Harini Iyer
@iyerharini.bsky.social
Assistant Professor at Rice Biosciences. Lover of all things microglia, lysosomes, and zebrafish. And dogs, of course! https://iyerlaboratory.org/
Don’t miss this amazing webinar tomorrow!
Don't miss out on this fantastic line-up of speakers at the Neural Disorders RIG meetup of the Zebrafish Disease Models Society! July 30, 10:00 EST. Registration details below:
July 30, 2025 at 12:30 AM
Don’t miss this amazing webinar tomorrow!
Don't miss out on this fantastic line-up of speakers at the Neural Disorders RIG meetup of the Zebrafish Disease Models Society! July 30, 10:00 EST. Registration details below:
July 25, 2025 at 5:47 PM
Don't miss out on this fantastic line-up of speakers at the Neural Disorders RIG meetup of the Zebrafish Disease Models Society! July 30, 10:00 EST. Registration details below:
Deepika Dogra, Karin Tuschl, and I are thrilled to host the Neural Disorders RIG meeting of the @ZDMSociety on July 30, 10:00-11:30 am ET. We have a fantastic line-up of speakers. Register here: zdmsociety.org/2025-zdms-ri....
July 8, 2025 at 2:48 PM
Deepika Dogra, Karin Tuschl, and I are thrilled to host the Neural Disorders RIG meeting of the @ZDMSociety on July 30, 10:00-11:30 am ET. We have a fantastic line-up of speakers. Register here: zdmsociety.org/2025-zdms-ri....
Reposted by Harini Iyer
If you think this is a good publishing experience, just wait until March. We’re announcing a game changing modification to peer review. Makes life better for editors, reviewers & especially authors
This is now published in @biologyopen.bsky.social! It was my first experience with this journal & it was outstanding. Their goal is to publish "rigorously conducted high-quality research across the breadth of biological/biomedical science "1/n
journals.biologists.com/bio/article/...
journals.biologists.com/bio/article/...
January 31, 2025 at 1:41 PM
If you think this is a good publishing experience, just wait until March. We’re announcing a game changing modification to peer review. Makes life better for editors, reviewers & especially authors
Reposted by Harini Iyer
I'm thrilled to announce that our paper describing Marigold, a free machine learning-based webapp for zebrafish behavioral analysis, is officially published! Marigold features a user friendly graphical user interface to enable training of a neural network for analyzing behavioral recordings.
January 28, 2025 at 4:23 PM
I'm thrilled to announce that our paper describing Marigold, a free machine learning-based webapp for zebrafish behavioral analysis, is officially published! Marigold features a user friendly graphical user interface to enable training of a neural network for analyzing behavioral recordings.
Reposted by Harini Iyer
GWAS provides a unique tool in human biology as it can establish causal links from variants to trait.
But interpretation is difficult as most effects flow through (unobserved) gene regulatory networks. Can we gain insight by linking to modern Perturb-seq data?
www.biorxiv.org/content/10.1...
But interpretation is difficult as most effects flow through (unobserved) gene regulatory networks. Can we gain insight by linking to modern Perturb-seq data?
www.biorxiv.org/content/10.1...
Causal modeling of gene effects from regulators to programs to traits: integration of genetic associations and Perturb-seq
Genetic association studies provide a unique tool for identifying causal links from genes to human traits and diseases. However, it is challenging to determine the biological mechanisms underlying mos...
www.biorxiv.org
January 26, 2025 at 12:13 AM
GWAS provides a unique tool in human biology as it can establish causal links from variants to trait.
But interpretation is difficult as most effects flow through (unobserved) gene regulatory networks. Can we gain insight by linking to modern Perturb-seq data?
www.biorxiv.org/content/10.1...
But interpretation is difficult as most effects flow through (unobserved) gene regulatory networks. Can we gain insight by linking to modern Perturb-seq data?
www.biorxiv.org/content/10.1...
Reposted by Harini Iyer
New paper out from the lab! Led by @gdfnunes.bsky.social and Lindsay Osso in collaboration with the lab of Dan Denman. Check it out! 🔬 🐭 🧠
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Incomplete remyelination via therapeutically enhanced oligodendrogenesis is sufficient to recover visual cortical function - Nature Communications
Remyelination can restore neural function. Here, the authors characterize the drivers and limits of endogenous remyelination and explore a therapy that rescued remyelination deficits and accelerated n...
www.nature.com
January 18, 2025 at 6:41 PM
New paper out from the lab! Led by @gdfnunes.bsky.social and Lindsay Osso in collaboration with the lab of Dan Denman. Check it out! 🔬 🐭 🧠
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Harini Iyer
Our latest paper, led by Emmy Li, is out on Neuron today:
CRISPRi-based screens in iAssembloids to elucidate neuron-glia interactions
www.cell.com/neuron/fullt...
CRISPRi-based screens in iAssembloids to elucidate neuron-glia interactions
www.cell.com/neuron/fullt...
CRISPRi-based screens in iAssembloids to elucidate neuron-glia interactions
Using a 3D co-culture system of iPSC-derived neurons and glia, termed iAssembloids,
combined with CRISPRi-based screening, Li et al. investigate the effect of glial cells
on neuronal activity and surv...
www.cell.com
January 14, 2025 at 6:27 PM
Our latest paper, led by Emmy Li, is out on Neuron today:
CRISPRi-based screens in iAssembloids to elucidate neuron-glia interactions
www.cell.com/neuron/fullt...
CRISPRi-based screens in iAssembloids to elucidate neuron-glia interactions
www.cell.com/neuron/fullt...
Reposted by Harini Iyer
Have you ever wanted to *see* receptor activity in embryos? If so, our new preprint is for you! In it, we showcase a new live-cell biosensor for visualizing receptor tyrosine kinase activity in living embryos – pYtags!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
January 7, 2025 at 5:46 PM
Have you ever wanted to *see* receptor activity in embryos? If so, our new preprint is for you! In it, we showcase a new live-cell biosensor for visualizing receptor tyrosine kinase activity in living embryos – pYtags!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Harini Iyer
Ooohhh-that's our paper! Check it out! @noahgurley.bsky.social @emily-mcparland.bsky.social
McParland, E. D., Butcher, T. A., Gurley, N. J., Johnson, R. I., Slep, K. C., Peifer, M. (2024). The Dilute domain in Canoe is not essential for linking cell junctions to the cytoskeleton but supports morphogenesis robustness. J Cell Sci, 137(6) journals.biologists.com/jcs/article/...
The Dilute domain in Canoe is not essential for linking cell junctions to the cytoskeleton but supports morphogenesis robustness
Highlighted Article: Cell junctions link cells and anchor the cytoskeleton. Here, we define the role in this process of the conserved Dilute domain in the complex multidomain Canoe protein (a homolog ...
journals.biologists.com
January 4, 2025 at 1:18 AM
Ooohhh-that's our paper! Check it out! @noahgurley.bsky.social @emily-mcparland.bsky.social
Reposted by Harini Iyer
Excited to see this out! A fantastic collaboration with Kirsten Sadler, spearheaded by Nouf and Talhah! Big thanks to DMM for highlighting our work as an Editors Choice, as well as the First Person Interview. 😀🔬🐟
🧪 Sadler, Cox & colleagues create a comparative resource to help make decisions on which method to use to analyse lipid droplets in #zebrafish larval livers. 🐟
Read the summary: https://journals.biologists.com/dmm/article/17/11/dmm052204/363211/Zebrafish-streamline-the-way-to-understanding
Read the summary: https://journals.biologists.com/dmm/article/17/11/dmm052204/363211/Zebrafish-streamline-the-way-to-understanding
January 2, 2025 at 2:18 AM
Excited to see this out! A fantastic collaboration with Kirsten Sadler, spearheaded by Nouf and Talhah! Big thanks to DMM for highlighting our work as an Editors Choice, as well as the First Person Interview. 😀🔬🐟
Reposted by Harini Iyer
Our new paper on recombinant tools for reversibly ablating excitatory and inhibitory synapses is out in eLife. Congrats to first author, Aida Bareghamyan!
elifesciences.org/reviewed-pre...
Plasmids, and hopefully AAVs, will be available soon on Addgene.
elifesciences.org/reviewed-pre...
Plasmids, and hopefully AAVs, will be available soon on Addgene.
December 8, 2024 at 7:50 PM
Our new paper on recombinant tools for reversibly ablating excitatory and inhibitory synapses is out in eLife. Congrats to first author, Aida Bareghamyan!
elifesciences.org/reviewed-pre...
Plasmids, and hopefully AAVs, will be available soon on Addgene.
elifesciences.org/reviewed-pre...
Plasmids, and hopefully AAVs, will be available soon on Addgene.
Reposted by Harini Iyer
#Devbio folks, mark your calendars:
SWSDB2025 at UNM in Albuquerque, NM, May 2-4!
Organizers Drs. Mubarak Hussain Syed, Lomeli Shull, Tou Yia Vue, Alexa Burger, & Marycruz Flores-Flores as US-Mexico liaison - more tk on their fabulous website:
www.swsdb2025.org
@socdevbio.bsky.social #SWSDB2025
SWSDB2025 at UNM in Albuquerque, NM, May 2-4!
Organizers Drs. Mubarak Hussain Syed, Lomeli Shull, Tou Yia Vue, Alexa Burger, & Marycruz Flores-Flores as US-Mexico liaison - more tk on their fabulous website:
www.swsdb2025.org
@socdevbio.bsky.social #SWSDB2025
December 20, 2024 at 10:17 PM
#Devbio folks, mark your calendars:
SWSDB2025 at UNM in Albuquerque, NM, May 2-4!
Organizers Drs. Mubarak Hussain Syed, Lomeli Shull, Tou Yia Vue, Alexa Burger, & Marycruz Flores-Flores as US-Mexico liaison - more tk on their fabulous website:
www.swsdb2025.org
@socdevbio.bsky.social #SWSDB2025
SWSDB2025 at UNM in Albuquerque, NM, May 2-4!
Organizers Drs. Mubarak Hussain Syed, Lomeli Shull, Tou Yia Vue, Alexa Burger, & Marycruz Flores-Flores as US-Mexico liaison - more tk on their fabulous website:
www.swsdb2025.org
@socdevbio.bsky.social #SWSDB2025
Reposted by Harini Iyer
Thrilled to see this paper out!! 🧪
Spatial transcriptomics of brain aging and 'spatial aging clocks' identify cells that have pro-aging or pro-rejuvenating effects on their neighbors!
Huge CONGRATS to Eric Sun and all authors! Fantastic collaboration with @jameszou.bsky.social!
rdcu.be/d33uQ 🧵
Spatial transcriptomics of brain aging and 'spatial aging clocks' identify cells that have pro-aging or pro-rejuvenating effects on their neighbors!
Huge CONGRATS to Eric Sun and all authors! Fantastic collaboration with @jameszou.bsky.social!
rdcu.be/d33uQ 🧵
Spatial transcriptomic clocks reveal cell proximity effects in brain ageing
Nature - A spatially resolved single-cell transcriptomics map of the mouse brain at different ages reveals signatures of ageing, rejuvenation and disease, including ageing effects associated with T...
rdcu.be
December 18, 2024 at 10:40 PM
Thrilled to see this paper out!! 🧪
Spatial transcriptomics of brain aging and 'spatial aging clocks' identify cells that have pro-aging or pro-rejuvenating effects on their neighbors!
Huge CONGRATS to Eric Sun and all authors! Fantastic collaboration with @jameszou.bsky.social!
rdcu.be/d33uQ 🧵
Spatial transcriptomics of brain aging and 'spatial aging clocks' identify cells that have pro-aging or pro-rejuvenating effects on their neighbors!
Huge CONGRATS to Eric Sun and all authors! Fantastic collaboration with @jameszou.bsky.social!
rdcu.be/d33uQ 🧵
Reposted by Harini Iyer
There are now 24 step-by-step guides, explaining how to create these ⬇️ data visualizations with R/ggplot2 - I hope this is a useful resource. Find them all here: joachimgoedhart.github.io/DataViz-prot...
December 16, 2024 at 9:25 AM
There are now 24 step-by-step guides, explaining how to create these ⬇️ data visualizations with R/ggplot2 - I hope this is a useful resource. Find them all here: joachimgoedhart.github.io/DataViz-prot...
Reposted by Harini Iyer
Heading to #CellBio2024? Do you love #lipids? Join us for an exciting subgroup on Lipids in Organelle Form and Function, Saturday at 1:45 PM! Lipid-themed happy hour to follow but you must attend the session to find out the location!
December 11, 2024 at 3:51 PM
Heading to #CellBio2024? Do you love #lipids? Join us for an exciting subgroup on Lipids in Organelle Form and Function, Saturday at 1:45 PM! Lipid-themed happy hour to follow but you must attend the session to find out the location!
Reposted by Harini Iyer
Updated Aging Starter Packs to find people and labs who work on aging!!
Aging Starter Pack 1 (already reached the maximum number!): go.bsky.app/5UXXaDA
Aging Starter Pack 2 (can still add!): go.bsky.app/RfFYndJ
Let me know if you'd like to be added! 😀
Aging Starter Pack 1 (already reached the maximum number!): go.bsky.app/5UXXaDA
Aging Starter Pack 2 (can still add!): go.bsky.app/RfFYndJ
Let me know if you'd like to be added! 😀
December 14, 2024 at 6:43 PM
Updated Aging Starter Packs to find people and labs who work on aging!!
Aging Starter Pack 1 (already reached the maximum number!): go.bsky.app/5UXXaDA
Aging Starter Pack 2 (can still add!): go.bsky.app/RfFYndJ
Let me know if you'd like to be added! 😀
Aging Starter Pack 1 (already reached the maximum number!): go.bsky.app/5UXXaDA
Aging Starter Pack 2 (can still add!): go.bsky.app/RfFYndJ
Let me know if you'd like to be added! 😀
Joey is such a fantastic person and a thoughtful and brilliant scientist! I would apply for a position in his lab if I was eligible!
December 10, 2024 at 3:55 PM
Joey is such a fantastic person and a thoughtful and brilliant scientist! I would apply for a position in his lab if I was eligible!
Reposted by Harini Iyer
I'll be presenting at #CellBio2024 on Monday, Dec. 16! I'll give a flash talk in the Cell Dynamics, Developmental and Structural Biology, and Signal Transduction microsymposium at 10 am and then will be at my poster 1:30–3 pm (Board No. B350) 1/3
#CellBio2024, the joint meeting of ASCB and EMBO, will take place December 14-18, 2024, in San Diego, California. Join us to connect with scientists, present your research, and explore the latest advancements in cell biology science and technology.
www.ascb.org/cellbio2024/
www.ascb.org/cellbio2024/
December 9, 2024 at 9:52 PM
I'll be presenting at #CellBio2024 on Monday, Dec. 16! I'll give a flash talk in the Cell Dynamics, Developmental and Structural Biology, and Signal Transduction microsymposium at 10 am and then will be at my poster 1:30–3 pm (Board No. B350) 1/3
Reposted by Harini Iyer
Ok, I made a starter pack for membrane trafficking and organelles (broadly defined). Feel free to self-nominate! go.bsky.app/RbtJjt7
November 11, 2024 at 5:03 PM
Ok, I made a starter pack for membrane trafficking and organelles (broadly defined). Feel free to self-nominate! go.bsky.app/RbtJjt7
Reposted by Harini Iyer
December 8, 2024 at 7:20 PM
Reposted by Harini Iyer
@devdynamics.bsky.social Welcome to Bluesky Developmental Dynamics, added to the Developmental Biology starter pack II.
You can also patch in to more #DevBio folks by checking out the first Developmental Biology start pack here:
go.bsky.app/M5AgJhn
You can also patch in to more #DevBio folks by checking out the first Developmental Biology start pack here:
go.bsky.app/M5AgJhn
November 16, 2024 at 11:20 PM
@devdynamics.bsky.social Welcome to Bluesky Developmental Dynamics, added to the Developmental Biology starter pack II.
You can also patch in to more #DevBio folks by checking out the first Developmental Biology start pack here:
go.bsky.app/M5AgJhn
You can also patch in to more #DevBio folks by checking out the first Developmental Biology start pack here:
go.bsky.app/M5AgJhn
I laughed till I cried. I needed that!
Waaaayy too real -
Yesterday I completed mine. www.mcsweeneys.net/articles/a-f...
December 8, 2024 at 7:56 PM
I laughed till I cried. I needed that!
Reposted by Harini Iyer
December 7, 2024 at 3:29 PM
Reposted by Harini Iyer
Resharing this for those new to bluesky. If you are interested in #innateimmunity or #inflammation, here’s a starter pack or researchers to follow! Leave a comment if you wanna be added too. #immunosky #academicchatter
go.bsky.app/QqJ9AgB
go.bsky.app/QqJ9AgB
December 6, 2024 at 7:21 PM
Resharing this for those new to bluesky. If you are interested in #innateimmunity or #inflammation, here’s a starter pack or researchers to follow! Leave a comment if you wanna be added too. #immunosky #academicchatter
go.bsky.app/QqJ9AgB
go.bsky.app/QqJ9AgB