Congrats Jan!

Congrats @niclag.bsky.social @pzareie.bsky.social and team! 🎉

Thanks Steve!

Not sure I would be able to focus on the pub😂

Thank you to all the collaborators, including @rauschlisa.bsky.social, @ajithvasanthan.bsky.social, @bendinglab.bsky.social and everyone @thedohertyinst.bsky.social & @petermaccc.bsky.social

How could this work?

IL-1 cytokines expand ID3+ stem-like T cells in vitro, boosting their ability to sustain T cell responses in chronic infections & cancer.

This could pave the way for next-gen T cell therapies with enhanced longevity & efficacy. Exciting possibilities ahead!

ID3+ T cells in acute settings show unique stem-like features, including the ability to sustain long-term immunity and exclusively form #Tpex cells in chronic infection & cancer.

Could this improve durability in T cell therapies? We think so! 🧬

#Tpex cells are key to sustaining T cell responses to chronic infection & cancer. Can we learn from #Tpex cells, and harness stem-like T cells in acute infection to improve chronic immune responses?

Yes! T cells identified in acute LCMV expressing ID3 and LY108 shape durable therapies