Mike Kalwat
@kalwat.bsky.social
enjoying #heavy_metal and figuring out how #beta_cells work
#hypersecretion #T1D #T2D #HI
#hypersecretion #T1D #T2D #HI
Pinned
Mike Kalwat
@kalwat.bsky.social
· Sep 12
Support my Breakthrough T1D Walk
Learn why I'm participating in the Breakthrough T1D Walk and raising funds to help create a world without type 1 diabetes (T1D).
p.bt1d.org
I'm raising money for Breakthrough T1D (new name for JDRF) to change the lives of people with type 1 diabetes.
We appreciate any support. This funding aids T1D research, which is even more important now with the uncertainty surrounding traditional research funding mechanisms.
p.bt1d.org/7ujvl
We appreciate any support. This funding aids T1D research, which is even more important now with the uncertainty surrounding traditional research funding mechanisms.
p.bt1d.org/7ujvl
I'm raising money for Breakthrough T1D (new name for JDRF) to change the lives of people with type 1 diabetes.
We appreciate any support. This funding aids T1D research, which is even more important now with the uncertainty surrounding traditional research funding mechanisms.
p.bt1d.org/7ujvl
We appreciate any support. This funding aids T1D research, which is even more important now with the uncertainty surrounding traditional research funding mechanisms.
p.bt1d.org/7ujvl
Support my Breakthrough T1D Walk
Learn why I'm participating in the Breakthrough T1D Walk and raising funds to help create a world without type 1 diabetes (T1D).
p.bt1d.org
September 12, 2025 at 12:25 PM
I'm raising money for Breakthrough T1D (new name for JDRF) to change the lives of people with type 1 diabetes.
We appreciate any support. This funding aids T1D research, which is even more important now with the uncertainty surrounding traditional research funding mechanisms.
p.bt1d.org/7ujvl
We appreciate any support. This funding aids T1D research, which is even more important now with the uncertainty surrounding traditional research funding mechanisms.
p.bt1d.org/7ujvl
Reposted by Mike Kalwat
I helped explain to the Chicago Tribune the enourmous and irrational damage the NIH funding freeze is causing at Northwestern. “You’re at risk of losing an entire next generation of scientists" "it’s terrifying; it’s completely senseless." www.chicagotribune.com/2025/06/07/w...
Worried Northwestern lab directors describe ‘bleak’ atmosphere in wake of Trump research funding freeze
The Trump administration’s freezing of $790 million in federal research funding for Northwestern University has left concerned lab directors without key grants and forced the university to spend mi…
www.chicagotribune.com
June 7, 2025 at 7:45 PM
I helped explain to the Chicago Tribune the enourmous and irrational damage the NIH funding freeze is causing at Northwestern. “You’re at risk of losing an entire next generation of scientists" "it’s terrifying; it’s completely senseless." www.chicagotribune.com/2025/06/07/w...
Actin remodeling in beta cells adds new layers of upstream regulation - Congrats! @ronnyhelman.bsky.social
Happy to share a work from the Helman lab on how beta cells sense and control their insulin secretion by Krell et al. in @CellReports.
Beta cells intrinsically sense and limit their secretory activity via mTORC1-RhoA signaling: Cell Reports www.cell.com/cell-reports...
Beta cells intrinsically sense and limit their secretory activity via mTORC1-RhoA signaling: Cell Reports www.cell.com/cell-reports...
Beta cells intrinsically sense and limit their secretory activity via mTORC1-RhoA signaling
Krell et al. show that mTORC1 in β cells acts as an activity sensor, activated by
the same signals that trigger insulin secretion. This activation, in turn, inhibits
insulin release via RhoA-dependent...
www.cell.com
May 19, 2025 at 11:33 AM
Actin remodeling in beta cells adds new layers of upstream regulation - Congrats! @ronnyhelman.bsky.social
Reposted by Mike Kalwat
Science is under attack. Proposed 40% NIH cut threatens jobs, research, and medical progress. Call your reps, governor, and mayor now—urge them to stand up for science.
www.ascb.org/science-poli...
www.ascb.org/science-poli...
NIH Research Funding at Risk—Take Action Now! - ASCB
Along with supporting important scientific discoveries, federally funded scientific research has significant impact on state and local economies. It is estimated that, on average, every $1 of National...
www.ascb.org
May 9, 2025 at 4:35 PM
Science is under attack. Proposed 40% NIH cut threatens jobs, research, and medical progress. Call your reps, governor, and mayor now—urge them to stand up for science.
www.ascb.org/science-poli...
www.ascb.org/science-poli...
take a metal break www.youtube.com/watch?v=e2ms...
Imminence - Heaven Shall Burn (Live at Ystads Teater)
YouTube video by Imminence
www.youtube.com
May 13, 2025 at 2:38 AM
take a metal break www.youtube.com/watch?v=e2ms...
Reposted by Mike Kalwat
Paradoxically, both GIPR agonism and antagonism potentiate weight loss when paired with GLP-1R agonism. Two new studies in @natmetabolism.nature.com decode the different neural mechanisms employed by each strategy.
Check out the #News&Views by @adriaenssenslab.bsky.social here.
Check out the #News&Views by @adriaenssenslab.bsky.social here.
April 30, 2025 at 9:47 AM
Paradoxically, both GIPR agonism and antagonism potentiate weight loss when paired with GLP-1R agonism. Two new studies in @natmetabolism.nature.com decode the different neural mechanisms employed by each strategy.
Check out the #News&Views by @adriaenssenslab.bsky.social here.
Check out the #News&Views by @adriaenssenslab.bsky.social here.
Reposted by Mike Kalwat
The notice and COMMENT PERIOD OPENED TODAY AND CLOSES MAY 23.
Anyone who would like to register an objection or comment should go to this page and click on the green “public comment” button at the top:
www.federalregister.gov/documents/20...
6/n
Anyone who would like to register an objection or comment should go to this page and click on the green “public comment” button at the top:
www.federalregister.gov/documents/20...
6/n
Improving Performance, Accountability and Responsiveness in the Civil Service
The Office of Personnel Management (OPM) is proposing a rule to increase career employee accountability. Agency supervisors report great difficulty removing employees for poor performance or misconduc...
www.federalregister.gov
April 23, 2025 at 6:17 PM
The notice and COMMENT PERIOD OPENED TODAY AND CLOSES MAY 23.
Anyone who would like to register an objection or comment should go to this page and click on the green “public comment” button at the top:
www.federalregister.gov/documents/20...
6/n
Anyone who would like to register an objection or comment should go to this page and click on the green “public comment” button at the top:
www.federalregister.gov/documents/20...
6/n
Reposted by Mike Kalwat
Just posting this starter pack for #PancSky again as I have added more people - let me know any other islet/pancreas scientists I've missed! go.bsky.app/3wdSpdi
March 6, 2025 at 5:09 PM
Just posting this starter pack for #PancSky again as I have added more people - let me know any other islet/pancreas scientists I've missed! go.bsky.app/3wdSpdi
Hey #PancSky and #islet people, we're hosting the 2025 Midwest Islet Club in Indianapolis May 7-8. Most of the talks are from students/postdocs. Help spread the word about abstract submission and registration! medicine.iu.edu/research-cen...
2025 Midwest Islet Club Meeting | Center for Diabetes and Metabolic Diseases | IU School of MedicineIndiana University School of MedicineFacebookInstagramLinkedInTwitterIndiana University School of Me...
medicine.iu.edu
March 1, 2025 at 1:36 PM
Hey #PancSky and #islet people, we're hosting the 2025 Midwest Islet Club in Indianapolis May 7-8. Most of the talks are from students/postdocs. Help spread the word about abstract submission and registration! medicine.iu.edu/research-cen...
Reposted by Mike Kalwat
Breaking: FDA's March meeting to select flu shot strains for 2025-2026 season has been canceled per email sent to committee members, a VRBPAC member told me. drug companies need about 6 months leeway to make shots in time for fall vax campaigns. #healthpolicy
February 26, 2025 at 11:17 PM
Breaking: FDA's March meeting to select flu shot strains for 2025-2026 season has been canceled per email sent to committee members, a VRBPAC member told me. drug companies need about 6 months leeway to make shots in time for fall vax campaigns. #healthpolicy
Reposted by Mike Kalwat
Join us! Science Homecoming helps scientists reconnect with communities by writing about the importance of science funding in their hometown newspapers. We’ve mapped every small newspaper in the U.S. and provide resources to get you started. Help science get back home 🧪🔬🧬 🏠
sciencehomecoming.com
sciencehomecoming.com
Science Homecoming
sciencehomecoming.com
February 18, 2025 at 5:12 PM
Join us! Science Homecoming helps scientists reconnect with communities by writing about the importance of science funding in their hometown newspapers. We’ve mapped every small newspaper in the U.S. and provide resources to get you started. Help science get back home 🧪🔬🧬 🏠
sciencehomecoming.com
sciencehomecoming.com
Reposted by Mike Kalwat
The National Institutes of Health had to stop considering new grant applications, delaying funding for research into diseases ranging from heart disease and cancer to Alzheimer's and allergies.
NIH funding freeze stalls applications on $1.5 billion in medical research funds
The National Institutes of Health had to stop considering new grant applications, delaying funding for research into diseases ranging from heart disease and cancer to Alzheimer's and allergies.
www.npr.org
February 22, 2025 at 6:39 PM
The National Institutes of Health had to stop considering new grant applications, delaying funding for research into diseases ranging from heart disease and cancer to Alzheimer's and allergies.
Reposted by Mike Kalwat
Ok scientists & those who love science 🧪: here is another exhortation. Call Congress TODAY about the freeze on NIH Council Meetings and Study Sections. Emphasize that this means NO new grants are being funded & labs will soon start to shut down and fire employees. Phone numbers are at:
5calls.org
5calls.org
5 Calls
Spend 5 minutes. Make 5 calls. Make your voice heard.
5calls.org
February 21, 2025 at 5:23 PM
Ok scientists & those who love science 🧪: here is another exhortation. Call Congress TODAY about the freeze on NIH Council Meetings and Study Sections. Emphasize that this means NO new grants are being funded & labs will soon start to shut down and fire employees. Phone numbers are at:
5calls.org
5calls.org
Reposted by Mike Kalwat
I've been developing a semantic search tool that covers not just bioRxiv and medRxiv, but the entire PubMed database. This means you can search across a massive collection of biomedical research using keywords, questions, hypotheses, or even full abstracts. Try it out: mssearch.xyz
Streamlit
mssearch.xyz
February 16, 2025 at 7:02 PM
I've been developing a semantic search tool that covers not just bioRxiv and medRxiv, but the entire PubMed database. This means you can search across a massive collection of biomedical research using keywords, questions, hypotheses, or even full abstracts. Try it out: mssearch.xyz
I don't think IIDP is on Bluesky yet, so just reposting.
iidp.coh.org/funding
Applications Due: February 14, 2025.
#islet #PancSky
iidp.coh.org/funding
Applications Due: February 14, 2025.
#islet #PancSky
February 5, 2025 at 4:29 AM
I don't think IIDP is on Bluesky yet, so just reposting.
iidp.coh.org/funding
Applications Due: February 14, 2025.
#islet #PancSky
iidp.coh.org/funding
Applications Due: February 14, 2025.
#islet #PancSky
Reposted by Mike Kalwat
Reminder: You can always submit a grant late and include a cover letter saying why. NIH receipt and referral may take it. Or not. If you end up missing deadline because of these Commons access issues, there is this potential save move.
February 3, 2025 at 8:31 PM
Reminder: You can always submit a grant late and include a cover letter saying why. NIH receipt and referral may take it. Or not. If you end up missing deadline because of these Commons access issues, there is this potential save move.
Reposted by Mike Kalwat
New preprint from the lab! 🚨
🧫 New galactose #CRISPR screening strategy
🎯 481 genes required for #OXPHOS
⚙️ #FAM136A in IMS proteostasis
👂Mito defects in #Menieres disease
by @marcellharhai.bsky.social @fbm-unil.bsky.social
A short thread 1/5
www.biorxiv.org/content/10.1...
🧫 New galactose #CRISPR screening strategy
🎯 481 genes required for #OXPHOS
⚙️ #FAM136A in IMS proteostasis
👂Mito defects in #Menieres disease
by @marcellharhai.bsky.social @fbm-unil.bsky.social
A short thread 1/5
www.biorxiv.org/content/10.1...
January 30, 2025 at 7:58 AM
New preprint from the lab! 🚨
🧫 New galactose #CRISPR screening strategy
🎯 481 genes required for #OXPHOS
⚙️ #FAM136A in IMS proteostasis
👂Mito defects in #Menieres disease
by @marcellharhai.bsky.social @fbm-unil.bsky.social
A short thread 1/5
www.biorxiv.org/content/10.1...
🧫 New galactose #CRISPR screening strategy
🎯 481 genes required for #OXPHOS
⚙️ #FAM136A in IMS proteostasis
👂Mito defects in #Menieres disease
by @marcellharhai.bsky.social @fbm-unil.bsky.social
A short thread 1/5
www.biorxiv.org/content/10.1...
Reposted by Mike Kalwat
"Of Wolf and Man" by Metallica x "Fifflas" by C418
January 23, 2025 at 4:45 AM
"Of Wolf and Man" by Metallica x "Fifflas" by C418
Will be very interesting to see how molecular biology changes in the next decade with these types of advances.
Whoa! When a large language of life model generates a protein equivalent to ~500 million years of evolution.
@science.org
science.org/doi/10.1126/...
@science.org
science.org/doi/10.1126/...
Simulating 500 million years of evolution with a language model
More than three billion years of evolution have produced an image of biology encoded into the space of natural proteins. Here we show that language models trained at scale on evolutionary data can gen...
science.org
January 17, 2025 at 12:40 PM
Will be very interesting to see how molecular biology changes in the next decade with these types of advances.
Reposted by Mike Kalwat
Re-upping this paper which is ‘out’ now in this month’s issue of Cell Metab. Working with a fantastic group of collaborators, we provide a resource for exploring human islet variation in health and diabetes.
https://www.cell.com/cell-metabolism/fulltext/S1550-4131(24)00365-6
https://www.cell.com/cell-metabolism/fulltext/S1550-4131(24)00365-6
January 10, 2025 at 7:38 PM
Re-upping this paper which is ‘out’ now in this month’s issue of Cell Metab. Working with a fantastic group of collaborators, we provide a resource for exploring human islet variation in health and diabetes.
https://www.cell.com/cell-metabolism/fulltext/S1550-4131(24)00365-6
https://www.cell.com/cell-metabolism/fulltext/S1550-4131(24)00365-6
Happy to finally have this preprint up which represents a lot of effort from first author Gitanjali Roy and important contributions from multiple labs. I hope this work enables the discovery of cool beta cell biology related to hypersecretion.
Target deconvolution of an insulin hypersecretion-inducer acting through VDAC1 with a distinct transcriptomic signature in beta-cells https://www.biorxiv.org/content/10.1101/2024.12.26.629558v1
December 28, 2024 at 7:30 PM
Happy to finally have this preprint up which represents a lot of effort from first author Gitanjali Roy and important contributions from multiple labs. I hope this work enables the discovery of cool beta cell biology related to hypersecretion.