Jan Huertas
@janhuemar.bsky.social
Postdoc at the Collepardo Lab. Understanding chromatin using simulations. I never read the abstract because I don't like spoilers.
Pinned
Jan Huertas
@janhuemar.bsky.social
· Oct 21
🚨 🚨 🚨 New preprint alert!!! 🚨 🚨 🚨
In the past, we have learnt that Oct4 can induce nucleosome breathing on the mono-nucleosome level.
But what happens when you have a fibre of multiple nucleosomes?
www.biorxiv.org/content/10.1...
@rcollepardo.bsky.social @juliamaristany.bsky.social
In the past, we have learnt that Oct4 can induce nucleosome breathing on the mono-nucleosome level.
But what happens when you have a fibre of multiple nucleosomes?
www.biorxiv.org/content/10.1...
@rcollepardo.bsky.social @juliamaristany.bsky.social
Reposted by Jan Huertas
Congratulations to @janhuemar.bsky.social (JRF at Catz since 2023) who is part of an international team of scientists responsible for a long-awaited visualisation of liquid droplets forming inside a cell known as condensates, key for processes such as DNA repair: caths.cam.ac.uk/cond... @cam.ac.uk
Visualising the creation of biomolecular condensates
A Junior Research Fellow at St Catharine's is part of an international team of scientists responsible for a long-awaited visualisation of liquid droplets forming inside a cell nucleus known as condensates, which help regulate essential processes such as gene expression, DNA repair and stress responses.
caths.cam.ac.uk
December 11, 2025 at 9:40 AM
Congratulations to @janhuemar.bsky.social (JRF at Catz since 2023) who is part of an international team of scientists responsible for a long-awaited visualisation of liquid droplets forming inside a cell known as condensates, key for processes such as DNA repair: caths.cam.ac.uk/cond... @cam.ac.uk
Super excited to share that our paper is now out in @science.org. Lots of work, but also lots of fun getting this out.
Be sure to check it out!
www.science.org/doi/10.1126/...
Also, follow:
@huabin-zhou.bsky.social @juliamaristany.bsky.social @kieran-russell.bsky.social @rcollepardo.bsky.social
Be sure to check it out!
www.science.org/doi/10.1126/...
Also, follow:
@huabin-zhou.bsky.social @juliamaristany.bsky.social @kieran-russell.bsky.social @rcollepardo.bsky.social
December 4, 2025 at 10:15 PM
Super excited to share that our paper is now out in @science.org. Lots of work, but also lots of fun getting this out.
Be sure to check it out!
www.science.org/doi/10.1126/...
Also, follow:
@huabin-zhou.bsky.social @juliamaristany.bsky.social @kieran-russell.bsky.social @rcollepardo.bsky.social
Be sure to check it out!
www.science.org/doi/10.1126/...
Also, follow:
@huabin-zhou.bsky.social @juliamaristany.bsky.social @kieran-russell.bsky.social @rcollepardo.bsky.social
Reposted by Jan Huertas
Very excited to present OpenCGChromatin🔥🔥🔥
A new coarse-grained model that probes full chromatin condensates at near-atomistic resolution to reveal the molecular regulation of chromatin structure and phase separation
Brilliantly led by @kieran-russell.bsky.social, with the Rosen and Orozco groups
A new coarse-grained model that probes full chromatin condensates at near-atomistic resolution to reveal the molecular regulation of chromatin structure and phase separation
Brilliantly led by @kieran-russell.bsky.social, with the Rosen and Orozco groups
November 18, 2025 at 3:07 PM
Very excited to present OpenCGChromatin🔥🔥🔥
A new coarse-grained model that probes full chromatin condensates at near-atomistic resolution to reveal the molecular regulation of chromatin structure and phase separation
Brilliantly led by @kieran-russell.bsky.social, with the Rosen and Orozco groups
A new coarse-grained model that probes full chromatin condensates at near-atomistic resolution to reveal the molecular regulation of chromatin structure and phase separation
Brilliantly led by @kieran-russell.bsky.social, with the Rosen and Orozco groups
So exciting to see this amazing paper out! Many thanks to @jojdavies.bsky.social for inviting us to contribute with our models to this fascinating story!
@rcollepardo.bsky.social @juliamaristany.bsky.social
@rcollepardo.bsky.social @juliamaristany.bsky.social
Our latest paper has just been published in Cell!
doi.org/10.1016/j.ce...
We developed a new method called MCC ultra, which allows 3D chromatin structure to be visualised with a 1 base pair pixel size.
doi.org/10.1016/j.ce...
We developed a new method called MCC ultra, which allows 3D chromatin structure to be visualised with a 1 base pair pixel size.
November 6, 2025 at 10:25 AM
So exciting to see this amazing paper out! Many thanks to @jojdavies.bsky.social for inviting us to contribute with our models to this fascinating story!
@rcollepardo.bsky.social @juliamaristany.bsky.social
@rcollepardo.bsky.social @juliamaristany.bsky.social
🚨 🚨 🚨 New preprint alert!!! 🚨 🚨 🚨
In the past, we have learnt that Oct4 can induce nucleosome breathing on the mono-nucleosome level.
But what happens when you have a fibre of multiple nucleosomes?
www.biorxiv.org/content/10.1...
@rcollepardo.bsky.social @juliamaristany.bsky.social
In the past, we have learnt that Oct4 can induce nucleosome breathing on the mono-nucleosome level.
But what happens when you have a fibre of multiple nucleosomes?
www.biorxiv.org/content/10.1...
@rcollepardo.bsky.social @juliamaristany.bsky.social
October 21, 2025 at 9:59 AM
🚨 🚨 🚨 New preprint alert!!! 🚨 🚨 🚨
In the past, we have learnt that Oct4 can induce nucleosome breathing on the mono-nucleosome level.
But what happens when you have a fibre of multiple nucleosomes?
www.biorxiv.org/content/10.1...
@rcollepardo.bsky.social @juliamaristany.bsky.social
In the past, we have learnt that Oct4 can induce nucleosome breathing on the mono-nucleosome level.
But what happens when you have a fibre of multiple nucleosomes?
www.biorxiv.org/content/10.1...
@rcollepardo.bsky.social @juliamaristany.bsky.social
Reposted by Jan Huertas
1/ New preprint alert!
In collaboration between the Rosen, Redding, Collepardo-Guevara & Gerlich labs, we uncover a surprising principle of chromosome organisation: electrostatic repulsion positions centromeres at the chromosome surface during mitosis.
🔗 doi.org/10.1101/2025...
In collaboration between the Rosen, Redding, Collepardo-Guevara & Gerlich labs, we uncover a surprising principle of chromosome organisation: electrostatic repulsion positions centromeres at the chromosome surface during mitosis.
🔗 doi.org/10.1101/2025...
An electrostatic repulsion model of centromere organisation
During cell division, chromosomes reorganise into compact bodies in which centromeres localise precisely at the chromatin surface to enable kinetochore-microtubule interactions essential for genome se...
doi.org
September 3, 2025 at 8:12 AM
1/ New preprint alert!
In collaboration between the Rosen, Redding, Collepardo-Guevara & Gerlich labs, we uncover a surprising principle of chromosome organisation: electrostatic repulsion positions centromeres at the chromosome surface during mitosis.
🔗 doi.org/10.1101/2025...
In collaboration between the Rosen, Redding, Collepardo-Guevara & Gerlich labs, we uncover a surprising principle of chromosome organisation: electrostatic repulsion positions centromeres at the chromosome surface during mitosis.
🔗 doi.org/10.1101/2025...
Reposted by Jan Huertas
🚨 New paper out in Nature Comms!
From the Rosen, Redding and Collepardo Labs, we uncover how #nucleosome spacing fine-tunes the architecture of #chromatin condensates.
👇 A short thread on how physical #genome organization emerges from molecular interactions:
www.nature.com/articles/s41...
From the Rosen, Redding and Collepardo Labs, we uncover how #nucleosome spacing fine-tunes the architecture of #chromatin condensates.
👇 A short thread on how physical #genome organization emerges from molecular interactions:
www.nature.com/articles/s41...
Nucleosome spacing can fine-tune higher-order chromatin assembly - Nature Communications
Internucleosomal linker length alters the stability and dynamics of chromatin condensates by shifting the balance between inter- and intramolecular interactions. Further, by changing the linker length...
www.nature.com
July 10, 2025 at 10:29 PM
🚨 New paper out in Nature Comms!
From the Rosen, Redding and Collepardo Labs, we uncover how #nucleosome spacing fine-tunes the architecture of #chromatin condensates.
👇 A short thread on how physical #genome organization emerges from molecular interactions:
www.nature.com/articles/s41...
From the Rosen, Redding and Collepardo Labs, we uncover how #nucleosome spacing fine-tunes the architecture of #chromatin condensates.
👇 A short thread on how physical #genome organization emerges from molecular interactions:
www.nature.com/articles/s41...
Reposted by Jan Huertas
So excited to finally see our CTPR-condensate work published! Well done Chris, Mateo, Julia et al. ❤️ @chemicalscience.rsc.org @phar.cam.ac.uk @rcollepardo.bsky.social @juliamaristany.bsky.social
doi.org/10.1039/D5SC...
doi.org/10.1039/D5SC...
Tandem-repeat proteins introduce tuneable properties to engineered biomolecular condensates
The cell’s ability to rapidly partition biomolecules into biomolecular condensates is linked to a diverse range of cellular functions. Understanding how the structural attributes of biomolecular conde...
doi.org
May 6, 2025 at 2:58 PM
So excited to finally see our CTPR-condensate work published! Well done Chris, Mateo, Julia et al. ❤️ @chemicalscience.rsc.org @phar.cam.ac.uk @rcollepardo.bsky.social @juliamaristany.bsky.social
doi.org/10.1039/D5SC...
doi.org/10.1039/D5SC...
Reposted by Jan Huertas
🌱Join us for the first #FragileNucleosome seminar of this spring! We are excited to host @juliamaristany.bsky.social & @chribue.bsky.social this week!
If you have registered before you can join from the same link, if not, don't forget to register!
us06web.zoom.us/webinar/regi...
If you have registered before you can join from the same link, if not, don't forget to register!
us06web.zoom.us/webinar/regi...
March 23, 2025 at 2:02 PM
🌱Join us for the first #FragileNucleosome seminar of this spring! We are excited to host @juliamaristany.bsky.social & @chribue.bsky.social this week!
If you have registered before you can join from the same link, if not, don't forget to register!
us06web.zoom.us/webinar/regi...
If you have registered before you can join from the same link, if not, don't forget to register!
us06web.zoom.us/webinar/regi...
Excited to share our newest collaboration with @kazu-maeshima.bsky.social and @masaashimazoe.bsky.social, where we show that H1 acts as a liquid-like glue in chromatin.
Go check the paper on the biorXiv!
Go check the paper on the biorXiv!
Our new preprint is out＠bioRxiv: www.biorxiv.org/content/10.1...
@masaashimazoe.bsky.social et al. reveal that linker histone H1 acts as a liquid-like glue to organize chromatin in living cells. 🎉 Fantastic collab with @rcollepardo.bsky.social @janhuemar.bsky.social and others—huge thanks! 🙌 1/
@masaashimazoe.bsky.social et al. reveal that linker histone H1 acts as a liquid-like glue to organize chromatin in living cells. 🎉 Fantastic collab with @rcollepardo.bsky.social @janhuemar.bsky.social and others—huge thanks! 🙌 1/
March 7, 2025 at 11:53 AM
Excited to share our newest collaboration with @kazu-maeshima.bsky.social and @masaashimazoe.bsky.social, where we show that H1 acts as a liquid-like glue in chromatin.
Go check the paper on the biorXiv!
Go check the paper on the biorXiv!
Reposted by Jan Huertas
We are happy to share our work on local #nucleosome dynamics integrating #temperature inputs into an #epigenetic switching mechanism.
⚠️ Preprint alert!!
www.biorxiv.org/content/10.1...
⚠️ Preprint alert!!
www.biorxiv.org/content/10.1...
Cold-induced nucleosome dynamics linked to silencing of Arabidopsis FLC
Temperature influences nucleosome dynamics, and thus chromatin, to regulate gene expression. Such mechanisms underlie the epigenetic silencing of Arabidopsis FLOWERING LOCUS C (FLC) by prolonged cold....
www.biorxiv.org
February 21, 2025 at 2:06 PM
We are happy to share our work on local #nucleosome dynamics integrating #temperature inputs into an #epigenetic switching mechanism.
⚠️ Preprint alert!!
www.biorxiv.org/content/10.1...
⚠️ Preprint alert!!
www.biorxiv.org/content/10.1...
Reposted by Jan Huertas
Proud to have the final version of our paper on mutations + condensates + scaling laws published in @elife.bsky.social! Work led by @juliamaristany.bsky.social w/ @rcollepardo.bsky.social ! Read the digest here: elifesciences.org/digests/9906...
Disrupting droplets
Mutations in certain protein regions have predictable effects on the stability of cellular droplets and the risk of harmful protein clumps forming inside them.
elifesciences.org
February 15, 2025 at 2:00 AM
Proud to have the final version of our paper on mutations + condensates + scaling laws published in @elife.bsky.social! Work led by @juliamaristany.bsky.social w/ @rcollepardo.bsky.social ! Read the digest here: elifesciences.org/digests/9906...
Who's going to #BPS2025?
Please join us at the MGO Symposium @mgo-bps.bsky.social on Saturday 1:30 pm Room 511ABC
Featuring experiments, simulations, and all the scales by
@serenasanulli.bsky.social @melikel.bsky.social
@maristizabal.bsky.social @janhuemar.bsky.social and more
Please repost! 🚀✨
Please join us at the MGO Symposium @mgo-bps.bsky.social on Saturday 1:30 pm Room 511ABC
Featuring experiments, simulations, and all the scales by
@serenasanulli.bsky.social @melikel.bsky.social
@maristizabal.bsky.social @janhuemar.bsky.social and more
Please repost! 🚀✨
February 15, 2025 at 3:14 PM
Reposted by Jan Huertas
Who's going to #BPS2025?
Please join us at the MGO Symposium @mgo-bps.bsky.social on Saturday 1:30 pm Room 511ABC
Featuring experiments, simulations, and all the scales by
@serenasanulli.bsky.social @melikel.bsky.social
@maristizabal.bsky.social @janhuemar.bsky.social and more
Please repost! 🚀✨
Please join us at the MGO Symposium @mgo-bps.bsky.social on Saturday 1:30 pm Room 511ABC
Featuring experiments, simulations, and all the scales by
@serenasanulli.bsky.social @melikel.bsky.social
@maristizabal.bsky.social @janhuemar.bsky.social and more
Please repost! 🚀✨
February 7, 2025 at 10:33 AM
Who's going to #BPS2025?
Please join us at the MGO Symposium @mgo-bps.bsky.social on Saturday 1:30 pm Room 511ABC
Featuring experiments, simulations, and all the scales by
@serenasanulli.bsky.social @melikel.bsky.social
@maristizabal.bsky.social @janhuemar.bsky.social and more
Please repost! 🚀✨
Please join us at the MGO Symposium @mgo-bps.bsky.social on Saturday 1:30 pm Room 511ABC
Featuring experiments, simulations, and all the scales by
@serenasanulli.bsky.social @melikel.bsky.social
@maristizabal.bsky.social @janhuemar.bsky.social and more
Please repost! 🚀✨
Exciting new preprint alert! 🚨 The Collepardo lab, teaming up with Huabin Zhou and the Rosen lab we took a deep, high-resolution look into chromatin condensates! [1/6] #Chromatin #MD @rcollepardo.bsky.social @juliamaristany.bsky.social
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
www.biorxiv.org
January 22, 2025 at 5:31 PM
Exciting new preprint alert! 🚨 The Collepardo lab, teaming up with Huabin Zhou and the Rosen lab we took a deep, high-resolution look into chromatin condensates! [1/6] #Chromatin #MD @rcollepardo.bsky.social @juliamaristany.bsky.social
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Jan Huertas
The Multiscale Genome Organisation is now on Bluesky!
Our first post is to announce our next webinar. Join us next week on Tuesday, Jan. 28th at 12:00 E.T. for two exciting talks by Pablo Dans and @gfudenberg.bsky.social
See you all there!
Link:
mit.zoom.us/j/91715298970
Our first post is to announce our next webinar. Join us next week on Tuesday, Jan. 28th at 12:00 E.T. for two exciting talks by Pablo Dans and @gfudenberg.bsky.social
See you all there!
Link:
mit.zoom.us/j/91715298970
January 20, 2025 at 11:47 AM
The Multiscale Genome Organisation is now on Bluesky!
Our first post is to announce our next webinar. Join us next week on Tuesday, Jan. 28th at 12:00 E.T. for two exciting talks by Pablo Dans and @gfudenberg.bsky.social
See you all there!
Link:
mit.zoom.us/j/91715298970
Our first post is to announce our next webinar. Join us next week on Tuesday, Jan. 28th at 12:00 E.T. for two exciting talks by Pablo Dans and @gfudenberg.bsky.social
See you all there!
Link:
mit.zoom.us/j/91715298970
Reposted by Jan Huertas
Happy holidays from the Collepardo group ♥️
December 26, 2024 at 3:45 PM
Happy holidays from the Collepardo group ♥️
Excited to be a part of this story!!! Check out our new manuscript exploring how linker DNA length controls chromatin's ability to phase separate
Is chromatin ordered or disordered? It all depends on the linker DNA length.
Check our latest work with Mike Rosen and Sy Redding. We explore how changes in linker DNA length (as small as 1 bp) fine-tune chromatin structure, between order and disorder, and the properties of chromatin droplets
Check our latest work with Mike Rosen and Sy Redding. We explore how changes in linker DNA length (as small as 1 bp) fine-tune chromatin structure, between order and disorder, and the properties of chromatin droplets
December 24, 2024 at 10:06 AM
Excited to be a part of this story!!! Check out our new manuscript exploring how linker DNA length controls chromatin's ability to phase separate
Reposted by Jan Huertas
Is chromatin ordered or disordered? It all depends on the linker DNA length.
Check our latest work with Mike Rosen and Sy Redding. We explore how changes in linker DNA length (as small as 1 bp) fine-tune chromatin structure, between order and disorder, and the properties of chromatin droplets
Check our latest work with Mike Rosen and Sy Redding. We explore how changes in linker DNA length (as small as 1 bp) fine-tune chromatin structure, between order and disorder, and the properties of chromatin droplets
December 24, 2024 at 9:48 AM
Is chromatin ordered or disordered? It all depends on the linker DNA length.
Check our latest work with Mike Rosen and Sy Redding. We explore how changes in linker DNA length (as small as 1 bp) fine-tune chromatin structure, between order and disorder, and the properties of chromatin droplets
Check our latest work with Mike Rosen and Sy Redding. We explore how changes in linker DNA length (as small as 1 bp) fine-tune chromatin structure, between order and disorder, and the properties of chromatin droplets