Reposted by Ronny Helman
Actin remodeling in beta cells adds new layers of upstream regulation - Congrats! @ronnyhelman.bsky.social
Happy to share a work from the Helman lab on how beta cells sense and control their insulin secretion by Krell et al. in @CellReports.
Beta cells intrinsically sense and limit their secretory activity via mTORC1-RhoA signaling: Cell Reports www.cell.com/cell-reports...
Beta cells intrinsically sense and limit their secretory activity via mTORC1-RhoA signaling: Cell Reports www.cell.com/cell-reports...
Beta cells intrinsically sense and limit their secretory activity via mTORC1-RhoA signaling
Krell et al. show that mTORC1 in β cells acts as an activity sensor, activated by
the same signals that trigger insulin secretion. This activation, in turn, inhibits
insulin release via RhoA-dependent...
www.cell.com
May 19, 2025 at 11:33 AM
Actin remodeling in beta cells adds new layers of upstream regulation - Congrats! @ronnyhelman.bsky.social
Happy to share a work from the Helman lab on how beta cells sense and control their insulin secretion by Krell et al. in @CellReports.
Beta cells intrinsically sense and limit their secretory activity via mTORC1-RhoA signaling: Cell Reports www.cell.com/cell-reports...
Beta cells intrinsically sense and limit their secretory activity via mTORC1-RhoA signaling: Cell Reports www.cell.com/cell-reports...
Beta cells intrinsically sense and limit their secretory activity via mTORC1-RhoA signaling
Krell et al. show that mTORC1 in β cells acts as an activity sensor, activated by
the same signals that trigger insulin secretion. This activation, in turn, inhibits
insulin release via RhoA-dependent...
www.cell.com
May 18, 2025 at 2:20 PM
Happy to share a work from the Helman lab on how beta cells sense and control their insulin secretion by Krell et al. in @CellReports.
Beta cells intrinsically sense and limit their secretory activity via mTORC1-RhoA signaling: Cell Reports www.cell.com/cell-reports...
Beta cells intrinsically sense and limit their secretory activity via mTORC1-RhoA signaling: Cell Reports www.cell.com/cell-reports...