Guido Meijer
@guidomeijer.com
👨🔬 Neuroscientist at the Donders Institute in the Battaglia lab.
🧠 Previously: International Brain Laboratory
Using Neuropixels and virtual-reality to understand how the brain creates internal models of the world.
www.guidomeijer.com
🧠 Previously: International Brain Laboratory
Using Neuropixels and virtual-reality to understand how the brain creates internal models of the world.
www.guidomeijer.com
Pinned
Guido Meijer
@guidomeijer.com
· Aug 5
Serotonin drives choice-independent reconfiguration of distributed neural activity
Serotonin (5-HT) is a central neuromodulator which is implicated in, amongst other functions, cognitive flexibility. 5-HT is released from the dorsal raphe nucleus (DRN) throughout nearly the entire f...
doi.org
🚨Pre-print alert🚨
We stimulated serotonin with optogenetics while doing large-scale Neuropixel recordings across the mouse brain. We found strong widespread modulation of neural activity, but no effect on the choices of the mouse 🐭
How is this possible? Strap in! (1/9) 👇🧵
doi.org/10.1101/2025...
We stimulated serotonin with optogenetics while doing large-scale Neuropixel recordings across the mouse brain. We found strong widespread modulation of neural activity, but no effect on the choices of the mouse 🐭
How is this possible? Strap in! (1/9) 👇🧵
doi.org/10.1101/2025...
The Power Pixels pipeline just keeps getting better! The latest update comes with:
- OpenEphys support
- AP_Histology support
- automatic high-frequency noise reduction
- NWB format export option
- zarr compression of raw data
And, most importantly: a cool new logo!
github.com/NeuroNetMem/...
- OpenEphys support
- AP_Histology support
- automatic high-frequency noise reduction
- NWB format export option
- zarr compression of raw data
And, most importantly: a cool new logo!
github.com/NeuroNetMem/...
November 11, 2025 at 11:25 AM
The Power Pixels pipeline just keeps getting better! The latest update comes with:
- OpenEphys support
- AP_Histology support
- automatic high-frequency noise reduction
- NWB format export option
- zarr compression of raw data
And, most importantly: a cool new logo!
github.com/NeuroNetMem/...
- OpenEphys support
- AP_Histology support
- automatic high-frequency noise reduction
- NWB format export option
- zarr compression of raw data
And, most importantly: a cool new logo!
github.com/NeuroNetMem/...
Halloween isn’t my thing. My idea of a scary night is reading the plots of horror movies on Wikipedia.
October 31, 2025 at 9:16 AM
Halloween isn’t my thing. My idea of a scary night is reading the plots of horror movies on Wikipedia.
I never understood why everyone always complains about the clocks changing.
Then I had a kid.
Then I had a kid.
October 25, 2025 at 10:13 AM
I never understood why everyone always complains about the clocks changing.
Then I had a kid.
Then I had a kid.
Want to make publication-ready figures come straight from Python without having to do any manual editing? Are you fed up with axes labels being unreadable during your presentations? Follow this short tutorial including code examples! 👇🧵
October 16, 2025 at 8:26 AM
Want to make publication-ready figures come straight from Python without having to do any manual editing? Are you fed up with axes labels being unreadable during your presentations? Follow this short tutorial including code examples! 👇🧵
I was doing the second-to-last recording of my project and was happily thinking to myself that I haven't broken a single Neuropixel in the entire two year project.
You can guess what happened next...
Now I have to install a new probe just for one final recording 🙃
You can guess what happened next...
Now I have to install a new probe just for one final recording 🙃
October 8, 2025 at 10:37 AM
I was doing the second-to-last recording of my project and was happily thinking to myself that I haven't broken a single Neuropixel in the entire two year project.
You can guess what happened next...
Now I have to install a new probe just for one final recording 🙃
You can guess what happened next...
Now I have to install a new probe just for one final recording 🙃
I love how they came up with all this random stuff but for this one area they were like "I really don't know, just put a question mark"
October 5, 2025 at 10:40 AM
I love how they came up with all this random stuff but for this one area they were like "I really don't know, just put a question mark"
When I told my dad I published in Nature he was like "wow, you must have made a lot of money with that"
September 20, 2025 at 9:31 AM
When I told my dad I published in Nature he was like "wow, you must have made a lot of money with that"
I don't know why people say X is going down the drain, my last post got lovely replies like this one:
September 12, 2025 at 12:52 PM
I don't know why people say X is going down the drain, my last post got lovely replies like this one:
Reposted by Guido Meijer
Want to collaborate with the International Brain Laboratory on your own project? We have funding to work with groups anywhere in the world to do new large-scale projects and we are looking for new partners! Learn more and apply: www.internationalbrainlab.com/ibl-core-apply
September 11, 2025 at 12:27 PM
Want to collaborate with the International Brain Laboratory on your own project? We have funding to work with groups anywhere in the world to do new large-scale projects and we are looking for new partners! Learn more and apply: www.internationalbrainlab.com/ibl-core-apply
Reposted by Guido Meijer
Thrilled to share that our work is now published in Science! ✨
We found a preference for visual objects in the mouse spatial navigation system where they dynamically refine head-direction coding. In short, objects boost our inner compass! 🧭
www.science.org/doi/10.1126/...
🧵1/
We found a preference for visual objects in the mouse spatial navigation system where they dynamically refine head-direction coding. In short, objects boost our inner compass! 🧭
www.science.org/doi/10.1126/...
🧵1/
September 11, 2025 at 8:14 PM
Thrilled to share that our work is now published in Science! ✨
We found a preference for visual objects in the mouse spatial navigation system where they dynamically refine head-direction coding. In short, objects boost our inner compass! 🧭
www.science.org/doi/10.1126/...
🧵1/
We found a preference for visual objects in the mouse spatial navigation system where they dynamically refine head-direction coding. In short, objects boost our inner compass! 🧭
www.science.org/doi/10.1126/...
🧵1/
Reposted by Guido Meijer
If you're into podcasts, here's a good one on the @intlbrainlab.bsky.social brainwide map, by @newscientist.com
www.newscientist.com/podcasts/fir...
www.newscientist.com/podcasts/fir...
September 9, 2025 at 1:22 PM
If you're into podcasts, here's a good one on the @intlbrainlab.bsky.social brainwide map, by @newscientist.com
www.newscientist.com/podcasts/fir...
www.newscientist.com/podcasts/fir...
Reposted by Guido Meijer
Sad day for peope who still believe brain areas are the primary organizational units of function in the brain.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
A brain-wide map of neural activity during complex behaviour - Nature
The International Brain Laboratory presents a brain-wide electrophysiological map obtained from pooling data from 12 laboratories that performed the same standardized perceptual decision-making task i...
www.nature.com
September 4, 2025 at 11:17 AM
Sad day for peope who still believe brain areas are the primary organizational units of function in the brain.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Guido Meijer
The @intlbrainlab.bsky.social published 2 papers today on their work to create a map of neural activity across the entire mouse brain. Learn more about the lab: https://www.simonsfoundation.org/2025/02/20/how-do-our-brains-make-decisions-the-international-brain-laboratory-is-closing-in-on-answers/
How Do Our Brains Make Decisions? The International Brain Laboratory Is Closing In on Answers
How Do Our Brains Make Decisions? The International Brain Laboratory Is Closing In on Answers on Simons Foundation
www.simonsfoundation.org
September 3, 2025 at 6:10 PM
The @intlbrainlab.bsky.social published 2 papers today on their work to create a map of neural activity across the entire mouse brain. Learn more about the lab: https://www.simonsfoundation.org/2025/02/20/how-do-our-brains-make-decisions-the-international-brain-laboratory-is-closing-in-on-answers/
Reposted by Guido Meijer
The first complete activity map of a mammalian brain has revealed unprecedented insights into how decisions are made – and may even hint at the roots of intuition.
First map of mammal brain activity may have shown intuition in action
Scientists have mapped the activity that takes place across a mouse's entire brain as it decides how to complete a task - and the results could explain the origin of our gut feelings
www.newscientist.com
September 3, 2025 at 5:58 PM
The first complete activity map of a mammalian brain has revealed unprecedented insights into how decisions are made – and may even hint at the roots of intuition.
Extremely proud to have contributed to this monumental effort of recording the entire mouse brain, at cellular resolution, during complex behavior 🧠🐭
Two flagship papers from the International Brain Laboratory, now out in @Nature.com:
🧠 Brain-wide map of neural activity during complex behaviour: doi.org/10.1038/s41586-025-09235-0
🧠 Brain-wide representations of prior information in mouse decision-making: doi.org/10.1038/s41586-025-09226-1 +
🧠 Brain-wide map of neural activity during complex behaviour: doi.org/10.1038/s41586-025-09235-0
🧠 Brain-wide representations of prior information in mouse decision-making: doi.org/10.1038/s41586-025-09226-1 +
September 3, 2025 at 6:21 PM
Extremely proud to have contributed to this monumental effort of recording the entire mouse brain, at cellular resolution, during complex behavior 🧠🐭
PSA: don't buy duragel from Cambridge Neurotech, it's a scam! 🚨
They charge $200 (incl. shipping) for a 16 ml spout. But duragel is just DOWSIL 3-4680 (see paper below) of which you can buy a large container of 210 ml for only $110. That's 24 times cheaper! 💸
www.sciencedirect.com/science/arti...
They charge $200 (incl. shipping) for a 16 ml spout. But duragel is just DOWSIL 3-4680 (see paper below) of which you can buy a large container of 210 ml for only $110. That's 24 times cheaper! 💸
www.sciencedirect.com/science/arti...
Artificial dural sealant that allows multiple penetrations of implantable brain probes
This study reports extensive characterization of the silicone gel (3-4680, Dow Corning, Midland, MI), for potential use as an artificial dural sealant…
www.sciencedirect.com
August 29, 2025 at 10:00 AM
PSA: don't buy duragel from Cambridge Neurotech, it's a scam! 🚨
They charge $200 (incl. shipping) for a 16 ml spout. But duragel is just DOWSIL 3-4680 (see paper below) of which you can buy a large container of 210 ml for only $110. That's 24 times cheaper! 💸
www.sciencedirect.com/science/arti...
They charge $200 (incl. shipping) for a 16 ml spout. But duragel is just DOWSIL 3-4680 (see paper below) of which you can buy a large container of 210 ml for only $110. That's 24 times cheaper! 💸
www.sciencedirect.com/science/arti...
Duct tape and hope are literally the only two things holding my rig together
🚨 NEW #FoSci post. "You don't build a mission on duct tape and hope."
Our VP of #ResearchIntegrity, Dr Leslie McIntosh @mcintold.bsky.social, reflects on almost a year of Forensic Scientometrics and its discussion of trust in science & research.
🔗 Read now: fosci.substack.com/p/beyond-duc...
Our VP of #ResearchIntegrity, Dr Leslie McIntosh @mcintold.bsky.social, reflects on almost a year of Forensic Scientometrics and its discussion of trust in science & research.
🔗 Read now: fosci.substack.com/p/beyond-duc...
August 13, 2025 at 2:59 PM
Duct tape and hope are literally the only two things holding my rig together
August 6, 2025 at 11:05 AM
🚨Pre-print alert🚨
We stimulated serotonin with optogenetics while doing large-scale Neuropixel recordings across the mouse brain. We found strong widespread modulation of neural activity, but no effect on the choices of the mouse 🐭
How is this possible? Strap in! (1/9) 👇🧵
doi.org/10.1101/2025...
We stimulated serotonin with optogenetics while doing large-scale Neuropixel recordings across the mouse brain. We found strong widespread modulation of neural activity, but no effect on the choices of the mouse 🐭
How is this possible? Strap in! (1/9) 👇🧵
doi.org/10.1101/2025...
Serotonin drives choice-independent reconfiguration of distributed neural activity
Serotonin (5-HT) is a central neuromodulator which is implicated in, amongst other functions, cognitive flexibility. 5-HT is released from the dorsal raphe nucleus (DRN) throughout nearly the entire f...
doi.org
August 5, 2025 at 12:32 PM
🚨Pre-print alert🚨
We stimulated serotonin with optogenetics while doing large-scale Neuropixel recordings across the mouse brain. We found strong widespread modulation of neural activity, but no effect on the choices of the mouse 🐭
How is this possible? Strap in! (1/9) 👇🧵
doi.org/10.1101/2025...
We stimulated serotonin with optogenetics while doing large-scale Neuropixel recordings across the mouse brain. We found strong widespread modulation of neural activity, but no effect on the choices of the mouse 🐭
How is this possible? Strap in! (1/9) 👇🧵
doi.org/10.1101/2025...
Was watching Clarkson's Farm and kept wondering how AI was going to help them get calves only to realize it stands for artificial insemination
July 31, 2025 at 5:29 PM
Was watching Clarkson's Farm and kept wondering how AI was going to help them get calves only to realize it stands for artificial insemination
Just added Bombcell 💣 to the suite of automatic curation tools that's included in the Power Pixels pipeline! It runs Bombcell, UnitRefine and the IBL algorithm to classify which of your units are good single neurons. You can can then use one (or more!) of these to filter your units before analysis.
Do you do Neuropixel recordings and are you struggling with preprocessing? The Power Pixels pipeline is an easy-to-use pipeline from raw data to neural activity of single neurons in specified brain regions 🧠 Now on bioRxiv!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Power Pixels: a turnkey pipeline for processing of Neuropixel recordings
There are many open-source tools available for the processing of neuronal data acquired using Neuropixels probes. Each of these tools, focuses on a part of the process from raw data to single neuron a...
www.biorxiv.org
July 4, 2025 at 8:33 AM
Just added Bombcell 💣 to the suite of automatic curation tools that's included in the Power Pixels pipeline! It runs Bombcell, UnitRefine and the IBL algorithm to classify which of your units are good single neurons. You can can then use one (or more!) of these to filter your units before analysis.
Reposted by Guido Meijer
🚀 We are excited to share that bombcell is now available in Python! 🐍 Automatically sort your units into good/MUA/noise/non-somatic using quality metrics and interpretable & adjustable classification thresholds.
pip install and play around with our toy dataset:
🔗 github.com/Julie-Fabre/...
pip install and play around with our toy dataset:
🔗 github.com/Julie-Fabre/...
GitHub - Julie-Fabre/bombcell: Automated quality control, curation and neuron classification of spike-sorted electrophysiology data
Automated quality control, curation and neuron classification of spike-sorted electrophysiology data - Julie-Fabre/bombcell
github.com
June 13, 2025 at 6:55 PM
🚀 We are excited to share that bombcell is now available in Python! 🐍 Automatically sort your units into good/MUA/noise/non-somatic using quality metrics and interpretable & adjustable classification thresholds.
pip install and play around with our toy dataset:
🔗 github.com/Julie-Fabre/...
pip install and play around with our toy dataset:
🔗 github.com/Julie-Fabre/...
Do you do Neuropixel recordings and are you struggling with preprocessing? The Power Pixels pipeline is an easy-to-use pipeline from raw data to neural activity of single neurons in specified brain regions 🧠 Now on bioRxiv!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Power Pixels: a turnkey pipeline for processing of Neuropixel recordings
There are many open-source tools available for the processing of neuronal data acquired using Neuropixels probes. Each of these tools, focuses on a part of the process from raw data to single neuron a...
www.biorxiv.org
July 1, 2025 at 9:48 AM
Do you do Neuropixel recordings and are you struggling with preprocessing? The Power Pixels pipeline is an easy-to-use pipeline from raw data to neural activity of single neurons in specified brain regions 🧠 Now on bioRxiv!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
My daughter can now understand two words! When I say "clap" she claps her hands and when I say "shake" she shakes her head. Ten months of development and she's reached the level of intelligence of a dog.
June 19, 2025 at 5:10 AM
My daughter can now understand two words! When I say "clap" she claps her hands and when I say "shake" she shakes her head. Ten months of development and she's reached the level of intelligence of a dog.
Reposted by Guido Meijer
Officially announcing my new game:
GARBAGE COUNTRY.
A lonely road trip through the ruins of a forgotten world.
feat. vast wastelands, tower-defense battles, upgrades, mysteries, & lots of driving.
GARBAGE COUNTRY.
A lonely road trip through the ruins of a forgotten world.
feat. vast wastelands, tower-defense battles, upgrades, mysteries, & lots of driving.
June 8, 2025 at 8:53 PM
Officially announcing my new game:
GARBAGE COUNTRY.
A lonely road trip through the ruins of a forgotten world.
feat. vast wastelands, tower-defense battles, upgrades, mysteries, & lots of driving.
GARBAGE COUNTRY.
A lonely road trip through the ruins of a forgotten world.
feat. vast wastelands, tower-defense battles, upgrades, mysteries, & lots of driving.