Iain Bressendorff, MD PhD
@ibressendorff.bsky.social
Nephrologist, clinical trials, PRIMETIME study.
CKD-MBD, GN, DKD, amateur 80’s musician, MTG
#NephSky
CKD-MBD, GN, DKD, amateur 80’s musician, MTG
#NephSky
Reposted by Iain Bressendorff, MD PhD
fun review if anyone is interested www.ahajournals.org/doi/10.1161/...
Vaughan Pendred was a house surgeon at Guy's hospital when he reported deaf-mutism with goitre www.sciencedirect.com/science/arti... in @thelancet.com - and went on to become a ....(not nephrologist) a general practitioner
Vaughan Pendred was a house surgeon at Guy's hospital when he reported deaf-mutism with goitre www.sciencedirect.com/science/arti... in @thelancet.com - and went on to become a ....(not nephrologist) a general practitioner
Regulation of Blood Pressure and Salt Balance By Pendrin-Positive Intercalated Cells: Donald Seldin Lecture 2020 | Hypertension
Intercalated cells make up about a third of all cells within the connecting tubule
and the collecting duct and are subclassified as type A, type B and non-A, non-B based
on the subcellular distributio...
www.ahajournals.org
February 13, 2026 at 6:32 PM
fun review if anyone is interested www.ahajournals.org/doi/10.1161/...
Vaughan Pendred was a house surgeon at Guy's hospital when he reported deaf-mutism with goitre www.sciencedirect.com/science/arti... in @thelancet.com - and went on to become a ....(not nephrologist) a general practitioner
Vaughan Pendred was a house surgeon at Guy's hospital when he reported deaf-mutism with goitre www.sciencedirect.com/science/arti... in @thelancet.com - and went on to become a ....(not nephrologist) a general practitioner
@dialysisbloke.bsky.social
Applied the VIPAR protocol to a patient with cAMR, first time in our centre.
Fingers crossed for positive results 🤞🏻
Just wanted to let you know that it’s being used out there 🤓
Applied the VIPAR protocol to a patient with cAMR, first time in our centre.
Fingers crossed for positive results 🤞🏻
Just wanted to let you know that it’s being used out there 🤓
February 20, 2026 at 8:48 AM
@dialysisbloke.bsky.social
Applied the VIPAR protocol to a patient with cAMR, first time in our centre.
Fingers crossed for positive results 🤞🏻
Just wanted to let you know that it’s being used out there 🤓
Applied the VIPAR protocol to a patient with cAMR, first time in our centre.
Fingers crossed for positive results 🤞🏻
Just wanted to let you know that it’s being used out there 🤓
Reposted by Iain Bressendorff, MD PhD
Another trial!
Albumin 20% for septic shock
Does not work - JAMA NO
jamanetwork.com/journals/jam...
#EMIMCC
Albumin 20% for septic shock
Does not work - JAMA NO
jamanetwork.com/journals/jam...
#EMIMCC
February 20, 2026 at 4:17 AM
Another trial!
Albumin 20% for septic shock
Does not work - JAMA NO
jamanetwork.com/journals/jam...
#EMIMCC
Albumin 20% for septic shock
Does not work - JAMA NO
jamanetwork.com/journals/jam...
#EMIMCC
Reposted by Iain Bressendorff, MD PhD
#OTD 1917 David Finney b (d 12 Nov 2018) CBE FRS; ASA Fellow 1951; Royal Statistical Society President 1973. Pioneered statistical methods of experimental design, statistical computing, pharmacovigilance, biological assay & probit analysis. 1/3
January 3, 2026 at 10:58 AM
#OTD 1917 David Finney b (d 12 Nov 2018) CBE FRS; ASA Fellow 1951; Royal Statistical Society President 1973. Pioneered statistical methods of experimental design, statistical computing, pharmacovigilance, biological assay & probit analysis. 1/3
Reposted by Iain Bressendorff, MD PhD
Still interested in the mechanisms of #SGLT2i? I did a video with #Vumedi going through our study on the effects of empagliflozin on fluid and electrolyte balance. check it out: www.vumedi.com/video/fluid-...
Link for the studies 👇
#medsky #nephsky
Link for the studies 👇
#medsky #nephsky
Fluid Balance in CKD: Empagliflozin Findings from SiRENA
A video from William Shaffer (as part of ASN Kidney Week Highlights), posted on Nov 26, 2025.
www.vumedi.com
December 16, 2025 at 11:07 AM
Still interested in the mechanisms of #SGLT2i? I did a video with #Vumedi going through our study on the effects of empagliflozin on fluid and electrolyte balance. check it out: www.vumedi.com/video/fluid-...
Link for the studies 👇
#medsky #nephsky
Link for the studies 👇
#medsky #nephsky
Reposted by Iain Bressendorff, MD PhD
Important study validating what has become my standard practice for relapsing MCD-NS
Response to Rituximab as a Maintenance Therapy in Adult Idiopathic Nephrotic Syndrome: A French Multicenter Cohort Study
bit.ly/4pDdIsn
bit.ly/4pDdIsn
December 16, 2025 at 5:40 PM
Important study validating what has become my standard practice for relapsing MCD-NS
Reposted by Iain Bressendorff, MD PhD
Join the Filtrate and Jon Barratt as he takes an IgAN inspired victory lap
FF 86 Atacicept for IgAN
www.nephjc.com/freelyfilter...
FF 86 Atacicept for IgAN
www.nephjc.com/freelyfilter...
FF 86 Atacicept for IgAN with Jon Barratt — NephJC
FF 86 Atacicept for IgAN with Jon Barratt
www.nephjc.com
November 28, 2025 at 3:01 PM
Join the Filtrate and Jon Barratt as he takes an IgAN inspired victory lap
FF 86 Atacicept for IgAN
www.nephjc.com/freelyfilter...
FF 86 Atacicept for IgAN
www.nephjc.com/freelyfilter...
I’m a little shocked at this review of resistant hypertension in CKD.
academic.oup.com/ckj/advance-...
- Weird take on BP targets (there are other trials besides SPRINT)
- Thiazides don’t work in CKD, except chlorthalidone (demonstrably false)
- Don’t use spiro if eGFR <45 because hyperK ?!?!?
1/2
academic.oup.com/ckj/advance-...
- Weird take on BP targets (there are other trials besides SPRINT)
- Thiazides don’t work in CKD, except chlorthalidone (demonstrably false)
- Don’t use spiro if eGFR <45 because hyperK ?!?!?
1/2
2025 Update on resistant hypertension in CKD: where do we stand and where do we go?
Abstract. Resistant hypertension is highly prevalent among individuals with chronic kidney disease (CKD) and is closely associated with accelerated decline
academic.oup.com
November 23, 2025 at 3:40 PM
I’m a little shocked at this review of resistant hypertension in CKD.
academic.oup.com/ckj/advance-...
- Weird take on BP targets (there are other trials besides SPRINT)
- Thiazides don’t work in CKD, except chlorthalidone (demonstrably false)
- Don’t use spiro if eGFR <45 because hyperK ?!?!?
1/2
academic.oup.com/ckj/advance-...
- Weird take on BP targets (there are other trials besides SPRINT)
- Thiazides don’t work in CKD, except chlorthalidone (demonstrably false)
- Don’t use spiro if eGFR <45 because hyperK ?!?!?
1/2
Reposted by Iain Bressendorff, MD PhD
7. Personal level. Beyond his talent and expertise, I met an extraordinary man. Humble, altruistic, wise, friendly, and with a great sense of humor. I brought him a vacuolar cast tie as a present and he wore it proudly right away 🤩
November 21, 2025 at 5:24 PM
7. Personal level. Beyond his talent and expertise, I met an extraordinary man. Humble, altruistic, wise, friendly, and with a great sense of humor. I brought him a vacuolar cast tie as a present and he wore it proudly right away 🤩
Reposted by Iain Bressendorff, MD PhD
1/n Recently attended an international congress about Urinalysis in Santiago, Chile 🇨🇱. I was expecting a small meeting. I was wrong. Pleasantly surprised with the size of the meeting and the energy and interest from the participants. Let me share the highlights of my experience:
November 21, 2025 at 5:24 PM
1/n Recently attended an international congress about Urinalysis in Santiago, Chile 🇨🇱. I was expecting a small meeting. I was wrong. Pleasantly surprised with the size of the meeting and the energy and interest from the participants. Let me share the highlights of my experience:
Reposted by Iain Bressendorff, MD PhD
Diagnosis unmasked. Young F with 2g proteinuria, weak +dsDNA. Membranous pattern, IF with C3 dominant staining. Pronase IF --> IgG-k. Membranous-like glomerulopathy with masked monotypic IgG-k deposits. Considered to be autoimmune; not MGRS. #renalpath #pathsky #nephsky.
November 20, 2025 at 1:01 PM
Diagnosis unmasked. Young F with 2g proteinuria, weak +dsDNA. Membranous pattern, IF with C3 dominant staining. Pronase IF --> IgG-k. Membranous-like glomerulopathy with masked monotypic IgG-k deposits. Considered to be autoimmune; not MGRS. #renalpath #pathsky #nephsky.
Reposted by Iain Bressendorff, MD PhD
Nothing works in dialysis - except fis oil. Truly amazing data from the PISCES. Should we begin perscribimg fish oil supplements to all our dialysis patients? In spite of my somewhat sceptical priors, I think the answer should be “yes” #NephSky #KidneyWk #nephrology
November 9, 2025 at 11:26 AM
Nothing works in dialysis - except fis oil. Truly amazing data from the PISCES. Should we begin perscribimg fish oil supplements to all our dialysis patients? In spite of my somewhat sceptical priors, I think the answer should be “yes” #NephSky #KidneyWk #nephrology
Reposted by Iain Bressendorff, MD PhD
Reposted by Iain Bressendorff, MD PhD
What mechanisms drive checkpoint inhibitor-associated interstitial nephritis (ICI-AIN)?
In our preprint, we identify CD8 T cells as a central player, inducing a proinflammatory myeloid cell state by IFNg and structuring lymphoid aggregates by CXCL13.
www.biorxiv.org/content/10.1...
1/n
#Nephsky 🧪
In our preprint, we identify CD8 T cells as a central player, inducing a proinflammatory myeloid cell state by IFNg and structuring lymphoid aggregates by CXCL13.
www.biorxiv.org/content/10.1...
1/n
#Nephsky 🧪
November 5, 2025 at 6:24 PM
What mechanisms drive checkpoint inhibitor-associated interstitial nephritis (ICI-AIN)?
In our preprint, we identify CD8 T cells as a central player, inducing a proinflammatory myeloid cell state by IFNg and structuring lymphoid aggregates by CXCL13.
www.biorxiv.org/content/10.1...
1/n
#Nephsky 🧪
In our preprint, we identify CD8 T cells as a central player, inducing a proinflammatory myeloid cell state by IFNg and structuring lymphoid aggregates by CXCL13.
www.biorxiv.org/content/10.1...
1/n
#Nephsky 🧪
Reposted by Iain Bressendorff, MD PhD
After a 40 minute handa on session where my station worked on kidney US we are back in the lecture room for a talk on lung ultrasound by Nathaniel Reisinger #KidneyWk
November 5, 2025 at 4:10 PM
After a 40 minute handa on session where my station worked on kidney US we are back in the lecture room for a talk on lung ultrasound by Nathaniel Reisinger #KidneyWk
Reposted by Iain Bressendorff, MD PhD
I enjoyed the Observer this morning @drjennings.bsky.social
In my considered view politicians and public bodies should not be on Twitter is for the same reason that a candidate should not attend a townhall meeting where he was put on a lower chair and very loud music played whenever he spoke.
In my considered view politicians and public bodies should not be on Twitter is for the same reason that a candidate should not attend a townhall meeting where he was put on a lower chair and very loud music played whenever he spoke.
November 2, 2025 at 7:16 AM
I enjoyed the Observer this morning @drjennings.bsky.social
In my considered view politicians and public bodies should not be on Twitter is for the same reason that a candidate should not attend a townhall meeting where he was put on a lower chair and very loud music played whenever he spoke.
In my considered view politicians and public bodies should not be on Twitter is for the same reason that a candidate should not attend a townhall meeting where he was put on a lower chair and very loud music played whenever he spoke.
Reposted by Iain Bressendorff, MD PhD
Clinic visit, pt w/type 2 diabetes + nephrotic range proteinuria. Persistent hematuria noted (normal cysto 3 mo ago) not c/w diabetic nephropathy. #UrinarySediment 🔬is performed: numerous acanthocytes and a few WBC casts. Serum IgA elevated. Normal C3/C4. Other tests pending. Kidney biopsy planned
October 23, 2025 at 3:46 AM
Clinic visit, pt w/type 2 diabetes + nephrotic range proteinuria. Persistent hematuria noted (normal cysto 3 mo ago) not c/w diabetic nephropathy. #UrinarySediment 🔬is performed: numerous acanthocytes and a few WBC casts. Serum IgA elevated. Normal C3/C4. Other tests pending. Kidney biopsy planned
Reposted by Iain Bressendorff, MD PhD
New episode of Freely Filtered with @brendonneuen.bsky.social @hswapnil.medsky.social @captainchloride.bsky.social @sophia-kidney.bsky.social and author Muth Vaduganathan discussing the CONVINCE trial
www.nephjc.com/freelyfilter...
With chapters, refs, and pictures
www.nephjc.com/freelyfilter...
With chapters, refs, and pictures
October 21, 2025 at 12:11 PM
New episode of Freely Filtered with @brendonneuen.bsky.social @hswapnil.medsky.social @captainchloride.bsky.social @sophia-kidney.bsky.social and author Muth Vaduganathan discussing the CONVINCE trial
www.nephjc.com/freelyfilter...
With chapters, refs, and pictures
www.nephjc.com/freelyfilter...
With chapters, refs, and pictures
A little opinion piece on the relationship between serum calcification propensity (T50) and progressive CAC in kidney transplant recipients 🤓
www.kireports.org/article/S246...
www.kireports.org/article/S246...
T50 and Calcification Progression in Kidney Transplant Recipients: Does it have to be “bad” to be useful?
The increased risk of cardiovascular disease (CVD) among kidney transplant recipients
(KTR)1 is challenging for the treating physician. For KTR, CVD risk remains higher
than for individuals with simil...
www.kireports.org
September 27, 2025 at 9:27 AM
A little opinion piece on the relationship between serum calcification propensity (T50) and progressive CAC in kidney transplant recipients 🤓
www.kireports.org/article/S246...
www.kireports.org/article/S246...
Reposted by Iain Bressendorff, MD PhD
And it’s live
Iptacopan in C3GN makes it to @thelancet.com
www.thelancet.com/journals/lan...
#NephSky
Iptacopan in C3GN makes it to @thelancet.com
www.thelancet.com/journals/lan...
#NephSky
September 26, 2025 at 9:37 AM
And it’s live
Iptacopan in C3GN makes it to @thelancet.com
www.thelancet.com/journals/lan...
#NephSky
Iptacopan in C3GN makes it to @thelancet.com
www.thelancet.com/journals/lan...
#NephSky
Reposted by Iain Bressendorff, MD PhD
Wide variety of morphologies in this case of crystalline light chain proximal tubulopathy: mottle lysosomes, crystals, and fibrils. #renalpath #nephsky #pathsky
August 6, 2025 at 9:32 PM
Wide variety of morphologies in this case of crystalline light chain proximal tubulopathy: mottle lysosomes, crystals, and fibrils. #renalpath #nephsky #pathsky
Reposted by Iain Bressendorff, MD PhD
Have hyperglycemia (and other DM badness) been hiding in plain sight in ESKD?
Probably.
Great study using CGMs in ESKD.
Pts with treated DM, mean TIR only 43% while mean HbA1c was 7.0%
journals.lww.com/jasn/abstrac...
Probably.
Great study using CGMs in ESKD.
Pts with treated DM, mean TIR only 43% while mean HbA1c was 7.0%
journals.lww.com/jasn/abstrac...
Glycemia Assessed by Continuous Glucose Monitoring among... : Journal of the American Society of Nephrology
ilure and its treatments disrupt glucose homeostasis in ways that may promote both hyperglycemia and hypoglycemia. Continuous glucose monitoring (CGM) delineates detailed glycemic profiles, but publis...
journals.lww.com
September 13, 2025 at 7:16 PM
Have hyperglycemia (and other DM badness) been hiding in plain sight in ESKD?
Probably.
Great study using CGMs in ESKD.
Pts with treated DM, mean TIR only 43% while mean HbA1c was 7.0%
journals.lww.com/jasn/abstrac...
Probably.
Great study using CGMs in ESKD.
Pts with treated DM, mean TIR only 43% while mean HbA1c was 7.0%
journals.lww.com/jasn/abstrac...
Reposted by Iain Bressendorff, MD PhD
RIP Nicolas Madias
Of the Adrogue-Madias formula and much more
I don’t know he wrote three textbooks as a medical student!
www.kidney-international.org/article/S008...
In @kidneyint.bsky.social
#NephSky
Of the Adrogue-Madias formula and much more
I don’t know he wrote three textbooks as a medical student!
www.kidney-international.org/article/S008...
In @kidneyint.bsky.social
#NephSky
August 23, 2025 at 1:22 AM
RIP Nicolas Madias
Of the Adrogue-Madias formula and much more
I don’t know he wrote three textbooks as a medical student!
www.kidney-international.org/article/S008...
In @kidneyint.bsky.social
#NephSky
Of the Adrogue-Madias formula and much more
I don’t know he wrote three textbooks as a medical student!
www.kidney-international.org/article/S008...
In @kidneyint.bsky.social
#NephSky
Reposted by Iain Bressendorff, MD PhD
Now online in @ndt-era.bsky.social
Perlecan is a novel target of autoantibodies in anti-glomerular basement membrane disease
🧐Triple-positive pts (anti-type IV collagen, -laminin 521, and -perlecan) = highest prevalence of lung hemorrhage and ESKD
▶️ academic.oup.com/ndt/article-...
Perlecan is a novel target of autoantibodies in anti-glomerular basement membrane disease
🧐Triple-positive pts (anti-type IV collagen, -laminin 521, and -perlecan) = highest prevalence of lung hemorrhage and ESKD
▶️ academic.oup.com/ndt/article-...
August 12, 2025 at 5:27 AM
Now online in @ndt-era.bsky.social
Perlecan is a novel target of autoantibodies in anti-glomerular basement membrane disease
🧐Triple-positive pts (anti-type IV collagen, -laminin 521, and -perlecan) = highest prevalence of lung hemorrhage and ESKD
▶️ academic.oup.com/ndt/article-...
Perlecan is a novel target of autoantibodies in anti-glomerular basement membrane disease
🧐Triple-positive pts (anti-type IV collagen, -laminin 521, and -perlecan) = highest prevalence of lung hemorrhage and ESKD
▶️ academic.oup.com/ndt/article-...