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DMM Journal
@dmmjournal.bsky.social
3.1K followers 100 following 320 posts
Disease Models & Mechanisms - discovery for human health. A
@biologists.bsky.social Open Access journal that publishes human disease research.
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DMM Journal @dmmjournal.bsky.social · Oct 21
Our new special issue on infectious diseases is now closed! bit.ly/4nc60U5

On the cover: 3D-volume render of tuberculosis granulomas in mice infected with E2Crimson-expressing Mycobacterium tuberculosis. Granuloma boundary in turquoise and infecting bacteria in red.
Three-dimensional volume render of tuberculosis granulomas in C3HeB/FeJ mice infected with E2Crimson-expressing Mycobacterium tuberculosis. Turquoise outlines mark the granuloma boundary, infecting bacteria are highlighted in red. Images were captured by light-sheet fluorescence microscopy and rendered in 3D at day 42 and day 70 post infection, revealing the spatial architecture of lesions and the pathogen distribution deep within intact lung tissue. See article by Beltran et al. (dmm052185).
dmmjournal.bsky.social
In 2025, we celebrated the 100-year anniversary of our not-for-profit publisher @biologists.bsky.social 🥳 In this article we look back on our year of celebrations and look forward to the next 100 years! journals.biologists.com/dmm/article/...
A photograph of (from left to right) Claire Moulton (Chief Executive Officer), Sarah Bray (Chair of the Board of Directors) and Katie Ward (Chief Financial Officer and Charity Director).
January 8, 2026 at 12:10 PM
dmmjournal.bsky.social
Sankalpa Chakraborty, Viswanathan Rajagopalan & co used the ZSF1 #RatModel to investigate early and severe age-related heart failure with preserved ejection fraction and showed novel noncoding and coding markers in early- and/or late-ageing-related hypothyroid #HFpEF.

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January 8, 2026 at 8:00 AM
dmmjournal.bsky.social
John Hellicar, Dominic Lenz, Martin Lowe & co used #fibroblasts from individuals with #CALFAN syndrome, which affects the nervous system and liver, and revealed an accumulation of the secretory cargo procollagen type I in the #EndoplasmicReticulum

#RareDisease

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January 7, 2026 at 12:01 PM
dmmjournal.bsky.social
Abigail Poff, Nicole Moss & @debbysilver.bsky.social generated a #MouseModel of the #DDX3XSyndrome and demonstrated that missense and loss-of-function variants have similar effects on #corticogenesis but act through distinct molecular targets.

#RareDisease

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January 6, 2026 at 12:01 PM
dmmjournal.bsky.social
DMM is supporting the Developmental origins of #PaediatricCancer symposium. Discover the latest cutting-edge research on the modelling, biology and treatment in the field.

Abstract submission until 28 Feb 2026

Info www.cclg.org.uk/information-...
Registration www.tickettailor.com/events/cclg/...
Developmental origins of paediatric cancer symposium
A one-day event showcasing the latest cutting-edge research on the modelling, biology and treatment of paediatric cancers in the context of their developmental origins.
www.cclg.org.uk
January 5, 2026 at 12:01 PM
dmmjournal.bsky.social
Biqin Zhang, Hrvoje Augustin & co used #Drosophila model of PLA2G6-associated #neurodegeneration and showed that treatment with decanoic acid significantly extends the lifespan, reduces bang sensitivity and improves resistance to heat shock stress.
#RareDisease

More details doi.org/10.1242/dmm....
January 2, 2026 at 12:00 PM
dmmjournal.bsky.social
In December's #EditorsChoice, Nayeli Reyes-Nava, @edwardmarcotte.bsky.social, @jbwallingford.bsky.social & co use #Xenopus model to study #Cilia motility disturbances in primary ciliary dyskinesia #PCD

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December 30, 2025 at 12:01 PM
dmmjournal.bsky.social
In November's #EditorsChoice, Katerina Yamamoto, @cswormlab.bsky.social & co investigate the connection between #InnateImmunity and #LipidMetabolism, using the worm model #Celegans

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📰https://doi.org/10.1242/dmm.052357
December 29, 2025 at 12:01 PM
dmmjournal.bsky.social
Anam Naseer, Pranoy Toppo, Mahmood Akbar, Aamir Nazir investigate the mechanistic aspect of mitochondrial #sirtuins in modulating age-associated #neurodegeneration, specifically #ParkinsonsDisease, using #Celegans

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December 29, 2025 at 8:01 AM
dmmjournal.bsky.social
In October's #EditorsChoice, Kenneth Katschke, Marion Jeanne & co investigate the role of #HTRA1 in age-related retinal degeneration #AMD.

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December 26, 2025 at 12:01 PM
dmmjournal.bsky.social
In September's #EditorsChoice, Victor Tapia, Catherine Lawrence, Paul Kasher & co investigate #cholesterol homeostasis connection to #COVID19 in #zebrafish and #CellCulture models.

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December 25, 2025 at 12:00 PM
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In August's #EditorsChoice, Gianna Maggiore, @haozhulab.bsky.social & co showed strong clinical potential in reducing #HepatocellularCarcinoma by targeting the actin-binding protein anillin via #siRNA knockdown in #MouseModel.

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Chemoprevention of hepatocellular carcinoma using N-acetylgalactosamine-conjugated siRNAs
Editor's choice: Comparison between five N-acetylgalactosamine-conjugated siRNAs in several mouse models of liver cancer found ANLN to be a promising target for hepatocellular carcinoma…
doi.org
December 24, 2025 at 12:02 PM
dmmjournal.bsky.social
December Issue's #EditorsChoice highlights an article that uses the #Xenopus cell model to study vertebrate motile #cilia and the involvement of LRRC56 protein in #PrimaryCiliary Dyskinesia #PCD

#RareDisease

Read the short, simple retelling here doi.org/10.1242/dmm....
Details in the thread.
December 24, 2025 at 8:00 AM
dmmjournal.bsky.social
In July's #EditorsChoice, Kamila Karimjee, Richard J. Piercy & co develop long-term, age-associated activity quantification for dog model of #DuchenneMuscularDystrophy #DMD

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December 23, 2025 at 12:02 PM
dmmjournal.bsky.social
Yeon Ja Choi, Jiang Chen & co developed a genetically engineered mouse model expressing a mutant Wdpcp gene, implicated in several ciliopathies, including Bardet-Biedl syndrome. This model provides new insights into WDPCP’s structure–function relationships.

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December 23, 2025 at 8:01 AM
dmmjournal.bsky.social
In June's #EditorsChoice, Laetitia Pinte, Ludovic Vallier & co investigate the function of EHF transcription factor in #LungHomeostasis and #LungDisease.
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December 22, 2025 at 12:03 PM
dmmjournal.bsky.social
In May's #EditorsChoice, Stephanie May, Tom Bird & co explore targeted radiation in #LiverCancer ablation
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December 19, 2025 at 12:01 PM
dmmjournal.bsky.social
In April's #EditorsChoice, @daniyaljafree.bsky.social & co explore microvascular abnormalities that arise early in polycystic #KidneyDisease
⚡https://doi.org/10.1242/dmm.052437
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#PCKD
December 18, 2025 at 12:04 PM
dmmjournal.bsky.social
Christian Gonzalez, @simonytanglab.bsky.social & co show that a chronic high-fat diet and impaired β-cell function mouse model more accurately captures the multifactorial inflammatory microenvironment of intervertebral disc degeneration induced by #Type2Diabetes #T2D

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Degenerating intervertebral discs in the streptozotocin-high-fat diet model of type 2 diabetes show extensive inflammation
Summary: The streptozotocin-high-fat diet mouse model recapitulates the complexities of the chronic inflammatory processes in the intervertebral disc during type 2 diabetes in humans.
doi.org
December 18, 2025 at 8:01 AM
dmmjournal.bsky.social
In March's #EditorsChoice, Griffin, Saint-Jeannet & co come face to face with a new #Xenopus model for a rare #SplicingDisorder
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#CraniofacialDevelopment
December 17, 2025 at 12:01 PM
dmmjournal.bsky.social
In February's #EditorsChoice Thornton, Sharma & co turn #HIV treatment up a Notch(3)
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December 16, 2025 at 12:01 PM
dmmjournal.bsky.social
Roza Masalmeh, @margaretframe.bsky.social & co uncover a FAK–ROCK-driven mechanism that links #ExtracellularMatrix mechanical cues to the rewiring of energy #metabolism, affecting mitochondrial function and malignant behaviour.
#mitochondria #cancer

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FAK modulates glioblastoma stem cell energetics via regulation of glycolysis and glutamine oxidation
Summary: The key adhesion protein focal adhesion kinase (FAK) transduces adhesion signals to enhance glycolysis and oxidative phosphorylation in a glioblastoma stem-cell model, highlighting a…
doi.org
December 16, 2025 at 8:02 AM
dmmjournal.bsky.social
In January's #EditorsChoice, Wu, @richardbartfai.bsky.social & co de-liver insights into improving organoid-derived #hepatocyte culture by analysing transcription factor networks
⚡https://doi.org/10.1242/dmm.052296
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December 15, 2025 at 12:01 PM
dmmjournal.bsky.social
This month's Editor's Choice highlights an article on the connection between #InnateImmunity and #LipidMetabolism, investigated using the worm model #Celegans

Read the short, simple retelling here journals.biologists.com/dmm/article/...
More details in the thread.

@cswormlab.bsky.social
December 12, 2025 at 12:03 PM
dmmjournal.bsky.social
The tiny hero behind advances in developmental biology, toxicology, immunology & genetics? The #Zebrafish, a key model for human disease. Researchers now urge standardised reporting to boost #reproducibility

@aburger2009.bsky.social @khaichung.bsky.social

journals.biologists.com/dmm/article/...
Building a framework for reproducibility: the case for standardized data reporting and metadata integration in zebrafish research
Summary: This Editorial calls for active participation in data standardization for reporting and metadata integration to strengthen reproducibility, data integration and AI readiness for biomedical…
journals.biologists.com
December 11, 2025 at 12:02 PM