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DMM Journal
@dmmjournal.bsky.social
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Disease Models & Mechanisms - discovery for human health. A
@biologists.bsky.social Open Access journal that publishes human disease research.
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DMM Journal @dmmjournal.bsky.social · 20d
Our new special issue on infectious diseases is now closed! bit.ly/4nc60U5

On the cover: 3D-volume render of tuberculosis granulomas in mice infected with E2Crimson-expressing Mycobacterium tuberculosis. Granuloma boundary in turquoise and infecting bacteria in red.
Three-dimensional volume render of tuberculosis granulomas in C3HeB/FeJ mice infected with E2Crimson-expressing Mycobacterium tuberculosis. Turquoise outlines mark the granuloma boundary, infecting bacteria are highlighted in red. Images were captured by light-sheet fluorescence microscopy and rendered in 3D at day 42 and day 70 post infection, revealing the spatial architecture of lesions and the pathogen distribution deep within intact lung tissue. See article by Beltran et al. (dmm052185).
dmmjournal.bsky.social
For our #InfectiousDisease Special Issue we interviewed the marvelous @harmitmalik.bsky.social ! We discussed the #viral arms race, how to support mentees and the beauty of basic science 🔬

journals.biologists.com/dmm/article/...
The viral arms race: an interview with Harmit Malik
Harmit Malik. Photo credit: Fred Hutchinson Cancer Research Center.Harmit Malik is Professor and Associate Director of the Basic Sciences Division at the Fred Hutchinson Cancer Center in Seattle, WA,…
journals.biologists.com
November 10, 2025 at 2:05 PM
dmmjournal.bsky.social
Two closely related fungi – Cryptococcus deneoformans (Cd) and Cryptococcus neoformans (Cn) – can cause serious infections. Charles-Niño & co explore how Cd and Cn respond to temperature and how they interact with human tissues, including infection. doi.org/10.1242/dmm....
Cn and Cd skin infection pathogenesis and host responses. In cutaneous wounds infected with Cn H99 strain, there is a massive increase in cellular recruitment to the damaged tissue and substantial release of immune molecules (e.g. MPO and proinflammatory cytokines) compared to that in wounds infected with Cd B3501 strain. High GXM release occurs in the superficial area of the wound infected by H99, whereas hsp60 and hsp70 are highly expressed in dermal tissue as temperature increases due to inflammation, which results in increased wound healing. In cutaneous wounds infected with Cd B3501 strain, robust biofilm formation on the surface of the wound takes place, facilitating fungal survival. There is also a reduction in cellular infiltration and immune molecule production, resulting in delayed wound healing. hsp60 and hsp70 expression in Cd strains is less than that in Cn strains. Created in BioRender by Charles-Niño, C. L. (2025). https://BioRender.com/h63r638.
November 6, 2025 at 2:26 PM
dmmjournal.bsky.social
Caroline Beltran & co describe a novel and unbiased 3D imaging approach that visualises how the lung granulomas that are characteristic of TB infection form, evolve & spatially organise. 🐭 🫁 doi.org/10.1242/dmm....

#Tuberculosis #Granuloma
November 6, 2025 at 9:01 AM
dmmjournal.bsky.social
Bats can carry deadly viruses without getting sick. Now, Ng & Wang give a timely & fascinating #DMMPerspective on the possible translation of discoveries from bats to humans, in the context of treating and preventing #infectiousdiseases. 🦇🧫 doi.org/10.1242/dmm....
Translational value of bat research to humans. (A-D) Investigating emerging infectious disease (A), inflammation (B), longevity (C), metabolism (D).
November 4, 2025 at 5:21 PM
Reposted by DMM Journal
prelights.bsky.social
Biological conduction bridges skip a beat. ❤️

#preLight (from Theodora Stougiannou) of a study generating stem-cell derived AVN-like pacemaker cells + demonstrating their functionality for biological conduction bridge applications in vivo. @uhnresearch.ca
prelights.biologists.com/highlights/h...
Human pluripotent stem cell-derived atrioventricular node-like pacemaker cells exhibit biological conduction bridge properties in vitro and in vivo - preLights
Biological conduction bridges skip a beat. The preprint authors generate AV node-like pacemaker cells from human pluripotent stem cell populations in order to create a biological conduction bridge.
prelights.biologists.com
October 29, 2025 at 3:16 PM
dmmjournal.bsky.social
The G307D variant of TOM1, an endosomal adaptor protein, is linked to inborn errors of immunity. Ryhänen & co use patient cells to show that this mutation disrupts the interaction of TOM1 with TOLLIP, impairing cargo trafficking & autophagy regulation. doi.org/10.1242/dmm....
November 3, 2025 at 2:26 PM
dmmjournal.bsky.social
Using a zebrafish model & human brain tissue, Tapia & co find that high levels of CH25H and 25HC are linked to small brain bleeds following COVID-19 infection. They show that 25HC can damage endothelial cells, especially when cholesterol levels are low. doi.org/10.1242/dmm....
25HC remodels cholesterol metabolism in human brain endothelial cells. (A) Cellular cholesterol remodelling induced by 25HC. 25HC inhibits cholesterol synthesis (1), promotes cholesterol efflux (2), and induces the internalisation and storage of cholesterol in the form of lipid droplets (3). These changes lead to the depletion of plasma membrane-accessible cholesterol (4), which can be rescued with cholesterol supplementation (5).
November 2, 2025 at 8:43 PM
dmmjournal.bsky.social
The deadline to submit to our Special Issue 'In Vitro Models of Human Disease to Inform Mechanism and Drug Discovery' is tomorrow.🚨

We look forward to receiving your next submission for this exciting special issue!
#OpenAccess
bit.ly/4h1092r
Special Issue In Vitro Models of Human Disease to Inform Mechanism and Drug Discovery Edited by Vivian Li, Austin Smith and Joseph Wu Extended deadline: 3 November 2025
November 2, 2025 at 11:13 AM
Reposted by DMM Journal
biologists.bsky.social
Save the date and register for abstract updates for @dmmjournal.bsky.social's 2026 Journal Meeting. 'Innovative Preclinical Models for Pediatric Cancer Research'. biologists.com/meetings/dmm... #DMM2026cancer
Innovative Preclinical Models for Pediatric Cancer Research Organisers: James Amatruda, Pratiti (Mimi) Bandopadhayay, Ana Banito and Elaine Mardis Date: 13 - 15 October 2026 Location: Nationwide Children's Hospital Conference Center, Columbus, Ohio, USA
October 31, 2025 at 8:01 AM
dmmjournal.bsky.social
The call for papers deadline for our Special Issue 'In Vitro Models of Human Disease to Inform Mechanism and Drug Discovery' is less than one week away!🚨

We're looking forward to receiving your next paper for this exciting special issue!
#OpenAccess
bit.ly/4h1092r
Special Issue In Vitro Models of Human Disease to Inform Mechanism and Drug Discovery Edited by Vivian Li, Austin Smith and Joseph Wu Extended deadline: 3 November 2025
October 28, 2025 at 3:29 PM
dmmjournal.bsky.social
In this 'At a Glance' article, Kandas Traore & co highlight how engineered #bacteriophages can be tailored to enhance antibacterial therapies and diagnostics and to support innovative biomedical applications beyond antimicrobial resistance challenges. doi.org/10.1242/dmm....

#nanomedicine
At a Glance poster titled Engineered bacteriophages for therapeutic and diagnostic applications
October 24, 2025 at 6:05 PM
dmmjournal.bsky.social
Analyses of #zebrafish and human #neutrophils by Muir & co show that a subset of neutrophil phagosomes can remain unsealed and might retain the ability to modulate phagosome content post-engulfment, potentially influencing microbial killing, antigen presentation and more. doi.org/10.1242/dmm....
October 23, 2025 at 5:03 PM
dmmjournal.bsky.social
In this Editorial, DMM Guest Editors, including @tobinlab.bsky.social & @profjudiallen.bsky.social, introduce our special issue on #InfectiousDiseases & describe the articles in it, highlighting the breadth of research encompassed by the infectious disease research community. doi.org/10.1242/dmm....
The Special Issue Editors (left to right): Judi Allen, Sumana Sanyal, David M. Tobin and Russell Vance
October 22, 2025 at 1:26 PM
Reposted by DMM Journal
biologists.bsky.social
As part of our commitment to Open Access, we support libraries, consortia and researchers. For #OAWeek, we share a recent webinar that includes tips and recommendations for navigating the editorial process and publishing #OA
youtu.be/PjD5QQ-p0Xg
#OAWeek25
Publishing with The Company of Biologists: supporting biologists, inspiring biology
YouTube video by The Company of Biologists
youtu.be
October 22, 2025 at 11:23 AM
dmmjournal.bsky.social
Our new special issue on infectious diseases is now closed! bit.ly/4nc60U5

On the cover: 3D-volume render of tuberculosis granulomas in mice infected with E2Crimson-expressing Mycobacterium tuberculosis. Granuloma boundary in turquoise and infecting bacteria in red.
Three-dimensional volume render of tuberculosis granulomas in C3HeB/FeJ mice infected with E2Crimson-expressing Mycobacterium tuberculosis. Turquoise outlines mark the granuloma boundary, infecting bacteria are highlighted in red. Images were captured by light-sheet fluorescence microscopy and rendered in 3D at day 42 and day 70 post infection, revealing the spatial architecture of lesions and the pathogen distribution deep within intact lung tissue. See article by Beltran et al. (dmm052185).
October 21, 2025 at 1:14 PM
Reposted by DMM Journal
biologists.bsky.social
Call for papers: In Vitro Models of Human Disease to Inform Mechanism and Drug Discovery

Deadline approaching: Monday 3 November 2025

journals.biologists.com/dmm/pages/in...

#Biology #Research #Disease #Discovery #Organoids #Tumours #Gastruloids #Assembloids
Promotional graphic for a special issue of Disease Models & Mechanisms titled "In Vitro Models of Human Disease to Inform Mechanism and Drug Discovery." The left side of the image contains text announcing the call for papers, edited by Vivian Li, Austin Smith, and Joseph Wu, with a submission deadline of 3 November 2025. The right side features a vibrant, microscopic image of biological tissue or cell structures in vivid pink, blue, and yellow hues, representing the complexity of in vitro disease models. The design combines scientific detail with visual appeal to attract submissions for the issue.
October 20, 2025 at 2:25 PM
Reposted by DMM Journal
biologists.bsky.social
This week has been special for us, marking 100 years of supporting biologists and inspiring biology. We celebrated our achievements at @zoologymuseum.bsky.social last night. We want to thank all our staff, whose continual inspiration and daily support for one another make our work possible.
Photo of whale at Museum of Zoology and photo of 100 cake
October 17, 2025 at 1:11 PM
dmmjournal.bsky.social
Abril Morales & co demonstrate that neurons lacking MECP2 show signs of elevated DNA damage and senescence transcriptional signatures, which could contribute to phenotypes in patients with Rett syndrome. doi.org/10.1242/dmm....

#RettSyndrome #DNADamage
sn-RNA-seq analysis of wild-type and RTT rat brain. Nuclei were isolated from brains of wild-type rats and transgenic rats with loss of MECP2. (A) 10× single-cell RNA sequencing was performed, and single-cell profiles were obtained. (B) Gene expression profiles were plotted with UMAP, and several different neuronal subtypes were identified in various clusters as indicated. (C) A plot of DEGs between wild-type (WT) and RTT (MT) rat brain. (D) Plotted are the number of DEGs (upregulated and downregulated) in each neuronal subtype.
October 17, 2025 at 10:57 AM
dmmjournal.bsky.social
Gowri Nayak & co suggest a protective role for MSRB3 in the maintenance and maturation of mouse stereocilia and hair cells, a conserved mechanism aimed at maintaining actin redox dynamics in these sensory cells. doi.org/10.1242/dmm....
Generation and validation of Msrb3 knockout mice. (A) Schematic representation of generation of Msrb3−/− mice. (B) Quantification of MSR family member expression, normalized against Gapdh, in the cochleae of Msrb3−/− mutant mice and their control littermates (Msrb3+/+ and Msrb3+/−) at postnatal day (P)0. (C) Maximum-intensity projections of confocal z-stacks of whole-mount cochleae at P16, labeled with anti-MSRB3 antibody (green) and phalloidin (red), are shown. Insets in both images show a y-z projection of the organ of Corti's epithelium. Whereas in wild-type Msrb3+/+ mice (left), MSRB3 protein (green) is localized in the cytoplasm of the outer (OHC) and inner (IHC) hair cells, no immunolabeling was detected in Msrb3−/− mutant mice (right). Scale bar: 10 µm. (D,E) X-galactosidase staining was performed on Msrb3+/− mice to document Msrb3 promoter activity in the organ of Corti from P6 mice.
October 16, 2025 at 1:26 PM
Reposted by DMM Journal
katiepickup.bsky.social
Great panel discussion @helloeacr.bsky.social on the future of #CancerNeuroscience and the importance of balancing multiple disease models. This recent @dmmjournal.bsky.social Perspective from Eva Hernando provides a great exploration of pros and cons of metastasis models
tinyurl.com/dmm-metastas...
Modeling metastasis – leveraging novel tools to streamline discovery in advanced cancer
Summary: We comprehensively review current cancer metastasis models, highlight advances and gaps, and advocate open data sharing to enhance model selection, experimental rigor and clinical relevance.
tinyurl.com
October 15, 2025 at 4:17 PM
Reposted by DMM Journal
katiepickup.bsky.social
Excited to be in beautiful Bilbao for @helloeacr.bsky.social Cancer Neuroscience this week on behalf of @dmmjournal.bsky.social. Looking forward to learning more about interactions between tumours and the nervous system #EACR
Photo of the Guggenheim museum in Bilbao in golden morning light with red autumn trees in the background. Photo of red autumn trees in front of a building reflected in the river.
October 14, 2025 at 9:57 AM
Reposted by DMM Journal
biologists.bsky.social
2008: Disease Models & Mechanisms @dmmjournal.bsky.social is an international peer-reviewed #OpenAccess biomedical journal, founded in 2008 with the goal to “foster a connection between the model organism scientists and the clinicians”. Read DMM's anniversary collection bit.ly/4mJwXOt
Poster of DMM timeline and history
October 15, 2025 at 1:00 PM
dmmjournal.bsky.social
Gain new insights into emerging immune-based cancer treatments, resistance mechanisms, and innovative therapeutic strategies at the virtual conference Next Generation Immunotherapies: From Innovative Approaches to Overcoming Resistance and Beyond bit.ly/3USUi57
Next Generation Immunotherapies: From Innovative Approaches to Overcoming Resistance and Beyond Virtual Event : 24 - 25 February 2026
October 14, 2025 at 3:15 PM
dmmjournal.bsky.social
The call for papers deadline for our Special Issue 'In Vitro Models of Human Disease to Inform Mechanism and Drug Discovery' is three weeks away🚨

We're looking forward to receiving your next paper for this exciting special issue!
#OpenAccess #DiseaseModelling

bit.ly/4h1092r
Special Issue In Vitro Models of Human Disease to Inform Mechanism and Drug Discovery Edited by Vivian Li, Austin Smith and Joseph Wu Extended deadline: 3 November 2025
October 13, 2025 at 6:41 PM
dmmjournal.bsky.social
Amber Juba & co show that sexual dimorphism in the brain redox environment may contribute to sexually dimorphic park −/− Drosophila phenotypes. Degenerating and non-degenerating neurons have different redox environments. doi.org/10.1242/dmm....
Decreases in climbing capability and motivation in park−/− Drosophila are accompanied by elevated levels of PPL1 mitochondrial hydrogen peroxide. (A) Average height climbed and climbing attempts were recorded for individual flies over 20 min. (B) Contingency graphs demonstrate that fewer female park−/− flies attempt to climb (C) Representative images of PPL1 regions from female (F) or male (M) flies expressing mito-roGFP2-Orp1. Top row: Raw images showing PPL1 regions stained for tyrosine hydroxylase (red) in flies expressing TH-driven mito-roGFP2-Orp1. Middle and bottom rows: Selected volume isosurfaces of oxidized (blue, middle row) and non-oxidized (green, bottom row) mito-roGFP2-Orp1 above threshold. Scale bar: 10 µm. (D) Each data point represents the ratio of the total oxidized/non-oxidized roGFP2 volume from one PPL1 region.
October 13, 2025 at 1:26 PM