Jason Casler
@jasoncasler.bsky.social
Cell biologist, organelle enthusiast. Postdoctoral fellow at Northwestern University - currently studying mitochondrial membrane contact sites in the Lackner Lab.
Reposted by Jason Casler
A pleasure to write this short review on lipid droplets for
@jcb.org together with Will Prinz and amazing artist Emma Reynolds!
We discuss 5 pervasive questions surrounding these remarkable little lipid organelles.
doi.org/10.1083/jcb....
@jcb.org together with Will Prinz and amazing artist Emma Reynolds!
We discuss 5 pervasive questions surrounding these remarkable little lipid organelles.
doi.org/10.1083/jcb....
Lipid droplets: Open questions and conceptual advances around a unique organelle | Journal of Cell Biology | Rockefeller University Press
Henne and Prinz discuss the lipid droplet field and pervasive questions surrounding droplets and their roles in physiology and disease.
doi.org
September 11, 2025 at 2:04 PM
A pleasure to write this short review on lipid droplets for
@jcb.org together with Will Prinz and amazing artist Emma Reynolds!
We discuss 5 pervasive questions surrounding these remarkable little lipid organelles.
doi.org/10.1083/jcb....
@jcb.org together with Will Prinz and amazing artist Emma Reynolds!
We discuss 5 pervasive questions surrounding these remarkable little lipid organelles.
doi.org/10.1083/jcb....
Reposted by Jason Casler
Thompson, Stevenson et al @bristoluni.bsky.social show that two cis-Golgi golgins, GMAP210 & Golgin-160, have distinct roles in maintaining #Golgi organization & that both are required to support the efficient secretion, assembly, and modification of ECM proteins rupress.org/jcb/article/...
August 18, 2025 at 4:30 PM
Thompson, Stevenson et al @bristoluni.bsky.social show that two cis-Golgi golgins, GMAP210 & Golgin-160, have distinct roles in maintaining #Golgi organization & that both are required to support the efficient secretion, assembly, and modification of ECM proteins rupress.org/jcb/article/...
Reposted by Jason Casler
(Yet another) shout-out to @joachimgoedhart.bsky.social and colleagues for their ongoing technical service to the cell biology community – in this case, the yeast cell biology community. Special kudos for making all the key plasmids available on @addgene.bsky.social. Stellar work all around!
Side-by-side systematic characterization of novel FPs in budding yeast
Fluorescent proteins (FPs) have become indispensable for biological research. Since the discovery of the first FP, Aequorea victoria green fluorescent protein (avGFP), new fluorescent proteins are con...
doi.org
August 15, 2025 at 8:39 PM
(Yet another) shout-out to @joachimgoedhart.bsky.social and colleagues for their ongoing technical service to the cell biology community – in this case, the yeast cell biology community. Special kudos for making all the key plasmids available on @addgene.bsky.social. Stellar work all around!
Reposted by Jason Casler
🚨BREAKING NEWS: RFK Jr. is a danger to this nation. Don’t give in to Trump & his cronies: we are NOT trading innovation for ideology. We demand the immediate IMPEACHMENT and REMOVAL of RFK. Stop the quack. Protect Science. Protect Democracy
Sign & share here: zurl.co/PEPyD
#StandUpForScience
Sign & share here: zurl.co/PEPyD
#StandUpForScience
August 14, 2025 at 12:00 PM
🚨BREAKING NEWS: RFK Jr. is a danger to this nation. Don’t give in to Trump & his cronies: we are NOT trading innovation for ideology. We demand the immediate IMPEACHMENT and REMOVAL of RFK. Stop the quack. Protect Science. Protect Democracy
Sign & share here: zurl.co/PEPyD
#StandUpForScience
Sign & share here: zurl.co/PEPyD
#StandUpForScience
Reposted by Jason Casler
🍹Banerjee et al. report that the Vps13-like #lipid transport protein BLTP2 regulates plasma membrane fluidity by maintaining phosphatidylethanolamine homeostasis. BLTP2 also facilitates #BreastCancer cell growth, suggesting a separate role in tumorigenesis.
bit.ly/45ieyD9
bit.ly/45ieyD9
The Vps13-like protein BLTP2 regulates phosphatidylethanolamine levels to maintain plasma membrane fluidity and breast cancer aggressiveness - Nature Cell Biology
Banerjee et al. report that the Vps13-like lipid transport protein BLTP2 regulates plasma membrane fluidity by maintaining phosphatidylethanolamine homeostasis. BLTP2 also facilitates breast cancer ce...
bit.ly
August 13, 2025 at 7:50 PM
🍹Banerjee et al. report that the Vps13-like #lipid transport protein BLTP2 regulates plasma membrane fluidity by maintaining phosphatidylethanolamine homeostasis. BLTP2 also facilitates #BreastCancer cell growth, suggesting a separate role in tumorigenesis.
bit.ly/45ieyD9
bit.ly/45ieyD9
Reposted by Jason Casler
We are proud to be a founding contributor to lipidinteractome.org, a repository developed by @tafesselab.bsky.social & Schultz lab to increase accessibility to proteomics data from multi-functionalized lipid analogs! Check out the website & preprint: arxiv.org/abs/2507.23101 #lipidtime
The Lipid Interactome Repository – Lipid Interactome Repository
lipidinteractome.org
August 5, 2025 at 1:06 PM
We are proud to be a founding contributor to lipidinteractome.org, a repository developed by @tafesselab.bsky.social & Schultz lab to increase accessibility to proteomics data from multi-functionalized lipid analogs! Check out the website & preprint: arxiv.org/abs/2507.23101 #lipidtime
Reposted by Jason Casler
Juhi Narula and Sarah Wignall (@sadiewignall.bsky.social) identify a new role for the conserved kinase PLK-1 in suppressing centrosome maturation in oocytes, which surprisingly is opposite to its role in mitosis. rupress.org/jcb/article/...
#CellCycle #Genetics #Cytoskeleton #Development
#CellCycle #Genetics #Cytoskeleton #Development
June 27, 2025 at 6:01 PM
Juhi Narula and Sarah Wignall (@sadiewignall.bsky.social) identify a new role for the conserved kinase PLK-1 in suppressing centrosome maturation in oocytes, which surprisingly is opposite to its role in mitosis. rupress.org/jcb/article/...
#CellCycle #Genetics #Cytoskeleton #Development
#CellCycle #Genetics #Cytoskeleton #Development
Reposted by Jason Casler
Proud to be a signatory on this letter in support of the courageous staff at the NIH who penned the Bethesda Declaration to decry the ongoing politicization and damage to the US biomedical research infrastructure which has been the envy of the world.
I wanted to show support for these brave public servants and to allow others, including the scientific community, to join me. In partnership with @standupforscience.bsky.social, we have a way for you to do that... www.standupforscience.net/bethesda-dec...
Bethesda Declaration — STAND UP FOR SCIENCE
Support NIH Staff Now!
www.standupforscience.net
June 9, 2025 at 12:35 PM
Proud to be a signatory on this letter in support of the courageous staff at the NIH who penned the Bethesda Declaration to decry the ongoing politicization and damage to the US biomedical research infrastructure which has been the envy of the world.
Reposted by Jason Casler
All of NIH funding to Northwestern University is frozen. This pause includes noncompeting approved funding, new and competing grants with fundable scores. No reimbursements for money already spent have been received since March. This situation is rarely reported so please Please get the word out!
May 23, 2025 at 5:56 PM
All of NIH funding to Northwestern University is frozen. This pause includes noncompeting approved funding, new and competing grants with fundable scores. No reimbursements for money already spent have been received since March. This situation is rarely reported so please Please get the word out!
Reposted by Jason Casler
Northwestern has not received any NIH funds since March. No written communication about why or what can be done. Thank you Ben Singer for raising awareness at #ATS2025
May 18, 2025 at 10:44 PM
Northwestern has not received any NIH funds since March. No written communication about why or what can be done. Thank you Ben Singer for raising awareness at #ATS2025
Reposted by Jason Casler
Jason Casler @jasoncasler.bsky.social, Clare Harper and Laura Lackner @lllackner.bsky.social find that mitochondria–plasma membrane contact sites regulate the ER–mitochondria encounter structure.
journals.biologists.com/jcs/article/...
#JCSMitoSI #OpenAccess #ReadandPublish
journals.biologists.com/jcs/article/...
#JCSMitoSI #OpenAccess #ReadandPublish
May 7, 2025 at 8:27 AM
Jason Casler @jasoncasler.bsky.social, Clare Harper and Laura Lackner @lllackner.bsky.social find that mitochondria–plasma membrane contact sites regulate the ER–mitochondria encounter structure.
journals.biologists.com/jcs/article/...
#JCSMitoSI #OpenAccess #ReadandPublish
journals.biologists.com/jcs/article/...
#JCSMitoSI #OpenAccess #ReadandPublish
Reposted by Jason Casler
"If we cut or limit funding for curiosity-driven research, we risk shutting down the pipeline of future innovation. While the outcomes of basic science may seem unclear or esoteric at first, such work frequently forms the bedrock of future technologies, treatments, and therapies." 👏👏👏
April 3, 2025 at 4:27 PM
"If we cut or limit funding for curiosity-driven research, we risk shutting down the pipeline of future innovation. While the outcomes of basic science may seem unclear or esoteric at first, such work frequently forms the bedrock of future technologies, treatments, and therapies." 👏👏👏
Reposted by Jason Casler
Join us March 26th at 12pm ET - @asbmb.bsky.social LRD seminar series.
We have two great mitochondria-focused lipid talks planned from @jasoncasler.bsky.social from @lllackner.bsky.social's lab and Kailash Venkatraman from @ibudin.bsky.social's lab.
Register here! www.asbmb.org/meetings-eve...
We have two great mitochondria-focused lipid talks planned from @jasoncasler.bsky.social from @lllackner.bsky.social's lab and Kailash Venkatraman from @ibudin.bsky.social's lab.
Register here! www.asbmb.org/meetings-eve...
Lipid Research Division Seminar Series
March 26, 2025 | 12 p.m. Eastern
www.asbmb.org
March 14, 2025 at 5:35 PM
Join us March 26th at 12pm ET - @asbmb.bsky.social LRD seminar series.
We have two great mitochondria-focused lipid talks planned from @jasoncasler.bsky.social from @lllackner.bsky.social's lab and Kailash Venkatraman from @ibudin.bsky.social's lab.
Register here! www.asbmb.org/meetings-eve...
We have two great mitochondria-focused lipid talks planned from @jasoncasler.bsky.social from @lllackner.bsky.social's lab and Kailash Venkatraman from @ibudin.bsky.social's lab.
Register here! www.asbmb.org/meetings-eve...
Today's the day to make our voices heard. Hope to see everyone there who is able. www.eventbrite.com/e/stand-up-f...
Stand Up for Science 2025 - Chicago, IL
Stand up for science with us on March 7th, 2025, because science is for everyone! More info at www.standupforscience2025.org
www.eventbrite.com
March 7, 2025 at 3:48 PM
Today's the day to make our voices heard. Hope to see everyone there who is able. www.eventbrite.com/e/stand-up-f...
It's going to take a massive amount of public pressure to end the dismantling of the American scientific enterprise. Time for action. To anyone in the Chicagoland area who is able and wants to vocalize their support for science, please join us on March 7th.
www.eventbrite.com/e/stand-up-f...
www.eventbrite.com/e/stand-up-f...
Stand Up for Science 2025 - Chicago, IL
Stand up for science with us on March 7th, 2025, because science is for everyone! More info at www.standupforscience2025.org
www.eventbrite.com
February 25, 2025 at 8:30 PM
It's going to take a massive amount of public pressure to end the dismantling of the American scientific enterprise. Time for action. To anyone in the Chicagoland area who is able and wants to vocalize their support for science, please join us on March 7th.
www.eventbrite.com/e/stand-up-f...
www.eventbrite.com/e/stand-up-f...
Reposted by Jason Casler
“There’s going to be a missing age class of researchers that will reverberate for years.” scim.ag/3ERRLDo
U.S. early-career researchers struggling amid chaos
Uncertain funding, government firings, and distressed universities hit vulnerable groups especially hard
scim.ag
February 24, 2025 at 2:59 PM
“There’s going to be a missing age class of researchers that will reverberate for years.” scim.ag/3ERRLDo
Reposted by Jason Casler
NIH indirects case update:
Hearing ongoing now, and I'll try to live tweet some notable exchanges.
Prior to more detailed arguments, Judge Kelley starts off with a few point questions to both sides:
(I'm paraphrasing here)
Hearing ongoing now, and I'll try to live tweet some notable exchanges.
Prior to more detailed arguments, Judge Kelley starts off with a few point questions to both sides:
(I'm paraphrasing here)
February 21, 2025 at 3:19 PM
NIH indirects case update:
Hearing ongoing now, and I'll try to live tweet some notable exchanges.
Prior to more detailed arguments, Judge Kelley starts off with a few point questions to both sides:
(I'm paraphrasing here)
Hearing ongoing now, and I'll try to live tweet some notable exchanges.
Prior to more detailed arguments, Judge Kelley starts off with a few point questions to both sides:
(I'm paraphrasing here)
Reposted by Jason Casler
How do #mitochondria decide when to divide or fuse? I’ve always thought mtDNA played a key role in this process, so I was very surprised by this finding: The loss of mtDNA does not affect mitochondrial fission and fusion rates.
www.molbiolcell.org/doi/10.1091/...
www.molbiolcell.org/doi/10.1091/...
Significantly reduced, but balanced, rates of mitochondrial fission and fusion are sufficient to maintain the integrity of yeast mitochondrial DNA | Molecular Biology of the Cell
Mitochondria exist as dynamic tubular networks and the morphology of these networks impacts organelle function and cell health. Mitochondrial morphology is maintained in part by the opposing activitie...
www.molbiolcell.org
November 23, 2024 at 8:37 AM
How do #mitochondria decide when to divide or fuse? I’ve always thought mtDNA played a key role in this process, so I was very surprised by this finding: The loss of mtDNA does not affect mitochondrial fission and fusion rates.
www.molbiolcell.org/doi/10.1091/...
www.molbiolcell.org/doi/10.1091/...
Reposted by Jason Casler
We are happy to report that our journals and community sites now have Bluesky accounts. Follow them at:
@dev-journal.bsky.social
@jcellsci.bsky.social
@jexpbiol.bsky.social
@dmmjournal.bsky.social
@biologyopen.bsky.social
@the-node.bsky.social
@prelights.bsky.social
@focalplane.bsky.social
@dev-journal.bsky.social
@jcellsci.bsky.social
@jexpbiol.bsky.social
@dmmjournal.bsky.social
@biologyopen.bsky.social
@the-node.bsky.social
@prelights.bsky.social
@focalplane.bsky.social
November 25, 2024 at 2:44 PM
We are happy to report that our journals and community sites now have Bluesky accounts. Follow them at:
@dev-journal.bsky.social
@jcellsci.bsky.social
@jexpbiol.bsky.social
@dmmjournal.bsky.social
@biologyopen.bsky.social
@the-node.bsky.social
@prelights.bsky.social
@focalplane.bsky.social
@dev-journal.bsky.social
@jcellsci.bsky.social
@jexpbiol.bsky.social
@dmmjournal.bsky.social
@biologyopen.bsky.social
@the-node.bsky.social
@prelights.bsky.social
@focalplane.bsky.social
I will use my first post here to contribute to the growing scientific community and plug our lab's newest paper
www.molbiolcell.org/doi/full/10.....
We demonstrate that, surprisingly, a massive reduction in the rates of mitochondrial fission and fusion has no adverse effects on mtDNA integrity
www.molbiolcell.org/doi/full/10.....
We demonstrate that, surprisingly, a massive reduction in the rates of mitochondrial fission and fusion has no adverse effects on mtDNA integrity
Molecular Biology of the Cell (MBoC)
www.molbiolcell.org
November 22, 2024 at 3:08 PM
I will use my first post here to contribute to the growing scientific community and plug our lab's newest paper
www.molbiolcell.org/doi/full/10.....
We demonstrate that, surprisingly, a massive reduction in the rates of mitochondrial fission and fusion has no adverse effects on mtDNA integrity
www.molbiolcell.org/doi/full/10.....
We demonstrate that, surprisingly, a massive reduction in the rates of mitochondrial fission and fusion has no adverse effects on mtDNA integrity