Haley Randolph
@herandolph.bsky.social
Helen Hay Whitney postdoctoral research fellow // human genomics and immune response variation // i like horror books, cats, and the real housewives
Reposted by Haley Randolph
If we want to connect genetic variation to disease, we need to move beyond baseline conditions. Our study shows that dynamic, context-specific regulation holds the key to understanding many unexplained GWAS signals. The preprint again:
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Disease-associated loci share properties with response eQTLs under common environmental exposures
Many of the genetic loci associated with disease are expected to have context-dependent regulatory effects that are underrepresented in the transcriptomes of healthy, steady-state adult tissues. To un...
www.biorxiv.org
June 10, 2025 at 2:20 PM
If we want to connect genetic variation to disease, we need to move beyond baseline conditions. Our study shows that dynamic, context-specific regulation holds the key to understanding many unexplained GWAS signals. The preprint again:
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...