Hayley Bounds
@hayleybounds.bsky.social
Systems/computational neuroscience postdoc @ UCL in Carandini & Harris lab. Schmidt Science Fellow. Formerly Adesnik lab @ UC Berkeley.
Pinned
Hayley Bounds
@hayleybounds.bsky.social
· May 15
Excited to share my PhD paper! In it, we use targeted 2-photon optogenetic stimulation to determine how V1 activity is read-out in a detection task. We found that network influence, not visual coding properties, predicted the impact of ensembles on behavior - contradicting our expectations (1/5).
Reposted by Hayley Bounds
🔬🧠 Releasing the 1.0 version of #Suite2p and THE PAPER w/ @marius10p.bsky.social! Now with GPU acceleration. Want to use Suite2p but don’t have 100,000 neuron recordings? We show you how to get those with a standard 2p microscope #neuroscience #imaging #neuroAI www.biorxiv.org/content/10.6...
February 12, 2026 at 1:33 AM
🔬🧠 Releasing the 1.0 version of #Suite2p and THE PAPER w/ @marius10p.bsky.social! Now with GPU acceleration. Want to use Suite2p but don’t have 100,000 neuron recordings? We show you how to get those with a standard 2p microscope #neuroscience #imaging #neuroAI www.biorxiv.org/content/10.6...
Really interesting work on sequential activity in the odor system!
Excited to share our new preprint for this project!
How do past sensory experiences prepare us for new ones? Our new paper tackles this long-standing question, revealing a role for activity sequences in the olfactory bulb. Excited to share our work led by @jonvgill.bsky.social with Mursel Karadas & Shy Shoham
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
January 27, 2026 at 10:35 AM
Really interesting work on sequential activity in the odor system!
Reposted by Hayley Bounds
Democrats in the Senate must grow a spine. They can rein in this murderous regime next week. Why on Earth would they continue to fund this tyranny?
Call your senators now: indivisible.org/campaigns/ho...
Call your senators now: indivisible.org/campaigns/ho...
How to Rein in ICE–NOW | Indivisible
Act now with Indivisible to demand Congress rein in ICE, end aggressive enforcement, restrict ICE and Border Patrol funding, and protect communities.
indivisible.org
January 24, 2026 at 7:20 PM
Democrats in the Senate must grow a spine. They can rein in this murderous regime next week. Why on Earth would they continue to fund this tyranny?
Call your senators now: indivisible.org/campaigns/ho...
Call your senators now: indivisible.org/campaigns/ho...
Reposted by Hayley Bounds
It's difficult to know how motivated a fly is, and how motivated behaviors change with experience. To do this, we've been developing new ways to measure operant learning in flies, as described in our new Open-LA paper below.
Ever wonder how individuals decide what to eat & what to avoid? We used our novel #OperantLearningAssay (Open-LA) to let #Drosophila control their sensory world and study their motivated choices over time. Read my full work with @karlakaun.bsky.social & co-authors at doi.org/10.1242/jeb....
Shaping of olfactory responses by taste in a new assay for operant learning in Drosophila melanogaster
Summary: A new assay that characterizes subtle behaviors and assesses operant learning in freely behaving Drosophila reveals that olfaction more strongly influences stimulus-seeking behavior than tast...
doi.org
January 15, 2026 at 4:36 PM
It's difficult to know how motivated a fly is, and how motivated behaviors change with experience. To do this, we've been developing new ways to measure operant learning in flies, as described in our new Open-LA paper below.
Reposted by Hayley Bounds
Sequences are everywhere! In every brain region. And are written in stone.
Invariant Activity Sequences Across the Mouse Brain.
Out today, by Célian Bimbard, with @kenneth-harris.bsky.social.
Based on data by Célian and by @intlbrainlab.bsky.social.
www.biorxiv.org/content/10.6...
Invariant Activity Sequences Across the Mouse Brain.
Out today, by Célian Bimbard, with @kenneth-harris.bsky.social.
Based on data by Célian and by @intlbrainlab.bsky.social.
www.biorxiv.org/content/10.6...
December 22, 2025 at 11:59 AM
Sequences are everywhere! In every brain region. And are written in stone.
Invariant Activity Sequences Across the Mouse Brain.
Out today, by Célian Bimbard, with @kenneth-harris.bsky.social.
Based on data by Célian and by @intlbrainlab.bsky.social.
www.biorxiv.org/content/10.6...
Invariant Activity Sequences Across the Mouse Brain.
Out today, by Célian Bimbard, with @kenneth-harris.bsky.social.
Based on data by Célian and by @intlbrainlab.bsky.social.
www.biorxiv.org/content/10.6...
Reposted by Hayley Bounds
Most iPSC lines come from European donors. Now, two teams in Africa are studying neurodevelopment and neurodegeneration using iPSCs and organoids from African donors.
By Lauren Schenkman
www.thetransmitter.org/cellular-neu...
By Lauren Schenkman
www.thetransmitter.org/cellular-neu...
Bringing African ancestry into cellular neuroscience
Two independent teams in Africa are developing stem cell lines and organoids from local populations to explore neurodevelopmental and neurodegenerative conditions.
www.thetransmitter.org
January 14, 2026 at 4:38 PM
Most iPSC lines come from European donors. Now, two teams in Africa are studying neurodevelopment and neurodegeneration using iPSCs and organoids from African donors.
By Lauren Schenkman
www.thetransmitter.org/cellular-neu...
By Lauren Schenkman
www.thetransmitter.org/cellular-neu...
Reposted by Hayley Bounds
By the way, if you’re interested in working together on problems like this, I’m starting my lab at UCSF this summer. Get in touch if you’re interested in doing a postdoc! More info here: wj2.github.io/postdoc_ad (7/7)
W. Jeffrey Johnston - Postdoctoral position ad
wj2.github.io
January 9, 2026 at 7:06 PM
By the way, if you’re interested in working together on problems like this, I’m starting my lab at UCSF this summer. Get in touch if you’re interested in doing a postdoc! More info here: wj2.github.io/postdoc_ad (7/7)
Reposted by Hayley Bounds
When and why do modular representations emerge in neural networks?
@stefanofusi.bsky.social and I posted a preprint answering this question last year, and now it has been extensively revised, refocused, and generalized. Read more here: doi.org/10.1101/2024... (1/7)
@stefanofusi.bsky.social and I posted a preprint answering this question last year, and now it has been extensively revised, refocused, and generalized. Read more here: doi.org/10.1101/2024... (1/7)
January 9, 2026 at 7:06 PM
When and why do modular representations emerge in neural networks?
@stefanofusi.bsky.social and I posted a preprint answering this question last year, and now it has been extensively revised, refocused, and generalized. Read more here: doi.org/10.1101/2024... (1/7)
@stefanofusi.bsky.social and I posted a preprint answering this question last year, and now it has been extensively revised, refocused, and generalized. Read more here: doi.org/10.1101/2024... (1/7)
Reposted by Hayley Bounds
Caleb Watney of IFP talking about why academia and science sucks.
Broken record here, but we can’t have this discussion without talking about agendas and conflicts of interest.
IFP is funded by tech and rightwing billionaires who want to privatize science. 1/
Broken record here, but we can’t have this discussion without talking about agendas and conflicts of interest.
IFP is funded by tech and rightwing billionaires who want to privatize science. 1/
December 15, 2025 at 6:00 AM
Caleb Watney of IFP talking about why academia and science sucks.
Broken record here, but we can’t have this discussion without talking about agendas and conflicts of interest.
IFP is funded by tech and rightwing billionaires who want to privatize science. 1/
Broken record here, but we can’t have this discussion without talking about agendas and conflicts of interest.
IFP is funded by tech and rightwing billionaires who want to privatize science. 1/
Reposted by Hayley Bounds
"pattern completion circuits in lower cortical areas may reinforce activity patterns that match prior expectations..."
Yes. That's active filtering. Sensory cortical recurrent networks learn the structure of the sensory world.
New paper from Shin, Adesnik et al. 🧠🤖🧪
Yes. That's active filtering. Sensory cortical recurrent networks learn the structure of the sensory world.
New paper from Shin, Adesnik et al. 🧠🤖🧪
Recurrent pattern completion drives the neocortical representation of sensory inference
Nature Neuroscience - Neurons that respond emergently to illusory contours drive pattern completion in V1. Pattern completion in lower cortical areas may therefore mediate perceptual inference by...
www.nature.com
October 10, 2025 at 12:05 AM
"pattern completion circuits in lower cortical areas may reinforce activity patterns that match prior expectations..."
Yes. That's active filtering. Sensory cortical recurrent networks learn the structure of the sensory world.
New paper from Shin, Adesnik et al. 🧠🤖🧪
Yes. That's active filtering. Sensory cortical recurrent networks learn the structure of the sensory world.
New paper from Shin, Adesnik et al. 🧠🤖🧪
Reposted by Hayley Bounds
Does predictive coding work in SPACE or in TIME? Most neuroscientists assume TIME, i.e. neurons predict their future sensory inputs. We show that in visual cortex predictive coding actually works across SPACE, just like the original Rao+Ballard theory #neuroscience
www.biorxiv.org/cgi/content/...
www.biorxiv.org/cgi/content/...
September 22, 2025 at 7:09 PM
Does predictive coding work in SPACE or in TIME? Most neuroscientists assume TIME, i.e. neurons predict their future sensory inputs. We show that in visual cortex predictive coding actually works across SPACE, just like the original Rao+Ballard theory #neuroscience
www.biorxiv.org/cgi/content/...
www.biorxiv.org/cgi/content/...
Reposted by Hayley Bounds
The two key studies of the International Brain Laboratory @intlbrainlab.bsky.social are out today!
A brain-wide map of neural activity during complex behaviour
www.nature.com/articles/s41...
Brain-wide representations of prior information in mouse decision-making
www.nature.com/articles/s41...
A brain-wide map of neural activity during complex behaviour
www.nature.com/articles/s41...
Brain-wide representations of prior information in mouse decision-making
www.nature.com/articles/s41...
A brain-wide map of neural activity during complex behaviour - Nature
The International Brain Laboratory presents a brain-wide electrophysiological map obtained from pooling data from 12 laboratories that performed the same standardized perceptual decision-making task i...
www.nature.com
September 3, 2025 at 3:46 PM
The two key studies of the International Brain Laboratory @intlbrainlab.bsky.social are out today!
A brain-wide map of neural activity during complex behaviour
www.nature.com/articles/s41...
Brain-wide representations of prior information in mouse decision-making
www.nature.com/articles/s41...
A brain-wide map of neural activity during complex behaviour
www.nature.com/articles/s41...
Brain-wide representations of prior information in mouse decision-making
www.nature.com/articles/s41...
Reposted by Hayley Bounds
My first paper with @naoshigeuchida.bsky.social is finally out in @natcomms.nature.com ! rdcu.be/eACGf
TL;DR: asymmetric learning rates can be induced by shifts in tonic dopamine giving rise to pessimistic/optimistic biases in agents or animals undergoing reinforcement learning .
TL;DR: asymmetric learning rates can be induced by shifts in tonic dopamine giving rise to pessimistic/optimistic biases in agents or animals undergoing reinforcement learning .
Tonic dopamine and biases in value learning linked through a biologically inspired reinforcement learning model
Nature Communications - Accurate future predictions are essential for guiding behavior, and disruptions in this process are associated with psychiatric disorders. Here the authors show that changes...
rdcu.be
August 13, 2025 at 9:55 PM
My first paper with @naoshigeuchida.bsky.social is finally out in @natcomms.nature.com ! rdcu.be/eACGf
TL;DR: asymmetric learning rates can be induced by shifts in tonic dopamine giving rise to pessimistic/optimistic biases in agents or animals undergoing reinforcement learning .
TL;DR: asymmetric learning rates can be induced by shifts in tonic dopamine giving rise to pessimistic/optimistic biases in agents or animals undergoing reinforcement learning .
Reposted by Hayley Bounds
Thrilled to share our new Adesnik lab paper!!
Using holography in excitatory & inhibitory neurons, we reveal how a single cortical circuit can both complete and cancel predictable sensory activity, sharpening representations
📄https://www.biorxiv.org/content/10.1101/2025.08.02.668307v1
🧵
Using holography in excitatory & inhibitory neurons, we reveal how a single cortical circuit can both complete and cancel predictable sensory activity, sharpening representations
📄https://www.biorxiv.org/content/10.1101/2025.08.02.668307v1
🧵
August 5, 2025 at 4:17 PM
Thrilled to share our new Adesnik lab paper!!
Using holography in excitatory & inhibitory neurons, we reveal how a single cortical circuit can both complete and cancel predictable sensory activity, sharpening representations
📄https://www.biorxiv.org/content/10.1101/2025.08.02.668307v1
🧵
Using holography in excitatory & inhibitory neurons, we reveal how a single cortical circuit can both complete and cancel predictable sensory activity, sharpening representations
📄https://www.biorxiv.org/content/10.1101/2025.08.02.668307v1
🧵
Reposted by Hayley Bounds
When neurons change, but behavior doesn’t: Excitability changes driving representational drift
New preprint of work with Christian Machens: www.biorxiv.org/content/10.1...
New preprint of work with Christian Machens: www.biorxiv.org/content/10.1...
Representational drift without synaptic plasticity
Neural computations support stable behavior despite relying on many dynamically changing biological processes. One such process is representational drift (RD), in which neurons' responses change over ...
www.biorxiv.org
July 29, 2025 at 2:02 PM
When neurons change, but behavior doesn’t: Excitability changes driving representational drift
New preprint of work with Christian Machens: www.biorxiv.org/content/10.1...
New preprint of work with Christian Machens: www.biorxiv.org/content/10.1...
Reposted by Hayley Bounds
Oh! Seems like a big deal, this. Makes sense too. Like, how would the rest of the brain know which neurons to sample, and if it did already know what the stimulus is, then it wouldn't need those neurons' signals to classify it.
Some neurons respond more strongly to visual stimuli than others. But the rest of the brain doesn’t prioritize signals from those neurons, according to a new study. Read more in this month’s Null and Noteworthy.
By @ldattaro.bsky.social
#neuroskyence
www.thetransmitter.org/null-and-not...
By @ldattaro.bsky.social
#neuroskyence
www.thetransmitter.org/null-and-not...
Null and Noteworthy: Downstream brain areas read visual cortex signals en masse in mice
The finding contradicts a theory that the regions prioritize neurons that are adept at identifying specific stimuli. Plus, a response to a study that questioned immune memory in astrocytes.
www.thetransmitter.org
August 2, 2025 at 12:27 PM
Oh! Seems like a big deal, this. Makes sense too. Like, how would the rest of the brain know which neurons to sample, and if it did already know what the stimulus is, then it wouldn't need those neurons' signals to classify it.
Thanks to @thetransmitter.bsky.social and @ldattaro.bsky.social for this coverage of our recent paper!
Some neurons respond more strongly to visual stimuli than others. But the rest of the brain doesn’t prioritize signals from those neurons, according to a new study. Read more in this month’s Null and Noteworthy.
By @ldattaro.bsky.social
#neuroskyence
www.thetransmitter.org/null-and-not...
By @ldattaro.bsky.social
#neuroskyence
www.thetransmitter.org/null-and-not...
Null and Noteworthy: Downstream brain areas read visual cortex signals en masse in mice
The finding contradicts a theory that the regions prioritize neurons that are adept at identifying specific stimuli. Plus, a response to a study that questioned immune memory in astrocytes.
www.thetransmitter.org
August 1, 2025 at 1:56 AM
Thanks to @thetransmitter.bsky.social and @ldattaro.bsky.social for this coverage of our recent paper!
Reposted by Hayley Bounds
This is a simplistic but commonly-held view about how science actually works.
Doing rigorous& impactful science often means ignoring (some) null results.
Intermediate results, null and positive, arise on the way to a publishable contribution, and not all are perfectly rigorous.🧪#neuroscience 1/
Doing rigorous& impactful science often means ignoring (some) null results.
Intermediate results, null and positive, arise on the way to a publishable contribution, and not all are perfectly rigorous.🧪#neuroscience 1/
“just 68% of the 7,057 researchers whose work had produced null results had shared them in some form, and just 30% had tried to publish them in a journal.”
What a joke.
#NullEffectsMatter
www.nature.com/articles/d41...
What a joke.
#NullEffectsMatter
www.nature.com/articles/d41...
Researchers value null results, but struggle to publish them
Survey finds that fear of reputational harm and a lack of support and publication platforms are among respondents’ key concerns.
www.nature.com
July 24, 2025 at 12:49 AM
This is a simplistic but commonly-held view about how science actually works.
Doing rigorous& impactful science often means ignoring (some) null results.
Intermediate results, null and positive, arise on the way to a publishable contribution, and not all are perfectly rigorous.🧪#neuroscience 1/
Doing rigorous& impactful science often means ignoring (some) null results.
Intermediate results, null and positive, arise on the way to a publishable contribution, and not all are perfectly rigorous.🧪#neuroscience 1/
Reposted by Hayley Bounds
A new study led by @timothysit.bsky.social reveals that different layers of mouse V1 integrate visual and non-visual signals differently.
Activity is dominated by vision (or spontaneous fluctuations) in L2/3 and by movement in L5. This leads to different geometries.
www.biorxiv.org/content/10.1...
Activity is dominated by vision (or spontaneous fluctuations) in L2/3 and by movement in L5. This leads to different geometries.
www.biorxiv.org/content/10.1...
July 18, 2025 at 4:55 PM
A new study led by @timothysit.bsky.social reveals that different layers of mouse V1 integrate visual and non-visual signals differently.
Activity is dominated by vision (or spontaneous fluctuations) in L2/3 and by movement in L5. This leads to different geometries.
www.biorxiv.org/content/10.1...
Activity is dominated by vision (or spontaneous fluctuations) in L2/3 and by movement in L5. This leads to different geometries.
www.biorxiv.org/content/10.1...
Reposted by Hayley Bounds
Reminder that we still have time to fight this! This bill is being crafted & debated in the coming days and weeks. Organize NOW to do outreach and get people in your neighborhood contacting their reps. @standupforscience.bsky.social has resources. Instructions for Postcards-for-Science are here:
July 7, 2025 at 2:06 PM
Reminder that we still have time to fight this! This bill is being crafted & debated in the coming days and weeks. Organize NOW to do outreach and get people in your neighborhood contacting their reps. @standupforscience.bsky.social has resources. Instructions for Postcards-for-Science are here:
Reposted by Hayley Bounds
Mahmoud Khalil is free.
June 21, 2025 at 12:17 AM
Mahmoud Khalil is free.
Reposted by Hayley Bounds
Breaking: The Trevor Project received a stop-work order last night on its contract with the national 988 suicide prevention hotline. The Trump administration is eliminating the option for LGBTQ callers to the hotline to press 3 and connect with someone who specializes in LGBTQ mental health.
June 18, 2025 at 1:59 PM
Breaking: The Trevor Project received a stop-work order last night on its contract with the national 988 suicide prevention hotline. The Trump administration is eliminating the option for LGBTQ callers to the hotline to press 3 and connect with someone who specializes in LGBTQ mental health.
Reposted by Hayley Bounds
The firing of neural populations is high-dim even if their subthreshold activity is low-dim! This work by @bio-emergent.bsky.social and @haydari.bsky.social shows how, with a solvable model, a data analysis technique, and data from mouse visual cortex: www.biorxiv.org/content/10.1...
High-dimensional neuronal activity from low-dimensional latent dynamics: a solvable model
Computation in recurrent networks of neurons has been hypothesized to occur at the level of low-dimensional latent dynamics, both in artificial systems and in the brain. This hypothesis seems at odds ...
www.biorxiv.org
June 9, 2025 at 11:49 AM
The firing of neural populations is high-dim even if their subthreshold activity is low-dim! This work by @bio-emergent.bsky.social and @haydari.bsky.social shows how, with a solvable model, a data analysis technique, and data from mouse visual cortex: www.biorxiv.org/content/10.1...
Reposted by Hayley Bounds
New #NeuroAI #compneurosky preprint! To better understand how target-directed learning works in the brain, we sought to engineer an artificial neural network capable of solving complex image classification tasks that comprises only experimentally-supported biological building blocks. (1/15)
May 27, 2025 at 6:40 PM
New #NeuroAI #compneurosky preprint! To better understand how target-directed learning works in the brain, we sought to engineer an artificial neural network capable of solving complex image classification tasks that comprises only experimentally-supported biological building blocks. (1/15)
Reposted by Hayley Bounds
We're now appreciating how the immune and nervous systems communicate across body & brain, and there's still more to explore!
Had a fun time co-writing this with some amazing immunologists and neuroscientists @nickmroz.bsky.social @arimolofskylab.bsky.social @annamolofskylab.bsky.social 😎🧠
Had a fun time co-writing this with some amazing immunologists and neuroscientists @nickmroz.bsky.social @arimolofskylab.bsky.social @annamolofskylab.bsky.social 😎🧠
Cross-regulation between the nervous system and type 2 immunity
The nervous and type 2 immune systems regulate each other via cytokines and neurotransmitters, suggesting previously unidentified therapeutic avenues.
www.science.org
May 23, 2025 at 11:28 PM
We're now appreciating how the immune and nervous systems communicate across body & brain, and there's still more to explore!
Had a fun time co-writing this with some amazing immunologists and neuroscientists @nickmroz.bsky.social @arimolofskylab.bsky.social @annamolofskylab.bsky.social 😎🧠
Had a fun time co-writing this with some amazing immunologists and neuroscientists @nickmroz.bsky.social @arimolofskylab.bsky.social @annamolofskylab.bsky.social 😎🧠