Pirooz Zareie
@pzareie.bsky.social
Excited to share our review on the vital role of skin-resident T cells in protecting the body’s largest barrier organ. We explore their contributions to immune surveillance, tissue homeostasis, and skin disease. Check it out!
www.nature.com/articles/s41...
@danhkaplan.bsky.social @LMackayLab
www.nature.com/articles/s41...
@danhkaplan.bsky.social @LMackayLab
Cutaneous T cell immunity - Nature Immunology
In this Review, the authors discuss the latest in skin immunology research with a special focus on the role of skin-resident T cells.
www.nature.com
May 8, 2025 at 4:38 AM
Excited to share our review on the vital role of skin-resident T cells in protecting the body’s largest barrier organ. We explore their contributions to immune surveillance, tissue homeostasis, and skin disease. Check it out!
www.nature.com/articles/s41...
@danhkaplan.bsky.social @LMackayLab
www.nature.com/articles/s41...
@danhkaplan.bsky.social @LMackayLab
Check out our new paper!
Our paper is out!
LCK–co-receptor association ensures T cell lineage fidelity and maximizes epitope-specific TCR diversity | Science Immunology www.science.org/doi/10.1126/...
LCK–co-receptor association ensures T cell lineage fidelity and maximizes epitope-specific TCR diversity | Science Immunology www.science.org/doi/10.1126/...
LCK–co-receptor association ensures T cell lineage fidelity and maximizes epitope-specific TCR diversity
LCK-mutant mice help define the role of LCK–co-receptor association in T cell development and immune responses.
www.science.org
February 22, 2025 at 8:44 PM
Check out our new paper!
Reposted by Pirooz Zareie
Now in #Science #Immunology: Justin Zhang, Jamie Rossjohn, @pzareie.bsky.social, @niclag.bsky.social, & al. generate LCK-FREE mice expressing mutated form of endogenous LCK that cannot bind to #CD4 or #CD8. These animals show defects in #TCell lineage fidelity & antigen-specific #TCR diversity!
LCK–co-receptor association ensures T cell lineage fidelity and maximizes epitope-specific TCR diversity
LCK-mutant mice help define the role of LCK–co-receptor association in T cell development and immune responses.
www.science.org
February 21, 2025 at 8:24 PM
Now in #Science #Immunology: Justin Zhang, Jamie Rossjohn, @pzareie.bsky.social, @niclag.bsky.social, & al. generate LCK-FREE mice expressing mutated form of endogenous LCK that cannot bind to #CD4 or #CD8. These animals show defects in #TCell lineage fidelity & antigen-specific #TCR diversity!