Gerlich Lab
@gerlichlab.bsky.social
Getting to grips with chromosome organisation and dynamics using ‘scopes, sequencing and silicon.
Located at @imbavienna.bsky.social - @viennabiocenter.bsky.social
Located at @imbavienna.bsky.social - @viennabiocenter.bsky.social
Reposted by Gerlich Lab
The Vienna BioCenter Summer School 2026 call is now open for talented undergrads, it's a great for those interested in graduate study in the life sciences. Daniel Gerlich from Institute of Molecular Biotechnology is recruiting! Please share
https://training.vbc.ac.at/summer-school/
https://training.vbc.ac.at/summer-school/
December 5, 2025 at 12:36 PM
The Vienna BioCenter Summer School 2026 call is now open for talented undergrads, it's a great for those interested in graduate study in the life sciences. Daniel Gerlich from Institute of Molecular Biotechnology is recruiting! Please share
https://training.vbc.ac.at/summer-school/
https://training.vbc.ac.at/summer-school/
Excited to share our latest fully in-house paper! 🎉
We show how cohesin integrates loop extrusion with sister tethering to guide the homology search during DNA repair.
Huge congratulations to all authors, and to @fedeteloni.bsky.social for leading this work 👏
We’re excited to see his next steps!
We show how cohesin integrates loop extrusion with sister tethering to guide the homology search during DNA repair.
Huge congratulations to all authors, and to @fedeteloni.bsky.social for leading this work 👏
We’re excited to see his next steps!
I am happy to share that my postdoctoral work in the @gerlichlab.bsky.social at @imbavienna.bsky.social is finally out 🎉!
Our study reveals how cohesin guides focused and accurate homology search.
Read more 👉 www.science.org/doi/10.1126/...
Follow along for key insights and updates! 🧵
Our study reveals how cohesin guides focused and accurate homology search.
Read more 👉 www.science.org/doi/10.1126/...
Follow along for key insights and updates! 🧵
Cohesin guides homology search during DNA repair using loops and sister chromatid linkages
Accurate repair of DNA double-strand breaks (DSBs) is essential for genome stability, and defective repair underlies diseases such as cancer. Homologous recombination uses an intact homologous sequenc...
www.science.org
December 5, 2025 at 7:46 AM
Excited to share our latest fully in-house paper! 🎉
We show how cohesin integrates loop extrusion with sister tethering to guide the homology search during DNA repair.
Huge congratulations to all authors, and to @fedeteloni.bsky.social for leading this work 👏
We’re excited to see his next steps!
We show how cohesin integrates loop extrusion with sister tethering to guide the homology search during DNA repair.
Huge congratulations to all authors, and to @fedeteloni.bsky.social for leading this work 👏
We’re excited to see his next steps!
Reposted by Gerlich Lab
🚨 New Science paper from the Gerlich lab!
The team shows how cohesin helps broken DNA find the right template: by opening local DNA loops to shrink the search area and by keeping the damaged strand close to its sister copy: science.org/doi/10.1126/science.adw0566
The team shows how cohesin helps broken DNA find the right template: by opening local DNA loops to shrink the search area and by keeping the damaged strand close to its sister copy: science.org/doi/10.1126/science.adw0566
December 4, 2025 at 7:18 PM
🚨 New Science paper from the Gerlich lab!
The team shows how cohesin helps broken DNA find the right template: by opening local DNA loops to shrink the search area and by keeping the damaged strand close to its sister copy: science.org/doi/10.1126/science.adw0566
The team shows how cohesin helps broken DNA find the right template: by opening local DNA loops to shrink the search area and by keeping the damaged strand close to its sister copy: science.org/doi/10.1126/science.adw0566
Huge congratulations to @mfdspicer.bsky.social, PhD student in our lab, for winning the Best Poster Prize at the 2nd Spatial Genome Organization Conference! 🎉
A proud moment for the lab and well-deserved recognition for his creativity and dedication. 👏
@fusionconf.bsky.social #SGO25
A proud moment for the lab and well-deserved recognition for his creativity and dedication. 👏
@fusionconf.bsky.social #SGO25
November 11, 2025 at 11:00 AM
Huge congratulations to @mfdspicer.bsky.social, PhD student in our lab, for winning the Best Poster Prize at the 2nd Spatial Genome Organization Conference! 🎉
A proud moment for the lab and well-deserved recognition for his creativity and dedication. 👏
@fusionconf.bsky.social #SGO25
A proud moment for the lab and well-deserved recognition for his creativity and dedication. 👏
@fusionconf.bsky.social #SGO25
1/ New preprint alert!
In collaboration between the Rosen, Redding, Collepardo-Guevara & Gerlich labs, we uncover a surprising principle of chromosome organisation: electrostatic repulsion positions centromeres at the chromosome surface during mitosis.
🔗 doi.org/10.1101/2025...
In collaboration between the Rosen, Redding, Collepardo-Guevara & Gerlich labs, we uncover a surprising principle of chromosome organisation: electrostatic repulsion positions centromeres at the chromosome surface during mitosis.
🔗 doi.org/10.1101/2025...
An electrostatic repulsion model of centromere organisation
During cell division, chromosomes reorganise into compact bodies in which centromeres localise precisely at the chromatin surface to enable kinetochore-microtubule interactions essential for genome se...
doi.org
September 3, 2025 at 8:12 AM
1/ New preprint alert!
In collaboration between the Rosen, Redding, Collepardo-Guevara & Gerlich labs, we uncover a surprising principle of chromosome organisation: electrostatic repulsion positions centromeres at the chromosome surface during mitosis.
🔗 doi.org/10.1101/2025...
In collaboration between the Rosen, Redding, Collepardo-Guevara & Gerlich labs, we uncover a surprising principle of chromosome organisation: electrostatic repulsion positions centromeres at the chromosome surface during mitosis.
🔗 doi.org/10.1101/2025...
Our lab is now on Bluesky! 🚀 Kicking things off by sharing
@fedeteloni.bsky.social latest preprint on the role of cohesin in homology search. Check out the thread for more details!
@fedeteloni.bsky.social latest preprint on the role of cohesin in homology search. Check out the thread for more details!
New preprint from the @gerlichlab.bsky.social @imbavienna.bsky.social!
How do DNA breaks locate homology sites in the vast space of the human genome? We show how cohesin guides homology search for faithful repair!
Read more 👉 https://doi.org/10.1101/2025.02.10
Follow along for key insights! 🧵
How do DNA breaks locate homology sites in the vast space of the human genome? We show how cohesin guides homology search for faithful repair!
Read more 👉 https://doi.org/10.1101/2025.02.10
Follow along for key insights! 🧵
February 12, 2025 at 5:17 PM
Our lab is now on Bluesky! 🚀 Kicking things off by sharing
@fedeteloni.bsky.social latest preprint on the role of cohesin in homology search. Check out the thread for more details!
@fedeteloni.bsky.social latest preprint on the role of cohesin in homology search. Check out the thread for more details!