Daniel Utzschneider
@danielutzschneider.bsky.social
Lab Head @thedohertyinst.bsky.social | University of Melbourne
CSL Centenary Fellow
views my own
https://www.doherty.edu.au/people/dr-daniel-utzschneider
CSL Centenary Fellow
views my own
https://www.doherty.edu.au/people/dr-daniel-utzschneider
Pinned
Stem-like memory and precursors of exhausted T cells share a common progenitor defined by ID3 expression
ID3 defines stem-like T cells with high developmental potential that sustain T cell responses to chronic infection and cancer.
www.science.org
Excited for our lab's FIRST paper #ScienceImmunology! 🎉
Led by @categraca.bsky.social & Amania Sheikh, with amazing collabs from Axel Kallies, Dane Newman, & @rickyjohnstone.bsky.social
Huge thanks to reviewers & @claireolingy.bsky.social 🙌
#Tpex #onthescoreboard
www.science.org/doi/full/10....
Led by @categraca.bsky.social & Amania Sheikh, with amazing collabs from Axel Kallies, Dane Newman, & @rickyjohnstone.bsky.social
Huge thanks to reviewers & @claireolingy.bsky.social 🙌
#Tpex #onthescoreboard
www.science.org/doi/full/10....
Reposted by Daniel Utzschneider
Right now, the Government is starving medical research of full funding, even as it claims that science and research are national priorities. If our leaders truly value science as much as they say, then they must back their words with action—and fund it properly.
Join the campaign!
Join the campaign!
Medical Research Matters
www.moniqueryan.com.au
January 23, 2026 at 5:23 AM
Right now, the Government is starving medical research of full funding, even as it claims that science and research are national priorities. If our leaders truly value science as much as they say, then they must back their words with action—and fund it properly.
Join the campaign!
Join the campaign!
Reposted by Daniel Utzschneider
Thanks to funding through the NHMRC's 2025 Synergy and Ideas grants, 27 UniMelb projects have secured $52 million to help turn bold ideas into meaningful impact.
Congratulations to everyone involved 👏
Tap through to read more → unimelb.me/4b6xNms
Congratulations to everyone involved 👏
Tap through to read more → unimelb.me/4b6xNms
January 19, 2026 at 5:00 AM
Thanks to funding through the NHMRC's 2025 Synergy and Ideas grants, 27 UniMelb projects have secured $52 million to help turn bold ideas into meaningful impact.
Congratulations to everyone involved 👏
Tap through to read more → unimelb.me/4b6xNms
Congratulations to everyone involved 👏
Tap through to read more → unimelb.me/4b6xNms
Looking forward to @categraca.bsky.social presenting our recent work. Tune in!
Built for Uncertainty: How CD8 T cells Prepare for Acute & Chronic Infection
🎙️ OBS Speaker Highlight
🔬Catarina Gago da Graça
@categraca.bsky.social
📢 Paper in @sciimmunology.bsky.social (2025)
📅 Jan 15, 2026 | ⏰5pm ET/ 4pm CT/ 2pm PT
📌 Register here: us02web.zoom.us/meeting/regi...
🎙️ OBS Speaker Highlight
🔬Catarina Gago da Graça
@categraca.bsky.social
📢 Paper in @sciimmunology.bsky.social (2025)
📅 Jan 15, 2026 | ⏰5pm ET/ 4pm CT/ 2pm PT
📌 Register here: us02web.zoom.us/meeting/regi...
January 8, 2026 at 5:47 AM
Looking forward to @categraca.bsky.social presenting our recent work. Tune in!
Reposted by Daniel Utzschneider
Reposted by Daniel Utzschneider
Online now: Microbiota-derived butyrate promotes a FOXO1-induced stemness program and preserves CD8+ T cell immunity against melanoma
Microbiota-derived butyrate promotes a FOXO1-induced stemness program and preserves CD8+ T cell immunity against melanoma
The gut microbiome impacts immunity at various levels, including response to immunotherapy. Bachem et al. find that metabolic pathways shared across different microbiota constituents, including SCFA synthesis, modulate stem-like tumor-specific CD127+CD8+ T cells in the tumor-draining lymph node and impact control of melanoma.
dlvr.it
November 3, 2025 at 3:48 PM
Online now: Microbiota-derived butyrate promotes a FOXO1-induced stemness program and preserves CD8+ T cell immunity against melanoma
Reposted by Daniel Utzschneider
‼️Deadline approaching - Don't miss your chance to submit an oral abstract for 16th Annual Lorne Infection & Immunity Conference
📍Held 18-20 of February 2026 at the Mantra Lorne
📝 Career Development Awards also available
Apply at www.lorneinfectionimmunity.org
Deadline: Friday, 10th of October
📍Held 18-20 of February 2026 at the Mantra Lorne
📝 Career Development Awards also available
Apply at www.lorneinfectionimmunity.org
Deadline: Friday, 10th of October
October 8, 2025 at 9:22 AM
‼️Deadline approaching - Don't miss your chance to submit an oral abstract for 16th Annual Lorne Infection & Immunity Conference
📍Held 18-20 of February 2026 at the Mantra Lorne
📝 Career Development Awards also available
Apply at www.lorneinfectionimmunity.org
Deadline: Friday, 10th of October
📍Held 18-20 of February 2026 at the Mantra Lorne
📝 Career Development Awards also available
Apply at www.lorneinfectionimmunity.org
Deadline: Friday, 10th of October
Reposted by Daniel Utzschneider
Reposted by Daniel Utzschneider
TGFβ-driven, HOBIT-dependent tissue-residency programs promote tumor-infiltration of CD8 T cells, but disruption of TGFβ in these tumor-infiltrating cells enhances tumor control @natimmunol.nature.com www.nature.com/articles/s41...
www.nature.com/articles/s41...
www.nature.com/articles/s41...
July 29, 2025 at 5:19 PM
TGFβ-driven, HOBIT-dependent tissue-residency programs promote tumor-infiltration of CD8 T cells, but disruption of TGFβ in these tumor-infiltrating cells enhances tumor control @natimmunol.nature.com www.nature.com/articles/s41...
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Congrats @yannick-alexandre.bsky.social and team. Great study
I’m pleased to share my latest work, published in Science Advances.
In this study, we investigated how fibroblastic reticular cells (FRCs) that populate the white pulp of the spleen regulate immune responses to viral infections.
#immunology #immunosky
www.science.org/doi/10.1126/...
In this study, we investigated how fibroblastic reticular cells (FRCs) that populate the white pulp of the spleen regulate immune responses to viral infections.
#immunology #immunosky
www.science.org/doi/10.1126/...
Splenic fibroblastic reticular cells orchestrate dendritic cell maturation and facilitate CD8+ T cell priming and protective memory
Fibroblastic reticular cells of the spleen coordinate inflammation for optimal antiviral T cell responses and protective memory.
www.science.org
June 5, 2025 at 1:09 AM
Congrats @yannick-alexandre.bsky.social and team. Great study
Reposted by Daniel Utzschneider
We're looking for an experienced lab manager to join our wonderful team investigating fundamental T cell biology 🤓
careers.pageuppeople.com/513/cw/en/jo...
careers.pageuppeople.com/513/cw/en/jo...
Job Search
careers.pageuppeople.com
May 12, 2025 at 9:23 AM
We're looking for an experienced lab manager to join our wonderful team investigating fundamental T cell biology 🤓
careers.pageuppeople.com/513/cw/en/jo...
careers.pageuppeople.com/513/cw/en/jo...
Great meeting to (be) lock(ed) in!
Register TODAY: Melbourne Immunotherapy Network, 2-day Spring Symposium, Pentridge Prison, Coburg! 2-3 Sept '25.
Student Early Bird: $250, inc. conference dinner (No metal prison trays, I promise!)
Click below to register and submit your Abstract.
www.melbourneimmunotherapy.org/registration
Student Early Bird: $250, inc. conference dinner (No metal prison trays, I promise!)
Click below to register and submit your Abstract.
www.melbourneimmunotherapy.org/registration
March 11, 2025 at 5:17 AM
Great meeting to (be) lock(ed) in!
Reposted by Daniel Utzschneider
We are recruiting a group leader in laboratory research at Peter Mac Cancer Centre in
Melbourne, Australia 🔬🦘💥
Work in a cutting edge research environment in a vibrant world city!
We value research excellence, creativity and diversity.
Join us!
careers.petermac.org/job/MELBOURN...
Melbourne, Australia 🔬🦘💥
Work in a cutting edge research environment in a vibrant world city!
We value research excellence, creativity and diversity.
Join us!
careers.petermac.org/job/MELBOURN...
Group Leader
Group Leader
careers.petermac.org
March 5, 2025 at 8:04 AM
We are recruiting a group leader in laboratory research at Peter Mac Cancer Centre in
Melbourne, Australia 🔬🦘💥
Work in a cutting edge research environment in a vibrant world city!
We value research excellence, creativity and diversity.
Join us!
careers.petermac.org/job/MELBOURN...
Melbourne, Australia 🔬🦘💥
Work in a cutting edge research environment in a vibrant world city!
We value research excellence, creativity and diversity.
Join us!
careers.petermac.org/job/MELBOURN...
Reposted by Daniel Utzschneider
Inexplicably, US administration has launched an unprecedented assault on science, on research institutions & on vital international organizations & initiatives.
An assault on science anywhere is an assault on science everywhere; the global community must unite
🧪
www.nature.com/articles/d41...
An assault on science anywhere is an assault on science everywhere; the global community must unite
🧪
www.nature.com/articles/d41...
Trump 2.0: an assault on science anywhere is an assault on science everywhere
US President Donald Trump is taking a wrecking ball to science and to international institutions. The global research community must take a stand against these attacks.
www.nature.com
February 25, 2025 at 7:48 PM
Inexplicably, US administration has launched an unprecedented assault on science, on research institutions & on vital international organizations & initiatives.
An assault on science anywhere is an assault on science everywhere; the global community must unite
🧪
www.nature.com/articles/d41...
An assault on science anywhere is an assault on science everywhere; the global community must unite
🧪
www.nature.com/articles/d41...
Reposted by Daniel Utzschneider
Check out our new paper!
Our paper is out!
LCK–co-receptor association ensures T cell lineage fidelity and maximizes epitope-specific TCR diversity | Science Immunology www.science.org/doi/10.1126/...
LCK–co-receptor association ensures T cell lineage fidelity and maximizes epitope-specific TCR diversity | Science Immunology www.science.org/doi/10.1126/...
LCK–co-receptor association ensures T cell lineage fidelity and maximizes epitope-specific TCR diversity
LCK-mutant mice help define the role of LCK–co-receptor association in T cell development and immune responses.
www.science.org
February 22, 2025 at 8:44 PM
Check out our new paper!
Reposted by Daniel Utzschneider
In the media over the weekend, groundbreaking research from Peter Mac & The Doherty has uncovered a new way to enhance the immune system’s ability to fight cancer.
Work at Peter Mac led by @JohnstoneRicky and Dane Newman. More via @australian or here: www.petermac.org/about-us/new...
Work at Peter Mac led by @JohnstoneRicky and Dane Newman. More via @australian or here: www.petermac.org/about-us/new...
New immune system discovery could boost cancer treatment effectiveness - Peter MacCallum Cancer Centre
www.petermac.org
February 2, 2025 at 11:39 PM
In the media over the weekend, groundbreaking research from Peter Mac & The Doherty has uncovered a new way to enhance the immune system’s ability to fight cancer.
Work at Peter Mac led by @JohnstoneRicky and Dane Newman. More via @australian or here: www.petermac.org/about-us/new...
Work at Peter Mac led by @JohnstoneRicky and Dane Newman. More via @australian or here: www.petermac.org/about-us/new...
Reposted by Daniel Utzschneider
Very excited about this collaborative study between @petermaccc.bsky.social @danielutzschneider.bsky.social and Kallies lab
Excited for our lab's FIRST paper #ScienceImmunology! 🎉
Led by @categraca.bsky.social & Amania Sheikh, with amazing collabs from Axel Kallies, Dane Newman, & @rickyjohnstone.bsky.social
Huge thanks to reviewers & @claireolingy.bsky.social 🙌
#Tpex #onthescoreboard
www.science.org/doi/full/10....
Led by @categraca.bsky.social & Amania Sheikh, with amazing collabs from Axel Kallies, Dane Newman, & @rickyjohnstone.bsky.social
Huge thanks to reviewers & @claireolingy.bsky.social 🙌
#Tpex #onthescoreboard
www.science.org/doi/full/10....
Stem-like memory and precursors of exhausted T cells share a common progenitor defined by ID3 expression
ID3 defines stem-like T cells with high developmental potential that sustain T cell responses to chronic infection and cancer.
www.science.org
January 31, 2025 at 11:46 PM
Very excited about this collaborative study between @petermaccc.bsky.social @danielutzschneider.bsky.social and Kallies lab
Reposted by Daniel Utzschneider
ID3 defines stem-like T cells with high developmental potential that sustain T cell responses to chronic infection and cancer
www.science.org/doi/10.1126/...
@sciimmunology.bsky.social
www.science.org/doi/10.1126/...
@sciimmunology.bsky.social
January 31, 2025 at 11:23 PM
ID3 defines stem-like T cells with high developmental potential that sustain T cell responses to chronic infection and cancer
www.science.org/doi/10.1126/...
@sciimmunology.bsky.social
www.science.org/doi/10.1126/...
@sciimmunology.bsky.social
Reposted by Daniel Utzschneider
Very happy to share our new work!
Excited for our lab's FIRST paper #ScienceImmunology! 🎉
Led by @categraca.bsky.social & Amania Sheikh, with amazing collabs from Axel Kallies, Dane Newman, & @rickyjohnstone.bsky.social
Huge thanks to reviewers & @claireolingy.bsky.social 🙌
#Tpex #onthescoreboard
www.science.org/doi/full/10....
Led by @categraca.bsky.social & Amania Sheikh, with amazing collabs from Axel Kallies, Dane Newman, & @rickyjohnstone.bsky.social
Huge thanks to reviewers & @claireolingy.bsky.social 🙌
#Tpex #onthescoreboard
www.science.org/doi/full/10....
Stem-like memory and precursors of exhausted T cells share a common progenitor defined by ID3 expression
ID3 defines stem-like T cells with high developmental potential that sustain T cell responses to chronic infection and cancer.
www.science.org
January 31, 2025 at 8:58 PM
Very happy to share our new work!
Excited for our lab's FIRST paper #ScienceImmunology! 🎉
Led by @categraca.bsky.social & Amania Sheikh, with amazing collabs from Axel Kallies, Dane Newman, & @rickyjohnstone.bsky.social
Huge thanks to reviewers & @claireolingy.bsky.social 🙌
#Tpex #onthescoreboard
www.science.org/doi/full/10....
Led by @categraca.bsky.social & Amania Sheikh, with amazing collabs from Axel Kallies, Dane Newman, & @rickyjohnstone.bsky.social
Huge thanks to reviewers & @claireolingy.bsky.social 🙌
#Tpex #onthescoreboard
www.science.org/doi/full/10....
Stem-like memory and precursors of exhausted T cells share a common progenitor defined by ID3 expression
ID3 defines stem-like T cells with high developmental potential that sustain T cell responses to chronic infection and cancer.
www.science.org
January 31, 2025 at 7:51 PM
Excited for our lab's FIRST paper #ScienceImmunology! 🎉
Led by @categraca.bsky.social & Amania Sheikh, with amazing collabs from Axel Kallies, Dane Newman, & @rickyjohnstone.bsky.social
Huge thanks to reviewers & @claireolingy.bsky.social 🙌
#Tpex #onthescoreboard
www.science.org/doi/full/10....
Led by @categraca.bsky.social & Amania Sheikh, with amazing collabs from Axel Kallies, Dane Newman, & @rickyjohnstone.bsky.social
Huge thanks to reviewers & @claireolingy.bsky.social 🙌
#Tpex #onthescoreboard
www.science.org/doi/full/10....
Really enjoyed writing this News & Views for @natimmunol.bsky.social on @tcellogic.bsky.social & teams recent @science.org paper - the first one 😉
Really beautiful work!!!
www.nature.com/articles/s41...
Really beautiful work!!!
www.nature.com/articles/s41...
January 31, 2025 at 10:31 AM
Really enjoyed writing this News & Views for @natimmunol.bsky.social on @tcellogic.bsky.social & teams recent @science.org paper - the first one 😉
Really beautiful work!!!
www.nature.com/articles/s41...
Really beautiful work!!!
www.nature.com/articles/s41...
Reposted by Daniel Utzschneider
🐳 Join us in sunny Lorne, Australia next month, 19-21 Feb, for the @theviin.bsky.social Infection and Immunity Conference. 🪼 Absolutely great line-up this year! In person (sea-side🐚) and virtual registration options available too. Don't miss out- www.lorneinfectionimmunity.org/registration
January 29, 2025 at 5:17 AM
🐳 Join us in sunny Lorne, Australia next month, 19-21 Feb, for the @theviin.bsky.social Infection and Immunity Conference. 🪼 Absolutely great line-up this year! In person (sea-side🐚) and virtual registration options available too. Don't miss out- www.lorneinfectionimmunity.org/registration
Reposted by Daniel Utzschneider
Share your #cancer #immunology research w/ #CSCancerImmunity2025 organizers Ignacio Melero, Ira Mellman, Fabiola Rivas @cp-immunity.bsky.social
& Montse Rojo de la Vega @cp-cancercell.bsky.social . hubs.li/Q033hK4y0
& Montse Rojo de la Vega @cp-cancercell.bsky.social . hubs.li/Q033hK4y0
January 21, 2025 at 5:44 PM
Share your #cancer #immunology research w/ #CSCancerImmunity2025 organizers Ignacio Melero, Ira Mellman, Fabiola Rivas @cp-immunity.bsky.social
& Montse Rojo de la Vega @cp-cancercell.bsky.social . hubs.li/Q033hK4y0
& Montse Rojo de la Vega @cp-cancercell.bsky.social . hubs.li/Q033hK4y0
Reposted by Daniel Utzschneider
Special thanks to my PhD mentor Rafi, my co-first author, Rajesh Valanparambil, and all the rest of our co-authors.
Image above shows CD8 T cells asking a crystal ball to predict infection outcome. Credit: ChatGPT4
Also see our companion paper from Dietmar Zehn's lab: tinyurl.com/yck3mdup
Image above shows CD8 T cells asking a crystal ball to predict infection outcome. Credit: ChatGPT4
Also see our companion paper from Dietmar Zehn's lab: tinyurl.com/yck3mdup
Precursors of exhausted T cells are preemptively formed in acute infection - Nature
Nature - Precursors of exhausted T cells are preemptively formed in acute infection
tinyurl.com
January 15, 2025 at 10:23 PM
Special thanks to my PhD mentor Rafi, my co-first author, Rajesh Valanparambil, and all the rest of our co-authors.
Image above shows CD8 T cells asking a crystal ball to predict infection outcome. Credit: ChatGPT4
Also see our companion paper from Dietmar Zehn's lab: tinyurl.com/yck3mdup
Image above shows CD8 T cells asking a crystal ball to predict infection outcome. Credit: ChatGPT4
Also see our companion paper from Dietmar Zehn's lab: tinyurl.com/yck3mdup
Two studies published in @nature.com today showing that Tpex-like cells develop independent from acute or chronic infection
#Tpex
www.nature.com/articles/s41...
#Tpex
www.nature.com/articles/s41...
January 9, 2025 at 8:33 AM
Two studies published in @nature.com today showing that Tpex-like cells develop independent from acute or chronic infection
#Tpex
www.nature.com/articles/s41...
#Tpex
www.nature.com/articles/s41...