment uncovered a new function of mTOR: 3’mediated translation control in primary human T cells, mediated through DDX21. AU-rich elements are required for this effect. Happy reading!
authors.elsevier.com/a/1mDFf3vVUP...
What was supposed to be a control experiment uncovered a new function of mTOR: 3’mediated translation control in primary human T cells, mediated through DDX21. AU-rich elements are required for this effect. Happy reading!
authors.elsevier.com/a/1mDFf3vVUP...
authors.elsevier.com
December 5, 2025 at 8:24 AM
👇See our newest study:
What was supposed to be a control experiment uncovered a new function of mTOR: 3’mediated translation control in primary human T cells, mediated through DDX21. AU-rich elements are required for this effect. Happy reading!
authors.elsevier.com/a/1mDFf3vVUP...
What was supposed to be a control experiment uncovered a new function of mTOR: 3’mediated translation control in primary human T cells, mediated through DDX21. AU-rich elements are required for this effect. Happy reading!
authors.elsevier.com/a/1mDFf3vVUP...
Reposted by Ian Parish
1/ We are making progress towards finding a cure for HIV. In a trial @UCSF led by Steve Deeks and @michaelpelusomd.bsky.social, 7/10 participants who received a combination of immunotherapies achieved partial control of HIV after stopping antiretroviral therapy (ART).🧵 www.nature.com/articles/s41...
Correlates of HIV-1 control after combination immunotherapy - Nature
Nature - Correlates of HIV-1 control after combination immunotherapy
www.nature.com
December 2, 2025 at 6:50 AM
1/ We are making progress towards finding a cure for HIV. In a trial @UCSF led by Steve Deeks and @michaelpelusomd.bsky.social, 7/10 participants who received a combination of immunotherapies achieved partial control of HIV after stopping antiretroviral therapy (ART).🧵 www.nature.com/articles/s41...
Reposted by Ian Parish
We're hiring! We are looking for a Research Assistant with protein biochemistry skills to develop novel protein-based immunotherapeutics targeting Treg cells in cancer. You'll join
@roychoudhurilab.bsky.social @campathology.bsky.social @crukcamcentre.bsky.social Apply: jobs.cam.ac.uk/job/53219/
@roychoudhurilab.bsky.social @campathology.bsky.social @crukcamcentre.bsky.social Apply: jobs.cam.ac.uk/job/53219/
November 10, 2025 at 7:40 AM
We're hiring! We are looking for a Research Assistant with protein biochemistry skills to develop novel protein-based immunotherapeutics targeting Treg cells in cancer. You'll join
@roychoudhurilab.bsky.social @campathology.bsky.social @crukcamcentre.bsky.social Apply: jobs.cam.ac.uk/job/53219/
@roychoudhurilab.bsky.social @campathology.bsky.social @crukcamcentre.bsky.social Apply: jobs.cam.ac.uk/job/53219/
Reposted by Ian Parish
Happy to announce the publication using advanced models to understand how T cells mediate efficient immunoediting in early sarcomas.
This was a collaboration between Julie Cheung and Brian Hunt
in the lab
Thanks to Cancer Cell for publishing our work.
www.cell.com/cancer-cell/...
This was a collaboration between Julie Cheung and Brian Hunt
in the lab
Thanks to Cancer Cell for publishing our work.
www.cell.com/cancer-cell/...
Distinct T cell functions enable efficient immunoediting and prevent tumor emergence of developing sarcomas
Cheung et al. describe efficient T cell control of nascent neoantigen+ and nearby
neoantigen-negative sarcoma cells, underlying a ∼50% reduction in tumor penetrance.
This otherwise imperceptible immun...
www.cell.com
October 2, 2025 at 4:50 PM
Happy to announce the publication using advanced models to understand how T cells mediate efficient immunoediting in early sarcomas.
This was a collaboration between Julie Cheung and Brian Hunt
in the lab
Thanks to Cancer Cell for publishing our work.
www.cell.com/cancer-cell/...
This was a collaboration between Julie Cheung and Brian Hunt
in the lab
Thanks to Cancer Cell for publishing our work.
www.cell.com/cancer-cell/...
Reposted by Ian Parish
Thrilled to have our latest research @wehi-research.bsky.social published in @natimmunol.nature.com
www.nature.com/articles/s41...
This work was an outstanding partnership between talented PhD student Len Dalit (now postdoc, no 🦋) and bioinformatician @chinweetan.bsky.social
Thread below...
www.nature.com/articles/s41...
This work was an outstanding partnership between talented PhD student Len Dalit (now postdoc, no 🦋) and bioinformatician @chinweetan.bsky.social
Thread below...
Divergent cytokine and transcriptional signatures control functional T follicular helper cell heterogeneity - Nature Immunology
Dalit, Tan and colleagues provide a multiomic profile of T follicular helper (TFH) cells responses to diverse pathogens, revealing a blueprint for transcriptional flexibility and new tools to interrog...
www.nature.com
September 12, 2025 at 2:20 AM
Thrilled to have our latest research @wehi-research.bsky.social published in @natimmunol.nature.com
www.nature.com/articles/s41...
This work was an outstanding partnership between talented PhD student Len Dalit (now postdoc, no 🦋) and bioinformatician @chinweetan.bsky.social
Thread below...
www.nature.com/articles/s41...
This work was an outstanding partnership between talented PhD student Len Dalit (now postdoc, no 🦋) and bioinformatician @chinweetan.bsky.social
Thread below...
Reposted by Ian Parish
What's the difference between Trm and exhausted CD8 T cells? Simone Park's new work dissects this important question. These cell types are often confused, but are ontologically and mechanistically distinct with implications for immunotherapy responses. www.biorxiv.org/content/10.1...
Divergent ontogeny of Tissue Resident Memory and Tissue Resident Exhausted CD8+ T cells underlies distinct functional potential
Persistent antigen stimulation promotes differentiation of exhausted CD8+ T (TEX) cells. TEX cells are distinct from circulating memory T (TCIRCM) cells but share many features with tissue-resident me...
www.biorxiv.org
August 14, 2025 at 5:30 PM
What's the difference between Trm and exhausted CD8 T cells? Simone Park's new work dissects this important question. These cell types are often confused, but are ontologically and mechanistically distinct with implications for immunotherapy responses. www.biorxiv.org/content/10.1...
It was a privilege and a pleasure for both myself and @menezesnmaria.bsky.social to preview a great upcoming article in @cp-immunity.bsky.social by @kamphorstlab.bsky.social showing an unexpected inhibitory role for ICOS in exhausted CD8+ T cells.
www.cell.com/immunity/abs...
www.cell.com/immunity/abs...
The high (I)COSt of costimulation for exhausted T cells
ICOS agonists are being investigated for cancer immunotherapy based on the idea that
they will reinvigorate exhausted CD8+ T cell anti-cancer immunity. Humblin et al.
unexpectedly find the opposite—th...
www.cell.com
August 13, 2025 at 11:33 AM
It was a privilege and a pleasure for both myself and @menezesnmaria.bsky.social to preview a great upcoming article in @cp-immunity.bsky.social by @kamphorstlab.bsky.social showing an unexpected inhibitory role for ICOS in exhausted CD8+ T cells.
www.cell.com/immunity/abs...
www.cell.com/immunity/abs...
Reposted by Ian Parish
Online now: The costimulatory molecule ICOS limits memory-like properties and function of exhausted PD-1+CD8+ T cells
The costimulatory molecule ICOS limits memory-like properties and function of exhausted PD-1+CD8+ T cells
Understanding regulation of progenitor exhausted CD8+ T (Tpex) cell differentiation is important for immunotherapies. Humblin et al. report that sustained ICOS costimulation is detrimental to PD-1+CD8+ T cell responses. Limiting ICOS signaling enhances Tpex cell stemness and differentiation into effector-like cells with improved survival and functionality. ICOSL blockade reinvigorates PD-1+CD8+ T cells and promotes viral or tumor control, potentiating PD-1 targeted immunotherapy.
dlvr.it
July 7, 2025 at 2:49 PM
Online now: The costimulatory molecule ICOS limits memory-like properties and function of exhausted PD-1+CD8+ T cells
Reposted by Ian Parish
NR4A2 & RGS16 promoters support delivery of cytokines (e.g. IL-12) directly to the tumor site, leading to enhanced antitumor efficacy and long-term survival of mice in both syngeneic and xenogeneic models @nature.com @paulbeavis4.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
July 2, 2025 at 8:01 PM
NR4A2 & RGS16 promoters support delivery of cytokines (e.g. IL-12) directly to the tumor site, leading to enhanced antitumor efficacy and long-term survival of mice in both syngeneic and xenogeneic models @nature.com @paulbeavis4.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Ian Parish
🎓 PhD positions available @MonashUni
Join our lab to explore how neurons and immune cells shape gut immunity!
🧬 Single-cell RNAseq
🔬 3D imaging
🧠 Neuro-immune interactions
👥 Great mentoring & collaborations
Apply now 👉 tinyurl.com/Seilletlab
Join our lab to explore how neurons and immune cells shape gut immunity!
🧬 Single-cell RNAseq
🔬 3D imaging
🧠 Neuro-immune interactions
👥 Great mentoring & collaborations
Apply now 👉 tinyurl.com/Seilletlab
Understanding the neuroimmune regulation of innate immunity | Supervisor Connect
tinyurl.com
June 2, 2025 at 6:59 AM
🎓 PhD positions available @MonashUni
Join our lab to explore how neurons and immune cells shape gut immunity!
🧬 Single-cell RNAseq
🔬 3D imaging
🧠 Neuro-immune interactions
👥 Great mentoring & collaborations
Apply now 👉 tinyurl.com/Seilletlab
Join our lab to explore how neurons and immune cells shape gut immunity!
🧬 Single-cell RNAseq
🔬 3D imaging
🧠 Neuro-immune interactions
👥 Great mentoring & collaborations
Apply now 👉 tinyurl.com/Seilletlab
Reposted by Ian Parish
We're looking for an experienced lab manager to join our wonderful team investigating fundamental T cell biology 🤓
careers.pageuppeople.com/513/cw/en/jo...
careers.pageuppeople.com/513/cw/en/jo...
Job Search
careers.pageuppeople.com
May 12, 2025 at 9:23 AM
We're looking for an experienced lab manager to join our wonderful team investigating fundamental T cell biology 🤓
careers.pageuppeople.com/513/cw/en/jo...
careers.pageuppeople.com/513/cw/en/jo...
Reposted by Ian Parish
Join us as a group leader!!! Only a week left to apply to become part of our talented, fun and enthusiastic cancer research faculty in Melbourne.
👇
👇
A group leader position is open at Peter Mac in Melbourne, Australia!
Join us! Applications until May 5.
👇👇
www.nature.com/naturecareer...
Join us! Applications until May 5.
👇👇
www.nature.com/naturecareer...
Group Leader - Melbourne (Suburb), Greater Melbourne (Inner) (AU) job with Peter MacCallum Cancer Centre | 12837590
Peter Mac is recruiting a Group Leader to increase the capacity and efficiency of our “discovery to translation” cancer research pipeline.
www.nature.com
May 1, 2025 at 10:21 AM
Join us as a group leader!!! Only a week left to apply to become part of our talented, fun and enthusiastic cancer research faculty in Melbourne.
👇
👇
Reposted by Ian Parish
A group leader position is open at Peter Mac in Melbourne, Australia!
Join us! Applications until May 5.
👇👇
www.nature.com/naturecareer...
Join us! Applications until May 5.
👇👇
www.nature.com/naturecareer...
Group Leader - Melbourne (Suburb), Greater Melbourne (Inner) (AU) job with Peter MacCallum Cancer Centre | 12837590
Peter Mac is recruiting a Group Leader to increase the capacity and efficiency of our “discovery to translation” cancer research pipeline.
www.nature.com
March 21, 2025 at 9:13 PM
A group leader position is open at Peter Mac in Melbourne, Australia!
Join us! Applications until May 5.
👇👇
www.nature.com/naturecareer...
Join us! Applications until May 5.
👇👇
www.nature.com/naturecareer...
Reposted by Ian Parish
Thrilled to share new work led by @jieyang437.bsky.social in the lab published today in @Nature. We find that Aspirin prevents metastasis by releasing T cells from immune suppression by platelet TXA2. @Cambridge_Uni @CRUKCamCentre rdcu.be/eci1U
March 5, 2025 at 6:56 PM
Thrilled to share new work led by @jieyang437.bsky.social in the lab published today in @Nature. We find that Aspirin prevents metastasis by releasing T cells from immune suppression by platelet TXA2. @Cambridge_Uni @CRUKCamCentre rdcu.be/eci1U
Reposted by Ian Parish
Register for the 2025 Mini Symposium to hear talks from @ralfhadams.bsky.social , A/Prof Sanjay Patel, @ianparish.bsky.social and @cgerlachlab.bsky.social - Taking place on 26 March and free for ISEH members, you can register here: www.iseh.org/2025MiniSymposium
March 5, 2025 at 3:15 PM
Register for the 2025 Mini Symposium to hear talks from @ralfhadams.bsky.social , A/Prof Sanjay Patel, @ianparish.bsky.social and @cgerlachlab.bsky.social - Taking place on 26 March and free for ISEH members, you can register here: www.iseh.org/2025MiniSymposium
Reposted by Ian Parish
We are recruiting a group leader in laboratory research at Peter Mac Cancer Centre in
Melbourne, Australia 🔬🦘💥
Work in a cutting edge research environment in a vibrant world city!
We value research excellence, creativity and diversity.
Join us!
careers.petermac.org/job/MELBOURN...
Melbourne, Australia 🔬🦘💥
Work in a cutting edge research environment in a vibrant world city!
We value research excellence, creativity and diversity.
Join us!
careers.petermac.org/job/MELBOURN...
Group Leader
Group Leader
careers.petermac.org
March 5, 2025 at 8:04 AM
We are recruiting a group leader in laboratory research at Peter Mac Cancer Centre in
Melbourne, Australia 🔬🦘💥
Work in a cutting edge research environment in a vibrant world city!
We value research excellence, creativity and diversity.
Join us!
careers.petermac.org/job/MELBOURN...
Melbourne, Australia 🔬🦘💥
Work in a cutting edge research environment in a vibrant world city!
We value research excellence, creativity and diversity.
Join us!
careers.petermac.org/job/MELBOURN...
Reposted by Ian Parish
Excited for our lab's FIRST paper #ScienceImmunology! 🎉
Led by @categraca.bsky.social & Amania Sheikh, with amazing collabs from Axel Kallies, Dane Newman, & @rickyjohnstone.bsky.social
Huge thanks to reviewers & @claireolingy.bsky.social 🙌
#Tpex #onthescoreboard
www.science.org/doi/full/10....
Led by @categraca.bsky.social & Amania Sheikh, with amazing collabs from Axel Kallies, Dane Newman, & @rickyjohnstone.bsky.social
Huge thanks to reviewers & @claireolingy.bsky.social 🙌
#Tpex #onthescoreboard
www.science.org/doi/full/10....
Stem-like memory and precursors of exhausted T cells share a common progenitor defined by ID3 expression
ID3 defines stem-like T cells with high developmental potential that sustain T cell responses to chronic infection and cancer.
www.science.org
January 31, 2025 at 7:51 PM
Excited for our lab's FIRST paper #ScienceImmunology! 🎉
Led by @categraca.bsky.social & Amania Sheikh, with amazing collabs from Axel Kallies, Dane Newman, & @rickyjohnstone.bsky.social
Huge thanks to reviewers & @claireolingy.bsky.social 🙌
#Tpex #onthescoreboard
www.science.org/doi/full/10....
Led by @categraca.bsky.social & Amania Sheikh, with amazing collabs from Axel Kallies, Dane Newman, & @rickyjohnstone.bsky.social
Huge thanks to reviewers & @claireolingy.bsky.social 🙌
#Tpex #onthescoreboard
www.science.org/doi/full/10....
Reposted by Ian Parish
We're #hiring a #postdoc to join our lab 🧪 in Melbourne 🇦🇺🦘 in #StemCell and #Cancer #Epigenetics. Great opportunity to lead a research project within the broader vision of the lab, with plenty of scope to develop as an independent leader 👩🔬🔬
Apply by 27 Feb
careers.petermac.org/job/MELBOURN...
Apply by 27 Feb
careers.petermac.org/job/MELBOURN...
Postdoctoral Researcher - Eckersley Maslin Lab
Postdoctoral Researcher - Eckersley Maslin Lab
careers.petermac.org
January 30, 2025 at 9:29 PM
We're #hiring a #postdoc to join our lab 🧪 in Melbourne 🇦🇺🦘 in #StemCell and #Cancer #Epigenetics. Great opportunity to lead a research project within the broader vision of the lab, with plenty of scope to develop as an independent leader 👩🔬🔬
Apply by 27 Feb
careers.petermac.org/job/MELBOURN...
Apply by 27 Feb
careers.petermac.org/job/MELBOURN...