Haley Randolph
@herandolph.bsky.social
Helen Hay Whitney postdoctoral research fellow // human genomics and immune response variation // i like horror books, cats, and the real housewives
Pinned
Widespread gene-environment interactions shape the immune response to SARS-CoV-2 infection in hospitalized COVID-19 patients https://www.biorxiv.org/content/10.1101/2024.12.03.626676v1
Widespread gene-environment interactions shape the immune response to SARS-CoV-2 infection in hospitalized COVID-19 patients https://www.biorxiv.org/content/10.1101/2024.12.03.626676v1
Genome-wide association studies performed in patients with coronavirus disease 2019 (COVID-19) have
www.biorxiv.org
very excited to share the last chunk of my PhD work, now available on @biorxivpreprint.bsky.social! in this work, we explore how cis-regulatory variation and gene-environment (GxE) interactions influence immune response diversity directly in a cohort of hospitalized COVID-19 patients 1/n
Reposted by Haley Randolph
Exciting updates!!
(1) I just opened my lab at Boston Children’s Hospital (Harvard-affiliated)
(2) I’m hiring a postdoc focused on integrating GWAS and functional genomic data. Reach out if you’re interested or connect at ASHG next week!
(3) Learn more at stroberlab.com
(1) I just opened my lab at Boston Children’s Hospital (Harvard-affiliated)
(2) I’m hiring a postdoc focused on integrating GWAS and functional genomic data. Reach out if you’re interested or connect at ASHG next week!
(3) Learn more at stroberlab.com
Strober Lab
The Strober lab is a computational group at Boston Children's Hospital (a Harvard Medical School affiliated hospital) focused on developing statistical and machine learning tools applied to human gene...
stroberlab.com
October 7, 2025 at 6:55 PM
Exciting updates!!
(1) I just opened my lab at Boston Children’s Hospital (Harvard-affiliated)
(2) I’m hiring a postdoc focused on integrating GWAS and functional genomic data. Reach out if you’re interested or connect at ASHG next week!
(3) Learn more at stroberlab.com
(1) I just opened my lab at Boston Children’s Hospital (Harvard-affiliated)
(2) I’m hiring a postdoc focused on integrating GWAS and functional genomic data. Reach out if you’re interested or connect at ASHG next week!
(3) Learn more at stroberlab.com
Reposted by Haley Randolph
I'm hiring a computational biologist interested in complex trait genetics using deep learning approaches. Reach out to me, if interested.
September 12, 2025 at 7:00 PM
I'm hiring a computational biologist interested in complex trait genetics using deep learning approaches. Reach out to me, if interested.
Reposted by Haley Randolph
yet, I constantly find myself having to explain this in most spaces where important conversations and decisions (regulatory, policy, higher education, etc) take place
If I have to explain to you why it's a bad idea to use a machine that makes shit up 15-80% of the time AND destroys the environment AND contributes to rising fascism and genocide AND puts brilliant skillful creatives out of work by stealing their work, then we're already speaking different languages
August 6, 2025 at 12:37 PM
yet, I constantly find myself having to explain this in most spaces where important conversations and decisions (regulatory, policy, higher education, etc) take place
Reposted by Haley Randolph
It is depressing, but all too predictable, how swiftly we’ve gone from the Social Science Genetic Association Consortium offering reassurances about the uses of behavioural polygenic scores to one of their lead authors marketing embryo selection for IQ
August 2, 2025 at 2:15 AM
It is depressing, but all too predictable, how swiftly we’ve gone from the Social Science Genetic Association Consortium offering reassurances about the uses of behavioural polygenic scores to one of their lead authors marketing embryo selection for IQ
Reposted by Haley Randolph
Staff scientist position (computational):
I am looking for a computational scientist to join my genomics lab at Stanford. They should have an outstanding skillset in ML/statistical methods for genomic applications, postdoc experience and a strong publication record.
#sciencejobs
I am looking for a computational scientist to join my genomics lab at Stanford. They should have an outstanding skillset in ML/statistical methods for genomic applications, postdoc experience and a strong publication record.
#sciencejobs
July 7, 2025 at 3:27 PM
Staff scientist position (computational):
I am looking for a computational scientist to join my genomics lab at Stanford. They should have an outstanding skillset in ML/statistical methods for genomic applications, postdoc experience and a strong publication record.
#sciencejobs
I am looking for a computational scientist to join my genomics lab at Stanford. They should have an outstanding skillset in ML/statistical methods for genomic applications, postdoc experience and a strong publication record.
#sciencejobs
Reposted by Haley Randolph
ICE just arrested Brad Lander, the NYC Comptroller and one of the leading candidates for Mayor, without grounds.
He was conducting routine immigration court work, escorting individuals from hearings.
He asked ICE for their warrant - well within his legal rights.
This is political intimidation.
He was conducting routine immigration court work, escorting individuals from hearings.
He asked ICE for their warrant - well within his legal rights.
This is political intimidation.
Whoa! NYC mayoral candidate and current city Comptroller Brad Lander seemingly arrested at the NYC immigration court while attending to escort someone attending their hearing.
Lander just got detained by federal agents as he tried to escort a man out of the courtroom. Lander was taken in an elevator with masked agents, along with one member of his NYPD security detail.
June 17, 2025 at 4:59 PM
ICE just arrested Brad Lander, the NYC Comptroller and one of the leading candidates for Mayor, without grounds.
He was conducting routine immigration court work, escorting individuals from hearings.
He asked ICE for their warrant - well within his legal rights.
This is political intimidation.
He was conducting routine immigration court work, escorting individuals from hearings.
He asked ICE for their warrant - well within his legal rights.
This is political intimidation.
Reposted by Haley Randolph
what the actual fuck
June 16, 2025 at 7:40 PM
what the actual fuck
Reposted by Haley Randolph
If we want to connect genetic variation to disease, we need to move beyond baseline conditions. Our study shows that dynamic, context-specific regulation holds the key to understanding many unexplained GWAS signals. The preprint again:
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Disease-associated loci share properties with response eQTLs under common environmental exposures
Many of the genetic loci associated with disease are expected to have context-dependent regulatory effects that are underrepresented in the transcriptomes of healthy, steady-state adult tissues. To un...
www.biorxiv.org
June 10, 2025 at 2:20 PM
If we want to connect genetic variation to disease, we need to move beyond baseline conditions. Our study shows that dynamic, context-specific regulation holds the key to understanding many unexplained GWAS signals. The preprint again:
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Haley Randolph
Delighted to share that one of my major PhD projects has been published today in Current Biology.
In this paper, we look into the genetic population structure and demographic histories of two populations in Sri Lanka: the Sinhalese and Adivasi [1/n]. www.cell.com/current-biol...
In this paper, we look into the genetic population structure and demographic histories of two populations in Sri Lanka: the Sinhalese and Adivasi [1/n]. www.cell.com/current-biol...
Population histories of the Indigenous Adivasi and Sinhalese from Sri Lanka using whole genomes
Sri Lanka is home to diverse ethnic groups with different genetic histories. Urban
Aragon et al. find that despite close genetic affinities, Indigenous Adivasi have
more hunter-gatherer ancestry and l...
www.cell.com
June 9, 2025 at 10:59 PM
Delighted to share that one of my major PhD projects has been published today in Current Biology.
In this paper, we look into the genetic population structure and demographic histories of two populations in Sri Lanka: the Sinhalese and Adivasi [1/n]. www.cell.com/current-biol...
In this paper, we look into the genetic population structure and demographic histories of two populations in Sri Lanka: the Sinhalese and Adivasi [1/n]. www.cell.com/current-biol...
Reposted by Haley Randolph
Now published in PNAS: www.pnas.org/doi/10.1073/...
May 23, 2025 at 6:39 PM
Now published in PNAS: www.pnas.org/doi/10.1073/...
Reposted by Haley Randolph
I didn't have much hope that we'd find genetic determinants of long-COVID, but after years of work, Vilma Aho, Tomoko Nakanisha, Hugo Zeberg and Hanna Ollila made it happen! (Among a few others :-))
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Genome-wide association study of long COVID - Nature Genetics
A genome-wide study by the Long COVID Host Genetics Initiative identifies an association between the FOXP4 locus and long COVID, implicating altered lung function in its pathophysiology.
www.nature.com
May 22, 2025 at 5:55 PM
I didn't have much hope that we'd find genetic determinants of long-COVID, but after years of work, Vilma Aho, Tomoko Nakanisha, Hugo Zeberg and Hanna Ollila made it happen! (Among a few others :-))
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Haley Randolph
“Should AI be allowed to review papers or grant proposals” always reveals a thing I think people don’t understand about algorithmic bias 🧵
May 19, 2025 at 5:47 PM
“Should AI be allowed to review papers or grant proposals” always reveals a thing I think people don’t understand about algorithmic bias 🧵
PIs who think their research isn’t political: yes it is, it always is
May 17, 2025 at 4:16 AM
PIs who think their research isn’t political: yes it is, it always is
Reposted by Haley Randolph
📣Online now from Fu et al!
📄Role of X chromosome and dosage-compensation mechanisms in complex trait genetics
📄Role of X chromosome and dosage-compensation mechanisms in complex trait genetics
Role of X chromosome and dosage-compensation mechanisms in complex trait genetics
We show that the X chromosome, understudied in genome-wide association studies, contributes
to complex traits in a manner shaped by dosage-compensation mechanisms. We find near-full
X inactivation bal...
www.cell.com
May 12, 2025 at 3:34 PM
📣Online now from Fu et al!
📄Role of X chromosome and dosage-compensation mechanisms in complex trait genetics
📄Role of X chromosome and dosage-compensation mechanisms in complex trait genetics
Reposted by Haley Randolph
Reposted by Haley Randolph
Scientists must push back against the threat of rising white nationalism and the dangerous and pseudoscientific ideas of eugenics
https://go.nature.com/4jGqiUc
https://go.nature.com/4jGqiUc
Eugenics is on the rise again: human geneticists must take a stand
Scientists must push back against the threat of rising white nationalism and the dangerous and pseudoscientific ideas of eugenics.
go.nature.com
April 24, 2025 at 1:18 PM
Scientists must push back against the threat of rising white nationalism and the dangerous and pseudoscientific ideas of eugenics
https://go.nature.com/4jGqiUc
https://go.nature.com/4jGqiUc
Reposted by Haley Randolph
They are coming for every university, if you think you’re safe because it hasn’t been yours yet I don’t know what to tell you. Join AAUP, refuse to comply, organize your colleagues
Trump administration freezes $175 million in federal funding to Penn
According to a White House tweet, Wednesday's decision is a result of Penn's
www.thedp.com
March 19, 2025 at 2:36 PM
They are coming for every university, if you think you’re safe because it hasn’t been yours yet I don’t know what to tell you. Join AAUP, refuse to comply, organize your colleagues
Reposted by Haley Randolph
Biomedical value of studying human diversity spotlighted by 5-nation asian Immune Diversity Atlas (AIDA) of circulating immune cells from healthy donors
www.cell.com/cell/fulltex...
@cellcellpress.bsky.social @jayshin.bsky.social
www.cell.com/cell/fulltex...
@cellcellpress.bsky.social @jayshin.bsky.social
March 19, 2025 at 5:50 PM
Biomedical value of studying human diversity spotlighted by 5-nation asian Immune Diversity Atlas (AIDA) of circulating immune cells from healthy donors
www.cell.com/cell/fulltex...
@cellcellpress.bsky.social @jayshin.bsky.social
www.cell.com/cell/fulltex...
@cellcellpress.bsky.social @jayshin.bsky.social
Reposted by Haley Randolph
The @nytimes.com just discovered parallel computing.
March 17, 2025 at 6:11 PM
The @nytimes.com just discovered parallel computing.
Reposted by Haley Randolph
How do you study gene-environment (GxE) interactions in humans? Well, there's probably no way to avoid studying each exposure individually, but what about the cellular context? If you choose directed differentiation, you have to study GxE one cell type at a time. If you choose an organoid system -
February 26, 2025 at 8:29 PM
How do you study gene-environment (GxE) interactions in humans? Well, there's probably no way to avoid studying each exposure individually, but what about the cellular context? If you choose directed differentiation, you have to study GxE one cell type at a time. If you choose an organoid system -
for Sasha & his family www.gofundme.com/f/rememberin...
Donate to Remembering Sasha Kirsanov: In Our Hearts Always, organized by Michelle Dumler-McKeever
In memory of Alexandr “Sasha” Kirsanov. We will keep you in o… Michelle Dumler-McKeever needs your support for Remembering Sasha Kirsanov: In Our Hearts Always
www.gofundme.com
January 31, 2025 at 12:48 PM
for Sasha & his family www.gofundme.com/f/rememberin...
absolutely devastating — i feel incredibly grateful to have had you as a coach and you will be missed dearly, Sasha 🤍
In a letter from University of Delaware President, Dennis Assanis, a former UD Figure Skating Club coach, Alexandr ‘Sasha’ Kirsanov was among those who died in the plane crash over Washington D.C. Wednesday night.
Former University of Delaware figure skating club coach among dead in plane crash over Washington D.C.
NEWARK, Del. - In a letter from University of Delaware President, Dennis Assanis, a former UD Figure Skating Club coach, Alexandr ‘Sasha’ Kirsanov was among those who died in the
www.coasttv.com
January 31, 2025 at 1:13 AM
absolutely devastating — i feel incredibly grateful to have had you as a coach and you will be missed dearly, Sasha 🤍
Reposted by Haley Randolph
Here’s what’s what at UChicago. Not good.
January 28, 2025 at 3:55 PM
Here’s what’s what at UChicago. Not good.
Reposted by Haley Randolph
The sword has now been brandished over civil society, including scientists, universities, and other NGOs. Who, including university presidents, will have any backbone in defending their jnstitutions’ missions? Or will they take on the Zuckerberg/ Bezos pose? www.nytimes.com/live/2025/01...
Trump Administration Live Updates: White House Orders Federal Grants Pause (Gift Article)
www.nytimes.com
January 28, 2025 at 2:22 PM
The sword has now been brandished over civil society, including scientists, universities, and other NGOs. Who, including university presidents, will have any backbone in defending their jnstitutions’ missions? Or will they take on the Zuckerberg/ Bezos pose? www.nytimes.com/live/2025/01...
Reposted by Haley Randolph
Very excited about this new work from our lab! Explainer thread coming soon
@minetoota.bsky.social
@minetoota.bsky.social
Causal modeling of gene effects from regulators to programs to traits: integration of genetic associations and Perturb-seq https://www.biorxiv.org/content/10.1101/2025.01.22.634424v1
January 24, 2025 at 4:45 PM
Very excited about this new work from our lab! Explainer thread coming soon
@minetoota.bsky.social
@minetoota.bsky.social