Hiro Ebina / 蛯名裕久
@hiroebina.bsky.social
A wandering and wondering molecular biologist and geneticist, currently at Switzerland🇨🇭| Posdoc in Barral lab, ETH Zürich @barrallabeth.bsky.social | pombe | Interested in the stability and plasticity of the genome, genetic immunity in eukaryotes
Reposted by Hiro Ebina / 蛯名裕久
This one feels special: our latest work on subtelomeric heterochromatin is now on www.biorxiv.org/content/10.1....
This story was driven by the virtuoso PhD work of Agnisrota Mazumder @agnisrota.bsky.social, co-mentored with @al-sadylab.bsky.social, and grew out of our #MSCA Cell2Cell network.
This story was driven by the virtuoso PhD work of Agnisrota Mazumder @agnisrota.bsky.social, co-mentored with @al-sadylab.bsky.social, and grew out of our #MSCA Cell2Cell network.
Discrete Subdomains Establish Epigenetic Diversity in Subtelomeric Heterochromatin
Subtelomeres are imperfect repeats adjacent to telomeres that are repressed by heterochromatin. Although essential for genome integrity, their repetitive nature has thwarted dissection of local hetero...
www.biorxiv.org
September 27, 2025 at 6:55 AM
This one feels special: our latest work on subtelomeric heterochromatin is now on www.biorxiv.org/content/10.1....
This story was driven by the virtuoso PhD work of Agnisrota Mazumder @agnisrota.bsky.social, co-mentored with @al-sadylab.bsky.social, and grew out of our #MSCA Cell2Cell network.
This story was driven by the virtuoso PhD work of Agnisrota Mazumder @agnisrota.bsky.social, co-mentored with @al-sadylab.bsky.social, and grew out of our #MSCA Cell2Cell network.
Reposted by Hiro Ebina / 蛯名裕久
Sex or growth? Life must continually balance these strategies. We forced yeast to choose and captured the trade-off in real time. Evolution rewired existing regulators and fixed them through genetic assimilation, creating specialists for sex at the cost of growth.
www.biorxiv.org/cgi/content/...
www.biorxiv.org/cgi/content/...
September 28, 2025 at 12:30 PM
Sex or growth? Life must continually balance these strategies. We forced yeast to choose and captured the trade-off in real time. Evolution rewired existing regulators and fixed them through genetic assimilation, creating specialists for sex at the cost of growth.
www.biorxiv.org/cgi/content/...
www.biorxiv.org/cgi/content/...
Reposted by Hiro Ebina / 蛯名裕久
Mammalian cells have KSR, budding yeast has Ste5… and fission yeast has Sms1 as the MAPK scaffold for sexual reproduction!
Very excited to share my postdoc work where we discover that the hemi-arrestin Sms1 binds all components of the MAPK cascade, including ERK-like Spk1
doi.org/10.1101/2025...
Very excited to share my postdoc work where we discover that the hemi-arrestin Sms1 binds all components of the MAPK cascade, including ERK-like Spk1
doi.org/10.1101/2025...
September 25, 2025 at 4:27 PM
Mammalian cells have KSR, budding yeast has Ste5… and fission yeast has Sms1 as the MAPK scaffold for sexual reproduction!
Very excited to share my postdoc work where we discover that the hemi-arrestin Sms1 binds all components of the MAPK cascade, including ERK-like Spk1
doi.org/10.1101/2025...
Very excited to share my postdoc work where we discover that the hemi-arrestin Sms1 binds all components of the MAPK cascade, including ERK-like Spk1
doi.org/10.1101/2025...
Reposted by Hiro Ebina / 蛯名裕久
New preprint from the lab: we show that the ability to switch mating type was lost at least 13 times independently in the evolution of S. cerevisiae. At least 27% of isolates are heterothallic with a strong association with polyploidy and heterozygosity
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Repeated losses of self-fertility shaped heterozygosity and polyploidy in yeast evolution
Evolutionary transitions in mating strategy have profound consequences for genetic variation and adaptation. In Saccharomyces cerevisiae, mating-type switching is a central feature of the life cycle t...
www.biorxiv.org
September 16, 2025 at 6:42 PM
New preprint from the lab: we show that the ability to switch mating type was lost at least 13 times independently in the evolution of S. cerevisiae. At least 27% of isolates are heterothallic with a strong association with polyploidy and heterozygosity
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Hiro Ebina / 蛯名裕久
コウイカは「手話」で話す？ 触手のダンスでコミュニケーション（無料記事）
www.nikkei.com/article/DGXZQO...
触手をダンスのように振る動きが4パターンあることがわかりました。
視覚的にコミュニケーションしている可能性があります。
コウイカが様々な状況でサインを示す様子を録画し別のコウイカに見せたところ、サインを返したといいます。
www.nikkei.com/article/DGXZQO...
触手をダンスのように振る動きが4パターンあることがわかりました。
視覚的にコミュニケーションしている可能性があります。
コウイカが様々な状況でサインを示す様子を録画し別のコウイカに見せたところ、サインを返したといいます。
September 13, 2025 at 4:10 AM
コウイカは「手話」で話す？ 触手のダンスでコミュニケーション（無料記事）
www.nikkei.com/article/DGXZQO...
触手をダンスのように振る動きが4パターンあることがわかりました。
視覚的にコミュニケーションしている可能性があります。
コウイカが様々な状況でサインを示す様子を録画し別のコウイカに見せたところ、サインを返したといいます。
www.nikkei.com/article/DGXZQO...
触手をダンスのように振る動きが4パターンあることがわかりました。
視覚的にコミュニケーションしている可能性があります。
コウイカが様々な状況でサインを示す様子を録画し別のコウイカに見せたところ、サインを返したといいます。
Reposted by Hiro Ebina / 蛯名裕久
How many chromosomes can an animal have?
In our paper out now in @currentbiology.bsky.social we show that the Atlas blue butterfly has 229 chromosome pairs- the highest in diploid Metazoa! These arose by rapid autosome fragmentation while sex chromosomes stayed intact.
www.cell.com/current-biol...
In our paper out now in @currentbiology.bsky.social we show that the Atlas blue butterfly has 229 chromosome pairs- the highest in diploid Metazoa! These arose by rapid autosome fragmentation while sex chromosomes stayed intact.
www.cell.com/current-biol...
Constraints on chromosome evolution revealed by the 229 chromosome pairs of the Atlas blue butterfly
The genome of the Atlas blue butterfly contains ten times more chromosomes than most
butterflies, and more than any other known diploid animal. Wright et al. show that
this extraordinary karyotype is ...
tinyurl.com
September 11, 2025 at 3:22 PM
How many chromosomes can an animal have?
In our paper out now in @currentbiology.bsky.social we show that the Atlas blue butterfly has 229 chromosome pairs- the highest in diploid Metazoa! These arose by rapid autosome fragmentation while sex chromosomes stayed intact.
www.cell.com/current-biol...
In our paper out now in @currentbiology.bsky.social we show that the Atlas blue butterfly has 229 chromosome pairs- the highest in diploid Metazoa! These arose by rapid autosome fragmentation while sex chromosomes stayed intact.
www.cell.com/current-biol...
Reposted by Hiro Ebina / 蛯名裕久
1/ New preprint alert!
In collaboration between the Rosen, Redding, Collepardo-Guevara & Gerlich labs, we uncover a surprising principle of chromosome organisation: electrostatic repulsion positions centromeres at the chromosome surface during mitosis.
🔗 doi.org/10.1101/2025...
In collaboration between the Rosen, Redding, Collepardo-Guevara & Gerlich labs, we uncover a surprising principle of chromosome organisation: electrostatic repulsion positions centromeres at the chromosome surface during mitosis.
🔗 doi.org/10.1101/2025...
An electrostatic repulsion model of centromere organisation
During cell division, chromosomes reorganise into compact bodies in which centromeres localise precisely at the chromatin surface to enable kinetochore-microtubule interactions essential for genome se...
doi.org
September 3, 2025 at 8:12 AM
1/ New preprint alert!
In collaboration between the Rosen, Redding, Collepardo-Guevara & Gerlich labs, we uncover a surprising principle of chromosome organisation: electrostatic repulsion positions centromeres at the chromosome surface during mitosis.
🔗 doi.org/10.1101/2025...
In collaboration between the Rosen, Redding, Collepardo-Guevara & Gerlich labs, we uncover a surprising principle of chromosome organisation: electrostatic repulsion positions centromeres at the chromosome surface during mitosis.
🔗 doi.org/10.1101/2025...
Reposted by Hiro Ebina / 蛯名裕久
Exciting to see our protein binder design pipeline BindCraft published in its final form in @Nature ! This has been an amazing collaborative effort with Lennart, Christian, @sokrypton.org, Bruno and many other amazing lab members and collaborators.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
August 27, 2025 at 4:14 PM
Exciting to see our protein binder design pipeline BindCraft published in its final form in @Nature ! This has been an amazing collaborative effort with Lennart, Christian, @sokrypton.org, Bruno and many other amazing lab members and collaborators.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Hiro Ebina / 蛯名裕久
🚨 Fungi + viruses + mammalian lungs? Buckle up! Our new paper in
@natmicrobiol.nature.com
uncovers the story of a deadly fungus and its gnarly viral hitchhiker — and how this duo may change how we diagnose & treat fungal disease 🍄🫁🚨 doi.org/10.1038/s415... ⬇️
@natmicrobiol.nature.com
uncovers the story of a deadly fungus and its gnarly viral hitchhiker — and how this duo may change how we diagnose & treat fungal disease 🍄🫁🚨 doi.org/10.1038/s415... ⬇️
Aspergillus fumigatus dsRNA virus promotes fungal fitness and pathogenicity in the mammalian host - Nature Microbiology
A mycovirus infecting the pathogenic fungus Aspergillus fumigatus enhances its stress tolerance and virulence in mice.
doi.org
August 14, 2025 at 9:46 AM
🚨 Fungi + viruses + mammalian lungs? Buckle up! Our new paper in
@natmicrobiol.nature.com
uncovers the story of a deadly fungus and its gnarly viral hitchhiker — and how this duo may change how we diagnose & treat fungal disease 🍄🫁🚨 doi.org/10.1038/s415... ⬇️
@natmicrobiol.nature.com
uncovers the story of a deadly fungus and its gnarly viral hitchhiker — and how this duo may change how we diagnose & treat fungal disease 🍄🫁🚨 doi.org/10.1038/s415... ⬇️
Reposted by Hiro Ebina / 蛯名裕久
Outstanding Faculty opportunity in the broad area of 'life sciences engineering' @EPFL School of Life Sciences, open to both junior and senior researchers. We may prefer metabolism-centric applications but remain open to outstanding applications across domains:
www.epfl.ch/about/workin...
www.epfl.ch/about/workin...
Faculty Position in Life Science Engineering
The School of Life Sciences at EPFL invites applications for a faculty position in life science engineering. Appointments will be at Tenure Track Assistant Professor or at Associate Professor level. W...
www.epfl.ch
August 6, 2025 at 2:11 PM
Outstanding Faculty opportunity in the broad area of 'life sciences engineering' @EPFL School of Life Sciences, open to both junior and senior researchers. We may prefer metabolism-centric applications but remain open to outstanding applications across domains:
www.epfl.ch/about/workin...
www.epfl.ch/about/workin...
Hello everyone, I will give a talk at SSM 2025 in Interlaken, Switzerland (August 27th, Day 1, Session 8) with the title "Discrimination of exogenous DNA by mitotic heterochromatin in fission yeast." I'm looking forward to seeing many people in the room!
#SSM2025
www.meeting-com.ch/en/conferenc...
#SSM2025
www.meeting-com.ch/en/conferenc...
Event details
www.meeting-com.ch
July 29, 2025 at 9:13 PM
Hello everyone, I will give a talk at SSM 2025 in Interlaken, Switzerland (August 27th, Day 1, Session 8) with the title "Discrimination of exogenous DNA by mitotic heterochromatin in fission yeast." I'm looking forward to seeing many people in the room!
#SSM2025
www.meeting-com.ch/en/conferenc...
#SSM2025
www.meeting-com.ch/en/conferenc...
www.nature.com/articles/s41... Intracellular pathogen effector reprograms host gene expression by inhibiting mRNA decay | Nature Communications
Intracellular pathogen effector reprograms host gene expression by inhibiting mRNA decay - Nature Communications
Intracellular pathogens hijack host gene expression to subvert cellular processes. Here, the authors show that Legionella pneumophila’s PieF effector inhibits the human CCR4-NOT deadenylation machiner...
www.nature.com
July 26, 2025 at 6:03 PM
www.nature.com/articles/s41... Intracellular pathogen effector reprograms host gene expression by inhibiting mRNA decay | Nature Communications
www.biorxiv.org/content/10.1... NuMA promotes constitutive heterochromatin compaction by stabilizing linker histone H1 on chromatin | bioRxiv
NuMA promotes constitutive heterochromatin compaction by stabilizing linker histone H1 on chromatin
Heterochromatin has been widely recognized to exert pivotal functions of silencing specific genes and maintenance of genome stability. However, the mechanisms underlying heterochromatin formation and ...
www.biorxiv.org
July 18, 2025 at 4:26 PM
www.biorxiv.org/content/10.1... NuMA promotes constitutive heterochromatin compaction by stabilizing linker histone H1 on chromatin | bioRxiv
Reposted by Hiro Ebina / 蛯名裕久
We are looking for new colleagues to come join us in Galway as group leaders (Junior and Senior). The Centre for Chromosome Biology is a great place and it is a good time to join. Please reach out if you want to chat about the opportunity!
www.nature.com/naturecareer...
www.nature.com/naturecareer...
July 16, 2025 at 8:56 AM
We are looking for new colleagues to come join us in Galway as group leaders (Junior and Senior). The Centre for Chromosome Biology is a great place and it is a good time to join. Please reach out if you want to chat about the opportunity!
www.nature.com/naturecareer...
www.nature.com/naturecareer...
Reposted by Hiro Ebina / 蛯名裕久
We found a new asymmetry in the large-scale chromosome structure: sister chromatids are systematically shifted by hundreds of kb in the 5′→3′ direction of their inherited strands! The work was led by Flavia Corsi, in close collaboration with the Daniel Gerlich lab.
www.biorxiv.org/content/10.1...
1/
www.biorxiv.org/content/10.1...
1/
July 15, 2025 at 8:11 AM
We found a new asymmetry in the large-scale chromosome structure: sister chromatids are systematically shifted by hundreds of kb in the 5′→3′ direction of their inherited strands! The work was led by Flavia Corsi, in close collaboration with the Daniel Gerlich lab.
www.biorxiv.org/content/10.1...
1/
www.biorxiv.org/content/10.1...
1/
www.nature.com/articles/s41... HP1 loses its chromatin clustering and phase separation function across evolution | Nature Communications
HP1 loses its chromatin clustering and phase separation function across evolution - Nature Communications
Here, the authors compare HP1 from fission yeast, fly and mouse, and find that the propensity of HP1 to phase-separate and to cluster heterochromatin decrease in this order, suggesting an evolutionary...
www.nature.com
July 13, 2025 at 9:37 PM
www.nature.com/articles/s41... HP1 loses its chromatin clustering and phase separation function across evolution | Nature Communications
Hello everyone, I will give a talk at ICYGM32/Yeast 2025 in Paris (July 24th, Day 4, Workshop 18) with the title "Discrimination of exogenous DNA by mitotic heterochromatin in fission yeast." I'm looking forward to seeing many people in the room!
#ICYGM32
#yeast2025
#vivapombe
#ICYGM32
#yeast2025
#vivapombe
Yeast 2025 - PremC
premc.org
July 9, 2025 at 3:19 PM
Hello everyone, I will give a talk at ICYGM32/Yeast 2025 in Paris (July 24th, Day 4, Workshop 18) with the title "Discrimination of exogenous DNA by mitotic heterochromatin in fission yeast." I'm looking forward to seeing many people in the room!
#ICYGM32
#yeast2025
#vivapombe
#ICYGM32
#yeast2025
#vivapombe
Exploring the relationship of transposable elements and ageing: causes and consequences url:https://academic.oup.com/gbe/article/doi/10.1093/gbe/evaf088/8133184
May 22, 2025 at 1:26 PM
Exploring the relationship of transposable elements and ageing: causes and consequences url:https://academic.oup.com/gbe/article/doi/10.1093/gbe/evaf088/8133184
