Julia Maristany
@juliamaristany.bsky.social
Postdoctoral Researcher at the Collepardo Lab, in Cambridge, working on chromatin phase separation
She/Her :) A science, dog, photography person, and most of all, an absolute chromatin geek
She/Her :) A science, dog, photography person, and most of all, an absolute chromatin geek
New paper from the @rcollepardo.bsky.social lab!!!!!
This time, we turn our attention to Oct4, a key pioneer transcription factor 👇👇👇👇
With simulations by @janhuemar.bsky.social, we propose a mechanism through which the clustering of Oct4 upon chromatin binding enhances chromatin plasticity 🧬⚛️👩
This time, we turn our attention to Oct4, a key pioneer transcription factor 👇👇👇👇
With simulations by @janhuemar.bsky.social, we propose a mechanism through which the clustering of Oct4 upon chromatin binding enhances chromatin plasticity 🧬⚛️👩
🚨 🚨 🚨 New preprint alert!!! 🚨 🚨 🚨
In the past, we have learnt that Oct4 can induce nucleosome breathing on the mono-nucleosome level.
But what happens when you have a fibre of multiple nucleosomes?
www.biorxiv.org/content/10.1...
@rcollepardo.bsky.social @juliamaristany.bsky.social
In the past, we have learnt that Oct4 can induce nucleosome breathing on the mono-nucleosome level.
But what happens when you have a fibre of multiple nucleosomes?
www.biorxiv.org/content/10.1...
@rcollepardo.bsky.social @juliamaristany.bsky.social
October 21, 2025 at 10:11 AM
New paper from the @rcollepardo.bsky.social lab!!!!!
This time, we turn our attention to Oct4, a key pioneer transcription factor 👇👇👇👇
With simulations by @janhuemar.bsky.social, we propose a mechanism through which the clustering of Oct4 upon chromatin binding enhances chromatin plasticity 🧬⚛️👩
This time, we turn our attention to Oct4, a key pioneer transcription factor 👇👇👇👇
With simulations by @janhuemar.bsky.social, we propose a mechanism through which the clustering of Oct4 upon chromatin binding enhances chromatin plasticity 🧬⚛️👩
Reposted by Julia Maristany
🚨 🚨 🚨 New preprint alert!!! 🚨 🚨 🚨
In the past, we have learnt that Oct4 can induce nucleosome breathing on the mono-nucleosome level.
But what happens when you have a fibre of multiple nucleosomes?
www.biorxiv.org/content/10.1...
@rcollepardo.bsky.social @juliamaristany.bsky.social
In the past, we have learnt that Oct4 can induce nucleosome breathing on the mono-nucleosome level.
But what happens when you have a fibre of multiple nucleosomes?
www.biorxiv.org/content/10.1...
@rcollepardo.bsky.social @juliamaristany.bsky.social
October 21, 2025 at 9:59 AM
🚨 🚨 🚨 New preprint alert!!! 🚨 🚨 🚨
In the past, we have learnt that Oct4 can induce nucleosome breathing on the mono-nucleosome level.
But what happens when you have a fibre of multiple nucleosomes?
www.biorxiv.org/content/10.1...
@rcollepardo.bsky.social @juliamaristany.bsky.social
In the past, we have learnt that Oct4 can induce nucleosome breathing on the mono-nucleosome level.
But what happens when you have a fibre of multiple nucleosomes?
www.biorxiv.org/content/10.1...
@rcollepardo.bsky.social @juliamaristany.bsky.social
🚨 New paper out in Nature Comms!
From the Rosen, Redding and Collepardo Labs, we uncover how #nucleosome spacing fine-tunes the architecture of #chromatin condensates.
👇 A short thread on how physical #genome organization emerges from molecular interactions:
www.nature.com/articles/s41...
From the Rosen, Redding and Collepardo Labs, we uncover how #nucleosome spacing fine-tunes the architecture of #chromatin condensates.
👇 A short thread on how physical #genome organization emerges from molecular interactions:
www.nature.com/articles/s41...
Nucleosome spacing can fine-tune higher-order chromatin assembly - Nature Communications
Internucleosomal linker length alters the stability and dynamics of chromatin condensates by shifting the balance between inter- and intramolecular interactions. Further, by changing the linker length...
www.nature.com
July 10, 2025 at 10:29 PM
🚨 New paper out in Nature Comms!
From the Rosen, Redding and Collepardo Labs, we uncover how #nucleosome spacing fine-tunes the architecture of #chromatin condensates.
👇 A short thread on how physical #genome organization emerges from molecular interactions:
www.nature.com/articles/s41...
From the Rosen, Redding and Collepardo Labs, we uncover how #nucleosome spacing fine-tunes the architecture of #chromatin condensates.
👇 A short thread on how physical #genome organization emerges from molecular interactions:
www.nature.com/articles/s41...
Reposted by Julia Maristany
🌱Join us for the first #FragileNucleosome seminar of this spring! We are excited to host @juliamaristany.bsky.social & @chribue.bsky.social this week!
If you have registered before you can join from the same link, if not, don't forget to register!
us06web.zoom.us/webinar/regi...
If you have registered before you can join from the same link, if not, don't forget to register!
us06web.zoom.us/webinar/regi...
March 23, 2025 at 2:02 PM
🌱Join us for the first #FragileNucleosome seminar of this spring! We are excited to host @juliamaristany.bsky.social & @chribue.bsky.social this week!
If you have registered before you can join from the same link, if not, don't forget to register!
us06web.zoom.us/webinar/regi...
If you have registered before you can join from the same link, if not, don't forget to register!
us06web.zoom.us/webinar/regi...
Reposted by Julia Maristany
We are happy to share our work on local #nucleosome dynamics integrating #temperature inputs into an #epigenetic switching mechanism.
⚠️ Preprint alert!!
www.biorxiv.org/content/10.1...
⚠️ Preprint alert!!
www.biorxiv.org/content/10.1...
Cold-induced nucleosome dynamics linked to silencing of Arabidopsis FLC
Temperature influences nucleosome dynamics, and thus chromatin, to regulate gene expression. Such mechanisms underlie the epigenetic silencing of Arabidopsis FLOWERING LOCUS C (FLC) by prolonged cold....
www.biorxiv.org
February 21, 2025 at 2:06 PM
We are happy to share our work on local #nucleosome dynamics integrating #temperature inputs into an #epigenetic switching mechanism.
⚠️ Preprint alert!!
www.biorxiv.org/content/10.1...
⚠️ Preprint alert!!
www.biorxiv.org/content/10.1...
Reposted by Julia Maristany
What is the multiscale structure of chromatin condensates? How does it shape thermodynamic and material properties?
We address this at near-atomistic resolution🔥🔥🔥 using cryoET (Rosen & Villa labs, led by H Zhou), a new multiscale model (K Russell) and cryoET-guided sims (J Huertas & J Maristany)
We address this at near-atomistic resolution🔥🔥🔥 using cryoET (Rosen & Villa labs, led by H Zhou), a new multiscale model (K Russell) and cryoET-guided sims (J Huertas & J Maristany)
January 23, 2025 at 9:32 AM
What is the multiscale structure of chromatin condensates? How does it shape thermodynamic and material properties?
We address this at near-atomistic resolution🔥🔥🔥 using cryoET (Rosen & Villa labs, led by H Zhou), a new multiscale model (K Russell) and cryoET-guided sims (J Huertas & J Maristany)
We address this at near-atomistic resolution🔥🔥🔥 using cryoET (Rosen & Villa labs, led by H Zhou), a new multiscale model (K Russell) and cryoET-guided sims (J Huertas & J Maristany)
So excited to see our most recent paper in collaboration with the Rosen Lab out in Bioarxiv today!! 🔥🔥
We look into chromatin condensates in high resolution! 🧪🔬👩🔬 Using cryo-ET and MD sims, we studied chromatin condensates across scales, from individual amino acids to their network architecture!
We look into chromatin condensates in high resolution! 🧪🔬👩🔬 Using cryo-ET and MD sims, we studied chromatin condensates across scales, from individual amino acids to their network architecture!
Exciting new preprint alert! 🚨 The Collepardo lab, teaming up with Huabin Zhou and the Rosen lab we took a deep, high-resolution look into chromatin condensates! [1/6] #Chromatin #MD @rcollepardo.bsky.social @juliamaristany.bsky.social
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
www.biorxiv.org
January 22, 2025 at 5:37 PM
So excited to see our most recent paper in collaboration with the Rosen Lab out in Bioarxiv today!! 🔥🔥
We look into chromatin condensates in high resolution! 🧪🔬👩🔬 Using cryo-ET and MD sims, we studied chromatin condensates across scales, from individual amino acids to their network architecture!
We look into chromatin condensates in high resolution! 🧪🔬👩🔬 Using cryo-ET and MD sims, we studied chromatin condensates across scales, from individual amino acids to their network architecture!
Reposted by Julia Maristany
Exciting new preprint alert! 🚨 The Collepardo lab, teaming up with Huabin Zhou and the Rosen lab we took a deep, high-resolution look into chromatin condensates! [1/6] #Chromatin #MD @rcollepardo.bsky.social @juliamaristany.bsky.social
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
www.biorxiv.org
January 22, 2025 at 5:31 PM
Exciting new preprint alert! 🚨 The Collepardo lab, teaming up with Huabin Zhou and the Rosen lab we took a deep, high-resolution look into chromatin condensates! [1/6] #Chromatin #MD @rcollepardo.bsky.social @juliamaristany.bsky.social
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Julia Maristany
The Multiscale Genome Organisation is now on Bluesky!
Our first post is to announce our next webinar. Join us next week on Tuesday, Jan. 28th at 12:00 E.T. for two exciting talks by Pablo Dans and @gfudenberg.bsky.social
See you all there!
Link:
mit.zoom.us/j/91715298970
Our first post is to announce our next webinar. Join us next week on Tuesday, Jan. 28th at 12:00 E.T. for two exciting talks by Pablo Dans and @gfudenberg.bsky.social
See you all there!
Link:
mit.zoom.us/j/91715298970
January 20, 2025 at 11:47 AM
The Multiscale Genome Organisation is now on Bluesky!
Our first post is to announce our next webinar. Join us next week on Tuesday, Jan. 28th at 12:00 E.T. for two exciting talks by Pablo Dans and @gfudenberg.bsky.social
See you all there!
Link:
mit.zoom.us/j/91715298970
Our first post is to announce our next webinar. Join us next week on Tuesday, Jan. 28th at 12:00 E.T. for two exciting talks by Pablo Dans and @gfudenberg.bsky.social
See you all there!
Link:
mit.zoom.us/j/91715298970
How does chromatin linker length affect its emergent phase behavior? 🧬👩🔬
We explore this question via microscopy and MD simulations: Our new paper, in collaboration with the Rosen and Redding Labs, is out today!! 🔥
We explore this question via microscopy and MD simulations: Our new paper, in collaboration with the Rosen and Redding Labs, is out today!! 🔥
Is chromatin ordered or disordered? It all depends on the linker DNA length.
Check our latest work with Mike Rosen and Sy Redding. We explore how changes in linker DNA length (as small as 1 bp) fine-tune chromatin structure, between order and disorder, and the properties of chromatin droplets
Check our latest work with Mike Rosen and Sy Redding. We explore how changes in linker DNA length (as small as 1 bp) fine-tune chromatin structure, between order and disorder, and the properties of chromatin droplets
December 24, 2024 at 10:57 AM
How does chromatin linker length affect its emergent phase behavior? 🧬👩🔬
We explore this question via microscopy and MD simulations: Our new paper, in collaboration with the Rosen and Redding Labs, is out today!! 🔥
We explore this question via microscopy and MD simulations: Our new paper, in collaboration with the Rosen and Redding Labs, is out today!! 🔥