@grahamabra.bsky.social
Nephrologist @StanfordNeph, Chair @HDAE_Official, Director Social Media @HemodialysisInt, Defender of the 4 nephrons.
Reposted
This study in #ASNKidney360 examined depletion of the antioxidant ergothioneine in patients undergoing dialysis. They compared levels in blood from patients on peritoneal dialysis hemodialysis, and healthy controls. Read more about what they found: kidney.pub/KID1105 @grahamabra.bsky.social
January 14, 2026 at 5:00 PM
This study in #ASNKidney360 examined depletion of the antioxidant ergothioneine in patients undergoing dialysis. They compared levels in blood from patients on peritoneal dialysis hemodialysis, and healthy controls. Read more about what they found: kidney.pub/KID1105 @grahamabra.bsky.social
Reposted
New out today:
Antiproteinuric Effect of Sparsentan in Patients with Genetic-Associated FSGS Enrolled in the DUPLEX Trial
Genetic FSGS CAN be treated. journals.lww.com/cjasn/abstra...
Antiproteinuric Effect of Sparsentan in Patients with Genetic-Associated FSGS Enrolled in the DUPLEX Trial
Genetic FSGS CAN be treated. journals.lww.com/cjasn/abstra...
December 23, 2025 at 8:16 PM
New out today:
Antiproteinuric Effect of Sparsentan in Patients with Genetic-Associated FSGS Enrolled in the DUPLEX Trial
Genetic FSGS CAN be treated. journals.lww.com/cjasn/abstra...
Antiproteinuric Effect of Sparsentan in Patients with Genetic-Associated FSGS Enrolled in the DUPLEX Trial
Genetic FSGS CAN be treated. journals.lww.com/cjasn/abstra...
Reposted
I’ll do a pitch for the ASN AKI-D guidance document here #nephjc
@nephroninja.bsky.social
pubmed.ncbi.nlm.nih.gov/40014384/
@nephroninja.bsky.social
pubmed.ncbi.nlm.nih.gov/40014384/
ASN Kidney Health Guidance on the Outpatient Management of Patients with Dialysis-Requiring Acute Kidney Injury - PubMed
This article contains a podcast at https://dts.podtrac.com/redirect.mp3/www.asn-online.org/media/podcast/JASN/2025_03_11_KTS_March2025.mp3
pubmed.ncbi.nlm.nih.gov
December 17, 2025 at 2:59 AM
I’ll do a pitch for the ASN AKI-D guidance document here #nephjc
@nephroninja.bsky.social
pubmed.ncbi.nlm.nih.gov/40014384/
@nephroninja.bsky.social
pubmed.ncbi.nlm.nih.gov/40014384/
Reposted
#NephJC The traditional approach is increase in native renal function and then dialysis cessation. We proposes a different paradigm: dialysis cessation to promote increase in native renal function.
December 17, 2025 at 2:46 AM
#NephJC The traditional approach is increase in native renal function and then dialysis cessation. We proposes a different paradigm: dialysis cessation to promote increase in native renal function.
Reposted
#NephJC it is important to point out that ‘1st day of recovery’ was defined retrospective. On that day, GFR may be very low (so not ‘recovered’ in the way many people use the word). See 2 figures below for illustration. Both these patients contributed to those Kaplan-Meier curves separating early.
December 17, 2025 at 2:37 AM
#NephJC it is important to point out that ‘1st day of recovery’ was defined retrospective. On that day, GFR may be very low (so not ‘recovered’ in the way many people use the word). See 2 figures below for illustration. Both these patients contributed to those Kaplan-Meier curves separating early.
Reposted
T2f
Dialysis-Free Days by Day 28:
Conservative: 21 days
Conventional: 5 days
Most pronounced divergence within the first 10-12 days
Clinically, this means these patients spent most of their hospital course not needing dialysis, something no earlier AKI-D trial has demonstrated so clearly. #NephJC
Dialysis-Free Days by Day 28:
Conservative: 21 days
Conventional: 5 days
Most pronounced divergence within the first 10-12 days
Clinically, this means these patients spent most of their hospital course not needing dialysis, something no earlier AKI-D trial has demonstrated so clearly. #NephJC
December 17, 2025 at 2:31 AM
T2f
Dialysis-Free Days by Day 28:
Conservative: 21 days
Conventional: 5 days
Most pronounced divergence within the first 10-12 days
Clinically, this means these patients spent most of their hospital course not needing dialysis, something no earlier AKI-D trial has demonstrated so clearly. #NephJC
Dialysis-Free Days by Day 28:
Conservative: 21 days
Conventional: 5 days
Most pronounced divergence within the first 10-12 days
Clinically, this means these patients spent most of their hospital course not needing dialysis, something no earlier AKI-D trial has demonstrated so clearly. #NephJC
Reposted
T1c
#NephJC
1️⃣Conservative RRT group
RRT was done only if one of the following occurred:
✅BUN >112 mg/dL
✅Potassium >6.0 mmol/L, >5.5 after meds
✅pH <7.15 or HCO3 < 12 meq/L
✅Hypoxemia or pulmonary edema
✅Symptomatic overload
✅Clinician judgment
2️⃣ Conventional RRT was 3x/wk
#NephJC
1️⃣Conservative RRT group
RRT was done only if one of the following occurred:
✅BUN >112 mg/dL
✅Potassium >6.0 mmol/L, >5.5 after meds
✅pH <7.15 or HCO3 < 12 meq/L
✅Hypoxemia or pulmonary edema
✅Symptomatic overload
✅Clinician judgment
2️⃣ Conventional RRT was 3x/wk
December 17, 2025 at 2:18 AM
T1c
#NephJC
1️⃣Conservative RRT group
RRT was done only if one of the following occurred:
✅BUN >112 mg/dL
✅Potassium >6.0 mmol/L, >5.5 after meds
✅pH <7.15 or HCO3 < 12 meq/L
✅Hypoxemia or pulmonary edema
✅Symptomatic overload
✅Clinician judgment
2️⃣ Conventional RRT was 3x/wk
#NephJC
1️⃣Conservative RRT group
RRT was done only if one of the following occurred:
✅BUN >112 mg/dL
✅Potassium >6.0 mmol/L, >5.5 after meds
✅pH <7.15 or HCO3 < 12 meq/L
✅Hypoxemia or pulmonary edema
✅Symptomatic overload
✅Clinician judgment
2️⃣ Conventional RRT was 3x/wk
Reposted
T1a
Population: stable AKI-D patients with realistic renal recovery potential
Exactly the “gray zone” group we debate daily whether dialysis continuation is necessary.
👀Check out the inclusion/exclusion criteria #NephJC
Population: stable AKI-D patients with realistic renal recovery potential
Exactly the “gray zone” group we debate daily whether dialysis continuation is necessary.
👀Check out the inclusion/exclusion criteria #NephJC
December 17, 2025 at 2:16 AM
T1a
Population: stable AKI-D patients with realistic renal recovery potential
Exactly the “gray zone” group we debate daily whether dialysis continuation is necessary.
👀Check out the inclusion/exclusion criteria #NephJC
Population: stable AKI-D patients with realistic renal recovery potential
Exactly the “gray zone” group we debate daily whether dialysis continuation is necessary.
👀Check out the inclusion/exclusion criteria #NephJC
Reposted
Hi! I'm a nephrologist and clinical researcher at UCSF.
COI: I was one of the LIBERATE-D investigators at the UCSF site.
I made a BlueSky account today to join this discussion. #NephJC
COI: I was one of the LIBERATE-D investigators at the UCSF site.
I made a BlueSky account today to join this discussion. #NephJC
December 17, 2025 at 2:06 AM
Hi! I'm a nephrologist and clinical researcher at UCSF.
COI: I was one of the LIBERATE-D investigators at the UCSF site.
I made a BlueSky account today to join this discussion. #NephJC
COI: I was one of the LIBERATE-D investigators at the UCSF site.
I made a BlueSky account today to join this discussion. #NephJC
December 17, 2025 at 2:05 AM
Reposted
#NephJC This is Chi Hsu, senior author and one of the two PI’s for LIBERATE-D. Thanks for choosing our paper. I am borrowing UCSF Nephrology Division’s BlueSky account.
December 17, 2025 at 2:02 AM
#NephJC This is Chi Hsu, senior author and one of the two PI’s for LIBERATE-D. Thanks for choosing our paper. I am borrowing UCSF Nephrology Division’s BlueSky account.
Reposted
Excited about this @theisn.org initiative, especially under the leadership of @hswapnil.medsky.social as EIC. Nephrology needed this
www.theisn.org/blog/2025/12...
www.theisn.org/blog/2025/12...
Turning clinical experience into shared knowledge: ISN launches Kidney International Case ReportsTM - International Society of Nephrology
www.theisn.org
December 9, 2025 at 4:11 AM
Excited about this @theisn.org initiative, especially under the leadership of @hswapnil.medsky.social as EIC. Nephrology needed this
www.theisn.org/blog/2025/12...
www.theisn.org/blog/2025/12...
Reposted
The Stanford African Scholars in #GlobalHealth (SASH) program is fostering innovation at a time of growing global health challenges. Through partnerships & knowledge exchange, physician-leaders from African countries gain skills & insights to improve care at home. https://stanford.io/4pt5IKq
December 8, 2025 at 9:10 PM
The Stanford African Scholars in #GlobalHealth (SASH) program is fostering innovation at a time of growing global health challenges. Through partnerships & knowledge exchange, physician-leaders from African countries gain skills & insights to improve care at home. https://stanford.io/4pt5IKq
Reposted
It was really interesting researching this topic. Hope it’s useful.
Dr. Sarah Sanghavi (@sarahsanghavi.bsky.social) presents "Prolonging Circuit Life in CRRT" and discusses the consequences of CRRT interruptions as well as strategies to improve circuit life. #vascular #antigoagulation #kidney #nephrology #nephsky @uwmedicine.bsky.social
youtu.be/JnOa6yQtPfQ
youtu.be/JnOa6yQtPfQ
Sarah Sanghavi, MD - Prolonging Circuit Life in CRRT
YouTube video by University of Washington Division of Nephrology
youtu.be
December 5, 2025 at 1:31 AM
It was really interesting researching this topic. Hope it’s useful.
Reposted
#NephSky as I ask every match day, what is the deal? Endocrinology and Rheumatology (what I would consider the closest comps to nephro) are following almost of their spots while we continue to...not. Do we simply have too many spots?
December 3, 2025 at 9:58 PM
#NephSky as I ask every match day, what is the deal? Endocrinology and Rheumatology (what I would consider the closest comps to nephro) are following almost of their spots while we continue to...not. Do we simply have too many spots?
Reposted
Yup
Figure 1.1 in incidence rate of ESRD in the US
Seems to have slipped most people’s awareness 🤷🏽♂️
Figure 1.1 in incidence rate of ESRD in the US
Seems to have slipped most people’s awareness 🤷🏽♂️
December 3, 2025 at 10:46 PM
Yup
Figure 1.1 in incidence rate of ESRD in the US
Seems to have slipped most people’s awareness 🤷🏽♂️
Figure 1.1 in incidence rate of ESRD in the US
Seems to have slipped most people’s awareness 🤷🏽♂️
Reposted
EPA and DHA has an effect on arrhythmias and SCD, especially formation of reentry arrhythmias. e.g. EPA and DHA modulates sodium, calcium and potassium ion channels affecting the cardiac action potential. #NephJC
December 3, 2025 at 2:30 AM
EPA and DHA has an effect on arrhythmias and SCD, especially formation of reentry arrhythmias. e.g. EPA and DHA modulates sodium, calcium and potassium ion channels affecting the cardiac action potential. #NephJC
Reposted
Indeed! We did not know what to expect, but hopeful. Having worked on this for over a decade, I was initially "stunned" by the result but then not really surprised given the multitude of potential effects of EPA and DHA on the cardiovasculature, and our HD patients deficiencies in it #NephJC
December 3, 2025 at 2:43 AM
Indeed! We did not know what to expect, but hopeful. Having worked on this for over a decade, I was initially "stunned" by the result but then not really surprised given the multitude of potential effects of EPA and DHA on the cardiovasculature, and our HD patients deficiencies in it #NephJC
Reposted
Stop complaining about pill burden in ESRD!
There is no pill you are giving your dialysis patient that has data half as impressive as this study. If they are taking too many pills have them stop any of the dozen pills they are taking with ZEERO data in ESRD. #NephJC
There is no pill you are giving your dialysis patient that has data half as impressive as this study. If they are taking too many pills have them stop any of the dozen pills they are taking with ZEERO data in ESRD. #NephJC
December 3, 2025 at 2:51 AM
Stop complaining about pill burden in ESRD!
There is no pill you are giving your dialysis patient that has data half as impressive as this study. If they are taking too many pills have them stop any of the dozen pills they are taking with ZEERO data in ESRD. #NephJC
There is no pill you are giving your dialysis patient that has data half as impressive as this study. If they are taking too many pills have them stop any of the dozen pills they are taking with ZEERO data in ESRD. #NephJC
Reposted
Actually, we actually found the opposite - many patients were wanting a "natural" treatment and didnt mind! Some actually left the study to buy commercial fish oil as they didnt know if they had placebo. But to be fair, some also left the study due to pill burden #NephJC
December 3, 2025 at 2:53 AM
Actually, we actually found the opposite - many patients were wanting a "natural" treatment and didnt mind! Some actually left the study to buy commercial fish oil as they didnt know if they had placebo. But to be fair, some also left the study due to pill burden #NephJC
Reposted
Reposted
Up next 12/16/25 (our last #NephJC of the year)
LIBERATE, A Conservative Dialysis Strategy and Kidney Function Recovery in
Dialysis-Requiring Acute Kidney Injury.
jamanetwork.com/jour...
December 3, 2025 at 2:59 AM
Up next 12/16/25 (our last #NephJC of the year)
LIBERATE, A Conservative Dialysis Strategy and Kidney Function Recovery in
Dialysis-Requiring Acute Kidney Injury.
jamanetwork.com/jour...
Reposted
We need a daily dose of
1600 mg EPA
800 mg DHA
in an ethylester mix of fish oil
Did I get that right @kidneyboy.bsky.social @pisces01.bsky.social ?
The same company that made it for FISH and PISCES may come out with their formulation soon
#NephJC
1600 mg EPA
800 mg DHA
in an ethylester mix of fish oil
Did I get that right @kidneyboy.bsky.social @pisces01.bsky.social ?
The same company that made it for FISH and PISCES may come out with their formulation soon
#NephJC
December 3, 2025 at 12:00 PM
We need a daily dose of
1600 mg EPA
800 mg DHA
in an ethylester mix of fish oil
Did I get that right @kidneyboy.bsky.social @pisces01.bsky.social ?
The same company that made it for FISH and PISCES may come out with their formulation soon
#NephJC
1600 mg EPA
800 mg DHA
in an ethylester mix of fish oil
Did I get that right @kidneyboy.bsky.social @pisces01.bsky.social ?
The same company that made it for FISH and PISCES may come out with their formulation soon
#NephJC
Reposted
Since we don’t know the mechanism (secret sauce) hard to say. Is it the EPA/DHA quantities or the ratio or the “quality”, or something else that hasn’t been considered. This is also likely the basis of conflicting data #NephJC
a baby is making a funny face with the words this is confusing me written above it .
ALT: a baby is making a funny face with the words this is confusing me written above it .
media.tenor.com
December 3, 2025 at 3:03 PM
Since we don’t know the mechanism (secret sauce) hard to say. Is it the EPA/DHA quantities or the ratio or the “quality”, or something else that hasn’t been considered. This is also likely the basis of conflicting data #NephJC